Perelman School of Medicine at the University of Pennsylvania

Brady Lab

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*shared first author or #shared corresponding author 

  1. Sadeghi R.S., Kulej, K., Kathayat, R.S., Garcia, B.A., Dickinson, B.C., Brady, D.C.#, & Witze, E.S.# Wnt5a Signaling Induced Phosphorylation Increases Acyl Protein Thioesterase 1 Activity and Promotes Melanoma Metastatic Behavior.  Elife In Press (2018). 
  2. Brady, D.C.*#, Crowe, M. S.*, Greenberg, D.N. & Counter, C.M.# Copper chelation inhibits BRAFV600E-driven melanomagenesis and counters resistance to BRAFV600E and MEK1/2 inhibitors. Cancer Res 77, 6240-6252 (2017).   
  3. Rebecca, V.W.*, Nicastri, M.C.*, McLaughlin, N., Fennelly, C., Mcafee, Q.W., Ronghe, A., Nofal, M., Lim, C.Y., Witze, E.S., Chude, C.I., Zhang, G., Alicea, G.M., Piao, S., Murugan, S., Ojha, R., Levi, S., Wei, Z., Barber-Rotenberg, J., Murphy, M.E., Dr. Mills, G.B., Lu, Y., Rabinowitz, J.D., Marmorstein, R., Liu, Q., Liu, S., Xu, X., Herlyn, M., Zoncu, R., Brady, D.C., Speicher, D.W., Winkler, J.D.#, & Amaravadi, R.K.# A unified approach to targeting the lysosome's degradative and growth signaling roles. Cancer Discov 7,1266-1283 (2017)
  4. Sammons, S., Brady, D.C., Vahdat, L.T., & Salama, A.K.S. Copper suppression as a cancer therapy: the rationale for copper chelating agents in BRAFV600 mutated melanoma. Melanoma Manag 3, 207-216, (2016).  
  5. Chen, H.Y., Brady, D.C., & Villanueva, J. Double Trouble: Kinase domain duplication as a new path to drug resistance. Pigment Cell Melanoma Res 29, 493-495 (2016).
  6. Brady, D. C., Crowe, M. S., Turski, M. L., Hobbs, G. A., Yao, X., Chaikuad, A., Knapp, S., Xiao, K., Campbell, S. L., Thiele, D. J. & Counter, C. M. Copper is required for oncogenic BRAF signalling and tumorigenesis. Nature 509, 492-496 (2014).
  7. Turski, M. L.*, Brady, D. C.*, Kim, H. J., Kim, B. E., Nose, Y., Counter, C. M., Winge, D. R. & Thiele, D. J. A novel role for copper in Ras/mitogen-activated protein kinase signaling. Mol Cell Biol 32, 1284-1295 (2012).
  8. Kashatus, D. F., Lim, K. H., Brady, D. C., Pershing, N. L., Cox, A. D. & Counter, C. M. RALA and RALBP1 regulate mitochondrial fission at mitosis. Nat Cell Biol 13, 1108-1115 (2011).
  9. Zipfel, P. A., Brady, D. C., Kashatus, D. F., Ancrile, B. D., Tyler, D. S.#& Counter, C. M.Ral activation promotes melanomagenesis. Oncogene 29, 4859-4864 (2010).
  10. Lim, K. H.*, Brady, D. C.*, Kashatus, D. F., Ancrile, B. B., Der, C. J., Cox, A. D.#& Counter, C. M.Aurora-A phosphorylates, activates, and relocalizes the small GTPase RalA. Mol Cell Biol 30, 508-523 (2010).
  11. O'Hayer, K. M., Brady, D. C. & Counter, C. M. ELR+ CXC chemokines and oncogenic Ras-mediated tumorigenesis. Carcinogenesis 30, 1841-1847 (2009).
  12. Madigan, J. P., Bodemann, B. O., Brady, D. C., Dewar, B. J., Keller, P. J., Leitges, M., Philips, M. R., Ridley, A. J., Der, C. J. & Cox, A. D. Regulation of Rnd3 localization and function by protein kinase C alpha-mediated phosphorylation. Biochem J 424, 153-161 (2009).
  13. Brady, D. C., Alan, J. K., Madigan, J. P., Fanning, A. S. & Cox, A. D. The transforming Rho family GTPase Wrch-1 disrupts epithelial cell tight junctions and epithelial morphogenesis. Mol Cell Biol 29, 1035-1049 (2009).