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Neil R. Malhotra, M.D.

Neil R. Malhotra, M.D.

faculty photo
Assistant Professor of Neurosurgery at the Hospital of the University of Pennsylvania
Department: Neurosurgery

Contact information
Department of Neurological Surgery
3rd Floor Silverstein Pavilion
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-615-5454
Fax: 215-349-5534
Lab: 215-662-6137 (Eileen Stewert)
Education:
BA (High Distinction Scholar)
University of Virginia, 1997.
MD (Doctor of Medicine)
University of Virginia, 2002.
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Description of Research Expertise

As Co-Director of the Translational Spinal Research Laboratory (TSRL), Dr. Malhotra's primary research interests focus on restorative approaches to treat disc degeneration. His novel approaches have led to multiple awards and research grants. Through his work, Dr. Malhotra hopes to reduce the need for spinal surgery and offer better treatments for disc degeneration. His interests focus on tissue engineering in order to develop treatments to restore native tissue mechanics of the spine while also delivering therapeutic agents and supporting tissue regeneration.

Description of Clinical Expertise

Dr. Malhotra is the Vice Chairman for Operations and Associate Program Director of the Department of Neurological Surgery at the University of Pennsylvania. He oversees strategic initiatives to enhance the quality of patient care. Dr. Malhotra has published more than 50 articles and book chapters related to his clinical and research work. Dr. Malhotra's work, along with that of his partners, has led to the University of Pennsylvania being the top rated neurosurgical department in the region for every year that the rankings have been completed. Further, the department is consistently ranked amongst the top 10 in the United States.

From a clinical standpoint, Dr. Malhotra provides expertise in the care of brain and spine neurological disorders. His clinical goals focus on optimizing quality of life as well as life expectancy for disorders of the nervous system. He takes particular interest in the development of advanced approaches to brain and spinal lesion treatment (such as meningioma) and spinal column reconstruction in addition to the treatment of cervical and lumbar disc herniation and spondylolisthesis. He is the first to have performed Endoscopic and Exoscopic Spinal Fusion Surgery (a less invasive form of spinal nerve decompression and fusion).

As director and creator of the Neurosurgery Quality Improvement Initiative Dr. Malhotra has developed a software system within the electronic medical record system to enhance disease management and predict response to therapy. His system, the EpiLog project, has completed beta testing and is now in use to enhance all patient care.

In 2011, Dr. Malhotra developed an outreach program in order to enhance and facilitate patient care. To support this program Dr. Malhotra sees patients in King of Prussia and Chestnut Hill, in addition to his primary site at the University of Pennsylvania.

Selected Publications

Nayak NR, Coats JM, Abdullah KG, Stein SC, Malhotra NR: Tracking Patient-Reported Outcomes in Spinal Disorders. Surg Neurol Int 8(6(Suppl 19)): S490-9, October 2015 Notes: 2015 Oct 8;6(Suppl 19):S490-9. doi: 10.4103/2152-7806.166892. eCollection 2015. PubMed PMID: 26605111; PubMed Central PMCID: PMC4617013.

Gorth DJ, Lothstein KE, Chiaro JA, Farrell MJ, Dodge GR, Elliott DM, Malhotra NR, Mauck RL, Smith LJ: Hypoxic Regulation of Functional Extracellular Matrix Elaboration by Nucleus Pulposus Cells in Long-Term Agarose Culture. J Orthop Res 33(5): 747-54, May 2015 Notes: doi: 10.1002/jor.22821. Epub 2015 Mar 8. PubMed PMID: 25640328; PubMed Central PMCID: PMC4408762.

Showalter BL, Elliott DM, Chen W, Malhotra NR: Evaluation of an In Situ Gelable and Injectable Hydrogel Treatment to Preserve Human Disc Mechanical Function Undergoing Physiologic Cyclic Loading Followed by Hydrated Recovery. J Biomech Eng 137(8), August 2015 Notes: 081008. doi: 10.1115/1.4030530. Epub 2015 Jun 16. PubMed PMID: 25950273; PubMed Central PMCID: PMC4476030.

Whitmore RG, Curran JN, Ali ZS, Mummaneni PV, Shaffrey CI, Heary RF, Kaiser MG, Asher AL, Malhotra NR, Cheng JS, Hurlbert J, Smith JS, Magge SN, Steinmetz MP, Resnick DK, Ghogawala Z: Predictive Value of 3-Month Lumbar Discectomy Outcomes in the NeuroPoint-SD. J Neurosurg Spine 23(4): 459-66, October 2015 Notes: doi: 10.3171/2015.1.SPINE14890. Epub 2015 Jul 3. PubMed PMID: 26140406.

