Publications

  1. Jgamadze, D., Lim, J. T., Zhang, Z., Harary, P. M., Germi, J., Mensah-Brown, K., ... & Chen, H. C. I. (2023). Structural and functional integration of human forebrain organoids with the injured adult rat visual system. Cell Stem Cell, 30(2), 137-152.
  2. Harary PM, Blue R, Castellanos M et al. Human brain organoid transplantation: ethical implications of enhancing specific cerebral functions in small-animal models. Mol. Psychol. 2023, 2:14 (https://doi.org/10.12688/molpsychol.17544.1)
  3. Jgamadze, Dennis, et al. "Protocol for human brain organoid transplantation into a rat visual cortex to model neural repair." STAR protocols 4.3 (2023): 102470.

  1. Struzyna LA, Browne KD, Burrell JC, Vélez WJG, Wofford KL, Kaplan HM, Murthy NS, Chen HI, Duda JE, España RA, Cullen DK. Axonal Tract Reconstruction Using a Tissue-Engineered Nigrostriatal Pathway in a Rat Model of Parkinson's Disease. Int J Mol Sci. 2022 Nov 12;23(22).
  2. Smith DH, Burrell JC, Browne KD, Katiyar KS, Ezra MI, Dutton JL, Morand JP, Struzyna LA, Laimo FA, Chen HI, Wolf JA, Kaplan HM, Rosen JM, Ledebur HC, Zager EL, Ali ZS, Cullen DK. Tissue-engineered grafts exploit axon-facilitated axon regeneration and pathway protection to enable recovery after 5-cm nerve defects in pigs. Sci Adv. 2022 Nov 4;8(44):eabm3291. 
  3. Zhou Y, Su Y, Li S, Kennedy BC, Zhang DY, Bond AM, Sun Y, Jacob F, Lu L, Hu P, Viaene AN, Helbig I, Kessler SK, Lucas T, Salinas RD, Gu X, Chen HI, Wu H, Kleinman JE, Hyde TM, Nauen DW, Weinberger DR, Ming GL, Song H. Molecular landscapes of human hippocampal immature neurons across lifespan.Nature. 2022 Jul;607(7919):527-533.

  1. Gordián-Vélez WJ, Chouhan D, España RA, Chen HI, Burdick JA, Duda JE, Cullen DK. Restoring lost nigrostriatal fibers in Parkinson's disease based on clinically-inspired design criteria. Brain Res Bull. 2021 Oct;175:168-185.
  2. Driscoll N, Erickson B, Murphy BB, Richardson AG, Robbins G, Apollo NV, Mentzelopoulos G, Mathis T, Hantanasirisakul K, Bagga P, Gullbrand SE, Sergison M, Reddy R, Wolf JA, Chen HI, Lucas TH, Dillingham TR, Davis KA, Gogotsi Y, Medaglia JD, Vitale F. MXene-infused bioelectronic interfaces for multiscale electrophysiology and stimulation. Sci Transl Med. 2021 Sep 22;13(612):eabf8629. 
  3. Adewole DO, Struzyna LA, Burrell JC, Harris JP, Nemes AD, Petrov D, Kraft RH, Chen HI, Serruya MD, Wolf JA, Cullen DK. Development of optically controlled "living electrodes" with long-projecting axon tracts for a synaptic brain-machine interface. Sci Adv. 2021 Jan;7(4).

