TB/HIV Coinfection Working Group
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University of Washington CFAR

Primary contacts

Matthew Arentz:            marentz@uw.edu
Judd Walson                  walson@u.washington.edu
http://depts.washington.edu/cfas/cfar/center/

1. HIV/TB Co-infection Projects:
In Mombasa, Dr. McClelland conducted a study of initiation of Isoniazid Preventive Therapy in 490 HIV positive individuals.  His research identified factors associated with failure to complete treatment in a cohort of female sex-workers.

In Nairobi, Dr. John-Stewart evaluated IGRA results in a maternal/ child HIV+ cohort.  She found an association between positive IGRA results and subsequent TB disease and death in immunosuppressed women.

Drs. Walson and Arentz conducted an evaluation of TB treatment patterns in Kenya.  They evaluated treatment information from over 15,000 patients in sites across the country. The data from this project is being analyzed for results.

2. Inter-CFAR Shared Resources:
Our group in Kenya has multiple, large HIV cohorts that have allowed numerous research studies.  Kenya is estimated to have a high rate of co-infection (>50%) in those who are treated for tuberculosis. We have a long history of collaboration with the Kenyan Ministry of Health and the Kenyan Medical Research Institute (KEMRI).  In addition, we have experience conducting research in multiple sites in Kenya, including Nairobi, Kisii, Kisumu, Mombasa, and Kilifi.  We have a cohort of HIV discordant couples, a cohort of HIV + mothers and infants, a cohort of HIV positive female sex workers, in addition to others.  We would be willing to discuss collaborations on TB/HIV research.