Rethinking Neurodegenerative Disease Treatment: Target Multiple Pathological Proteins, Not Just One
Nearly all major neurodegenerative diseases — from Alzheimer's to Parkinson's — are defined and diagnosed by the presence of one of four proteins that have gone rogue: tau, amyloid-beta (Aß), alpha-synuclein (a-syn), or TDP-43. As such, investigational drugs and studies aimed at preventing or slowing the disease often hone in on just one of these respective proteins. However, targeting multiple proteins — known as "proteinopathies" — at once may be the real key, according to a recent study published in Brain by Penn Medicine researchers.More Research
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Proteinopathies, the misfolded proteins responsible for neuron deaths, have a claim to fame when it comes to rare neurodegenerative diseases.
Researchers have long searched for an explanation for why there is so much variety in how abnormal aggregates of the protein tau occur in the brains of…
The epigenomic landscape of Alzheimer’s disease brains is profiled in a new study from from the Perelman School of Medicine.
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CNDR's Marian S. Ware Research Retreat 2018
Thursday, October 25, 2018
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CNDR Celebrates 25 Years of Groundbreaking Research
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