Faculty Publications 2012-2013
Marisa Bartolomei
Bisphenol a exposure disrupts genomic imprinting in the mouse. Susiarjo M, Sasson I, Mesaros C, Bartolomei MS. PLoS Genet. 2013 Apr;9(4):e1003401. doi: 10.1371/journal.pgen.1003401.
X-inactivation, imprinting, and long noncoding RNAs in health and disease. Lee JT, Bartolomei MS. Cell. 2013 Mar 14;152(6):1308-23. doi: 10.1016/j.cell.2013.02.016. Review.
A role for CTCF and cohesin in subtelomere chromatin organization, TERRA transcription, and telomere end protection. Deng Z, Wang Z, Stong N, Plasschaert R, Moczan A, Chen HS, Hu S, Wikramasinghe P, Davuluri RV, Bartolomei MS, Riethman H, Lieberman PM. EMBO J. 2012 Nov 5;31(21):4165-78
Shelley Berger
Genome-wide epigenetics. Capell BC, Berger SL. J Invest Dermatol. 2013 Jun;133(6):e9. doi: 10.1038/jid.2013.173.
Social insect genomes exhibit dramatic evolution in gene composition and regulation while preserving regulatory features linked to sociality. Simola DF, Wissler L, Donahue G, Waterhouse RM, Helmkampf M, Roux J, Nygaard S, Glastad K, Hagen DE, Viljakainen L, Reese JT, Hunt BG, Graur D, Elhaik E, Kriventseva E, Wen J, Parker BJ, Cash E, Privman E, Childers CP, Munos-Torres MC, Boomsma JJ, Bornberg-Bauer E, Currie C, Elsik CG, Suen G, Goodisman MA, Keller L, Liebig J, Rawls A, Reinberg D, Smith CD, Smith CR, Tsutsui N, Wurm Y, Zdobnov EM, Berger SL, Gadau J. Genome Res. 2013 May 1.
Depletion of the novel p53-target gene carnitine palmitoyltransferase 1C delays tumor growth in the neurofibromatosis type I tumor model. Sanchez-Macedo N, Feng J, Faubert B, Chang N, Elia A, Rushing EJ, Tsuchihara K, Bungard D, Berger SL, Jones RG, Mak TW, Zaugg K. Cell Death Differ. 2013 Apr;20(4):659-68. doi: 10.1038/cdd.2012.168.
Erfei Bi
Targeting and functional mechanisms of the cytokinesis-related F-BAR protein Hof1 during the cell cycle. Oh Y, Schreiter J, Nishihama R, Wloka C, Bi E. Mol Biol Cell. 2013 May;24(9):1305-20. doi: 10.1091/mbc.E12-11-0804.
Immobile myosin-II plays a scaffolding role during cytokinesis in budding yeast. Wloka C, Vallen EA, Thé L, Fang X, Oh Y, Bi E. J Cell Biol. 2013 Feb 4;200(3):271-86.
Mechanisms of cytokinesis in budding yeast. Wloka C, Bi E. Cytoskeleton (Hoboken). 2012 Jun 26.
Maya Capelson
Chromatin-bound nuclear pore components regulate gene expression in higher eukaryotes. Capelson M, Liang Y, Schulte R, Mair W, Wagner U, Hetzer MW. Cell. 2010 Feb 5;140(3):372-83. doi: 10.1016/j.cell.2009.12.054.
Steve DiNardo
magu is required for germline stem cell self-renewal through BMP signaling in the Drosophila testis. Zheng Q, Wang Y, Vargas E, Dinardo SDev Biol.
2011 Sep 1;357(1):202-10
J.A. Epstein
Molecular determinants of lung development. Morrisey EE, Cardoso WV, Lane RH, Rabinovitch M, Abman SH, Ai X, Albertine KH, Bland RD, Chapman HA, Checkley W, Epstein JA, Kintner CR, Kumar M, Minoo P, Mariani TJ, McDonald DM, Mukouyama YS, Prince LS, Reese J, Rossant J, Shi W, Sun X, Werb Z, Whitsett JA, Gail D, Blaisdell CJ, Lin QS. Ann Am Thorac Soc. 2013 Apr;10(2):S12-6. doi: 10.1513/AnnalsATS.201207-036OT.