Peck SH, O'Donnell PJ, Kang JL, Malhotra NR, Dodge GR, Pacifici M, Shore EM, Haskins ME, Smith LJ: Delayed Hypertrophic Differentiation of Epiphyseal Chondrocytes Contributes to Failed Secondary Ossification in Mucopolysaccharidosis VII Dogs. Mol Genet Metab 116(3): 195-203, November 2015 Notes: doi: 10.1016/j.ymgme.2015.09.008. Epub 2015 Sep 26. PubMed PMID: 26422116; PubMed Central PMCID: PMC4641049.

Malhotra NR: The Best Operation for Chronic Subdural Hematoma: A Decision Analysis (Best Scientific Poster Award). Pennsylvania Neurosurgical Society July 2008 Notes: Co-author list.

Lewis DJ, Attiah MA, Malhotra NR, Burnett MG, Stein SC: Anterior Surgical Management of Single-Level Cervical Disc Disease: A Cost-effectiveness Analysis Spine (Phila Pa 1976) 39(25): 2084-92, December 2014.

Showalter BL, Elliott DM, Chen W, Smith LJ, Malhotra NR: Hydrogel Implant Stabilizes Human Disc Mechanics Under Physiologic Cyclic Loading Following Nucleotomy. American Association of Neurological Surgeons May 2014.

Showalter BL, Milby AH, Haughan J, Mauck RL, Elliott DM, Malhotra NR, Schaer TP, Smith LJ: Percutaneous Delivery of Chondroitinase ABC for Initiation of Disc Degeneration in a Goat Model. American Association of Neurological Surgeons May 2014.

Smith LJ, Chiaro JA, O'Donnell P, Ponder KP, Malhotra NR, Elliott DM, Shore EM, Haskins ME: Effects of Neonatal Enzyme Replacement Therapy and Simvastatin Treatment on Cervical Spine Disease in Mucopolysaccharidosis I Dogs. Lysosomal Disease Network's World Symposium February 2014.

Chiaro JA, O'Donnell P, Malhotra NR, Ponder KP, Haskins ME, Smith LJ: Effects of Combined Enzyme Replacement Therapy and Simvastatin Treatment on Cervical Spine Intervertebral Disc Disease in Mucopolysaccharidosis I. Orthopedic Research Society March 2014.

Smith LJ, Chiaro JA, McKee KK, Mauck RL, Malhotra NR, Harfe BD: Deep Sequencing of Notochord-Derived Cells During Embryonic Formation of the Nucleus Pulposus. Orthopedic Research Society March 2014 Notes: Co-author list.

Milby AH, Showalter BL, Haughan J, Mauck RL, Elliott DM, Malhotra NR, Schaer TP, Smith LJ: Percutaneous Delivery of Chondroitinase ABC Induces Moderate Disc Degeneration in a Goat Model. Orthopedic Research Society March 2014.

Showalter BL, Amin DB, Marcozzi AN, Elliott DM, Malhotra NR: Injectable Hydrogel Treatment Stabilizes Human Disc Mechanical Function Under Physiologic Cyclic Loading. Orthopedic Research Society March 2014.

Malhotra NR, Chiaro JA, O’Donnell P, Ponder KP, Haskins ME, Smith LJ: Combined Neonatal Enzyme Replacement Therapy and Simvastatin for Treatment of Cervical Spine Intervertebral Disc Disease in Mucopolysaccharidosis I Dogs. American Association of Neurological Surgeons April 2014 Notes: Co-author list.

Lewis DJ, Malhotra NR, Burnett MG, Attiah MA, Bailey RL, Stein SC: Comparative Effectiveness of Anterior Cervical Discectomy (With and Without Fusion) and Arthroplasty in Single-Level Disc Disease: A Decision Analysis American Association of Neurological Surgeons April 2014.

Milby AH, Showalter BL, Haughan J, Mauck RL, Elliott DM, Malhotra NR, Schaer TP, Smith LJ: Percutaneous Delivery of Chondroitinase ABC Induces Moderate Disc Degeneration in a Goat Model. McKay Orthopedics Research Symposium June 2014.

Smith LJ, Chiaro JC, O'Donnell P, Ponder KP, Malhotra NR, Elliott DM, Shore EM, Haskins ME: Leveraging Simvastatin Treatment Along with Neonatal Enzyme Replacement Therapy to Improve Cervical Spine Disease in Mucopolysaccharidosis I Dogs. Mckay Orthopedics Research Symposium June 2014.

Malhotra NR, Grady MS: An EMR Embedded, Clinical Information Acquisition System Enhances Care, Research, and Quality Improvement. Neurosurgical Society of America June 2014 Notes: Co-author list. St. Andrews-by-the-Sea, New Brunswick, Canada.

