Perelman School of Medicine at the University of Pennsylvania

Brady Lab

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  1. Brady, D.C.*, Crowe, M. S.*, Greenberg, D.N. & Counter, C.M. Copper chelation inhibits BRAFV600E-driven melanomagenesis and counters resistance to BRAFV600E and MEK1/2 inhibitors. Cancer Research In Press, 2017.   
  2. Rebecca, V.W.*, Nicastri, M.C.*, McLaughlin, N., Fennelly, C., Mcafee, Q.W., Ronghe, A., Nofal, M., Lim, C.Y., Witze, E.S., Chude, C.I., Zhang, G., Alicea, G.M., Piao, S., Murugan, S., Ojha, R., Levi, S., Wei, Z., Barber-Rotenberg, J., Murphy, M.E., Dr. Mills, G.B., Lu, Y., Rabinowitz, J.D., Marmorstein, R., Liu, Q., Liu, S., Xu, X., Herlyn, M., Zoncu, R., Brady, D.C., Speicher, D.W., Winkler, J.D.*, & Amaravadi, R.K.* A unified approach to targeting the lysosome's degradative and growth signaling roles. Cancer Discov In Press, 2017.
  3. Sammons, S., Brady, D.C., Vahdat, L.T., & Salama, A.K.S. Copper suppression as a cancer therapy: the rationale for copper chelating agents in BRAFV600 mutated melanoma. Melanoma Management 3(3): 207-216, Sep 2016.  
  4. Chen, H.Y., Brady, D.C., & Villanueva, J. Double Trouble: Kinase domain duplication as a new path to drug resistance. Pigment Cell Melanoma Research 29(5): 493-495, Sep 2016. 
  5. Brady D.C., Crowe M.S., Turski M.L., Hobbs G.A., Yao X., Chaikuad A., Knapp S., Xiao K., Campbell S.L., Thiele D.J., Counter C.M. Copper is required for oncogenic BRAF signalling and tumorigenesis. Nature 509(7501): 492-496, May 2014.
  6. Turski M.L.*, Brady D.C.*, Kim H.J., Kim B.E., Nose Y., Counter C.M., Winge D.R., Thiele D.J. A novel role for copper in Ras/mitogen-activated protein kinase signaling. Molecular and Cellular Biology 32(7): 1284-1295, Apr 2012.
  7. Kashatus D.F., Lim K.H., Brady D.C., Pershing N.L.K., Cox A.D., Counter C.M. RALA and RALBP1 regulate mitochondrial fission at mitosis. Nature Cell Biology 13(9): 1108-1115, Sep 2011.
  8. Zipfel P.A., Brady D.C., Kashatus D.F., Ancrile B.D., Tyler D.S.*, Counter C.M.*. Ral activation promotes melanomagenesis. Oncogene 29(34): 4859-4864, Aug 2010.
  9. Lim K.H.*, Brady D.C.*, Kashatus D.F., Ancrile B.B., Der C.J., Cox A.D.*, Counter C.M.*. Aurora-A phosphorylates, activates, and relocalizes the small GTPase RalA. Molecular and Cellular Biology 30(2): 508-523, Jan 2010.
  10. O'Hayer K.M., Brady D.C., Counter C.M. ELR+ CXC chemokines and oncogenic Ras-mediated tumorigenesis. Carcinogenesis 30(11): 1841-1847, Nov 2009.
  11. Madigan J.P., Bozeman B.O., Brady D.C., Dewar B.J., Keller P.J., Lieges M., Philips M.R., Ridley A.J., Der C.J., Cox A.D. Regulation of Rnd3 localization and function by protein kinase C alpha-mediated phosphorylation. The Biochemical Journal 424(1): 153-161, Nov 2009.
  12. Brady D.C., Alan J.K., Madigan J.P., Fanning A.S., Cox A.D. The transforming Rho family GTPase Wrch-1 disrupts epithelial cell tight junctions and epithelial morphogenesis. Molecular and Cellular Biology 29(4): 1035-1049, Feb 2009

*shared first author or shared corresponding author