  1. Burrell JC, Browne KD, Dutton JL, Laimo FA, Das S, Brown DP, Roberts S, Petrov D, Ali Z, Ledebur HC, Rosen JM, Kaplan HM, Wolf JA, Smith DH, Chen HI, Cullen DK. A Porcine Model of Peripheral Nerve Injury Enabling Ultra-Long Regenerative Distances: Surgical Approach, Recovery Kinetics, and Clinical Relevance. Neurosurgery. 2020 Sep 15;87(4):833-846.
  2. Blue R, Miranda SP, Gu BJ, Chen HI. A Primer on Human Brain Organoids for the Neurosurgeon. Neurosurgery. 2020 Sep 15;87(4):620-629. doi: 10.1093/neuros/nyaa171. Review. 
  3. Das S, Gordián-Vélez WJ, Ledebur HC, Mourkioti F, Rompolas P, Chen HI, Serruya MD, Cullen DK. Innervation: the missing link for biofabricated tissues and organs. NPJ Regen Med. 2020;5:11. doi: 10.1038/s41536-020-0096-1. eCollection 2020. Review. 
  4. Jgamadze D, Johnson VE, Wolf JA, Cullen DK, Song H, Ming GL, Smith DH, Chen HI. Modeling traumatic brain injury with human brain organoids. Curr Opin Biomed Eng. 2020 Jun;14:52-58.
  5. Qian X, Su Y, Adam CD, Deutschmann AU, Pather SR, Goldberg EM, Su K, Li S, Lu L, Jacob F, Nguyen PTT, Huh S, Hoke A, Swinford-Jackson SE, Wen Z, Gu X, Pierce RC, Wu H, Briand LA, Chen HI, Wolf JA, Song H, Ming GL. Sliced Human Cortical Organoids for Modeling Distinct Cortical Layer Formation. Cell Stem Cell. 2020 May 7;26(5):766-781.e9.
  6. Purvis EM, O'Donnell JC, Chen HI, Cullen DK. Tissue Engineering and Biomaterial Strategies to Elicit Endogenous Neuronal Replacement in the Brain.Front Neurol. 2020;11:344. doi: 10.3389/fneur.2020.00344. eCollection 2020. Review. 
  7. Jacob F, Salinas RD, Zhang DY, Nguyen PTT, Schnoll JG, Wong SZH, Thokala R, Sheikh S, Saxena D, Prokop S, Liu DA, Qian X, Petrov D, Lucas T, Chen HI, Dorsey JF, Christian KM, Binder ZA, Nasrallah M, Brem S, O'Rourke DM, Ming GL, Song H. A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intra-tumoral Heterogeneity. Cell. 2020 Jan 9;180(1):188-204.e22
  8. Harris JP, Burrell JC, Struzyna LA, Chen HI, Serruya MD, Wolf JA, Duda JE, Cullen DK. Emerging regenerative medicine and tissue engineering strategies for Parkinson's disease. NPJ Parkinsons Dis. 2020;6:4.

  1. Cullen DK, Gordián-Vélez WJ, Struzyna LA, Jgamadze D, Lim J, Wofford KL, Browne KD, Chen HI. Bundled Three-Dimensional Human Axon Tracts Derived from Brain Organoids. iScience. 2019 Nov 22;21:57-67. 
  2. Chen HI, Wolf JA, Blue R, Song MM, Moreno JD, Ming GL, Song H. Transplantation of Human Brain Organoids: Revisiting the Science and Ethics of Brain Chimeras. Cell Stem Cell. 2019 Oct 3;25(4):462-472. doi: 10.1016/j.stem.2019.09.002. Review. 
  3. Chen HI, Jgamadze D, Lim J, Mensah-Brown K, Wolf JA, Mills JA, Smith DH. Functional Cortical Axon Tracts Generated from Human Stem Cell-Derived Neurons. Tissue Eng Part A. 2019 May;25(9-10):736-745. doi: 10.1089/ten.TEA.2018.0270. Epub 2019 Mar 29.
  4. Ulyanova AV, Cottone C, Adam CD, Gagnon KG, Cullen DK, Holtzman T, Jamieson BG, Koch PF, Chen HI, Johnson VE, Wolf JA. Multichannel Silicon Probes for Awake Hippocampal Recordings in Large Animals. Front Neurosci. 2019;13:397.
  5. O'Donnell JC, Browne KD, Kilbaugh TJ, Chen HI, Whyte J, Cullen DK. Challenges and demand for modeling disorders of consciousness following traumatic brain injury. Neurosci Biobehav Rev. 2019 Mar;98:336-346.
  6. Liaudanskaya V, Jgamadze D, Berk AN, Bischoff DJ, Gu BJ, Hawks-Mayer H, Whalen MJ, Chen HI, Kaplan DL. Engineering advanced neural tissue constructs to mitigate acute cerebral inflammation after brain transplantation in rats. Biomaterials. 2019 Feb;192:510-522.
  7. Duong TT, Lim J, Vasireddy V, Papp T, Nguyen H, Leo L, Pan J, Zhou S, Chen HI, Bennett J, Mills JA. Comparative AAV-eGFP Transgene Expression Using Vector Serotypes 1-9, 7m8, and 8b in Human Pluripotent Stem Cells, RPEs, and Human and Rat Cortical Neurons. Stem Cells Int. 2019;2019:7281912. doi: 10.1155/2019/7281912.