Showalter BL, Elliott DM, Malhotra NR: Injectable Hydrogel Treatment Stabilizes Human Disc Range of Motion Under Physiologic Cyclic Loading (Special Oral Poster Presentation). The International Society for the Study of the Lumbar Spine (ISSLS) June 2014.

Malhotra NR, Lotier L, Becker W, Smith LJ: Using EpicCare ambulatory to support precision medicine, QI, and research. Epic International Physician Advisory Council September 2014 Notes: Co-author list.

Malhotra NR: Functional regeneration the human degenerative disc (Top Paper Award). Academy of Neurological Surgery September 2014 Notes: Co-author list.

Malhotra NR, Schuster JM, O’Rourke DM: Best of Both Worlds. Suburban Life, Main Line, Delaware County magazine. Author: Hengel A 5(10), June 2014.

Malhotra NR: Health-Real Life Drama: Neurosurgeon Saves Spinal Cord and a Patient Walks Again. CBS 3 Television News, Sweeps Week May 2014 Notes: Invited Television Broadcast Interview.

Stein SC, Malhotra NR, Burnett MG: Cost-Effectiveness Analysis. J Neurosurg Spine 20(4): 474, April 2014.

Kelz M, Malhotra NR: The Neurosurgical operative experience, a patients perspective. WHYY “The Pulse”, Host: Maiken Scott January 2014.

Lang SS, Malhotra NR: Interviewing for Pediatric Fellowship: Finding the Right Work-Work Balance. AANS Neurosurgeon 23(1), March 2014.

Lang SS, Chen HI, Koch MJ, Kurash L, McGill-Armento KR, Palella JM, Stein SC, Malhotra NR: Development of an Outpatient Protocol for Lumbar Discectomy. World Neurosurg S1878-8750(14): 00542-00547, June 2014 Notes: Standard Peer Review Process.

Chiaro JA, O'Donnell P, Shore EM, Malhotra NR, Ponder KP, Haskins ME, Smith LJ: Effects of Neonatal Enzyme Replacement Therapy and Simvastatin Treatment on Cervical Spine Disease in Mucopolysaccharidosis I Dogs. J Bone Miner Res 29(12): 2610-2617, December 2014.

Showalter BL, Malhotra NR, Vresilovic EJ, Elliott DM: Nucleotomy Reduces the Effects of Cyclic Compressive Loading with Unloaded Recovery on Human Intervertebral Discs. J Biomech 47(11): 2633-2640, August 2014.

Smith LJ, Gorth DJ, Showalter BL, Chiaro JA, Beattie EE, Elliott DM, Mauck RL, Chen, Malhotra NR: In Vitro Characterization of a Stem-Cell-Seeded Triple-Interpenetrating-Network Hydrogel for Functional Regeneration of the Nucleus Pulposus. Tissue Eng Part A 20(13-14): 1841-1849, July 2014.

Malhotra NR, Kosty J, Sanborn M, Bekisz JM, Mooncai TW, Neustein TM, Ou J, Zhu A, Bernstein A, Stein SC: Optimal Approach to Circumferential Decompression and Reconstruction for Thoracic Spine Metastatic Disease. Ann Surg Oncol 21(9): 2864-2872, September 2014.

Ghogawala Zoher, Shaffrey Christopher I, Asher Anthony L, Heary Robert F, Logvinenko Tanya, Malhotra NR, Dante Stephen J, Hurlbert R John, Douglas Andrea F, Magge Subu N, Mummaneni Praveen V, Cheng Joseph S, Smith Justin S, Kaiser Michael G, Abbed Khalid M, Sciubba Daniel M, Resnick Daniel K: The Efficacy of Lumbar Discectomy and Single-Level Fusion for Spondylolisthesis: Results from the NeuroPoint-SD Registry. Journal of Neurosurgery, Spine 19(5): 555-63, November 2013.

Gorth, DJ, Elliott, DM, Mauck RL, Chen, W, Smith, LJ, Malhotra NR: Mechanical Properties and Cyto-Compatibility of an Injectable Hydrogel Implant for Nucleus Pulposus Repair. Orthopedic Research Society January 2013.

Gorth DJ, Martin JT, Dodge GR, Hebela N, Malhotra NR, Mauck RL, Elliott DM, Smith LJ: In Vivo Delivery of IL-1ra from PLGA Microspheres Prevents IL-1b Induced Glycosaminoglycan Loss in the Rat Caudal Intervertebral Disc. ASME global conference for nano engineering for medicine and biology (NEMB) February 2013.