Optimization of direct fibroblast reprogramming to cardiomyocytes using calcium activity as a functional measure of success. Addis RC, Ifkovits JL, Pinto F, Kellam LD, Esteso P, Rentschler S, Christoforou N, Epstein JA, Gearhart JD. J Mol Cell Cardiol. 2013 Jul;60:97-106. doi: 10.1016/j.yjmcc.2013.04.004.
Murine craniofacial development requires Hdac3-mediated repression of Msx gene expression. Singh N, Gupta M, Trivedi CM, Singh MK, Li L, Epstein JA. Dev Biol. 2013 May 15;377(2):333-44. doi: 10.1016/j.ydbio.2013.03.008.
Shannon Fisher
Skeletogenic fate of zebrafish cranial and trunk neural crest. Kague E, Gallagher M, Burke S, Parsons M, Franz-Odendaal T, Fisher S. PLoS One. 2012;7(11):e47394. doi: 10.1371/journal.pone.0047394. Epub 2012 Nov 14.
Multiple enhancers associated with ACAN suggest highly redundant transcriptional regulation in cartilage. Hu G, Codina M, Fisher S. Matrix Biol. 2012 Jul 20.
Evolution of the bone gene regulatory network. Fisher S, Franz-Odendaal T. Curr Opin Genet Dev. 2012 Aug;22(4):390-7. Epub 2012 Jun 2.
Clara Franzini-Armstrong
Stac3 is a component of the excitation-contraction coupling machinery and mutated in Native American myopathy. Horstick EJ, Linsley JW, Dowling JJ, Hauser MA, McDonald KK, Ashley-Koch A, Saint-Amant L, Satish A, Cui WW, Zhou W, Sprague SM, Stamm DS, Powell CM, Speer MC, Franzini-Armstrong C, Hirata H, Kuwada JY. Nat Commun. 2013;4:1952. doi: 10.1038/ncomms2952.
Domain cooperativity in the β1a subunit is essential for dihydropyridine receptor voltage sensing in skeletal muscle. Dayal A, Bhat V, Franzini-Armstrong C, Grabner M. Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7488-93. doi: 10.1073/pnas.1301087110.
Targeted ablation of the histidine-rich Ca(2+)-binding protein (HRC) gene is associated with abnormal SR Ca(2+)-cycling and severe pathology under pressure-overload stress. Park CS, Chen S, Lee H, Cha H, Oh JG, Hong S, Han P, Ginsburg KS, Jin S, Park I, Singh VP, Wang HS, Franzini-Armstrong C, Park WJ, Bers DM, Kranias EG, Cho C, Kim do H. Basic Res Cardiol. 2013 May;108(3):344. doi: 10.1007/s00395-013-0344-2.
John Gearhart
Optimization of direct fibroblast reprogramming to cardiomyocytes using calcium activity as a functional measure of success. Addis RC, Ifkovits JL, Pinto F, Kellam LD, Esteso P, Rentschler S, Christoforou N, Epstein JA, Gearhart JD. J Mol Cell Cardiol. 2013 Jul;60:97-106. doi: 10.1016/j.yjmcc.2013.04.004.
Genome-wide profiling of pluripotent cells reveals a unique molecular signature of human embryonic germ cells. Pashai N, Hao H, All A, Gupta S, Chaerkady R, De Los Angeles A, Gearhart JD, Kerr CL. PLoS One. 2012;7(6):e39088. Epub 2012 Jun 21.
Efficient conversion of astrocytes to functional midbrain dopaminergic neurons using a single polycistronic vector. Addis RC, Hsu FC, Wright RL, Dichter MA, Coulter DA, Gearhart JD. PLoS One. 2011;6(12):e28719. Epub 2011 Dec 9.
Amin Ghabrial
Focal Defects in Single-Celled Tubes Mutant for Cerebral Cavernous Malformation 3, GCKIII, or NSF2. Song Y, Eng M, Ghabrial AS. Dev Cell. 2013 Jun 10;25(5):507-19. doi: 10.1016/j.devcel.2013.05.002.
Osmotic regulation of seamless tube growth. Schottenfeld-Roames J, Ghabrial AS. Nat Cell Biol. 2013 Feb;15(2):137-9.
