Department of Psychiatry

Penn Behavioral Health

David S. Metzger, PhD


David S. Metzger, PhD, Director of the HIV/AIDS Prevention Research Division, is Research Associate Professor at the University of Pennsylvania. He is the Co-Principal Investigator for the Delaware Valley Node of the CTN, Principal Investigator for the NIH-funded HIV Prevention and HIV Vaccine Trials Units in Philadelphia, the Chair of the Substance Use Working Group for the HIV Prevention Trial Network, and the Director of the Social and Behavioral Sciences Core of the Penn Center for AIDS Research. Since 1989, he and colleagues from the Center for Studies of Addiction have been conducting AIDS-related longitudinal studies of injection and non-injection drug users. Under his direction, over 3,000 drug-using subjects from Philadelphia have been enrolled in HIV studies known collectively as the Risk Assessment Projects (RAP). Dr. Metzger's research division has developed innovative community-based strategies for recruiting and retaining individuals at high risk of HIV infection into longitudinal studies. Currently, his work involves testing the safety and efficacy of behavioral and biomedical prevention interventions including vaginal microbicides, HIV vaccines, social networks, and agonist treatment strategies in Philadelphia, Thailand, China, and Ukraine. A primary objective of this work has been to provide valid and reliable data that can increase understanding of the protective effects of participation in substance abuse treatment.

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