Cell & Developmental Biology

UPenn Cell & Developmental Biology

Recent Faculty Publications

Marisa Bartolomei

Shelley Berger

The SAGA Histone Deubiquitinase Module Controls Yeast Replicative Lifespan via Sir2 Interaction. McCormick MA, Mason AG, Guyenet SJ, Dang W, Garza RM, Ting MK, Moller RM, Berger SL, Kaeberlein M, Pillus L, La Spada AR, Kennedy BK. Cell Rep. 2014 Jul 24;8(2):477-86. doi: 10.1016/j.celrep.2014.06.037. Epub 2014 Jul 18.

Inactivation of yeast Isw2 chromatin remodeling enzyme mimics longevity effect of calorie restriction via induction of genotoxic stress response. Dang W, Sutphin GL, Dorsey JA, Otte GL, Cao K, Perry RM, Wanat JJ, Saviolaki D, Murakami CJ, Tsuchiyama S, Robison B, Gregory BD, Vermeulen M, Shiekhattar R, Johnson FB, Kennedy BK, Kaeberlein M, Berger SL. Cell Metab. 2014 Jun 3;19(6):952-66. doi: 10.1016/j.cmet.2014.04.004. Epub 2014 May 8.

Erfei Bi

Cytokinesis defines a spatial landmark for hepatocyte polarization and apical lumen formation. Wang T, Yanger K, Stanger BZ, Cassio D, Bi E. J Cell Sci. 2014 Apr 4.

Targeting and functional mechanisms of the cytokinesis-related F-BAR protein Hof1 during the cell cycle. Oh Y, Schreiter J, Nishihama R, Wloka C, Bi E. Mol Biol Cell. 2013 May;24(9):1305-20. doi: 10.1091/mbc.E12-11-0804.

Immobile myosin-II plays a scaffolding role during cytokinesis in budding yeast. Wloka C, Vallen EA, Thé L, Fang X, Oh Y, Bi E. J Cell Biol. 2013 Feb 4;200(3):271-86.

Roberto Bonasio

The role of chromatin and epigenetics in the polyphenisms of ant castes. Bonasio R. Brief Funct Genomics. 2014 Jan 24.

Maya Capelson

Nuclear pores as versatile platforms for gene regulation. Pascual-Garcia P, Capelson M. Curr Opin Genet Dev. 2014 Mar 11;25C:110-117.

Stephen DiNardo

Drosophila Dachsous and Fat polarize actin-based protrusions over a restricted domain of the embryonic denticle field. Lawlor KT, Ly DC, DiNardo S. Dev Biol. 2013 Nov 15;383(2):285-94.

magu is required for germline stem cell self-renewal through BMP signaling in the Drosophila testis. Zheng Q, Wang Y, Vargas E, Dinardo S. Dev Biol. 2011 Sep 1;357(1):202-10

J.A. Epstein

Repair and Regeneration of the Respiratory System: Complexity, Plasticity, and Mechanisms of Lung Stem Cell Function. Hogan BL, Barkauskas CE, Chapman HA, Epstein JA, Jain R, Hsia CC, Niklason L, Calle E, Le A, Randell SH, Rock J, Snitow M, Krummel M, Stripp BR, Vu T, White ES, Whitsett JA, Morrisey EE. Cell Stem Cell. 2014 Aug 7;15(2):123-138. doi: 10.1016/j.stem.2014.07.012. Review.

Semaphorin 3d and Semaphorin 3e Direct Endothelial Motility through Distinct Molecular Signaling Pathways. Aghajanian H, Choi C, Ho VC, Gupta M, Singh MK, Epstein JA. J Biol Chem. 2014 Jun 27;289(26):17971-9. doi: 10.1074/jbc.M113.544833. Epub 2014 May 13.

