James M. Wilson, MD, PhD
Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations
Contact information
125 S. 31st Street,
Suite 2000 TRL
Philadelphia, PA 19104-3403
Suite 2000 TRL
Philadelphia, PA 19104-3403
Office: 215-898-0226
Fax: 215-494-5444
Fax: 215-494-5444
Email:
wilsonjm@mail.med.upenn.edu
wilsonjm@mail.med.upenn.edu
Publications
Education:
B.A. (Chemistry)
Albion College, 1977.
Ph.D. (Biological Chemistry)
University of Michigan Medical School, 1984.
M.D.
University of Michigan Medical School, 1984.
Permanent linkB.A. (Chemistry)
Albion College, 1977.
Ph.D. (Biological Chemistry)
University of Michigan Medical School, 1984.
M.D.
University of Michigan Medical School, 1984.
Description of CVI Expertise
CVI Program Unit(s):Lipid / Atherosclerosis / CAD / ACS / Prevention
CVI Research Description:
1. Inherited disorders of lipid metabolism
2. Gene transfer to liver for treatment of dyslipidemias
3. The development of novel vectors to target heart for treatment of CAD and CHF
Selected Publications
Brantly, M. L., Chulay, J. D., Wang, L., Mueller, C., Humphries, M., Spencer, L. T., Rouhani, F., Conlon, T. J., Calcedo, R., Betts, M. R., Spencer, C., Byrne, B. J., Wilson, J. M., Flotte, T. R.: Sustained transgene expression despite T lymphocyte responses in a clinical trial of rAAV1-AAT gene therapy. Proc Natl Acad Sci U S A 2009.Limberis, M. P., Bell, C. L., Wilson, J. M.: Identification of the murine firefly luciferase-specific CD8 T-cell epitopes. Gene Ther 16(3): 441-7, 2009.
Limberis, M. P., Bell, C. L., Heath, J., Wilson, J. M.: Activation of Transgene-specific T Cells Following Lentivirus-mediated Gene Delivery to Mouse Lung. Mol Ther 2009.
Gao, G., Wang, Q., Calcedo, R., Mays, L., Bell, P., Wang, L., Vandenberghe, L. H., Grant, R., Sanmiguel, J., Furth, E. E., Wilson, J. M.: Adeno-Associated Virus-Mediated Gene Transfer to Nonhuman Primate Liver Can Elicit Destructive Transgene-Specific T Cell Responses. Hum Gene Ther 2009.
Flotte, T. R., Fischer, A. C., Goetzmann, J., Mueller, C., Cebotaru, L., Yan, Z., Wang, L., Wilson, J. M., Guggino, W. B., Engelhardt, J. F.: Dual Reporter Comparative Indexing of rAAV Pseudotyped Vectors in Chimpanzee Airway. Mol Ther 2009.
Fein, D. E., Limberis, M. P., Maloney, S. F., Heath, J. M., Wilson, J. M., Diamond, S. L.: Cationic Lipid Formulations Alter the In Vivo Tropism of AAV2/9 Vector in Lung. Mol Ther 2009.
Calcedo, R., Vandenberghe, L. H., Roy, S., Somanathan, S., Wang, L., Wilson, J. M.: Host immune responses to chronic adenovirus infections in human and nonhuman primates. J Virol 83(6): 2623-31, 2009.
Calcedo, R., Vandenberghe, L. H., Gao, G., Lin, J., Wilson, J. M.: Worldwide epidemiology of neutralizing antibodies to adeno-associated viruses. J Infect Dis 199(3): 381-90, 2009.
Breous, E., Somanathan, S., Wilson, J. M.: Identification of the immunodominant cytotoxic T-cell epitope of human alpha-1 antitrypsin. Gene Ther 16(11): 1380-2, 2009.
Breous, E., Somanathan, S., Vandenberghe, L. H., Wilson, J. M.: Hepatic regulatory T cells and Kupffer cells are crucial mediators of systemic T cell tolerance to antigens targeting murine liver. Hepatology 50(2): 612-21, 2009.