Perelman School of Medicine at the University of Pennsylvania

Chen Laboratory



Pisapia JM, Kayak NR, Salinas RD, Macyzsyn L, Lee JYK, Lucas TH, Malhotra NR, Chen HI, Schuster JM: Navigated odontoid screw placement using the O-arm: technical note and case series. Journal of Neurosurgery: Spine (in press).

Richardson AG, Attiah MA, Berman JI, Chen HI, Liu X, Zhang M, Van der Spiegel J, Lucas TH: The effects of acute cortical somatosensory deafferentation on grip force control.  Cortex  74:1-8, 2016.

Chen HI, Jgamadze D, Serruya MD, Cullen DK, Wolf JA, Smith DH: Neural substrate expansion for the restoration of brain function. Frontiers in System Neuroscience 10(1), 2016.



Struzyna L, Wolf JA, Mietus C, Adewole DO, Chen HI, Smith DH, Cullen DK: Rebuilding brain circuitry with living micro-tissue engineered neural networks.  Tissue Engineering Part A 21(21-22):2744-2756, 2015.

Chen HI, Bohman L, Emery L, Martinez-Lage M, Richardson AG, Davis KA, Pollard JR, Litt B, Gausas RE, Lucas TL: Lateral transorbital endoscopic access to the hippocampus, amygdala, and entorhinal cortex: Initial clinical experience.  ORL; Journal of Oto-rhino-laryngology and its Related Specialties 77(6):321-332, 2015.

Struzyna LA, Harris J, Katiyar K, Chen HI, Cullen DK: Restoring nervous system structure and function using tissue engineered living scaffolds.  Neural Regeneration Research 10(5):115-28, 2015.



Lang SS, Chen HI, Koch MJ, Kurash L, McGill-Armento KR, Palella JM, Stein SC, Malhotra NR: Development of an outpatient protocol for lumbar discectomy: Our institutional experience.  World Neurosurgery 82(5):897-901, 2014.

Chen HI, Bohman L, Loevner L, Lucas TH: Transorbital endoscopic amygdalo-hippocampectomy: a feasibility investigation.  Journal of Neurosurgery 120(6):1428-1436, 2014.  [Cover article]

Chen HI, Attiah M, Baltuch G, Smith DH, Hamilton RH, Lucas TH: Harnessing plasticity for the treatment of neurosurgical disorders.  World Neurosurgery 82(5):648-659, 2014.



Chen HI, Lang SS, Coyne TM, Malhotra NR, Schuster JM: Intramedullary spinal sarcoidosis masquerading as cervical stenosis.  World Neurosurgery 80(6):e375-380, 2013.



Lang SS, Chen HI, Lee JYK.  Endoscopic microvascular decompression: a step-wise operative technique.  ORL; Journal of Oto-rhino-laryngology and its Related Specialties 74:293-298,2012.



Chen HI, Stiefel MF, Oddo M, Milby AH, Maloney-Wilensky E, Frangos S, Levine JM, Kofke WA, LeRoux PD: Detection of cerebral compromise with multimodality monitoring in patients with subarachnoid hemorrhage.  Neurosurgery 69:53-63, 2011.



Lee JYK, Chen HI, Urban C, Hojat A, Church E, Farrar JT: Development and psychometric testing of the Brief Pain Inventory-Facial for patients with facial pain.  Journal of Neurosurgery 113(3):516-523, 2010.

Oddo M, Nduom E, Frangos S, Mackenzie L, Chen HI, Maloney-Wilensky E, Kofke WA, Levine JM, LeRoux PD: Acute lung injury is an independent risk factor for brain hypoxia after severe traumatic brain injury.  Neurosurgery 67(2):338-344, 2010.

Magge SN, Chen HI, Cen L, Chen Z, Elliott JP, Winn HR, LeRoux PD: Association of younger age with an increased risk of angiographic and symptomatic vasospasm after subarachnoid hemorrhage.  Journal of Neurosurgery 112(6):1208-1215, 2010.

