Cell & Developmental Biology

UPenn Cell & Developmental Biology

Recent Faculty Publications - 2014

Marisa Bartolomei

Anton L, Brown AG, Bartolomei MS, Elovitz MA. Differential methylation of genes associated with cell adhesion in preeclamptic placentas. PloS one. 2014;9(6):e100148. PMCID: 4070941.

de Waal E, Mak W, Calhoun S, Stein P, Ord T, Krapp C, Coutifaris C, Schultz RM, Bartolomei MS. In vitro culture increases the frequency of stochastic epigenetic errors at imprinted genes in placental tissues from mouse concepti produced through assisted reproductive technologies. Biology of reproduction. 2014;90(2):22. PMCID: 4076403.

Ideraabdullah FY, Thorvaldsen JL, Myers JA, Bartolomei MS. Tissue-specific insulator function at H19/Igf2 revealed by deletions at the imprinting control region. Human molecular genetics. 2014;23(23):6246-59. PMCID: 4222363.

Kalish JM, Jiang C, Bartolomei MS. Epigenetics and imprinting in human disease. The International journal of developmental biology. 2014;58(2-4):291-8.

Mainigi MA, Olalere D, Burd I, Sapienza C, Bartolomei M, Coutifaris C. Peri-implantation hormonal milieu: elucidating mechanisms of abnormal placentation and fetal growth. Biology of reproduction. 2014;90(2):26. PMCID: 4076405.

Martinez FP, Cruz R, Lu F, Plasschaert R, Deng Z, Rivera-Molina YA, Bartolomei MS, Lieberman PM, Tang Q. CTCF binding to the first intron of the major immediate early (MIE) gene of human cytomegalovirus (HCMV) negatively regulates MIE gene expression and HCMV replication. Journal of virology. 2014;88(13):7389-401. PMCID: 4054410.

Plasschaert RN, Bartolomei MS. Tissue-specific regulation and function of Grb10 during growth and neuronal commitment. Proceedings of the National Academy of Sciences of the United States of America. 2014.

Plasschaert RN, Bartolomei MS. Genomic imprinting in development, growth, behavior and stem cells. Development. 2014;141(9):1805-13. PMCID: 3994769.

Plasschaert RN, Vigneau S, Tempera I, Gupta R, Maksimoska J, Everett L, Davuluri R, Mamorstein R, Lieberman PM, Schultz D, Hannenhalli S, Bartolomei MS. CTCF binding site sequence differences are associated with unique regulatory and functional trends during embryonic stem cell differentiation. Nucleic acids research. 2014;42(2):774-89. PMCID: 3902912.

Susiarjo M, Bartolomei MS. Epigenetics. You are what you eat, but what about your DNA? Science. 2014;345(6198):733-4.

Weaver JR, Bartolomei MS. Chromatin regulators of genomic imprinting. Biochimica et biophysica acta. 2014;1839(3):169-77. PMCID: 3951659.

Shelley Berger

Brunet A, Berger SL. Epigenetics of aging and aging-related disease. The journals of gerontology Series A, Biological sciences and medical sciences. 2014;69 Suppl 1:S17-20. PMCID: 4022130.

Dang W, Sutphin GL, Dorsey JA, Otte GL, Cao K, Perry RM, Wanat JJ, Saviolaki D, Murakami CJ, Tsuchiyama S, Robison B, Gregory BD, Vermeulen M, Shiekhattar R, et al. Inactivation of yeast Isw2 chromatin remodeling enzyme mimics longevity effect of calorie restriction via induction of genotoxic stress response. Cell metabolism. 2014;19(6):952-66. PMCID: 4106248.

Kennedy BK, Berger SL, Brunet A, Campisi J, Cuervo AM, Epel ES, Franceschi C, Lithgow GJ, Morimoto RI, Pessin JE, Rando TA, Richardson A, Schadt EE, Wyss-Coray T, et al. Geroscience: linking aging to chronic disease. Cell. 2014;159(4):709-13.

