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Center for Pharmacoepidemiology Research and Training (CPeRT)

CPeRT News Items and Recent Publication

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Congratulations to Charles E. Leonard, PharmD, MSCE for receiving the Drug Therapy Research Award for his study entitled “Empiric Potassium Supplementation and Increased Survival in Users of Loop Diuretics”.

Congratulations to Brain L. Strom, MD, MPH for receiving the Oscar B. Hunter Career Award in Therapeutics from the American Society for Clinical Pharmacology and Therapeutics (ASCPT)!

Congratulations to Vincent Lo Re, MD, MSCE for being elected to a 3-year term on the Board of Directors of the International Society for Pharmacoepidemiology!



  • David S. Goldberg, MD, MSCE; Emily Blumberg, MD; Maureen McCauley; Peter Abt, MD; and Matthew Levine, MD, PhD publish "Improving Organ Utilization to Help Overcome the Tragedies of the Opioid Epidemic" in the American Journal of Transplantation, Epub ahead of print July 2016. Read full article.

  • Ben Boursi; Harry J Han; Kevin Haynes, PharmD, MSCE; Ronac Mamtani, MD, MSCE; and Yu-Xiao Yang, MD, MSCE publish "Ion channel blockers and glioblastoma risk and outcome: a nested case–control and retrospective cohort studies" in Pharmacoepidemiology and Drug Safety, Epub ahead of print 7 July 2016. Read full article.

  • Joshua J. Gagne, PharmD, ScD; Xu Han, MS, PhD; Sean Hennessy PharmD, PhD; Charles E. Leonard PharmD, MSCE; Elizabeth A. Chrischilles MS, PhD; Ryan M. Carnahan, PharmD, MS; Shirley V. Wang, PhD, ScM; Candace Fuller, PhD, MPH; Aarthi Iyer, JD, MPH; Hannah Katcoff, MPH; Tiffany S. Woodworth, MPH; Patrick Archdeacon, MD; Tamra E. Meyer, PhD, MPH; and Sengwee Toh, ScD publish “Successful comparison of US Food and Drug Administration Sentinel analysis tools to traditional approaches in quantifying a known drug-adverse event association” Clinical Pharmacology and Therapeutics, Epub ahead of print July 2016. Read full article.

  • Benjamin French, PhD; Le Wang, MS; Brian F. Gagec, MD; Richard B. Horensteind; Nita A. Limdie; and Stephen E. Kimmel, MD, MSCE publish "A systematic analysis and comparison of warfarin initiation strategies" in Pharmacogenetics and Genomics, Epub ahead of print July 2016. Read full article.

  • Laura Folgori, MD; Julia Bielicki,MD; Beatriz Ruiz, MD; Mark A Turner, MD; Prof John S Bradley, MD; Prof Daniel K Benjamin Jr, MD; Prof Theoklis E Zaoutis, MD; Prof Irja Lutsar, MD; Prof Carlo Giaquinto, MD; Prof Paolo Rossi, MD; and Prof Mike Sharland, MD publish “Harmonisation in study design and outcomes in paediatric antibiotic clinical trials: a systematic review” in The Lancet Infectious Diseases, Epub ahead of print 30 June 2016.  Read full article.

  • M. Soledad Cepeda, MD, PhD; Paul M. Coplan, ScD, MBA;  Nathan W. Kopper, PharmD; Jean-Yves Maziere, MD, MS; Gregory P. Wedin, PharmD; and  Laura E. Wallace, MPH publish "ER/LA Opioid Analgesics REMS: Overview of Ongoing Assessments of Its Progress and Its Impact on Health Outcomes" in Pain Medicine , Epub ahead of print 2 July 2016. Read full article.

  • Howard D. Chilcoat; Paul M. Coplan, ScD, MBA; Venkatesh Harikrishnan; and Louis Alexander publish “Decreased diversion by doctor-shopping for a reformulated extended release oxycodone product (OxyContin)” in Drug and Alcohol Dependence, Epub ahead of print 16 June 2016.  Read full article.

  • Glenn R. Cunningham; Alisa J. Stephens-Shields, PhD; Raymond C. Rosen; Christina Wang; Shalender Bhasin; Alvin M. Matsumoto; J. Kellogg Parsons; Thomas M. Gill; Mark E. Molitch; John T. Farrar, MD, PhD; David Cella; Elizabeth Barrett-Connor; Jane A. Cauley; Denise Cifelli; Jill P. Crandal;, Kristine E. Ensrud; Laura Gallagher; Bret Zeldow; Cora E. Lewis; Marco Pahor; Ronald S. Swerdloff; Xiaoling Hou; Stephen Anton; Shehzad Basaria; Susan J. Diem; Vafa Tabatabaie; Susan S. Ellenberg, PhD; and Peter J. Snyder publish "Testosterone Treatment and Sexual Function in Older Men with Low Testosterone Levels" in The Journal of Clinical Endocrinology & Metabolism, Epub ahead of print 29 June 2016. Read full article.

