Cell & Developmental Biology

UPenn Cell & Developmental Biology

Faculty Publications 2012-2013

Marisa  Bartolomei

Autism: A long genetic explanation. Plasschaert RN, Bartolomei MS. Nature. 2013 Sep 5;501(7465):36-7. doi: 10.1038/nature12553. Epub 2013 Aug 28.

Maternal imprinting at the H19-Igf2 locus maintains adult haematopoietic stem cell quiescence. Venkatraman A, He XC, Thorvaldsen JL, Sugimura R, Perry JM, Tao F, Zhao M, Christenson MK, Sanchez R, Yu JY, Peng L, Haug JS, Paulson A, Li H, Zhong XB, Clemens TL, Bartolomei MS, Li L. Nature. 2013 Aug 15;500(7462):345-9. doi: 10.1038/nature12303. Epub 2013 Jul 17.

Clinical features of three girls with mosaic genome-wide paternal uniparental isodisomy. Kalish JM, Conlin LK, Bhatti TR, Dubbs HA, Harris MC, Izumi K, Mostoufi-Moab S, Mulchandani S, Saitta S, States LJ, Swarr DT, Wilkens AB, Zackai EH, Zelley K, Bartolomei MS, Nichols KE, Palladino AA, Spinner NB, Deardorff MA. Am J Med Genet A. 2013 Aug;161(8):1929-39. doi: 10.1002/ajmg.a.36045. Epub 2013 Jun 26.

Shelley  Berger

Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape. Shah PP, Donahue G, Otte GL, Capell BC, Nelson DM, Cao K, Aggarwala V, Cruickshanks HA, Rai TS, McBryan T, Gregory BD, Adams PD, Berger SL. Genes Dev. 2013 Aug 15;27(16):1787-99. doi: 10.1101/gad.223834.113. Epub 2013 Aug 9.

Genome-wide epigenetics. Capell BC, Berger SL. J Invest Dermatol. 2013 Jun;133(6):e9. doi: 10.1038/jid.2013.173.

Social insect genomes exhibit dramatic evolution in gene composition and regulation while preserving regulatory features linked to sociality. Simola DF, Wissler L, Donahue G, Waterhouse RM, Helmkampf M, Roux J, Nygaard S, Glastad K, Hagen DE, Viljakainen L, Reese JT, Hunt BG, Graur D, Elhaik E, Kriventseva E, Wen J, Parker BJ, Cash E, Privman E, Childers CP, Munos-Torres MC, Boomsma JJ, Bornberg-Bauer E, Currie C, Elsik CG, Suen G, Goodisman MA, Keller L, Liebig J, Rawls A, Reinberg D, Smith CD, Smith CR, Tsutsui N, Wurm Y, Zdobnov EM, Berger SL, Gadau J. Genome Res. 2013 May 1.

Erfei Bi

Targeting and functional mechanisms of the cytokinesis-related F-BAR protein Hof1 during the cell cycle. Oh Y, Schreiter J, Nishihama R, Wloka C, Bi E. Mol Biol Cell. 2013 May;24(9):1305-20. doi: 10.1091/mbc.E12-11-0804.

Immobile myosin-II plays a scaffolding role during cytokinesis in budding yeast. Wloka C, Vallen EA, Thé L, Fang X, Oh Y, Bi E. J Cell Biol. 2013 Feb 4;200(3):271-86.

Mechanisms of cytokinesis in budding yeast. Wloka C, Bi E. Cytoskeleton (Hoboken). 2012 Jun 26.

Maya Capelson

Chromatin-bound nuclear pore components regulate gene expression in higher eukaryotes. Capelson M, Liang Y, Schulte R, Mair W, Wagner U, Hetzer MW. Cell. 2010 Feb 5;140(3):372-83. doi: 10.1016/j.cell.2009.12.054.

Steve DiNardo

magu is required for germline stem cell self-renewal through BMP signaling in the Drosophila testis. Zheng Q, Wang Y, Vargas E, Dinardo SDev Biol. 2011 Sep 1;357(1):202-10

J.A. Epstein

Induced regeneration--the progress and promise of direct reprogramming for heart repair. Addis RC, Epstein JA. Nat Med. 2013 Jul;19(7):829-36. doi: 10.1038/nm.3225.