Lin S, Wein S, Gonzales-Cope M, Otte GL, Yuan ZF, Afjehi-Sadat L, Maile T, Berger SL, Rush J, Lill JR, Arnott D, Garcia BA. Stable-isotope-labeled histone peptide library for histone post-translational modification and variant quantification by mass spectrometry. Molecular & cellular proteomics : MCP. 2014;13(9):2450-66. PMCID: 4159661.

McCormick MA, Mason AG, Guyenet SJ, Dang W, Garza RM, Ting MK, Moller RM, Berger SL, Kaeberlein M, Pillus L, La Spada AR, Kennedy BK. The SAGA histone deubiquitinase module controls yeast replicative lifespan via Sir2 interaction. Cell reports. 2014;8(2):477-86.

Mews P, Zee BM, Liu S, Donahue G, Garcia BA, Berger SL. Histone methylation has dynamics distinct from those of histone acetylation in cell cycle reentry from quiescence. Molecular and cellular biology. 2014;34(21):3968-80.

Qin J, Rajaratnam R, Feng L, Salami J, Barber-Rotenberg JS, Domsic J, Reyes-Uribe P, Liu H, Dang W, Berger SL, Villanueva J, Meggers E, Marmorstein R. Development of Organometallic S6K1 Inhibitors. Journal of medicinal chemistry. 2014.

Sammons MA, Zhu J, Drake AM, Berger SL. TP53 engagement with the genome occurs in distinct local chromatin environments via pioneer factor activity. Genome research. 2014.

Yan H, Simola DF, Bonasio R, Liebig J, Berger SL, Reinberg D. Eusocial insects as emerging models for behavioural epigenetics. Nature reviews Genetics. 2014;15(10):677-88.

Erfei Bi

Jiang Y, Wang Y, Wang T, Hawke DH, Zheng Y, Li X, Zhou Q, Majumder S, Bi E, Liu DX, Huang S, Lu Z. PKM2 phosphorylates MLC2 and regulates cytokinesis of tumour cells. Nature communications. 2014;5:5566. PMCID: 4259466.

Ong K, Wloka C, Okada S, Svitkina T, Bi E. Architecture and dynamic remodelling of the septin cytoskeleton during the cell cycle. Nature communications. 2014;5:5698. PMCID: 4258872.

Wang T, Yanger K, Stanger BZ, Cassio D, Bi E. Cytokinesis defines a spatial landmark for hepatocyte polarization and apical lumen formation. Journal of cell science. 2014;127(Pt 11):2483-92. PMCID: 4038943.

Roberto Bonasio

Beck DB, Narendra V, Drury WJ, 3rd, Casey R, Jansen PW, Yuan ZF, Garcia BA, Vermeulen M, Bonasio R. In Vivo Proximity Labeling for the Detection of Protein-Protein and Protein-RNA Interactions. Journal of proteome research. 2014;13(12):6135-43.

Bonasio R. The role of chromatin and epigenetics in the polyphenisms of ant castes. Briefings in functional genomics. 2014;13(3):235-45.

Bonasio R, Lecona E, Narendra V, Voigt P, Parisi F, Kluger Y, Reinberg D. Interactions with RNA direct the Polycomb group protein SCML2 to chromatin where it represses target genes. eLife. 2014;3:e02637. PMCID: 4074974.

Bonasio R, Shiekhattar R. Regulation of Transcription by Long Noncoding RNAs. Annual review of genetics. 2014;48:433-55.

Kaneko S, Bonasio R, Saldana-Meyer R, Yoshida T, Son J, Nishino K, Umezawa A, Reinberg D. Interactions between JARID2 and noncoding RNAs regulate PRC2 recruitment to chromatin. Molecular cell. 2014;53(2):290-300. PMCID: 4026005.

Kaneko S, Son J, Bonasio R, Shen SS, Reinberg D. Nascent RNA interaction keeps PRC2 activity poised and in check. Genes & development. 2014;28(18):1983-8. PMCID: 4173153.

Saldana-Meyer R, Gonzalez-Buendia E, Guerrero G, Narendra V, Bonasio R, Recillas-Targa F, Reinberg D. CTCF regulates the human p53 gene through direct interaction with its natural antisense transcript, Wrap53. Genes & development. 2014;28(7):723-34. PMCID: 4015496.