Sanborn MR, Malhotra NR, Carr B, Kalian M, Grady MS, Stein SC: Endovascular Interventions and Duty Hour Restrictions Drastically Reduce Aneurysm Clip Ligation Experience by US Trainees. SNIS International Endovascular Stroke Conference and Joint Cerebrovascular Section February 2013.

Gorth DJ, Martin JT, Elliott DM, Dodge GR, Malhotra NR, Mauck RL, Smith LJ: In Vivo Retention and Bioactivity of IL-1RA Microspheres in the Rat Caudal Intervertebral Disc. International Society for the Study of the Lumbar Spine May 2013.

Shaffrey CI, Smith JS, Mummaneni PV, Ziewacz J, Cheng JS, Whitmore RG, Ghogawala Z, Malhotra NR, Magge S, Asher AL, Resnick D, Knightly J, Kaiser M, Abbed K, Heary RF: Establishing the Efficacy of Lumbar Discectomy and Single Level Fusion for Spondylolisthesis -Experience with the AANS’ NeuroPoint SD Registry. International Meeting on Advanced Spine Techniques (IMAST) July 2013 Notes: Co-author list.

Smith LJ, Chiaro JC, Ponder KP, Malhotra NR, Elliott DM, Shore EM, Haskins ME: Neonatal Enzyme Replacement Therapy Attenuates Vertebral Bone Disease in the Cervical Spines of Mucopolysaccharidosis I Dogs (Young Investigator Award winner). American Society for Bone and Mineral Research October 2013 Notes: Co-author list.

Smith LJ, Chiaro JA, McKee KK, Mauck RL, Malhotra NR, Harfe BD: Deep Sequencing of Notochord-Derived Cells During Embryonic Formation of the Nucleus Pulposus: Preliminary Findings. International Philadelphia Spine Research Symposium November 2013 Notes: Co-author list.

Chiaro JC, O'Donnell P, Shore EM, Malhotra NR, Elliott DM Ponder KP, Haskins ME, Smith LJ : Neonatal Enzyme Replacement Therapy Attenuates Cervical Spine Bone and Disc Disease in Mucopolysaccharidosis I Dogs. International Philadelphia Spine Research Symposium November 2013.

Showalter BL, Amin DB, Marcozzi AN, Elliott DM, Malhotra NR: Injectable Hydrogel Treatment Stabilizes Human Disc Mechanical Function Under Physiologic Cyclic Loading. Penn Center for Musculoskeletal Disorders Symposium November 2013 Notes: Co-author list.

Showalter BL, Elliott DM, Malhotra NR: Hydrogel Implant Restores Human Disc Mechanics Under Physiologic Cyclic Loading Following Nucleotomy. International Philadelphia Spine research Society November 2013 Notes: Co-author list.

Milby AH, Attiah M, Massey P, Malhotra NR, Stein SC: Surgical Management of Cervical Myelopathy Due to Ossification of the Posterior Longitudinal Ligament: a Decision Analysis. Cervical Spine Research Society December 2013 Notes: Co-author list.

Malhotra NR: New Options for Brain and Spinal Conditions. Chestnut Hill Local August 2013 Notes: Invited Newspaper Interview.

Malhotra NR: The Effect of July Admission on Inpatient Outcomes Following Spinal Surgery. Medscape Neurology January 2013 Notes: Invited Editorial. McDonald JS, Clarke MJ, Helm GA, Kallmes DF.

Malhotra NR: Improving Surgical Care of the Spinal Disorders: The Osteoporotic Spine. J Osteopor Phys Act June 2013 Notes: Invited Editorial.

Nestorovski D, Milby AH, Pallavi G, Smith LJ, Smith HE, Malhotra NR: Combined Treatment Approach for Rare Occipito-Cervical Spinal Lesions: Leiomyosarcoma. J Spine Neurosurg S1(003): doi: 10.4172/2325-9701.S1-003, July 2013 Notes: Internet-Only Publication. Standard Peer Review Process.

Bohman LE, Stephen JH, Ramakrishna R, Schuster JM, Malhotra NR : Postoperative Ambulatory Status Predicts Survival in Patients with Glioblastoma Multiforme. J Spine Neurosurg S1(001): doi:10.4172/2325-9701.S1-001, May 2013 Notes: Internet-Only Publication. Standard Peer Review Process.

Ali Z, Barkley A, Malhotra NR : Acute Spinal Subdural Hematoma Subsequent To Posterior Lumbar Fusion. J Osteopor Phys 1(1): doi: 10.4172/2329-9509.1000101, March 2013 Notes: Internet-Only Publication. Standard Peer Review Process.