The Notch1 transcriptional activation domain is required for development and reveals a novel role for Notch1 signaling in fetal hematopoietic stem cells. Gerhardt DM, Pajcini KV, D'altri T, Tu L, Jain R, Xu L, Chen MJ, Rentschler S, Shestova O, Wertheim GB, Tobias JW, Kluk M, Wood AW, Aster JC, Gimotty PA, Epstein JA, Speck N, Bigas A, Pear WS. Genes Dev. 2014 Mar 15;28(6):576-93.

Shannon Fisher

Distinct enhancers of ptf1a mediate specification and expansion of ventral pancreas in zebrafish. Pashos E, Park JT, Leach S, Fisher S. Dev Biol. 2013 Sep 15;381(2):471-81. doi: 10.1016/j.ydbio.2013.07.011. Epub 2013 Jul 20.

GRG5/AES interacts with T-cell factor 4 (TCF4) and downregulates Wnt signaling in human cells and zebrafish embryos. Costa AM, Pereira-Castro I, Ricardo E, Spencer F, Fisher S, da Costa LT. PLoS One. 2013 Jul 1;8(7):e67694. doi: 10.1371/journal.pone.0067694. Print 2013.

Skeletogenic fate of zebrafish cranial and trunk neural crest. Kague E, Gallagher M, Burke S, Parsons M, Franz-Odendaal T, Fisher S. PLoS One. 2012;7(11):e47394. doi: 10.1371/journal.pone.0047394. Epub 2012 Nov 14.

Clara Franzini-Armstrong

Memories of annemarie weber. Franzini-Armstrong C. Anat Rec (Hoboken). 2014 Sep;297(9):1543-7. doi: 10.1002/ar.22963. No abstract available.

Overexpression of junctophilin-2 does not enhance baseline function but attenuates heart failure development after cardiac stress. Guo A, Zhang X, Iyer VR, Chen B, Zhang C, Kutschke WJ, Weiss RM, Franzini-Armstrong C, Song LS. Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12240-5. doi: 10.1073/pnas.1412729111. Epub 2014 Aug 4.

Highly extensible skeletal muscle in snakes. Close M, Perni S, Franzini-Armstrong C, Cundall D. J Exp Biol. 2014 Jul 15;217(Pt 14):2445-8. doi: 10.1242/jeb.097634. Epub 2014 May 6.

John Gearhart

Inhibition of TGFß signaling increases direct conversion of fibroblasts to induced cardiomyocytes. Ifkovits JL, Addis RC, Epstein JA, Gearhart JD. PLoS One. 2014 Feb 26;9(2):e89678.

Optimal Isolation and Xeno-free culture conditions for limbal stem cell function. Stasi K, Goings D, Huang J, Herman L, Pinto F, Addis RC, Klein D, Massaro-Giordano M, Gearhart JD. Invest Ophthalmol Vis Sci. 2013 Sep 12. doi:pii: iovs.13-12517v1. 10.1167/iovs.13-12517.

The Epigenetic Modifier Ubiquitin-specific Protease 22 (USP22) Regulates Embryonic Stem Cell Differentiation via Transcriptional Repression of Sex-determining Region Y-box 2 (SOX2). Sussman RT, Stanek TJ, Esteso P, Gearhart JD, Knudsen KE, McMahon SB. J Biol Chem. 2013 Aug 16;288(33):24234-46. doi: 10.1074/jbc.M113.469783. Epub 2013 Jun 12.

Amin Ghabrial

Seamless tube shape is constrained by endocytosis-dependent regulation of active moesin. Schottenfeld-Roames J, Rosa JB, Ghabrial AS. Curr Biol. 2014 Aug 4;24(15):1756-64. doi: 10.1016/j.cub.2014.06.029. Epub 2014 Jul 24.

Focal Defects in Single-Celled Tubes Mutant for Cerebral Cavernous Malformation 3, GCKIII, or NSF2. Song Y, Eng M, Ghabrial AS. Dev Cell. 2013 Jun 10;25(5):507-19. doi: 10.1016/j.devcel.2013.05.002.