<i>Lgr5</i> Identifies Progenitor Cells Capable of Taste Bud Regeneration after Injury. Takeda N, Jain R, Li D, Li L, Lu MM, Epstein JA. PLoS One. 2013 Jun 18;8(6):e66314. Print 2013.

Molecular determinants of lung development. Morrisey EE, Cardoso WV, Lane RH, Rabinovitch M, Abman SH, Ai X, Albertine KH, Bland RD, Chapman HA, Checkley W, Epstein JA, Kintner CR, Kumar M, Minoo P, Mariani TJ, McDonald DM, Mukouyama YS, Prince LS, Reese J, Rossant J, Shi W, Sun X, Werb Z, Whitsett JA, Gail D, Blaisdell CJ, Lin QS. Ann Am Thorac Soc. 2013 Apr;10(2):S12-6. doi: 10.1513/AnnalsATS.201207-036OT.

Shannon Fisher

Distinct enhancers of ptf1a mediate specification and expansion of ventral pancreas in zebrafish. Pashos E, Park JT, Leach S, Fisher S. Dev Biol. 2013 Sep 15;381(2):471-81. doi: 10.1016/j.ydbio.2013.07.011. Epub 2013 Jul 20.

GRG5/AES interacts with T-cell factor 4 (TCF4) and downregulates Wnt signaling in human cells and zebrafish embryos. Costa AM, Pereira-Castro I, Ricardo E, Spencer F, Fisher S, da Costa LT. PLoS One. 2013 Jul 1;8(7):e67694. doi: 10.1371/journal.pone.0067694. Print 2013.

Skeletogenic fate of zebrafish cranial and trunk neural crest. Kague E, Gallagher M, Burke S, Parsons M, Franz-Odendaal T, Fisher S. PLoS One. 2012;7(11):e47394. doi: 10.1371/journal.pone.0047394. Epub 2012 Nov 14.

Clara Franzini-Armstrong

Novel details of calsequestrin gel conformation in situ. Perni S, Close M, Franzini-Armstrong C. J Biol Chem. 2013 Sep 11.

A method for the ultrastructural preservation of tiny percutaneous needle biopsy material from skeletal muscle. Pietrangelo T, Perni S, Di Tano G, Fanò-Illic G, Franzini-Armstrong C. Int J Mol Med. 2013 Oct;32(4):965-70. doi: 10.3892/ijmm.2013.1454. Epub 2013 Jul 23.

Stac3 is a component of the excitation-contraction coupling machinery and mutated in Native American myopathy. Horstick EJ, Linsley JW, Dowling JJ, Hauser MA, McDonald KK, Ashley-Koch A, Saint-Amant L, Satish A, Cui WW, Zhou W, Sprague SM, Stamm DS, Powell CM, Speer MC, Franzini-Armstrong C, Hirata H, Kuwada JY. Nat Commun. 2013;4:1952. doi: 10.1038/ncomms2952.

John Gearhart

Optimal Isolation and Xeno-free culture conditions for limbal stem cell function. Stasi K, Goings D, Huang J, Herman L, Pinto F, Addis RC, Klein D, Massaro-Giordano M, Gearhart JD. Invest Ophthalmol Vis Sci. 2013 Sep 12. doi:pii: iovs.13-12517v1. 10.1167/iovs.13-12517.

The Epigenetic Modifier Ubiquitin-specific Protease 22 (USP22) Regulates Embryonic Stem Cell Differentiation via Transcriptional Repression of Sex-determining Region Y-box 2 (SOX2). Sussman RT, Stanek TJ, Esteso P, Gearhart JD, Knudsen KE, McMahon SB. J Biol Chem. 2013 Aug 16;288(33):24234-46. doi: 10.1074/jbc.M113.469783. Epub 2013 Jun 12.

Optimization of direct fibroblast reprogramming to cardiomyocytes using calcium activity as a functional measure of success. Addis RC, Ifkovits JL, Pinto F, Kellam LD, Esteso P, Rentschler S, Christoforou N, Epstein JA, Gearhart JD. J Mol Cell Cardiol. 2013 Jul;60:97-106. doi: 10.1016/j.yjmcc.2013.04.004.

Amin Ghabrial

Focal Defects in Single-Celled Tubes Mutant for Cerebral Cavernous Malformation 3, GCKIII, or NSF2. Song Y, Eng M, Ghabrial AS. Dev Cell. 2013 Jun 10;25(5):507-19. doi: 10.1016/j.devcel.2013.05.002.