Yan H, Bonasio R, Simola DF, Liebig J, Berger SL, Reinberg D. DNA Methylation in Social Insects: How Epigenetics Can Control Behavior and Longevity. Annual review of entomology. 2014.

Yan H, Simola DF, Bonasio R, Liebig J, Berger SL, Reinberg D. Eusocial insects as emerging models for behavioural epigenetics. Nature reviews Genetics. 2014;15(10):677-88.

Maya Capelson

Pascual-Garcia P, Jeong J, Capelson M. Nucleoporin Nup98 Associates with Trx/MLL and NSL Histone-Modifying Complexes and Regulates Hox Gene Expression. Cell reports. 2014;9(2):433-42.

Panda D, Pascual-Garcia P, Dunagin M, Tudor M, Hopkins KC, Xu J, Gold B, Raj A, Capelson M, Cherry S. Nup98 promotes antiviral gene expression to restrict RNA viral infection in Drosophila. Proceedings of the National Academy of Sciences of the United States of America. 2014;111(37):E3890-9. PMCID: 4169978.

Pascual-Garcia P, Capelson M. Nuclear pores as versatile platforms for gene regulation. Current opinion in genetics & development. 2014;25:110-7.

J.A. Epstein

Manderfield LJ, Engleka KA, Aghajanian H, Gupta M, Yang S, Li L, Baggs JE, Hogenesch JB, Olson EN, Epstein JA. Pax3 and Hippo Signaling Coordinate Melanocyte Gene Expression in Neural Crest. Cell reports. 2014.

Li N, Yousefi M, Nakauka-Ddamba A, Jain R, Tobias J, Epstein JA, Jensen ST, Lengner CJ. Single-cell analysis of proxy reporter allele-marked epithelial cells establishes intestinal stem cell hierarchy. Stem cell reports. 2014;3(5):876-91. PMCID: 4235148.

Chen HI, Sharma B, Akerberg BN, Numi HJ, Kivela R, Saharinen P, Aghajanian H, McKay AS, Bogard PE, Chang AH, Jacobs AH, Epstein JA, Stankunas K, Alitalo K, et al. The sinus venosus contributes to coronary vasculature through VEGFC-stimulated angiogenesis. Development. 2014;141(23):4500-12.

Wolman MA, de Groh ED, McBride SM, Jongens TA, Granato M, Epstein JA. Modulation of cAMP and ras signaling pathways improves distinct behavioral deficits in a zebrafish model of neurofibromatosis type 1. Cell reports. 2014;8(5):1265-70.

Hogan BL, Barkauskas CE, Chapman HA, Epstein JA, Jain R, Hsia CC, Niklason L, Calle E, Le A, Randell SH, Rock J, Snitow M, Krummel M, Stripp BR, et al. Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function. Cell stem cell. 2014;15(2):123-38. PMCID: 4212493.

Aghajanian H, Choi C, Ho VC, Gupta M, Singh MK, Epstein JA. Semaphorin 3d and semaphorin 3e direct endothelial motility through distinct molecular signaling pathways. The Journal of biological chemistry. 2014;289(26):17971-9. PMCID: 4140303.

Gerhardt DM, Pajcini KV, D'Altri T, Tu L, Jain R, Xu L, Chen MJ, Rentschler S, Shestova O, Wertheim GB, Tobias JW, Kluk M, Wood AW, Aster JC, et al. The Notch1 transcriptional activation domain is required for development and reveals a novel role for Notch1 signaling in fetal hematopoietic stem cells. Genes & development. 2014;28(6):576-93. PMCID: 3967047.

Ifkovits JL, Addis RC, Epstein JA, Gearhart JD. Inhibition of TGFbeta signaling increases direct conversion of fibroblasts to induced cardiomyocytes. PloS one. 2014;9(2):e89678. PMCID: 3935923.