Whacked and Rab35 polarize dynein-motor-complex-dependent seamless tube growth. Schottenfeld-Roames J, Ghabrial AS. Nat Cell Biol. 2012 Mar 11. doi: 10.1038/ncb2454. [Epub ahead of print]
Michael Granato
Temporal requirement for SMN in motoneuron development. Hao LT, Duy PQ, Jontes JD, Wolman M, Granato M, Beattie CE. Hum Mol Genet. 2013 Mar 3.
A novel role for Lh3 dependent ECM modifications during neural crest cell migration in zebrafish. Banerjee S, Isaacman-Beck J, Schneider VA, Granato M. PLoS One. 2013;8(1):e54609. doi: 10.1371/journal.pone.0054609. Epub 2013 Jan 18.
Plexin A3 and turnout regulate motor axonal branch morphogenesis in zebrafish. Sainath R, Granato M. PLoS One. 2013;8(1):e54071. doi: 10.1371/journal.pone.0054071. Epub 2013 Jan 21.
The tumor suppressor gene retinoblastoma-1 is required for retinotectal development and visual function in zebrafish. Gyda M, Wolman M, Lorent K, Granato M. PLoS Genet. 2012;8(11):e1003106. doi: 10.1371/journal.pgen.1003106. Epub 2012 Nov 29.
Dan Kessler
Transcriptional integration of Wnt and Nodal pathways in establishment of the Spemann organizer. Reid CD, Zhang Y, Sheets MD, Kessler DS. Dev Biol. 2012 May 22
Mary Mullins
The chromosomal passenger protein birc5b organizes microfilaments and germ plasm in the zebrafish embryo. Nair S, Marlow F, Abrams E, Kapp L, Mullins MC, Pelegri F. PLoS Genet. 2013 Apr;9(4):e1003448. doi: 10.1371/journal.pgen.1003448.
Anteroposterior and dorsoventral patterning are coordinated by an identical patterning clock. Hashiguchi M, Mullins MC. Development. 2013 May;140(9):1970-80. doi: 10.1242/dev.088104
Dynamic Assembly of Brambleberry Mediates Nuclear Envelope Fusion during Early Development. Abrams EW, Zhang H, Marlow FL, Kapp L, Lu S, Mullins MC. Cell. 2012 Aug 3;150(3):521-32.
Neal Rubinstein
Identification of the neuromuscular junction (NMJ) transcriptome of extraocular muscle (EOM) by laser capture microdissection (LCM). Ketterer C, Zeiger U, Budak MT, Rubinstein NA, Khurana TS. Invest Ophthalmol Vis Sci. 2010 Apr 14.
Patrick Seale
Brown adipose tissue biology and therapeutic potential. Seale P. Front Endocrinol (Lausanne). 2013;4:14. doi: 10.3389/fendo.2013.00014.
EBF2 determines and maintains brown adipocyte identity. Rajakumari S, Wu J, Ishibashi J, Lim HW, Giang AH, Won KJ, Reed RR, Seale P. Cell Metab. 2013 Apr 2;17(4):562-74. doi: 10.1016/j.cmet.2013.01.015.
MicroRNA-133 Controls Brown Adipose Determination in Skeletal Muscle Satellite Cells by Targeting Prdm16. Yin H, Pasut A, Soleimani VD, Bentzinger CF, Antoun G, Thorn S, Seale P, Fernando P, van Ijcken W, Grosveld F, Dekemp RA, Boushel R, Harper ME, Rudnicki MA. Cell Metab. 2013 Feb 5;17(2):210-24.
Celeste Simon
Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress. Young RM, Ackerman D, Quinn ZL, Mancuso A, Gruber M, Liu L, Giannoukos DN, Bobrovnikova-Marjon E, Diehl JA, Keith B, Simon MC. Genes Dev. 2013 May 15;27(10):1115-31. doi: 10.1101/gad.198630.112.
HIF1α and HIF2α independently activate SRC to promote melanoma metastases. Hanna SC, Krishnan B, Bailey ST, Moschos SJ, Kuan PF, Shimamura T, Osborne LD, Siegel MB, Duncan LM, O'Brien ET 3rd, Superfine R, Miller CR, Simon MC, Wong KK, Kim WY. J Clin Invest. 2013 May 1;123(5):2078-93. doi: 10.1172/JCI66715.