Chen HI, Lang SS, Coyne TM, Malhotra NR, Schuster JM: Intramedullary Spinal Sarcoidosis Masquerading as Cervical Stenosis. World Neurosurgery 80(6): 375-380, December 2013 Notes: Standard Peer Review Process.

Clement RC, Carr BG, Kallan MJ, Wolff C, Reilly PM, Malhotra NR: Volume-Outcome Relationship in Neurotrauma Care. Journal of neurosurgery 118(3): 687-93, March 2013.

Macyszyn L, Lega B, Bohman LE, Latefi A, Smith MJ, Malhotra NR, Welch WC, Grady MS: Implementation of a Departmental Picture Archiving and Communication System: a Productivity and Cost Analysis. Neurosurgery 73(3): 528-33, September 2013.

Syre P, Petrov D, Malhotra NR: Management of Upper Cervical Spine Injuries (Invited Review). Journal of Neurosurgical Sciences 57(3): 219-40, September 2013.

Syre Peter, Rodriguez-Cruz Leonardo, Desai Rajiv, Greene Karl A, Hurst Robert, Schuster James, Malhotra NR, Marcotte Paul: Civilian Gunshot Wounds to the Atlantoaxial Spine: a Report of 10 Cases Treated Using a Multidisciplinary Approach. Journal of Neurosugery, Spine 19(6): 759-766, September 2013.

Sanborn MR, Thawani JP, Whitmore RG, Shmulevich M, Hardy B, Benedetto C, Malhotra NR, Marcotte P, Welch W, Dante S, Stein SC: Cost-Effectiveness of Confirmatory Techniques for the Placement of Lumbar Pedicle Screws. Neurosurgical Focus 33(1): E12, July 2012 Notes: Standard Peer Review Process.

Ghogawala Z, Shaffrey CI, Asher AL, Malhotra NR, Dante SJ, Hurlbert RJ, Douglas AF, Magge SN, Mummaneni PV, Cheng JS, Smith JS, Kaiser MG, Heary RF, Abbed KM, Sciubba DM, and Resnick DK: The Design and Development of the Neuropoint SD Spine Registry for Lumbar Discectomy and Single Level Fusion for Spondylolisthesis. AANS/CNS Section on Disorders of the Spine and Peripheral Nerves March 2012 Notes: Co-author list.

Ghogawala Z, Shaffrey CI, Asher AL, Malhotra NR, Dante SJ, Hurlbert RJ, Douglas AF, Magge SN, Mummaneni PV, Cheng JS, Smith JS, Kaiser MG, Heary RF, Abbed KM, Sciubba DM, Resnick DK: The Efficacy of Lumbar Discectomy and Single Level Fusion for Spondylolisthesis: Neuropoint SD Registry Results. American Association of Neurological Surgeons April 2012 Notes: Co-author list.

Clement RC, Kallan MJ, Carr BG, Reilly PM, Malhotra NR: Neurotrauma: Who Should Treat and Who Should Transfer? American Association of Neurological Surgeons May 2012.

McGill-Aremento K, Palella JM, Pasao NP, Gardiner D, Chen HI, Rupich K, Maloney E, Malhotra NR: Lumbar Discectomy Surgery as an Outpatient Procedure: A Paradigm Shift. American Association of Nurse Practitioners June 2012.

Showalter BL, MacLean IS, Elliott DM, Malhotra NR: Nucleotomy Alters Mechanical Function Following Cyclic Loading and Unloaded Recovery of Human Discs. American Society of Mechanical Engineering June 2012 Notes: Co-author list.

Koch M, Chen I, Lang SS, Mcgill-Armento K, Palella J, Pasao N, Malhotra NR: Initial Experience with Outpatient One-Level Lumbar Discectomy. Pennsylvania Neurosurgical Society July 2012 Notes: Co-author list.

Sanborn MR, Pisapia J, Carr M, Stein SC, Grady MS, Malhotra NR: Resident Training: The Impact of Duty Hours and the Rise of Endovascular Neurosurgery on Resident Operative Experience. Pennsylvania Neurosurgical Society July 2012 Notes: Co-author list.

Smith LJ, Gorth DJ, Chiaro JA, Martin JT, Dodge GR, Malhotra NR, Hebela NM, Mauck RL, Elliott DM: Targeting Inflammation in Intervertebral Disc Degeneration. International Symposium on Nanomedicine in Drug Delivery and Cancer Diagnosis August 2012 Notes: Co-author list.

Showalter BL, Malhotra NR, Elliott DM: Nucleotomy Alters Mechanical Response of Human Discs Undergoing Cyclic Loading and Hydrated Recovery. Philadelphia Spine Symposium November 2012 Notes: Co-author list.