Worzfeld T, Swiercz JM, Senturk A, Genz B, Korostylev A, Deng S, Xia J, Hoshino M, Epstein JA, Chan AM, Vollmar B, Acker-Palmer A, Kuner R, Offermanns S. Genetic dissection of plexin signaling in vivo. Proceedings of the National Academy of Sciences of the United States of America. 2014;111(6):2194-9. PMCID: 3926053.

Zhao T, Gan Q, Stokes A, Lassiter RN, Wang Y, Chan J, Han JX, Pleasure DE, Epstein JA, Zhou CJ. beta-catenin regulates Pax3 and Cdx2 for caudal neural tube closure and elongation. Development. 2014;141(1):148-57. PMCID: 3865756.

Shannon Fisher

Esteves FF, Springhorn A, Kague E, Taylor E, Pyrowolakis G, Fisher S, Bier E. BMPs regulate msx gene expression in the dorsal neuroectoderm of Drosophila and vertebrates by distinct mechanisms.PLoS Genet. 2014 Sep 11;10(9):e1004625

Clara Franzini-Armstrong

Eltit JM, Franzini-Armstrong C, Perez CF. Amino Acid Residues 489-503 of Dihydropyridine Receptor (DHPR) beta1a Subunit Are Critical for Structural Communication Between the Skeletal Muscle DHPR complex and Type-1 Ryanodine Receptor. The Journal of biological chemistry. 2014.

Rosenberg AF, Isaacman-Beck J, Franzini-Armstrong C, Granato M. Schwann cells and deleted in colorectal carcinoma direct regenerating motor axons towards their original path. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2014;34(44):14668-81. PMCID: 4212066.

Franzini-Armstrong C. Memories of Annemarie Weber. Anatomical record. 2014;297(9):1543-7. PMCID: 4196439.

Guo A, Zhang X, Iyer VR, Chen B, Zhang C, Kutschke WJ, Weiss RM, Franzini-Armstrong C, Song LS. Overexpression of junctophilin-2 does not enhance baseline function but attenuates heart failure development after cardiac stress. Proceedings of the National Academy of Sciences of the United States of America. 2014;111(33):12240-5. PMCID: 4143026.

Close M, Perni S, Franzini-Armstrong C, Cundall D. Highly extensible skeletal muscle in snakes. The Journal of experimental biology. 2014;217(Pt 14):2445-8.

John Gearhart

Ifkovits JL, Addis RC, Epstein JA, Gearhart JD. Inhibition of TGFbeta signaling increases direct conversion of fibroblasts to induced cardiomyocytes. PloS one. 2014;9(2):e89678. PMCID: 3935923.

Stasi K, Goings D, Huang J, Herman L, Pinto F, Addis RC, Klein D, Massaro-Giordano G, Gearhart JD. Optimal isolation and xeno-free culture conditions for limbal stem cell function. Investigative ophthalmology & visual science. 2014;55(1):375-86. PMCID: 3900275.

Amin Ghabrial

Schottenfeld-Roames J, Rosa JB, Ghabrial AS. Seamless tube shape is constrained by endocytosis-dependent regulation of active Moesin. Current biology : CB. 2014;24(15):1756-64. PMCID: 4125418.

Michael Granato

Rosenberg AF, Isaacman-Beck J, Franzini-Armstrong C, Granato M. Schwann cells and deleted in colorectal carcinoma direct regenerating motor axons towards their original path. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2014;34(44):14668-81. PMCID: 4212066.

Wolman MA, de Groh ED, McBride SM, Jongens TA, Granato M, Epstein JA. Modulation of cAMP and ras signaling pathways improves distinct behavioral deficits in a zebrafish model of neurofibromatosis type 1. Cell reports. 2014;8(5):1265-70.

Jain RA, Bell H, Lim A, Chien CB, Granato M. Mirror movement-like defects in startle behavior of zebrafish dcc mutants are caused by aberrant midline guidance of identified descending hindbrain neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2014;34(8):2898-909. PMCID: 3931503.

Mary Mullins

Ge X, Grotjahn D, Welch E, Lyman-Gingerich J, Holguin C, Dimitrova E, Abrams EW, Gupta T, Marlow FL, Yabe T, Adler A, Mullins MC, Pelegri F. Hecate/Grip2a acts to reorganize the cytoskeleton in the symmetry-breaking event of embryonic axis induction. PLoS genetics. 2014;10(6):e1004422. PMCID: 4072529.