  • JA Roy, PhD; KJ Lum; and MJ Daniels publish "A Bayesian nonparametric approach to marginal structural models for point treatments and a continuous or survival outcome" in Biostatistics, Epub ahead of print 26 June 2016. Read full article.

  • AS Himebauchab; TJ Kilbaugha; and AF Zuppaab publish "Pharmacotherapy during pediatric extracorporeal membrane oxygenation: a review" in Expert Opinion on Drug Metabolism & Toxicology, Epub ahead of print 20 June 2016. Read full article.

  • Jeanette M. Tetrault, MD, FACP; Janet P. Tate; E. Jennifer Edelman, MD, MHS; Adam J. Gordon, MD, MPH; Vincent Lo Re III, MD, MSCE; Joseph K. Lim, MD; David Rimland, MD; Joseph Goulet, PhD, MS; Stephen Crystal, PhD; Julie R. Gaither, RN, MPH; Cynthia L. Gibert; Maria C. Rodriguez-Barradas, MD; Lynn E. Fiellin, MD; Kendall Bryant; Amy C. Justice, MD, PhD; and David A. Fiellin publish “Hepatic safety of buprenorphine in HIV-infected and uninfected patients with opioid use disorder: The role of HCV-infection” in the Journal of Substance Abuse Treatment, Epub ahead of print 6 June 2016.  Read full article.

  • SL Mayne; ME Ross, PhD; L Song; B McCarn; J Steffes; W Liu; B Margolis; R Azuine; E Gotlieb; RW Grundmeier; LK Leslie; R Localio, PhD; R Wasserman; and AG Fiks publish “Variations in Mental Health Diagnosis and Prescribing Across Pediatric Primary Care Practices” in Pediatrics, 2016;137(5).  Read full article.

  • Ashkan Ertefaie; Dylan Small, PhD; James Flory, MD; and Sean Hennessy, PharmD, PhD publish “Selection Bias When Using Instrumental Variable Methods to Compare Two Treatments But More Than Two Treatments Are Available” in the International Journal of Biostatistics, 2016;12(1):219-32.  Read full article.
  • What is Pharmacoepidemiology?

    Pharmacoepidemiology is the study of the health effects of drugs and other medical products in populations. It is the basic science underlying the public health practice of medical product safety surveillance. Pharmacoepidemiologists apply the research methods of epidemiology (e.g., randomized trials, cohort studies, case-control studies, self-controlled designs) to the study of pharmacology (e.g., determinants of beneficial and adverse drug effects, effects of genetic variation on drug effect, dose-response relationships, duration-response relationships, drug-drug interactions, effects of non-adherence). Pharmacoepidemiologists also evaluate programmatic efforts to improve medication use.

    CPeRT Mission

    The Center for Pharmacoepidemiology Research and Training (CPeRT) was founded in 2012 (although Penn faculty member have been conducting pharmacoepidemiology research since the early 1980s) and is based in the Center for Clinical Epidemiology and Biostatistics (CCEB). Its mission is to:

    • Provide an intellectual home for pharmacoepidemiology at Penn
    • Promote the conduct of applied and methodologic pharmacoepidemiology research
    • Foster training of the next generation of pharmacoepidemiologists
    • Expand number of Penn faculty members performing pharmacoepidemiology research

    CPeRT members are leaders in the development and use of large administrative and medical record databases for studying drug effects. CPeRT is one of the academic partners of the Food and Drug Administration (FDA)-funded Mini-Sentinel Initiative. CPeRT members also edit Pharmacoepidemiology, 5th edition and Textbook of Pharmacoepidemiology.

    Training Programs

    Pilot Grant Program

    Open Faculty Positions

    View a listing of open faculty positions in Biostatistics and Epidemiology.



    Standing or Associated Penn faculty engaged in pharmacoepidemiologic research

    Associate Investigators

    Research staff who work with Penn faculty and who are engaged in pharmacoepidemiologic research

    Adjunct Investigators

    CCEB Adjunct Scholars engaged in pharmacoepidemiologic research

    For information on obtaining an Adjunct Scholar appointment within the CCEB, please contact Sue White, Manager of Faculty Affairs (; 215-573-3874).


    Trainees in Penn research training programs (including postdoctoral fellowships), instructors, and research associates, engaged in pharmacoepidemiologic research
    • Zelma Chiesa, MD
    • Jordy Cohen, MD
    • James Crispo, PhD
    • Caitlin Elgarten, MD
    • Darcy Ellis, MPH
    • Ashkan Ertefaie, MD
    • Michael George, MD
    • Erwin Calgua Guerra, MD
    • Eileen (Xu) Han, PhD
    • Xinyao Ji
    • Todd A. Miano, PharmD, MSCE
    • Young Hee Nam, PhD
    • Megan Noe, MD
    • M. Elle Saine, MA
    • Sony Tuteja-Stevens, PharmD, MS
    • Adam Waxman, MD
    • Jing Zhang, MHS
    • Quingyuan Zho, PhD
    • Meijia Zhou, MHS

    For infomation on joining CPeRT, please contact Sean Hennessy, PharmD, PhD, CPeRT Director (; 215-898-9112).