Osmotic regulation of seamless tube growth. Schottenfeld-Roames J, Ghabrial AS. Nat Cell Biol. 2013 Feb;15(2):137-9.

Michael Granato

Mirror movement-like defects in startle behavior of zebrafish dcc mutants are caused by aberrant midline guidance of identified descending hindbrain neurons. Jain RA, Bell H, Lim A, Chien CB, Granato M. J Neurosci. 2014 Feb 19;34(8):2898-909.

Temporal requirement for SMN in motoneuron development. Hao LT, Duy PQ, Jontes JD, Wolman M, Granato M, Beattie CE. Hum Mol Genet. 2013 Mar 3.

A novel role for Lh3 dependent ECM modifications during neural crest cell migration in zebrafish. Banerjee S, Isaacman-Beck J, Schneider VA, Granato M. PLoS One. 2013;8(1):e54609. doi: 10.1371/journal.pone.0054609. Epub 2013 Jan 18.

Dan Kessler

Transcriptional integration of Wnt and Nodal pathways in establishment of the Spemann organizer. Reid CD, Zhang Y, Sheets MD, Kessler DS. Dev Biol. 2012 May 22

Mary Mullins

Hecate/Grip2a acts to reorganize the cytoskeleton in the symmetry-breaking event of embryonic axis induction. Ge X, Grotjahn D, Welch E, Lyman-Gingerich J, Holguin C, Dimitrova E, Abrams EW, Gupta T, Marlow FL, Yabe T, Adler A, Mullins MC, Pelegri F. PLoS Genet. 2014 Jun 26;10(6):e1004422. doi: 10.1371/journal.pgen.1004422. eCollection 2014 Jun.

The integrator complex subunit 6 (Ints6) confines the dorsal organizer in vertebrate embryogenesis. Kapp LD, Abrams EW, Marlow FL, Mullins MC. PLoS Genet. 2013 Oct;9(10):e1003822.

The chromosomal passenger protein birc5b organizes microfilaments and germ plasm in the zebrafish embryo. Nair S, Marlow F, Abrams E, Kapp L, Mullins MC, Pelegri F. PLoS Genet. 2013 Apr;9(4):e1003448. doi: 10.1371/journal.pgen.1003448.

Neal Rubinstein

Identification of the neuromuscular junction (NMJ) transcriptome of extraocular muscle (EOM) by laser capture microdissection (LCM).  Ketterer C, Zeiger U, Budak MT, Rubinstein NA, Khurana TS.  Invest Ophthalmol Vis Sci. 2010 Apr 14.

Patrick Seale

Genetically altering organismal metabolism by leptin-deficiency benefits a mouse model of amyotrophic lateral sclerosis. Lim MA, Bence KK, Sandesara I, Andreux P, Auwerx J, Ishibashi J, Seale P, Kalb RG. Hum Mol Genet. 2014 Sep 15;23(18):4995-5008. doi: 10.1093/hmg/ddu214. Epub 2014 May 15.

Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice. Harms MJ, Ishibashi J, Wang W, Lim HW, Goyama S, Sato T, Kurokawa M, Won KJ, Seale P. Cell Metab. 2014 Apr 1;19(4):593-604.

p107 Is a Crucial Regulator for Determining the Adipocyte Lineage Fate Choices of Stem Cells. De Sousa M, Porras DP, Perry CG, Seale P, Scimè A. Stem Cells. 2014 May;32(5):1323-36.

Celeste Simon

Nontranscriptional Role of Hif-1α in Activation of γ-Secretase and Notch Signaling in Breast Cancer. Villa JC, Chiu D, Brandes AH, Escorcia FE, Villa CH, Maguire WF, Hu CJ, de Stanchina E, Simon MC, Sisodia SS, Scheinberg DA, Li YM. Cell Rep. 2014 Aug 21;8(4):1077-92. doi: 10.1016/j.celrep.2014.07.028. Epub 2014 Aug 14.