  1. Chen HI, Song H, Ming GL. Applications of Human Brain Organoids to Clinical Problems. Dev Dyn. 2019 Jan;248(1):53-64. 
  2. Ulyanova AV, Koch PF, Cottone C, Grovola MR, Adam CD, Browne KD, Weber MT, Russo RJ, Gagnon KG, Smith DH, Isaac Chen H, Johnson VE, Kacy Cullen D, Wolf JA. Electrophysiological Signature Reveals Laminar Structure of the Porcine Hippocampus. eNeuro. 2018 Sep-Oct;5(5).
  3. Struzyna LA, Browne KD, Brodnik ZD, Burrell JC, Harris JP, Chen HI, Wolf JA, Panzer KV, Lim J, Duda JE, España RA, Cullen DK. Tissue engineered nigrostriatal pathway for treatment of Parkinson's disease. J Tissue Eng Regen Med. 2018 Jul;12(7):1702-1716.
  4. Serruya MD, Harris JP, Adewole DO, Struzyna LA, Burrell JC, Nemes A, Petrov D, Kraft RH, Chen HI, Wolf JA, Cullen DK. Engineered Axonal Tracts as "Living Electrodes" for Synaptic-Based Modulation of Neural Circuitry. Adv Funct Mater. 2018 Mar 21;28(12).
  5. Cullen DK, Struzyna LA, Jgamadze D, Gordian-Velez WJ, Browne KD, Chen HI. Three-dimensional human axon tracts derived from cerebral organoids.bioRxiv. 2018 January.

  1. Morris J, Na YJ, Zhu H, Lee JH, Giang H, Ulyanova AV, Baltuch GH, Brem S, Chen HI, Kung DK, Lucas TH, O'Rourke DM, Wolf JA, Grady MS, Sul JY, Kim J, Eberwine J. Pervasive within-Mitochondrion Single-Nucleotide Variant Heteroplasmy as Revealed by Single-Mitochondrion Sequencing. Cell Rep. 2017 Dec 5;21(10):2706-2713. 
  2. Chen HI, Wolf JA, Smith DH. Multichannel activity propagation across an engineered axon network. J Neural Eng. 2017 Apr;14(2):026016. doi: 10.1088/1741-2552/aa5ccd. Epub 2017 Jan 31. 
  3. Spaethling JM, Na YJ, Lee J, Ulyanova AV, Baltuch GH, Bell TJ, Brem S, Chen HI, Dueck H, Fisher SA, Garcia MP, Khaladkar M, Kung DK, Lucas TH Jr, O'Rourke DM, Stefanik D, Wang J, Wolf JA, Bartfai T, Grady MS, Sul JY, Kim J, Eberwine JH. Primary Cell Culture of Live Neurosurgically Resected Aged Adult Human Brain Cells and Single Cell Transcriptomics. Cell Rep. 2017 Jan 17;18(3):791-803.
  4. Chen HI, Burke JF, Cohen AS. Editorial: Traumatic Brain Injury As a Systems Neuroscience Problem. Front Syst Neurosci. 2016;10:100. 