Decreased serum glucose and glycosylated hemoglobin levels in patients with Chuvash polycythemia: a role for HIF in glucose metabolism. McClain DA, Abuelgasim KA, Nouraie M, Salomon-Andonie J, Niu X, Miasnikova G, Polyakova LA, Sergueeva A, Okhotin DJ, Cherqaoui R, Okhotin D, Cox JE, Swierczek S, Song J, Simon MC, Huang J, Simcox JA, Yoon D, Prchal JT, Gordeuk VR. J Mol Med (Berl). 2013 Jan;91(1):59-67.
Nancy Speck
The expression of Sox17 identifies and regulates haemogenic endothelium. Clarke RL, Yzaguirre AD, Yashiro-Ohtani Y, Bondue A, Blanpain C, Pear WS, Speck NA, Keller G. Nat Cell Biol. 2013 May;15(5):502-10. doi: 10.1038/ncb2724.
Endothelio-mesenchymal interaction controls runx1 expression and modulates the notch pathway to initiate aortic hematopoiesis. Richard C, Drevon C, Canto PY, Villain G, Bollérot K, Lempereur A, Teillet MA, Vincent C, Rosselló Castillo C, Torres M, Piwarzyk E, Speck NA, Souyri M, Jaffredo T. Dev Cell. 2013 Mar 25;24(6):600-11. doi: 10.1016/j.devcel.2013.02.011.
Attenuation of AML1-ETO cellular dysregulation correlates with increased leukemogenic potential. Dekelver RC, Yan M, Ahn EY, Shia WJ, Speck NA, Zhang DE. Blood. 2013 Feb 20.
Phong Tran
Common mechanisms regulating cell cortex properties during cell division and cell migration. Roubinet C, Tran PT, Piel M. Cytoskeleton (Hoboken). 2012 Nov;69(11):957-72. doi: 10.1002/cm.21086. Epub 2012 Nov 1.
Estimating the microtubule GTP cap size in vivo. Seetapun D, Castle BT, McIntyre AJ, Tran PT, Odde DJ. Curr Biol. 2012 Sep 25;22(18):1681-7. doi: 10.1016/j.cub.2012.06.068.
Motor proteins: kinesin can replace Myosin. Scheffler K, Tran PT. Curr Biol. 2012 Jan 24;22(2):R52-4.
John Weisel
Molecular mechanisms, thermodynamics, and dissociation kinetics of knob-hole interactions in fibrin. Kononova O, Litvinov RI, Zhmurov A, Alekseenko A, Cheng CH, Agarwal S, Marx KA, Weisel JW, Barsegov V. J Biol Chem. 2013 May 31.
Hyaluronan and dextran modified tubes resist cellular activation with blood contact. Eckmann DM, Tsai IY, Tomczyk N, Weisel JW, Composto RJ. Colloids Surf B Biointerfaces. 2013 Aug 1;108:44-51. doi: 10.1016/j.colsurfb.2013.02.013.
Platelets lacking PIP5KIγ have normal integrin activation but impaired cytoskeletal-membrane integrity and adhesion. Wang Y, Zhao L, Suzuki A, Lian L, Min SH, Wang Z, Litvinov RI, Stalker TJ, Yago T, Klopocki AG, Schmidtke DW, Yin H, Choi JK, McEver RP, Weisel JW, Hartwig JH, Abrams CS. Blood. 2013 Jan 31.
Ken Zaret
Itm2a is a pax3 target gene, expressed at sites of skeletal muscle formation in vivo. Lagha M, Mayeuf-Louchart A, Chang T, Montarras D, Rocancourt D, Zalc A, Kormish J, Zaret KS, Buckingham ME, Relaix F. PLoS One. 2013 May 1;8(5):e63143. doi: 10.1371/journal.pone.0063143.
Understanding impediments to cellular conversion to pluripotency by assessing the earliest events in ectopic transcription factor binding to the genome. Soufi A, Zaret KS. Cell Cycle. 2013 May 15;12(10):1487-91. doi: 10.4161/cc.24663.
Bookmarking by specific and nonspecific binding of FoxA1 pioneer factor to mitotic chromosomes. Caravaca JM, Donahue G, Becker JS, He X, Vinson C, Zaret KS. Genes Dev. 2013 Feb 1;27(3):251-60.
