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Center for Pharmacoepidemiology Research and Training (CPeRT)

CPeRT News Items and Recent Publication

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Announcements

Congratulations to Charles E. Leonard, PharmD, MSCE for receiving the Drug Therapy Research Award for his study entitled “Empiric Potassium Supplementation and Increased Survival in Users of Loop Diuretics”.

Congratulations to Brain L. Strom, MD, MPH for receiving the Oscar B. Hunter Career Award in Therapeutics from the American Society for Clinical Pharmacology and Therapeutics (ASCPT)!

Congratulations to Vincent Lo Re, MD, MSCE for being elected to a 3-year term on the Board of Directors of the International Society for Pharmacoepidemiology!

 

Publications

  • M Fabbro; JT Gutsche; TA Miano, PharmD, MSCE; JG Augoustides, MD, FASE, FAHA; and PA Patel, MD publish "Comparison of Thrombelastography-Derived Fibrinogen Values at Rewarming and Following Cardiopulmonary Bypass in Cardiac Surgery Patients" in Anesthesia & Analgesia, 2016 Sep;123(3):570-7. Read Full article.

  • ZC Chiesa Fuxench, MD; AB Troxel, ScD; JM Gelfand, MD, MSCE publish "Validity of diagnosis codes for identifying cutaneous squamous cell carcinoma in The Health Improvement Network" in the British Journal of Dermatology, Epub ahead of print 12 August 2016. Read full article.

  • Jalpa A. Doshi, PhD; Raymond Lim, MA; Pengxiang Li, PhD; Peinie P. Young; Victor F. Lawnicki; Joseph J. State; Andrea B. Troxel, ScD; and Kevin G. Volpp, MD, PhD publish "A Synchronized Prescription Refill Program Improved Medication Adherence" in Health Affairs, 35(8):1504-1512, 2016. Read full article.

  • John S. Barbieri, MD,MBA; Ole Hoffstad, MA; and David J. Margolis, MD, PhD publish "Duration of oral tetracycline-class antibiotic therapy and use of topical retinoids for the treatment of acne among general practitioners (GP): A retrospective cohort study" in the Journal of the American Academy of Dermatology, Epub ahead of print 5 August 2016. Read full article.
     
  • K Chiotos; N Vendetti; TE Zaoutis, MD, MSCE; J Baddley; L Ostrosky-Zeichner; P Pappas; and BT Fisher, DO, MSCE, MPH publish "Comparative effectiveness of echinocandins versus fluconazole therapy for the treatment of adult candidaemia due to Candida parapsilosis: a retrospective observational cohort study of the Mycoses Study Group (MSG-12)" in the Journal Antimicrobial Chemotherapy, Epub ahead of print 27 July 2016. Read full article.

  • BS Finkelman; B French, PhD; L Bershaw; CM Brensinger; MB Streiff; AE Epstein, MD; and SE Kimmel, MD, MSCE publish "Predicting prolonged dose titration in patients starting warfarin" in Pharmacoepidemiology Drug Safety, Epub ahead of print 26 July 2016. Read full article.

  • Nabila Dahodwala; Allison W. Willis, MD, MS; Pengxiang Li; and Jalpa A. Doshi publish "Prevalence and correlates of anti-Parkinson drug use in a nationally representative sample" in Movement Disorders: Clinical Practice, Epub ahead of print July 2016. Read full article.

  • R Gross, MD, MSCE; SL Bellamy, ScD; B Ratshaa; X Han; AP Steenhoff; M Mosepele; and GP Bisson, MD, MSCE publilsh "Effects of Sex and Alcohol Use on Antiretroviral Therapy Outcomes in Botswana: A Cohort Study" in Addiction, Epub ahead of print 22 July 2016. Read full article.

  • JM Tetrault; JP Tate; EJ Edelman; AJ Gordon; V Lo Re 3rd, MD, MSCE; JK Lim; D Rimland; J Goulet; S Crystal; JR Gaither; CL Gibert; MC Rodriguez-Barradas; LE Fiellin; K Bryant; AC Justice; and DA Fiellin publish " Hepatic Safety of Buprenorphine in HIV-Infected and Uninfected Patients With Opioid Use Disorder: The Role of HCV-Infection " in the Journal of Substance Abuse Treatment, Epub ahead of print 6 June 2016. Read full article.

  • David S. Goldberg, MD, MSCE; Emily Blumberg, MD; Maureen McCauley; Peter Abt, MD; and Matthew Levine, MD, PhD publish "Improving Organ Utilization to Help Overcome the Tragedies of the Opioid Epidemic" in the American Journal of Transplantation, Epub ahead of print July 2016. Read full article.

