Perelman School of Medicine at the University of Pennsylvania

Dr. Facciabene Andrea, Radiation Oncology / OBGYN

Dr. Facciabene Andrea, Radiation Oncology / OBGYN



  1. Stefano Pierini, Chongyun Fang, Stavros Rafail, John G. Facciponte, Jialing Huang, Francesco De Sanctis, Mark A. Morgan, Mireia Uribe-Herranz, Janos L. Tanyi, Andrea Facciabene*. A Tumor Mitochondria Vaccine Protects Against Experimental Renal Cell Carcinoma The Journal of Immunology (in Press).  *Corresponding author
  2. Stefano Ugel, John G Facciponte, Francesco De Sanctis and Andrea Facciabene*. -Targeting tumor vasculature: expanding the potential of DNA cancer vaccine. - Cancer Immunology, Immunotherapy 2015 Oct; 64(10):1339-48. *Corresponding author
  3. John Facciponte, Stefano Ugel, Francesco De Sanctis, LiPing Wang, George Coukos, Andrea Facciabene*. Targeting tumor vasculature with a DNA vaccine against Endosialin (TEM1). Journal of Clinical Investigation. 2014 Apr. 1; 124(4):1497-511. *Corresponding author
  4. Andrea Facciabene, Santoro S, Coukos G.  Know thy enemy: Why are tumor-infiltrating regulatory T cells so deleterious? Oncoimmunology. 2012 July 1; 1(4):575-577.
  5. Andrea Facciabene, Gregory T. Motz, and George Coukos. Tregs facilitate angiogenesis and immune escape in cancer. Cancer Res. 2012 May 1; 72(9):2162-71.
  6. Andrea Facciabene, Xiaohui Peng, Ian S. Hagemann, Klara Balint, Andrea Barchetti, Li-PingWang, Phyllis A. Gimotty, C. Blake Gilks, Priti Lal, Lin Zhang, George Coukos - Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells – Nature. 2011 July 14, 475:226-232.
  7. Ioannis Alagkiozidis, Andrea Facciabene, Marinos Tsiatas, Carmine Carpenito, Fabian Benencia, Sarah Adams, Zdenka Jonak, Carl H June, Daniel J Powell Jr, George Coukos Time-dependent cytotoxic drugs selectively cooperate with IL-18 for cancer chemo-immunotherapy - Journal of Translational Medicine.  2011 May 25;9:77.
  8. Lana E. Kandalaft, Nathan Singh, John B. Liao, Andrea Facciabene, Jonathan Berek, Daniel J. Powell Jr., George Coukos - The emergence of immunomodulation: combinatorial immunochemotherapy opportunities for the next decade  - Gynecologic Oncology  2010 Feb.  12– 116(2): 222-233.
  9. Ioannis Alagkiozidis, Andrea Facciabene, Carmine Carpenito, Fabian Benencia, Zdenka  Jonak, Sarah Adams, Richard G Carroll, Phyllis A Gimotty, Rachel Hammond, Gwen-äel Danet-Desnoyers, Carl H June, Daniel J Powell Jr1, George Coukos -  Increased Immunogenicity of Surviving Tumor Cells Enables Cooperation between Liposomal Doxorubicin and IL-18 in Cancer Chemo-immunotherapy - Journal of Translational Medicine. 2009 Dec. 10.
  10. Lana E. Kandalaft, Andrea Facciabene, Ronald J. Buckanovich, George Coukos. Endothelin B Receptor, a New Target in Cancer Immune Therapy - Clinical Cancer Research. 2009 July 15, 4521-4528.
  11. Sarah F. Adams, Douglas A. Levine, Mark G. Cadungog, Rachel Hammond, Andrea Facciabene, Narciso Olvera, Stephen C. Rubin, Jeff Boyd, Phyllis A. Gimotty, George Coukos - Intraepithelial T Cells and Tumor Proliferation: Impact on the Benefit from Surgical Cytoreduction in Advanced Serous Ovarian Cancer – Cancer. 2009 01 July 115(13):2891-2902.