Osmotic regulation of seamless tube growth. Schottenfeld-Roames J, Ghabrial AS. Nat Cell Biol. 2013 Feb;15(2):137-9.

Whacked and Rab35 polarize dynein-motor-complex-dependent seamless tube growth. Schottenfeld-Roames J, Ghabrial AS. Nat Cell Biol. 2012 Mar 11. doi: 10.1038/ncb2454. [Epub ahead of print]

Michael Granato

Temporal requirement for SMN in motoneuron development. Hao LT, Duy PQ, Jontes JD, Wolman M, Granato M, Beattie CE. Hum Mol Genet. 2013 Mar 3.

A novel role for Lh3 dependent ECM modifications during neural crest cell migration in zebrafish. Banerjee S, Isaacman-Beck J, Schneider VA, Granato M. PLoS One. 2013;8(1):e54609. doi: 10.1371/journal.pone.0054609. Epub 2013 Jan 18.

Plexin A3 and turnout regulate motor axonal branch morphogenesis in zebrafish. Sainath R, Granato M. PLoS One. 2013;8(1):e54071. doi: 10.1371/journal.pone.0054071. Epub 2013 Jan 21.

The tumor suppressor gene retinoblastoma-1 is required for retinotectal development and visual function in zebrafish. Gyda M, Wolman M, Lorent K, Granato M. PLoS Genet. 2012;8(11):e1003106. doi: 10.1371/journal.pgen.1003106. Epub 2012 Nov 29.

Dan Kessler

Transcriptional integration of Wnt and Nodal pathways in establishment of the Spemann organizer. Reid CD, Zhang Y, Sheets MD, Kessler DS. Dev Biol. 2012 May 22

Mary Mullins

The chromosomal passenger protein birc5b organizes microfilaments and germ plasm in the zebrafish embryo. Nair S, Marlow F, Abrams E, Kapp L, Mullins MC, Pelegri F. PLoS Genet. 2013 Apr;9(4):e1003448. doi: 10.1371/journal.pgen.1003448.

Anteroposterior and dorsoventral patterning are coordinated by an identical patterning clock. Hashiguchi M, Mullins MC. Development. 2013 May;140(9):1970-80. doi: 10.1242/dev.088104

Dynamic Assembly of Brambleberry Mediates Nuclear Envelope Fusion during Early Development. Abrams EW, Zhang H, Marlow FL, Kapp L, Lu S, Mullins MC. Cell. 2012 Aug 3;150(3):521-32.

Neal Rubinstein

Identification of the neuromuscular junction (NMJ) transcriptome of extraocular muscle (EOM) by laser capture microdissection (LCM).  Ketterer C, Zeiger U, Budak MT, Rubinstein NA, Khurana TS.  Invest Ophthalmol Vis Sci. 2010 Apr 14.

Patrick Seale

Brown adipose tissue biology and therapeutic potential. Seale P. Front Endocrinol (Lausanne). 2013;4:14. doi: 10.3389/fendo.2013.00014.

EBF2 determines and maintains brown adipocyte identity. Rajakumari S, Wu J, Ishibashi J, Lim HW, Giang AH, Won KJ, Reed RR, Seale P. Cell Metab. 2013 Apr 2;17(4):562-74. doi: 10.1016/j.cmet.2013.01.015.

MicroRNA-133 Controls Brown Adipose Determination in Skeletal Muscle Satellite Cells by Targeting Prdm16. Yin H, Pasut A, Soleimani VD, Bentzinger CF, Antoun G, Thorn S, Seale P, Fernando P, van Ijcken W, Grosveld F, Dekemp RA, Boushel R, Harper ME, Rudnicki MA. Cell Metab. 2013 Feb 5;17(2):210-24.

Celeste Simon

A liver Hif-2α-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition. Wei K, Piecewicz SM, McGinnis LM, Taniguchi CM, Wiegand SJ, Anderson K, Chan CW, Mulligan KX, Kuo D, Yuan J, Vallon M, Morton LC, Lefai E, Simon MC, Maher JJ, Mithieux G, Rajas F, Annes JP, McGuinness OP, Thurston G, Giaccia AJ, Kuo CJ. Nat Med. 2013 Sep 15. doi: 10.1038/nm.3295.

