Decorative Globe

Clinical Research Computing Unit (CRCU)


The Clinical Research Computing Unit (CRCU) is an Academic Clinical Research Organization within the Center for Clinical Epidemiology and Biostatistics (CCEB) in the Perelman School of Medicine at the University of Pennsylvania. Since its inception in 1997, the CRCU has been expertly providing the full range of services essential for the conduct of clinical research projects, including Phase I-IV, multi-center, randomized, clinical trials, registry, and cohort studies utilizing state-of-the-art technology and tools to ensure superior data quality. The CRCU provides expertise in project management, data coordination and research computing tailored to meet your project requirements. The CRCU project teams partner with the BAC in the project design phase to plan accurate and precise data collection modules and to structure project reports for steady oversight. We specialize in study design and development, site management and training, data collection, processing, quality control, regulatory requirements and reporting, database development, administration, security, data storage and proposal development.

About the CRCU



The CRCU serves as a "Core Research Facility" within the University to allow researchers and investigators access to its services across a wide range of research programs and medical disciplines. These core services allow the CRCU to participate in various research programs within the University, as well as with external research-related entities. The CRCU provides a complete set of services to facilitate the collection, storage and management of clinical research data for any size research study conducted by University investigators and their collaborators. Whether the CRCU performs the myriad duties of a Data Coordinating Center for multi-center research networks or creates a simple database to organize cohort data, each project receives the right amount of specialized expertise and attention to ensure successful completion with accurate and reliable research data. The CRCU has extensive experience providing design, development and project and technology support services to the entire Penn Medicine clinical and translational research enterprise. Examples of projects for which we provide service are described below.

Data Coordinating Centers (DCC) 
CRCU functions as the coordinating center for a number of collaborative research networks,  providing comprehensive project oversight, all project management and regulatory compliance activities, data management services, database design and implementation, coordination for site management, lab & reading centers, and administrative coordination for all aspects of large multi-site projects.

Phase I – IV, Single & Multi-Site Projects
For these projects (national and international) the CRCU performs data management and research technology services (database development) for studies designed to assess the safety, efficacy, and pharmacodynamics of treatment.

Basic Science Projects
The CRCU designs and implements database tools for these laboratory studies in pharmacology, genomics and proteomics.

Research Domain Experience (but not limited to)

Aging Pharmacogenetics Pharmacogenetics
Behavioral Health Intervention Neonatology Pulmonary/Critical Care
Cancer Hepatology Schizophrenia
Cardiology HIV/Infectious Diseases Depression
Dermatology Nephrology Sleep/Sleep Apena
Endocrinology OB/Gynecology Urology


Contact Information

To receive the highest priority for services, investigators should complete the Grant Registration Form (for those within the CCEB) or the Collaboration Request Form (for those external to the CCEB). These forms will provide us with the specific information necessary to assess your needs.