Fructose-1,6-bisphosphatase opposes renal carcinoma progression. Li B, Qiu B, Lee DS, Walton ZE, Ochocki JD, Mathew LK, Mancuso A, Gade TP, Keith B, Nissim I, Simon MC. Nature. 2014 Jul 20. doi: 10.1038/nature13557. [Epub ahead of print]

Hypoxia-Inducible Factors Regulate Filaggrin Expression and Epidermal Barrier Function. Wong WJ, Richardson T, Seykora JT, Cotsarelis G, Simon MC. J Invest Dermatol. 2014 Jul 7. doi: 10.1038/jid.2014.283. [Epub ahead of print]

Nancy Speck

Runx1 and Cbfβ regulate the development of Flt3+ dendritic cell progenitors and restrict myeloproliferative disorder. Satpathy AT, Briseño CG, Cai X, Michael DG, Chou C, Hsiung S, Bhattacharya D, Speck NA, Egawa T. Blood. 2014 Mar 27.

Distinct temporal requirements for Runx1 in hematopoietic progenitors and stem cells. Tober J, Yzaguirre AD, Piwarzyk E, Speck NA. Development. 2013 Sep;140(18):3765-76. doi: 10.1242/dev.094961. Epub 2013 Aug 7.

The expression of Sox17 identifies and regulates haemogenic endothelium. Clarke RL, Yzaguirre AD, Yashiro-Ohtani Y, Bondue A, Blanpain C, Pear WS, Speck NA, Keller G. Nat Cell Biol. 2013 May;15(5):502-10. doi: 10.1038/ncb2724.

Phong Tran

Antagonistic spindle motors and MAPs regulate metaphase spindle length and chromosome segregation. Syrovatkina V, Fu C, Tran PT. Curr Biol. 2013 Dec 2;23(23):2423-9.

Imaging individual spindle microtubule dynamics in fission yeast. Costa J, Fu C, Syrovatkina V, Tran PT. Methods Cell Biol. 2013;115:385-94. doi: 10.1016/B978-0-12-407757-7.00024-4.

Common mechanisms regulating cell cortex properties during cell division and cell migration. Roubinet C, Tran PT, Piel M. Cytoskeleton (Hoboken). 2012 Nov;69(11):957-72. doi: 10.1002/cm.21086. Epub 2012 Nov 1.

John Weisel

Monitoring coagulopathies in fluid resuscitation for trauma or surgery. Weisel JW. Thromb Res. 2014 Sep;134(3):535-6. doi: 10.1016/j.thromres.2014.07.017. Epub 2014 Jul 17. No abstract available.

T2 Magnetic Resonance: A Diagnostic Platform for Studying Integrated Hemostasis in Whole Blood-Proof of Concept. Skewis LR, Lebedeva T, Papkov V, Thayer EC, Massefski W, Cuker A, Nagaswami C, Litvinov RI, Kowalska MA, Rauova L, Poncz M, Weisel JW, Lowery TJ, Cines DB. Clin Chem. 2014 Jun 23. pii: clinchem.2014.223735. [Epub ahead of print]

Structural basis for the nonlinear mechanics of fibrin networks under compression. Kim OV, Litvinov RI, Weisel JW, Alber MS. Biomaterials. 2014 Aug;35(25):6739-49. doi: 10.1016/j.biomaterials.2014.04.056. Epub 2014 May 16.

Ken Zaret

Dynamics of genomic H3K27me3 domains and role of EZH2 during pancreatic endocrine specification. Xu CR, Li LC, Donahue G, Ying L, Zhang YW, Gadue P, Zaret KS. EMBO J. 2014 Aug 8. pii: e201488671. [Epub ahead of print]

Genome reactivation after the silence in mitosis: recapitulating mechanisms of development? Zaret KS. Dev Cell. 2014 Apr 28;29(2):132-4.

Dept. of Cell & Developmental Biology
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