Welcome to the Chen Lab!
The brain dictates our interaction with the external world and defines our internal mindscape. Thus, disruption of this delicate organ leads to immense individual and societal costs.
The primary focus of our translational research is to develop novel methods for restoring the function of the brain after it has been damaged by combining aspects of stem cell biology, neural tissue engineering, and neural interface technologies. In addition, we are interested in new techniques for preserving brain function during neurosurgical procedures. The goal of these research endeavors is to improve the outcomes of patients suffering from a variety of brain disorders and diseases.
Society for Neuroscience: Nanosymposium & Poster
11/11/2017 - 11/15/2017
Check out our Nanosymposium: "Transplantation of human cortical organoid tissue for reconstruction of rat visual cortex" and Poster: "Characterization of cerebral organoid activity using two-photon calcium imaging and acute electrophysiology techniques" presentations given at the Society for Neuroscience Conference 2017. (https://www.abstractsonline.com/pp8/#!/4376/presentation/9226)(https://www.abstractsonline.com/pp8/#!/4376/presentation/18876)
Studying neural activity propagation in a "connectome unit"
We have just published a paper entitled "Multichannel activity propagation across an engineered axon network" in the Journal of Neural Engineering. Using a modular network consisting of two cortical neuron nodes connected by stretch-grown axon tracts, we examined how multichannel input patterns are represented by cortical networks, how these representations shift as they are transmitted between nodes, and and how well the downstream node can distinguish different patterns. Check it out (http://iopscience.iop.org/article/10.1088/1741-2552/aa5ccd/pdf)!