  1. Pisapia JM, Kayak NR, Salinas RD, Macyzsyn L, Lee JYK, Lucas TH, Malhotra NR, Chen HI, Schuster JM: Navigated odontoid screw placement using the O-arm: technical note and case series. Journal of Neurosurgery: Spine (in press).
  2. Richardson AG, Attiah MA, Berman JI, Chen HI, Liu X, Zhang M, Van der Spiegel J, Lucas TH: The effects of acute cortical somatosensory deafferentation on grip force control.  Cortex  74:1-8, 2016.
  3. Chen HI, Jgamadze D, Serruya MD, Cullen DK, Wolf JA, Smith DH: Neural substrate expansion for the restoration of brain function. Frontiers in System Neuroscience 10(1), 2016.

  1. Struzyna L, Wolf JA, Mietus C, Adewole DO, Chen HI, Smith DH, Cullen DK: Rebuilding brain circuitry with living micro-tissue engineered neural networks.  Tissue Engineering Part A 21(21-22):2744-2756, 2015.
  2. Chen HI, Bohman L, Emery L, Martinez-Lage M, Richardson AG, Davis KA, Pollard JR, Litt B, Gausas RE, Lucas TL: Lateral transorbital endoscopic access to the hippocampus, amygdala, and entorhinal cortex: Initial clinical experience.  ORL; Journal of Oto-rhino-laryngology and its Related Specialties 77(6):321-332, 2015.
  3. Struzyna LA, Harris J, Katiyar K, Chen HI, Cullen DK: Restoring nervous system structure and function using tissue engineered living scaffolds.  Neural Regeneration Research 10(5):115-28, 2015.

  1. Lang SS, Chen HI, Koch MJ, Kurash L, McGill-Armento KR, Palella JM, Stein SC, Malhotra NR: Development of an outpatient protocol for lumbar discectomy: Our institutional experience.  World Neurosurgery 82(5):897-901, 2014.
  2. Chen HI, Bohman L, Loevner L, Lucas TH: Transorbital endoscopic amygdalo-hippocampectomy: a feasibility investigation.  Journal of Neurosurgery 120(6):1428-1436, 2014.  [Cover article]
  3. Chen HI, Attiah M, Baltuch G, Smith DH, Hamilton RH, Lucas TH: Harnessing plasticity for the treatment of neurosurgical disorders.  World Neurosurgery 82(5):648-659, 2014.

Chen HI, Lang SS, Coyne TM, Malhotra NR, Schuster JM: Intramedullary spinal sarcoidosis masquerading as cervical stenosis.  World Neurosurgery 80(6):e375-380, 2013.

Lang SS, Chen HI, Lee JYK.  Endoscopic microvascular decompression: a step-wise operative technique.  ORL; Journal of Oto-rhino-laryngology and its Related Specialties 74:293-298,2012.

Chen HI, Stiefel MF, Oddo M, Milby AH, Maloney-Wilensky E, Frangos S, Levine JM, Kofke WA, LeRoux PD: Detection of cerebral compromise with multimodality monitoring in patients with subarachnoid hemorrhage.  Neurosurgery 69:53-63, 2011.

  1. Lee JYK, Chen HI, Urban C, Hojat A, Church E, Farrar JT: Development and psychometric testing of the Brief Pain Inventory-Facial for patients with facial pain.  Journal of Neurosurgery 113(3):516-523, 2010.
  2. Oddo M, Nduom E, Frangos S, Mackenzie L, Chen HI, Maloney-Wilensky E, Kofke WA, Levine JM, LeRoux PD: Acute lung injury is an independent risk factor for brain hypoxia after severe traumatic brain injury.  Neurosurgery 67(2):338-344, 2010.
  3. Magge SN, Chen HI, Cen L, Chen Z, Elliott JP, Winn HR, LeRoux PD: Association of younger age with an increased risk of angiographic and symptomatic vasospasm after subarachnoid hemorrhage.  Journal of Neurosurgery 112(6):1208-1215, 2010.
  4. Evans SM, Jenkins KT, Chen HI, Jenkins WT, Judy KD, Hwang WT, Lustig RA, Magarelli DR, Judkins A, Grady MS, Hahn SM, Koch CJ: The relationship among hypoxia, proliferation, and outcome in patients with de novo glioblastoma: A pilot study.  Translational Oncology 3(3):160-169, 2010.
  5. Chen HI, Lee JYK: The measurement of pain in trigeminal neuralgia patients.  Clinical Neurosurgery 57:129-133, 2010.