Gorth DJ, Elliott DM, Mauck RL, Chen W, Smith LJ, Malhotra NR: Mechanical Properties and Cyto-Compatibility of an Injectable Hydrogel Implant for Nucleus Pulposus Repair. Philadelphia Spine Symposium November 2012.

Sanborn M, Smith LJ, Malhotra NR: Spinal Cord and Spinal Column. The Trauma Manual: Trauma and Acute Care Surgery 4th Edition. Peitzman AB, Yealy DM, Fabian TC, Rhodes M, Schwab CW (eds.). Lippincott Williams and Wilkins of Wolters Kluwer Health. ISBN-10: 1451116799; ISBN-13: 978-1451116793, December 2012 Notes: Chapter 25.

Clement RC, Carr BG, Kallan MJ, Wolff C, Reilly PM, Malhotra NR: Volume-Outcome Relationship in Neurotrauma Care. J Neurosurg December 2012 Notes: PODCAST.

Malhotra NR, Whitmore R, Smith LJ, Welch WC, Schuster JM, Marcotte P, Dante S, Arlet V, Brem S, Grady MS: Future Directions in Spine: An Opportunity to Accelerate Quality Improvement. J Spine Neurosurg 1(2): doi: 10.4172.2325-9701.1000e105, October 2012.

Sanborn MR, Abdullah K, Smith MJ, Grady MS, Malhotra NR: Improving Core Residency Education: An Argument for Increased Incorporation of Endovascular Surgical Training. AANS Neurosurgeon 21(4), August 2012.

Bohman LE, Malhotra NR: The Value of an “Infolded” Fellowship. AANS Neurosurgeon 21(3), July 2012.

Macyszyn L, Malhotra NR: Counterpoint: The Intensivist is in Charge. AANS Neurosurgeon 21(3), March 2012.

Hwang SW, Malhotra NR, Shaffrey CI, Samdani AF: Intraoperative Neurophysiological Monitoring in Spine Deformity Surgery (Invited Review). Spine Deformity Page: DOI:/10.1016/j.jspd.2012.05.006, September 2012 Notes: Internet-Only Publication

Lang SS, Schuster JM, Smith LJ, Dwyer-Joyce L, Welch W, Marcotte P, Winkelstein B, Malhotra NR : Hemorrhage into Synovial Cysts as a Cause of Acute Radicular Symptoms. J Spine Neurosurg 2(1): doi:10.4172/2325-9701.1000106, December 2012 Notes: Internet-Only Publication. Standard Peer Review Process.

Malhotra NR, Han WM, Beckstein J, Cloyd J, Chen W, Elliott DM: An Injectable Nucleus Pulposus Implant Restores Compressive Range of Motion in the Ovine Disc. Spine 37(18): E1099-105, August 2012.

O'Connell Grace D, Malhotra Neil R, Vresilovic Edward J, Elliott Dawn M: The Effect of Nucleotomy and the Dependence of Degeneration of Human Intervertebral Disc Strain in Axial Compression. Spine 36(21): 1765-1771, October 2011.

Malhotra NR, Han W, Beckstein J, Cloyd J, Chen W, Elliott DM: An injectable Nucleus Pulposus Implant to Restore Spinal Range of Motion in Compression. Orthopeadic Research Society January 2011.

Gerasimowicz KM, Yoder JH, Tustison NJ, Song G, O’Connell G, Malhotra NR, Vresilovic EJ, Wright AC, Gee JC, Elliott DM: Optimization of Image Registration and Application to Human Disc Mechanics with Nucleotomy. Northeast Bioengineering April 2011 Notes: Co-author list.

Schuster JM, Malhotra NR: Posterior Thoracic Instrumentation. Youmans Neurological Surgery. Ed 6. Winn HR (Ed) (eds.). Saunders. Philadelphia, PA, USA. Page: 3061-3068, 2011, Page: 3061-3068, October 2011 Notes: Chapter 301.

Malhotra NR: Costotransversectomy and Corpectomy for Solitary Spinal Metastases. Pennsylvania Neurosurgical Society Clinical Education and Guidelines October 2011.

Malhotra NR: Medical Breakthrough: Spinal Surgery Today. XM National Radio-ReachMD August 2011 Notes: Radio Interview with Dr. Lee Freedman. XM National Radio-ReachMD XM167: The Channel for Medical Professionals.

Wendell LC, Khan A, Raser J, Lang SS, Malhotra NR, Kofke WA, LeRoux P, Park S, Levine JM.: Successful Management of Refractory Intracranial Hypertension from Acute Hyperammonemic Encephalopathy in a Woman with Ornithine Transcarbamylase Deficiency. Neurocrit Care 13(1): 113-117, August 2010 Notes: Standard Peer Review Process.

