Department of Psychiatry

Penn Behavioral Health

Zhaolan (Joe) Zhou, PhD

Associate Professor of Genetics
Department of Genetics Faculty Bio

The Zhou laboratory is interested in understanding the epigenetic mechanisms that integrate environmental factors with genetic code to govern neural network formation and function in the brain, and how defects in this process may lead to intellectual disability. We use a combination of genomic and genetic approaches, together with cellular and behavioral assays in genetically modified mice, to investigate the dynamic changes of the epigenome, the functional interpretation of the epigenome, the molecular basis of adaptive behaviors, and the pathogenic mechanisms of CDKL5-related disorders and Rett Syndrome. It is our hope to ultimately translate our findings into therapeutic development.

The Diseases/Disorders we study: Aging, Autism Spectrum Disorders, Depression, Epilepsy, Parkinson's Disease and Rett Syndrome

Models of Disease and Research: Behavioral Genetics, Chromatin Remodeling, Epigenetics, Gene Expression Regulation, Learning and Behavior, Molecular and Cellular Neuropathology, Neurodegeneration, Neurodevelopment

Areas of Investigation

  • Aging
  • Autism Spectrum Disorders
  • Behavioral Genetics
  • Chromatin Remodeling 
  • Depression
  • Epigenetics
  • Epilepsy
  • Gene Expression Regulation
  • Learning and Behavior
  • Molecular and Cellular Neuropathology
  • Neurodegeneration
  • Neurodevelopment
  • Parkinson's Disease
  • Rett Syndrome

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