Evans SM, Jenkins KT, Chen HI, Jenkins WT, Judy KD, Hwang WT, Lustig RA, Magarelli DR, Judkins A, Grady MS, Hahn SM, Koch CJ: The relationship among hypoxia, proliferation, and outcome in patients with de novo glioblastoma: A pilot study.  Translational Oncology 3(3):160-169, 2010.

Chen HI, Lee JYK: The measurement of pain in trigeminal neuralgia patients.  Clinical Neurosurgery 57:129-133, 2010.



Magge SN, Malik S, Royo NC, Chen HI, Yu L, Snyder EY, O‚ÄôRourke DM, Watson DJ: Role of monocyte chemoattractant protein-1 (MCP-1/CCL2) in migration of neural progenitor cells towards glial tumors.  Journal of Neuroscience Research 87(7):1547-55, 2009.

Oddo M, Frangos S, Milby A, Chen HI, Maloney-Wilensky E, MacMurtrie E, Stiefel MF, Kofke WA, LeRoux PD, Levine JM: Induced normothermia attenuates cerebral metabolic distress in patients with aneurysmal subarachnoid hemorrhage and refractory fever.  Stroke 40(5):1913-6, 2009.

Oddo M, Milby A, Chen HI, Frangos S, MacMurtrie E, Maloney-Wilensky E, Stiefel MF, Kofke WA, Levine JM, LeRoux PD: Hemoglobin concentration and cerebral metabolism in patients with aneurysmal subarachnoid hemorrhage.  Stroke 40(4):1275-81, 2009.



Chen HI, Malhotra NR, Oddo M, Heuer GG, Levine JM, LeRoux PD: Barbiturate infusion for intractable intracranial hypertension and its effects on brain oxygenation.  Neurosurgery 63(5):880-806, 2008.

Magge SN, Chen HI, Stiefel MF, Ernst L, Cahill AM, Hurst R, Storm PB: Multiple ruptured cerebral aneurysms in a child with Takayasu Arteritis.  Journal of Neurosurgery: Pediatrics 1(1):83-8, 2008.



Dahl J, Chen HI, George M, Benjamin TL: Polyoma small T antigen controls viral chromatin modifications through effects on kinetics of virus growth and cell cycle progression.  Journal of Virology:81(18):10064-10071, 2007.

Royo NC, LeBold D, Magge SN, Chen HI, Hauspurg A, Cohen AS, Watson DJ: Neurotrophin-mediated neuroprotection of hippocampal neurons following traumatic brain injury is not associated with acute recovery of hippocampal function.  Neuroscience 148(2):359-370, 2007.

Magge SN, Chen HI, Heuer G, Carracsco LR, Storm PB: Dislocation of the mandible into the middle cranial fossa.  Case report.  Journal of Neurosurgery: Pediatrics 107(1):75-78, 2007.

Chen HI, Heuer GG, Zaghloul K, Simon SL, Weigele JB, Grady MS: Lumbar vertebral hemangioma presenting with the acute onset of neurological symptoms.  Case report.  Journal of Neurosurgery: Spine 7(1):80-85, 2007.

Chen HI, Bakshi A, Royo NC, Magge SN, Watson DJ: Neural stem cells as biological minipumps: A faster route to cell therapy for the CNS?  Current Stem Cell Research and Therapy 2(1):13-22, 2007.



Chen HI, Burnett MG, Huse JT, Lustig RA, Bagley LJ, Zager EL: Recurrent late cerebral necrosis with aggressive characteristics after radiosurgical treatment of an arteriovenous malformation.  Journal of Neurosurgery 105(3):455-460, 2006.

Magge SN, Chen HI, Zager EL: Dystrophic calcification and infraclavicular brachial plexopathy: Case report.  Neurosurgery 58(6):E216, 2006.