Patrick Seale

Bartesaghi S, Hallen S, Huang L, Svensson PA, Momo RA, Wallin S, Carlsson EK, Forslow A, Seale P, Peng XR. Thermogenic Activity of UCP1 in Human White Fat-Derived Beige Adipocytes. Molecular endocrinology. 2014:me20141295.

Wang W, Kissig M, Rajakumari S, Huang L, Lim HW, Won KJ, Seale P. Ebf2 is a selective marker of brown and beige adipogenic precursor cells. Proceedings of the National Academy of Sciences of the United States of America. 2014;111(40):14466-71. PMCID: 4209986.

Lim MA, Bence KK, Sandesara I, Andreux P, Auwerx J, Ishibashi J, Seale P, Kalb RG. Genetically altering organismal metabolism by leptin-deficiency benefits a mouse model of amyotrophic lateral sclerosis. Human molecular genetics. 2014;23(18):4995-5008. PMCID: 4140473.

Harms MJ, Ishibashi J, Wang W, Lim HW, Goyama S, Sato T, Kurokawa M, Won KJ, Seale P. Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice. Cell metabolism. 2014;19(4):593-604. PMCID: 4012340.

De Sousa M, Porras DP, Perry CG, Seale P, Scime A. p107 is a crucial regulator for determining the adipocyte lineage fate choices of stem cells. Stem cells. 2014;32(5):1323-36.

Cohen P, Levy JD, Zhang Y, Frontini A, Kolodin DP, Svensson KJ, Lo JC, Zeng X, Ye L, Khandekar MJ, Wu J, Gunawardana SC, Banks AS, Camporez JP, et al. Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch. Cell. 2014;156(1-2):304-16. PMCID: 3922400.

Celeste Simon

Ackerman D, Simon MC. Hypoxia, lipids, and cancer: surviving the harsh tumor microenvironment. Trends in cell biology. 2014;24(8):472-8. PMCID: 4112153.

Furcht CM, Buonato JM, Skuli N, Mathew LK, Munoz Rojas AR, Simon MC, Lazzara MJ. Multivariate signaling regulation by SHP2 differentially controls proliferation and therapeutic response in glioma cells. Journal of cell science. 2014;127(Pt 16):3555-67. PMCID: 4132393.

Li B, Qiu B, Lee DS, Walton ZE, Ochocki JD, Mathew LK, Mancuso A, Gade TP, Keith B, Nissim I, Simon MC. Fructose-1,6-bisphosphatase opposes renal carcinoma progression. Nature. 2014;513(7517):251-5. PMCID: 4162811.

Mathew LK, Lee SS, Skuli N, Rao S, Keith B, Nathanson KL, Lal P, Simon MC. Restricted expression of miR-30c-2-3p and miR-30a-3p in clear cell renal cell carcinomas enhances HIF2alpha activity. Cancer discovery. 2014;4(1):53-60. PMCID: 3947282.

Mathew LK, Skuli N, Mucaj V, Lee SS, Zinn PO, Sathyan P, Imtiyaz HZ, Zhang Z, Davuluri RV, Rao S, Venneti S, Lal P, Lathia JD, Rich JN, et al. miR-218 opposes a critical RTK-HIF pathway in mesenchymal glioblastoma. Proceedings of the National Academy of Sciences of the United States of America. 2014;111(1):291-6. PMCID: 3890843.

Mucaj V, Lee SS, Skuli N, Giannoukos DN, Qiu B, Eisinger-Mathason TS, Nakazawa MS, Shay JE, Gopal PP, Venneti S, Lal P, Minn AJ, Simon MC, Mathew LK. MicroRNA-124 expression counteracts pro-survival stress responses in glioblastoma. Oncogene. 2014.

Shay JE, Imtiyaz HZ, Sivanand S, Durham AC, Skuli N, Hsu S, Mucaj V, Eisinger-Mathason TS, Krock BL, Giannoukos DN, Simon MC. Inhibition of hypoxia-inducible factors limits tumor progression in a mouse model of colorectal cancer. Carcinogenesis. 2014;35(5):1067-77. PMCID: 4004204.