Hypoxia-Dependent Modification of Collagen Networks Promotes Sarcoma Metastasis. Eisinger-Mathason TS, Zhang M, Qiu Q, Skuli N, Nakazawa MS, Karakasheva T, Mucaj V, Shay JE, Stangenberg L, Sadri N, Pure E, Yoon SS, Kirsch DG, Simon MC. Cancer Discov. 2013 Aug 1.

MYC Degradation under Low O2 Tension Promotes Survival by Evading Hypoxia-Induced Cell Death. Wong WJ, Qiu B, Nakazawa MS, Qing G, Simon MC. Mol Cell Biol. 2013 Sep;33(17):3494-504. doi: 10.1128/MCB.00853-12. Epub 2013 Jul 1.

Nancy Speck

Distinct temporal requirements for Runx1 in hematopoietic progenitors and stem cells. Tober J, Yzaguirre AD, Piwarzyk E, Speck NA. Development. 2013 Sep;140(18):3765-76. doi: 10.1242/dev.094961. Epub 2013 Aug 7.

The expression of Sox17 identifies and regulates haemogenic endothelium. Clarke RL, Yzaguirre AD, Yashiro-Ohtani Y, Bondue A, Blanpain C, Pear WS, Speck NA, Keller G. Nat Cell Biol. 2013 May;15(5):502-10. doi: 10.1038/ncb2724.

Endothelio-mesenchymal interaction controls runx1 expression and modulates the notch pathway to initiate aortic hematopoiesis. Richard C, Drevon C, Canto PY, Villain G, Bollérot K, Lempereur A, Teillet MA, Vincent C, Rosselló Castillo C, Torres M, Piwarzyk E, Speck NA, Souyri M, Jaffredo T. Dev Cell. 2013 Mar 25;24(6):600-11. doi: 10.1016/j.devcel.2013.02.011.

Phong Tran

Imaging individual spindle microtubule dynamics in fission yeast. Costa J, Fu C, Syrovatkina V, Tran PT. Methods Cell Biol. 2013;115:385-94. doi: 10.1016/B978-0-12-407757-7.00024-4.

Common mechanisms regulating cell cortex properties during cell division and cell migration. Roubinet C, Tran PT, Piel M. Cytoskeleton (Hoboken). 2012 Nov;69(11):957-72. doi: 10.1002/cm.21086. Epub 2012 Nov 1.

Estimating the microtubule GTP cap size in vivo. Seetapun D, Castle BT, McIntyre AJ, Tran PT, Odde DJ. Curr Biol. 2012 Sep 25;22(18):1681-7. doi: 10.1016/j.cub.2012.06.068.

John Weisel

Shear strengthens fibrin: the knob-hole interactions display "catch-slip" kinetics. Litvinov RI, Weisel JW. J Thromb Haemost. 2013 Aug 12. doi: 10.1111/jth.12374.

Functional impact of oxidative posttranslational modifications on fibrinogen and fibrin clots. Martinez M, Weisel JW, Ischiropoulos H. Free Radic Biol Med. 2013 Jul 11;65C:411-418. doi: 10.1016/j.freeradbiomed.2013.06.039.

Adaptation of fibrous biopolymers to recurring increasing strains. Weisel JW, Litvinov RI. Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12164-5. doi: 10.1073/pnas.1310351110. Epub 2013 Jul 10.

Ken Zaret

An iPSC line from human pancreatic ductal adenocarcinoma undergoes early to invasive stages of pancreatic cancer progression. Kim J, Hoffman JP, Alpaugh RK, Rhimm AD, Reichert M, Stanger BZ, Furth EE, Sepulveda AR, Yuan CX, Won KJ, Donahue G, Sands J, Gumbs AA, Zaret KS. Cell Rep. 2013 Jun 27;3(6):2088-99. doi: 10.1016/j.celrep.2013.05.036. Epub 2013 Jun 20.

Itm2a is a pax3 target gene, expressed at sites of skeletal muscle formation in vivo. Lagha M, Mayeuf-Louchart A, Chang T, Montarras D, Rocancourt D, Zalc A, Kormish J, Zaret KS, Buckingham ME, Relaix F. PLoS One. 2013 May 1;8(5):e63143. doi: 10.1371/journal.pone.0063143.

Understanding impediments to cellular conversion to pluripotency by assessing the earliest events in ectopic transcription factor binding to the genome. Soufi A, Zaret KS. Cell Cycle. 2013 May 15;12(10):1487-91. doi: 10.4161/cc.24663.

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