Penn Cardiovascular Institute

Penn Cardiovascular Institute Research Directory

faculty photo

James M. Wilson, MD, PhD

Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations

Contact information
125 S. 31st Street,
Suite 2000 TRL
Philadelphia, PA 19104-3403
Office: 215-573-9020
Fax: 215-494-5444
Education:
B.A. (Chemistry)
Albion College, 1977.
Ph.D. (Biological Chemistry)
University of Michigan Medical School, 1984.
M.D.
University of Michigan Medical School, 1984.
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Description of CVI Expertise

CVI Program Unit(s):
Lipid / Atherosclerosis / CAD / ACS / Prevention

CVI Research Description:
1. Inherited disorders of lipid metabolism
2. Gene transfer to liver for treatment of dyslipidemias
3. The development of novel vectors to target heart for treatment of CAD and CHF

Selected Publications

Tenney R, Bell C, Wilson JM: AAV8 capsid variable regions at the two-fold symmetry axis contribute to high liver transduction by mediating nuclear entry and capsid uncoating Virology 454-455: 227-236, April 2014.

Mays LE, Wang L, Lin J, Bell P, Crawford A, Wherry EJ, Wilson JM: AAV8 induces tolerance in murine muscle as a result of poor APC transduction, T cell exhaustion and minimal MHCI upregulation on target cells. Mol Ther 22(1): 28-41, Jan 2014.

Huang J, Li X, Coelho-dos-Reis JGA, Wilson JM, Tsuji M : An AAV Vector-Mediated Gene Delivery Approach Facilitates Reconstitution of Functional Human CD8+ T Cells in Mice. PLoS ONE 9(2), 2014.

Lock M, Alvira MR, Chen SJ, Wilson JM.: Absolute Determination of Single-Stranded and Self-Complementary AAV Vector Genome Titers by Droplet Digital PCR. Hum Gene Ther Methods Dec 2013 Notes: published on-line ahead of print (Feb 2014).

Mueller C, Chulay JD, Trapnell BC, Humphries M, Carey B, Sandhaus RA, McElvaney NG, Messina L, Tang Q, Rouhani FN, Campbell-Thompson M, Dongtao Fu A, Yachnis A, Knop DR, Ye G, Brantly M, Calcedo R, Somanathan S, Richman LP, Vonderheide RH, Hulme MA, Brusko TM, Wilson JM and Flotte TR: Human Treg responses allow sustained recombinant adeno-associated virus–mediated transgene expression. J Clin Invest 123(12): 5310-5318, Dec 2013.

Chen SJ, Sanmiguel J, Lock M, McMenamin D, Draper C, Limberis MP, Kassim SH, Somanathan S, Bell P, Johnston JC, Rader DJ, and Wilson JM: Bio-distribution of AAV8 vectors expressing human LDL receptor in a mouse model of homozygous familial hypercholesterolemia. Hum Gene Ther Clin Dev 24(4): 154-160, Dec 2013.

Faust SM, Bell P, Zhu Y, Sanmiguel J and Wilson JM: The Role of Apoptosis in Immune Hyporesponsiveness Following AAV8 Liver Gene Transfer. Molecular Therapy Oct 2013.

Mays LE, Wang L, Tenney R, Bell P, Nam HJ, Lin J, Gurda B, Van Vliet K, Mikals K, Agbandje-McKenna M, Wilson JM: Mapping the structural determinants responsible for enhanced T cell activation to the immunogenic adeno-associated virus capsid from isolate rhesus J Virol 87(17): 9473-85, Sept 2013.

Zhong L, Li S, Li M, Xie J, Zhang Y, Lee B, Batshaw ML, Wilson JM, Gao G: Vector sequences are not detected in tumor tissue from research subjects with ornithine transcarbamylase deficiency who previously received adenovirus gene transfer. Hum Gene Ther 24(9): 814-9, Sept 2013.

Calcedo R, Griesenbach U, Dorgan DJ, Soussi S, Boyd AC, Davies JC, Higgins TE, Hyde SC, Gill DR, Innes JA, Porteous DJ, Alton EW, Wilson JM, Limberis MP: Self-Reactive CFTR T Cells in Humans: Implications for Gene Therapy. Hum Gene Ther Clin Dev 24(3): 108-15, Sep 2013.

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Last updated: 03/19/2014
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