Thompson AA, Elks PM, Marriott HM, Eamsamarng S, Higgins KR, Lewis A, Williams L, Parmar S, Shaw G, McGrath EE, Formenti F, Van Eeden FJ, Kinnula VL, Pugh CW, et al. Hypoxia-inducible factor 2alpha regulates key neutrophil functions in humans, mice, and zebrafish. Blood. 2014;123(3):366-76. PMCID: 3894493.

Villa JC, Chiu D, Brandes AH, Escorcia FE, Villa CH, Maguire WF, Hu CJ, de Stanchina E, Simon MC, Sisodia SS, Scheinberg DA, Li YM. Nontranscriptional role of Hif-1alpha in activation of gamma-secretase and notch signaling in breast cancer. Cell reports. 2014;8(4):1077-92.

Wagage S, John B, Krock BL, Hall AO, Randall LM, Karp CL, Simon MC, Hunter CA. The aryl hydrocarbon receptor promotes IL-10 production by NK cells. Journal of immunology. 2014;192(4):1661-70. PMCID: 3955958.

Wong WJ, Richardson T, Seykora JT, Cotsarelis G, Simon MC. Hypoxia-Inducible Factors Regulate Filaggrin Expression and Epidermal Barrier Function. The Journal of investigative dermatology. 2014.

Ye J, Fan J, Venneti S, Wan YW, Pawel BR, Zhang J, Finley LW, Lu C, Lindsten T, Cross JR, Qing G, Liu Z, Simon MC, Rabinowitz JD, et al. Serine Catabolism Regulates Mitochondrial Redox Control during Hypoxia. Cancer discovery. 2014;4(12):1406-17. PMCID: 4258153.

Nancy Speck

Li Y, Esain V, Teng L, Xu J, Kwan W, Frost IM, Yzaguirre AD, Cai X, Cortes M, Maijenburg MW, Tober J, Dzierzak E, Orkin SH, Tan K, et al. Inflammatory signaling regulates embryonic hematopoietic stem and progenitor cell production. Genes & Development. 2014;28(23):2597-612. PMCID: 4248291.

Satpathy AT, Briseno CG, Cai X, Michael DG, Chou C, Hsiung S, Bhattacharya D, Speck NA, Egawa T. Runx1 and Cbfbeta regulate the development of Flt3+ dendritic cell progenitors and restrict myeloproliferative disorder. Blood. 2014;123(19):2968-77. PMCID: 4014839.

Imanirad P, Solaimani Kartalaei P, Crisan M, Vink C, Yamada-Inagawa T, de Pater E, Kurek D, Kaimakis P, van der Linden R, Speck N, Dzierzak E. HIF1a is a regulator of hematopoietic progenitor and stem cell development in hypoxic sites of the mouse embryo. Stem Cell Res. 12: 24-35 (2014). [PMCID: PMC3964602]

Gerhardt DM, Pajcini KV, D'altri T, Tu L, Jain R, Xu L, Chen MJ, Rentschler S, Shestova O, Wertheim GB, Tobias JW, Kluk M, Wood AW, Aster JC, Gimotty PA, Epstein JA, Speck N, Bigas A, Pear WS. The Notch1 transcriptional activation domain is required for development and reveals a novel role for Notch1 signaling in fetal hematopoietic cells. Genes Dev, 28:576-593 (2014) [PMCID: PMC3967047]

Phong Tran

Scheffler K, Recouvreux P, Paoletti A, Tran PT. Oscillatory AAA+ ATPase Knk1 constitutes a novel morphogenetic pathway in fission yeast. Proceedings of the National Academy of Sciences of the United States of America. 2014.

Costa J, Fu C, Khare VM, Tran PT. csi2p modulates microtubule dynamics and organizes the bipolar spindle for chromosome segregation. Molecular biology of the cell. 2014;25(24):3900-8. PMCID: 4244199.

