Foteini Mourkioti
Associate Professor of Orthopaedic Surgery
Co-Director, Penn Institute of Regenerative Medicine, Musculoskeletal Regeneration Program
Department: Orthopaedic Surgery
Graduate Group Affiliations
Contact information
McKay Orthopaedic Research Laboratory
377A Stemmler Hall
3450 Hamilton Walk
Philadelphia, PA 19104-6081
377A Stemmler Hall
3450 Hamilton Walk
Philadelphia, PA 19104-6081
Office: 215-898-8214
Fax: 215-573-2133
Lab: 215-573-3645
Fax: 215-573-2133
Lab: 215-573-3645
Email:
fmour@pennmedicine.upenn.edu
fmour@pennmedicine.upenn.edu
Publications
Links
Search PubMed for articles
Penn Institute of Regenerative Medicine
Penn Center for Musculoskeletal Disorders
The Pennsylvania Muscle Institute
Mourkioti Lab
Penn Cardiovascular Institute
McKay Orthopaedic Research Laboratory
Search PubMed for articles
Penn Institute of Regenerative Medicine
Penn Center for Musculoskeletal Disorders
The Pennsylvania Muscle Institute
Mourkioti Lab
Penn Cardiovascular Institute
McKay Orthopaedic Research Laboratory
Education:
BA (Biology)
University of Patras, Faculty of Biology, Greece, 1998.
PhD (Genetics and Developmental Biology)
Max-Planck Institute for Biophysical Chemistry, Department Molecular Developmental Biology, Goettingen, Germany, 2002.
BA (Biology)
University of Patras, Faculty of Biology, Greece, 1998.
PhD (Genetics and Developmental Biology)
Max-Planck Institute for Biophysical Chemistry, Department Molecular Developmental Biology, Goettingen, Germany, 2002.
Post-Graduate Training
Muscle Biology, Mouse Genetics and Heart Failure, European Molecular Biology Laboratory (EMBL), Mouse Biology Unit, Italy, 2003-2008.
Stem Cell Biology, Stanford University School of Medicine, Baxter Laboratory for Stem Cell Biology, Clinical Sciences Research Center, 2009-2009.
Permanent linkMuscle Biology, Mouse Genetics and Heart Failure, European Molecular Biology Laboratory (EMBL), Mouse Biology Unit, Italy, 2003-2008.
Stem Cell Biology, Stanford University School of Medicine, Baxter Laboratory for Stem Cell Biology, Clinical Sciences Research Center, 2009-2009.
Description of Itmat Expertise
stem cell biology, muscle diseases, muscle regeneration, muscular dystrophy, mechanobiology, piezo signaling, NF-kB, telomere biology, neuromuscular junction, muscle atrophyDescription of Research Expertise
Keywords: muscle stem cells, stem cell activation, muscle disorders, mechanobiology, aging, telomeres, NF-kB signaling, muscle regeneration, stem cell regulation, muscular dystrophy, cardiomyopathy, mitochondria, oxidative stress, M2 macrophages, muscle atrophy, muscle wasting.Selected Publications
Das S, Hilman MC, Yang F, Mourkioti F, Yang W, Cullen DK.: Motor neurons and endothelial cells additively promote development and fusion of human iPSC-derived skeletal myocytes. Skeletal Muscle 7(14), March 2024.Ma N., Mourkioti F: Ex vivo two-photon imaging of whole-mount skeletal muscles to visualize stem cell behavior. STAR Protocols 5(1): 1-14, December 2023.
Tichy ED, Lee JH, Li G, Estep KN, Johnson FB, Mourkioti F.: Impacts of radiation exposure, hindlimb unloading, and recovery on murine skeletal muscle cell telomere length. NPJ Microgravity July 2023 Notes: DOI : 10.1038/s41526-023-00303-1.
Bautista C.A., Srikumar A., Tichy E.D., Qian G., Jiang X., Qin L., Mourkioti F., Dyment N. CD206: CD206+ tendon resident macrophages and potential crosstalk with fibroblasts and the ECM during tendon growth and maturation. Front. Physiol., Sec. Skeletal Physiology 14, February 2023.
Ma N., Chen D., Lee, J.H., Kuri P., Hernandez E.B., Kocan B., Mahmood H., Tichy E.D., Rompolas P., Mourkioti F.: Piezo1 regulates the regenerative capacity of skeletal muscles via orchestration of stem cell morphological states. Science Advances. Science, 8(11): 1-14, March 2022.
Stanley A, Tichy ED, Kocan J, Roberts DW, Shore EM and Mourkioti F.: Dynamics of skeletal muscle-resident stem cells during myogenesis in fibrodysplasia ossificans progressiva NPJ Regenerative Medicine-Nature 7(1), January 2022 Notes: doi: 10.1038/s41536-021-00201-8.
Tichy ED, Mourkioti F. : Telomere length assessments of muscle stem cells in rodent and human skeletal muscle sections. STAR Protoc 2(4), September 2021 Notes: d10.1016/j.xpro.2021.100830.
Tichy ED, Ma N., Sidibe D., Loro E., Kocan J., Chen DZ., Khurana TS., Hasty P., Mourkioti F.: Persistent NF-κB activation in muscle stem cells induces proliferation-independent telomere shortening Cell Reports. Cell Press, 35(6), May 2021.
Lutian Yao, Elisia D. Tichy, Leilei Zhong, Sarthak Mohanty, Luqiang Wang, Emily Ai, Shuying Yang, Foteini Mourkioti1*, Ling Qin *: Gli1 defines a subset of fibroadipogenic progenitors that promote skeletal muscle regeneration with less fat accumulation. Journal of Bone and Mineral Research 36(6): 1159-1173, February 2021.
Suradip Das,, Kevin D. Browne, Franco A. Laimo, Joseph C. Maggiore, Melanie C. Hilman, Halimulati Kaisaier, Carlos A. Aguilar, Zarina S. Ali, Foteini Mourkioti, D. Kacy Cullen: Pre-Innervated Tissue Engineeried Muscle Promotes a Pro-Regenerative Microenvironment Following Volumetric Muscle Loss. Communications Biology-Nature 3(1), June 25 2020 Notes: doi: 10.1038/s42003-020-1056-4.