Welch WC, Tambi V, Sestokas AK, Dante SJ, Malhotra NR, Schwartz DM: Neurophysiological Detection and Reversal of Evolving Ishemic Injury During da Vinci Robot Assisted Anterior Lumbar Spinal Surgery. BIT World Congress January 2010 Notes: Co-author list.

Malhotra NR, Bhomick D, Hardesty D, Whitfield P: Intramedullary Spinal Cord Tumors: Diagnosis, Treatment and Outcomes (Invited Review). Advances in Clinical Neuroscience and Rehabilitation (ACNR) 10(4): 21-26, September 2010.

Lega BC, Danish SF, Malhotra NR, Sonnad SS, Stein SC: Choosing the Best Operation for Chronic Subdural Hematoma: a Decision Analysis. Journal of Neurosurgery 113(3): 615-21, September 2010.

Malhotra NR, Shaffrey CI: Intraoperative Electrophysiological Monitoring in Spine Surgery (Invited Review). Spine 35(25): 2167-79, December 2010.

Chen HI, Malhotra NR, Oddo M, Heuer GG, Levine JM, LeRoux PD: Barbiturate Infusion for Intractable Intracranial Hypertension and its Effect on Brain Oxygenation. Neurosurgery 63(5): 880-6, November 2008.

Heuer GG, Grant R, Shiveindra J, Malhotra NR, Whitmore R, Storm P, Schuster J: Expandable Cages for the Treatment of High Thoracic Lesions. Pennsylvania Neurosurgical Society July 2008.

Malhotra NR, Cloyd J, Beckstein J, Chen W, Elliott DM: An In-Situ Polymerizing Hydrogel to Mimic Nucleus Pulposus Ex Vivo and In Vitro. (Society Scientific Paper of the Year Award). Pennsylvania Neurosurgical Society July 2008 Notes: Co-author list.

Heuer GG, Grant RA, Jeyamohan S, Malhotra NR, Whitmore RG, Storm PB, Schuster J: Treatment of High Thoracic Lesions via an Entirely Posterior Approach with Placement of Expandable Cages. Congress of Neurological Surgeons September 2008.

O’Connell GD, Vresilovic EJ, Malhotra NR, Elliott DM: Discectomy Increases Internal Strains of the Disc Under Physiological Loads. The International Society for the Study of the Lumbar Spine (ISSLS) May 2009.

Plaha P, Malhotra NR, Heuer G, Whitfield P: Management of Chronic Subdural Hematoma (Invited Review). Advances in Clinical Neuroscience and Rehabilitation (ACNR) 8(5): 12-15, November 2008.

Espinoza Orías AA, Malhotra NR, Elliott DM: Rat Disc Torsional Mechanics: Effect of Lumbar and Caudal Levels and Axial Compression Load. The Spine Journal : official journal of the North American Spine Society 9(3): 204-9, March 2009.

Malhotra NR, Grady MS: Anterior Cervical Foraminotomy Technique. Spine Surgery: Tricks of the Trade, 2nd ed. Vacaro AR (eds.). Thieme Medical Publishers, Inc. Page: 54-56, October 2009 Notes: Chapter 15.

Thomas P, Malhotra NR, Grady MS: Injury to the Spinal Cord. Trauma: Contemporary Principles and Therapy. Flint, L., Meredith, W., Schwalb, W., Taheri, P., Trunkey, D. (Ed.) (eds.). Lippincott Williams & Wilkins, Philadelphia, PA, Page: 289-297, October 2008 Notes: Chapter 27.

Malhotra NR, Thomas P, Grady MS: Injury to the Spine. Trauma: Contemporary Principles and Therapy. Flint L, Meredith JW, Schwalb CW, Trunkey DD, Rue LW, Taheri PA (eds.). Lippincott Williams & Wilkins, Philadelphia, PA, Page: 297-304, October 2008 Notes: Chapter 28.

Malhotra NR, Whitfield P: Review of “The Legacy of Harvey Cushing” Advances in Clinical Neuroscience and Rehabilitation (ACNR) 8(3), November 2008.

Cloyd JM, Malhotra NR, Weng L, Chen W, Mauck RL, Elliott DM: Material Properties in Unconfined Compression of Human Nucleus Pulposus, Injectable Hyaluronic Acid-Based Hydrogels and Tissue Engineering Scaffolds. European Spine Journal 16(11): 1892-8, November 2007.

Malhotra NR, Cloyd J, Beckstein J, Chen W, Elliott DM: Reversing Disc Degeneration via Restoration of Nucleus Pulposus Functional Mechanics. Pan Philadelphia Neuroscience Meeting January 2007 Notes: Co-author list.