  • Ben Boursi; Harry J Han; Kevin Haynes, PharmD, MSCE; Ronac Mamtani, MD, MSCE; and Yu-Xiao Yang, MD, MSCE publish "Ion channel blockers and glioblastoma risk and outcome: a nested case–control and retrospective cohort studies" in Pharmacoepidemiology and Drug Safety, Epub ahead of print 7 July 2016. Read full article.

  • Joshua J. Gagne, PharmD, ScD; Xu Han, MS, PhD; Sean Hennessy PharmD, PhD; Charles E. Leonard PharmD, MSCE; Elizabeth A. Chrischilles MS, PhD; Ryan M. Carnahan, PharmD, MS; Shirley V. Wang, PhD, ScM; Candace Fuller, PhD, MPH; Aarthi Iyer, JD, MPH; Hannah Katcoff, MPH; Tiffany S. Woodworth, MPH; Patrick Archdeacon, MD; Tamra E. Meyer, PhD, MPH; and Sengwee Toh, ScD publish “Successful comparison of US Food and Drug Administration Sentinel analysis tools to traditional approaches in quantifying a known drug-adverse event association” Clinical Pharmacology and Therapeutics, Epub ahead of print July 2016. Read full article.

  • Benjamin French, PhD; Le Wang, MS; Brian F. Gagec, MD; Richard B. Horensteind; Nita A. Limdie; and Stephen E. Kimmel, MD, MSCE publish "A systematic analysis and comparison of warfarin initiation strategies" in Pharmacogenetics and Genomics, Epub ahead of print July 2016. Read full article.

    What is Pharmacoepidemiology?

    Pharmacoepidemiology is the study of the health effects of drugs and other medical products in populations. It is the basic science underlying the public health practice of medical product safety surveillance. Pharmacoepidemiologists apply the research methods of epidemiology (e.g., randomized trials, cohort studies, case-control studies, self-controlled designs) to the study of pharmacology (e.g., determinants of beneficial and adverse drug effects, effects of genetic variation on drug effect, dose-response relationships, duration-response relationships, drug-drug interactions, effects of non-adherence). Pharmacoepidemiologists also evaluate programmatic efforts to improve medication use.

    CPeRT Mission

    The Center for Pharmacoepidemiology Research and Training (CPeRT) was founded in 2012 (although Penn faculty member have been conducting pharmacoepidemiology research since the early 1980s) and is based in the Center for Clinical Epidemiology and Biostatistics (CCEB). Its mission is to:

    • Provide an intellectual home for pharmacoepidemiology at Penn
    • Promote the conduct of applied and methodologic pharmacoepidemiology research
    • Foster training of the next generation of pharmacoepidemiologists
    • Expand number of Penn faculty members performing pharmacoepidemiology research

    CPeRT members are leaders in the development and use of large administrative and medical record databases for studying drug effects. CPeRT is one of the academic partners of the Food and Drug Administration (FDA)-funded Mini-Sentinel Initiative. CPeRT members also edit Pharmacoepidemiology, 5th edition and Textbook of Pharmacoepidemiology.

    Training Programs

    Pilot Grant Program

    Open Faculty Positions

    View a listing of open faculty positions in Biostatistics and Epidemiology.

    Leadership

    Investigators

    Standing or Associated Penn faculty engaged in pharmacoepidemiologic research

    Associate Investigators

    Research staff who work with Penn faculty and who are engaged in pharmacoepidemiologic research

    Adjunct Investigators

    CCEB Adjunct Scholars engaged in pharmacoepidemiologic research

    For information on obtaining an Adjunct Scholar appointment within the CCEB, please contact Sue White, Manager of Faculty Affairs (susanlw@mail.med.upenn.edu; 215-573-3874).

    Investigators-in-Training

    Trainees in Penn research training programs (including postdoctoral fellowships), instructors, and research associates, engaged in pharmacoepidemiologic research
    • Zelma Chiesa, MD
    • Jordy Cohen, MD
    • James Crispo, PhD
    • Caitlin Elgarten, MD
    • Darcy Ellis, MPH
    • Ashkan Ertefaie, MD
    • Michael George, MD
    • Erwin Calgua Guerra, MD
    • Eileen (Xu) Han, PhD
    • Xinyao Ji
    • Todd A. Miano, PharmD, MSCE
    • Young Hee Nam, PhD
    • Megan Noe, MD
    • M. Elle Saine, MA
    • Sony Tuteja-Stevens, PharmD, MS
    • Adam Waxman, MD
    • Jing Zhang, MHS
    • Quingyuan Zho, PhD
    • Meijia Zhou, MHS

    For infomation on joining CPeRT, please contact Sean Hennessy, PharmD, PhD, CPeRT Director (hennessy@upenn.edu; 215-898-9112).

    Resources