  1. Magge SN, Malik S, Royo NC, Chen HI, Yu L, Snyder EY, O’Rourke DM, Watson DJ: Role of monocyte chemoattractant protein-1 (MCP-1/CCL2) in migration of neural progenitor cells towards glial tumors.  Journal of Neuroscience Research 87(7):1547-55, 2009.
  2. Oddo M, Frangos S, Milby A, Chen HI, Maloney-Wilensky E, MacMurtrie E, Stiefel MF, Kofke WA, LeRoux PD, Levine JM: Induced normothermia attenuates cerebral metabolic distress in patients with aneurysmal subarachnoid hemorrhage and refractory fever.  Stroke 40(5):1913-6, 2009.
  3. Oddo M, Milby A, Chen HI, Frangos S, MacMurtrie E, Maloney-Wilensky E, Stiefel MF, Kofke WA, Levine JM, LeRoux PD: Hemoglobin concentration and cerebral metabolism in patients with aneurysmal subarachnoid hemorrhage.  Stroke 40(4):1275-81, 2009.

  1. Chen HI, Malhotra NR, Oddo M, Heuer GG, Levine JM, LeRoux PD: Barbiturate infusion for intractable intracranial hypertension and its effects on brain oxygenation.  Neurosurgery 63(5):880-806, 2008.
  2. Magge SN, Chen HI, Stiefel MF, Ernst L, Cahill AM, Hurst R, Storm PB: Multiple ruptured cerebral aneurysms in a child with Takayasu Arteritis.  Journal of Neurosurgery: Pediatrics 1(1):83-8, 2008.

  1. Dahl J, Chen HI, George M, Benjamin TL: Polyoma small T antigen controls viral chromatin modifications through effects on kinetics of virus growth and cell cycle progression.  Journal of Virology:81(18):10064-10071, 2007.
  2. Royo NC, LeBold D, Magge SN, Chen HI, Hauspurg A, Cohen AS, Watson DJ: Neurotrophin-mediated neuroprotection of hippocampal neurons following traumatic brain injury is not associated with acute recovery of hippocampal function.  Neuroscience 148(2):359-370, 2007.
  3. Magge SN, Chen HI, Heuer G, Carracsco LR, Storm PB: Dislocation of the mandible into the middle cranial fossa.  Case report.  Journal of Neurosurgery: Pediatrics 107(1):75-78, 2007.
  4. Chen HI, Heuer GG, Zaghloul K, Simon SL, Weigele JB, Grady MS: Lumbar vertebral hemangioma presenting with the acute onset of neurological symptoms.  Case report.  Journal of Neurosurgery: Spine 7(1):80-85, 2007.
  5. Chen HI, Bakshi A, Royo NC, Magge SN, Watson DJ: Neural stem cells as biological minipumps: A faster route to cell therapy for the CNS?  Current Stem Cell Research and Therapy 2(1):13-22, 2007.

  1. Chen HI, Burnett MG, Huse JT, Lustig RA, Bagley LJ, Zager EL: Recurrent late cerebral necrosis with aggressive characteristics after radiosurgical treatment of an arteriovenous malformation.  Journal of Neurosurgery 105(3):455-460, 2006.
  2. Magge SN, Chen HI, Zager EL: Dystrophic calcification and infraclavicular brachial plexopathy: Case report.  Neurosurgery 58(6):E216, 2006.