Cloyd J, Malhotra NR, Weng L, Chen W, Mauck RL, Elliott D: Defining Unconfined Compression Modulus and Poisson’s Ratio for Human Nucleus Pulposus & Potential Nucleus Replacement Materials. Orthopedic Research Society February 2007.

Malhotra NR, Cloyd J, Beckstein J, Chen W, Elliott DM: A Novel Injectable Nucleus Pulposus Implant Restores Range of Motion. The Spine Arthroplasty Society May 2007.

Malhotra NR, Beckstein J, Cloyd J, Chen W, Elliott DM: Restoration of Nucleus Pulposus Functional Mechanics via a Novel Injectable Implant. International Society for the Study off The Lumbar Spine (ISSLS) June 2007.

Heuer GG, Jeyamohan S, Malhotra NR, Zaghloul KA, Magge SN, Storm PB: Use of Expandable Cages in Pediatric Lumbar Burst Fractures. Pennsylvania Neurosurgical Society July 2007.

Malhotra NR, Beckstein J, Cloyd J, Chen W, Elliott DM: An In-situ Polymerizing Hydrogel to Mimic Nucleus Pulposus Ex Vivo and In Vitro. International Meeting on Advanced Spinal Techniques (IMAST) July 2007 Notes: Co-author list.

Heuer GG, Magge SN, Jeyamohan S, Malhotra NR, Zaghloul KA, Storm PB: Use of Expandable Cages in Pediatric Lumbar Burst Fractures. Congress of Neurological Surgeons September 2007.

Malhotra NR, Beckstein J, Cloyd J, Chen W, Elliott DM: Criteria and Design Approach for Tissue Engineered Nucleus Pulposus Implants for Degenerative Disc Disease. Congress of Neurological Surgeons September 2007.

Chen I, Malhotra NR, Levine J, LeRoux PD: Barbiturate Infusion and Cerebral Oxygenation. Congress of Neurological Surgeons October 2006.

Malhotra NR, Huang J, Schuster J: Hemorrhage Into Synovial Cysts as a Cause of Acute Radicular Symptoms. AANS/CNS Section on disorders of the Spine and Peripheral Nerves March 2006.

Ramakrishna R, Malhotra NR, Burnett M, Maloney E, Schuster S: Survival in Patients with Glioblastoma Multiforme as a Function of Post-Operative Ambulation Status. American Association of Neurological Surgeons April 2006.

Chen I, Malhotra NR, Levine J, LeRoux PD: Effect of Barbiturate Infusion on Cerebral Oxygenation Pennsylvania Neurosurgical Society July 2006 Notes: Co-author list.

Malhotra NR, Cloyd J, Beckstein J, Chen W, Elliott DM: Injectable Hydrogels to Support Nucleus Pulposus Function: Implant Design. Pennsylvania Neurosurgical Society July 2006 Notes: Co-author list.

Boockvar JA, Stiefel M, Malhotra NR, Dolinskas C, Dwyer-Joyce C, LeRoux PD: Dural Cavernous Angioma of the Posterior Sagittal Sinus Surg Neurol 63(2): 178-181, February 2005.

Gaston B, Ratjen F, Vaughan JW, Malhotra NR, Canady RG, Snyder AH, Hunt JF, Gaertig S, Goldberg JB: Nitrogen Redox Balance in the Cystic Fibrosis Airway: Effects of Antipseudomonal Therapy. Am J Respir Crit Care Med 165(3): 387-90, February 2002.

Hunt JF, Erwin E, Palmer L, Vaughan J, Malhotra NR, Platts-Mills TA, Gaston B: Expression and Activity of pH-Regulatory Glutaminase in the Human Airway Epithelium. Am J Respir Crit Care Med 165(1): 101-7, January 2002.

Hunt JF, Fang K, Malik R, Snyder A, Malhotra NR, Platts-Mills TA, Gaston B: Endogenous Airway Acidification. Implications for Asthma Pathophysiology. Am J Respir Crit Care Med 161(3 part 1): 694-9, March 2000.

Stiefel M, Spiotta A, Gracias V, Heuer GG, Danish S, Magge S, Malhotra NR, Jackson E, Zaghloul K, Maloney E, Grady MS, Leroux PD: Brain Tissue Oxygen-Guided Management Reduces Mortality in Traumatic Brain Injury. Neurocritical Care Society February 2005.

Malhotra NR, Spiotta A, Jackson E, Maloney-Wilensky E, LeRoux P: Effects of DVT prophylaxis of Cerebral Oxygenation. Pennsylvania Neurosurgical Society August 2004 Notes: Co-authors listed.

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Last updated: 02/03/2016
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