Zheng F, Li T, Jin DY, Syrovatkina V, Scheffler K, Tran PT, Fu C. Csi1p recruits alp7p/TACC to the spindle pole bodies for bipolar spindle formation. Molecular biology of the cell. 2014;25(18):2750-60. PMCID: 4161510.

Carlier-Grynkorn F, Ji L, Fraisier V, Lombard B, Dingli F, Loew D, Paoletti A, Ronot X, Tran PT. Fission yeast mtr1p regulates interphase microtubule cortical dwell-time. Biology open. 2014;3(7):591-6. PMCID: 4154295.

Wang L, Tran PT. Visualizing single rod-shaped fission yeast vertically in micro-sized holes on agarose pad made by soft lithography. Methods in cell biology. 2014;120:227-34.

John Weisel

Lawrence MJ, Sabra A, Mills G, Pillai SG, Abdullah W, Hawkins K, Morris RH, Davidson SJ, D'Silva LA, Curtis DJ, Brown MR, Weisel JW, Williams PR, Evans PA. A new biomarker quantifies differences in clot microstructure in patients with venous thromboembolism. British journal of haematology. 2014.

Weisel JW. Monitoring coagulopathies in fluid resuscitation for trauma or surgery. Thrombosis research. 2014;134(3):535-6.

Skewis LR, Lebedeva T, Papkov V, Thayer EC, Massefski W, Cuker A, Nagaswami C, Litvinov RI, Kowalska MA, Rauova L, Poncz M, Weisel JW, Lowery TJ, Cines DB. T2 magnetic resonance: a diagnostic platform for studying integrated hemostasis in whole blood--proof of concept. Clinical chemistry. 2014;60(9):1174-82.

Kim OV, Litvinov RI, Weisel JW, Alber MS. Structural basis for the nonlinear mechanics of fibrin networks under compression. Biomaterials. 2014;35(25):6739-49. PMCID: 4104543.

Martinez MR, Cuker A, Mills AM, Crichlow A, Lightfoot RT, Chernysh IN, Nagaswami C, Weisel JW, Ischiropoulos H. Enhanced lysis and accelerated establishment of viscoelastic properties of fibrin clots are associated with pulmonary embolism. American journal of physiology Lung cellular and molecular physiology. 2014;306(5):L397-404. PMCID: 3949054.

Cines DB, Lebedeva T, Nagaswami C, Hayes V, Massefski W, Litvinov RI, Rauova L, Lowery TJ, Weisel JW. Clot contraction: compression of erythrocytes into tightly packed polyhedra and redistribution of platelets and fibrin. Blood. 2014;123(10):1596-603. PMCID: 3945867.

Bannish BE, Keener JP, Woodbury M, Weisel JW, Fogelson AL. Modelling fibrinolysis: 1D continuum models. Mathematical medicine and biology : a journal of the IMA. 2014;31(1):45-64.

Ken Zaret

Xu, C.-R., Li, L.-C., Donahue, G., Ying, L., Zhang, Y.-W., Gadue, P., and Zaret, K.S.  (2014) Dynamics of genomic H3K27me3 domains and role of EZH2 during pancreatic endocrine specification.  EMBO Journal 33, 2157-2170.

Bhatia, S.N., Underhill, G.H., Zaret, K.S., Fox, I.J.  (2014) Cell and tissue engineering for liver disease; State of the Art Review.  Science Translational Medicine 6, 245sr2.

Metzger, D.E., Liu, C., Ziaie, A.S., Naji, A., and Zaret, K.S.  (2014)  Grg3/TLE3 and Grg1/TLE1 Induce monohormonal Pancreatic β Cells While Repressing α Cell Functions.  Diabetes 63, 1804-1816.

Iwafuchi-Doi, M., and Zaret, K.S.  Pioneer transcription factors in cell reprogramming (2014) Genes and Development, in press.

Zaret, K.S.  (2014)  Genome reactivation after the silence in mitosis:  Recapitulating mechanisms of development?  Developmental Cell 29, 132-134.

Zaret, K.S. (2014) At the revolution with Fred Sherman.  Molecular and Cellular Biology 34, 922-925.

 

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