  12. Andrea Facciabene*, Ronald J Buckanovich*, Sarah Kim, Fabian Benencia, Dimitra Sasaroli, Klara Balint, Dionysios Katsaros, Anne O’Brien-Jenkins, Phyllis A Gimotty, George Coukos -  Endothelin B receptor mediates the endothelial barrier to T cell homing to tumors and disables immune therapy - Nature Medicine. 2008; Jan.14(1):28-36. 2008MH . *Equal fist-author contribution
  13. Andrea Facciabene, Luigi Aurisicchio, Leonardo Elia, Fabio Palombo, Carmela Mennuni, Gennaro Ciliberto, Nicola La Monica - Vectors encoding carcinoembryonic antigen fused to the B subunit of heat-labile enterotoxin elicit antigen-specific immune responses and antitumor effects - Vaccine. 2007 Dec. 21; 26(1):47-58.
  14. Leonardo Elia, Luigi Aurisicchio, Andrea Facciabene, Patrizia Giannetti, Gennaro Ciliberto, Nicola La Monica, Fabio Palombo - CD4+CD25+ regulatory T-cell-inactivation in combination with adenovirus vaccines enhances T-cell responses and protects mice from tumor challenge - Cancer Gene Therapy. 2007 Feb. 14(2):201-10.
  15. Patrizia Giannetti, Andrea Facciabene, Nicola La Monica, Luigi Aurisicchio - Individual mouse analysis of the cellular immune response to tumor antigens in peripheral blood by intracellular staining for cytokines - Journal of Immunology Methods. 2006 Oct 20; 316(1-2):84-96.
  16. Andrea Facciabene, Luigi Aurisicchio, Leonardo Elia, Fabio Palombo, Carmela Mennuni, Gennaro Ciliberto and Nicola La Monica - Immunogenic and antitumor efficiency of plasmid DNA and Adenovirus vectors encoding CEA fusion proteins - Human Gene Therapy. 2005 Jan; 17(1):81-92.
  17. Carmela Mennuni, Francesco Calvaruso, Andrea Facciabene, Luigi Aurisicchio, Mariangela Storto, Elisa Scarselli, Gennaro Ciliberto, Nicola La Monica - Efficient induction of T-cell responses to carcinoembryonic antigen by a heterologous prime-boost regimen using DNA and adenovirus vectors carrying a codon usage optimized cDNA - International Journal of Cancer. 2005 Nov 10; 117(3):444-55.
  18. Andrea Facciabene, Luigi Aurisicchio, and Nicola La Monica. Baculovirus vectors elicit antigen specific Immune responses in mice - Journal of Virology. 2004 Aug 78(16):8663-72.
  19. Saverio Giampaoli, Andrea Facciabene and Carmela Mennuni - A protocol to guide development of a sensitive ELISA for canine erythropoietin - Veterinary Clinical Pathology. 2003 32(4):199-201.

In review:

Andrea Facciabene†, Bradley J. Monk†, William E. Brady, Carol Aghajanian, Paula M. Fracasso, Joan L. Walker, Gregory N. Dietsch, Heather A. Lankes, Kristi L. Manjarrez, Gwenn-äel Danet-Desnoyers, Katherine M. Bell-McGuinn, Carolyn K. McCourt, Alexander Malykhin, Robert M. Hershberg, George Coukos.- “ Integrative Development of a TLR8 Agonist for Ovarian Cancer Chemo-immunotherapy †equal contribution” †Equal contribution.

Andrea Facciabene, Francesco De Sanctis, Klara Balint, Paola Magotti, John Facciponte, Robert A. DeAngelis, Jian Yian, Wenchao C. Song, John D. Lambris, George Coukos- Local Endothelial Complement Activation Reverses Endothelial Anergy and Mediates T Cell Homing and Tumor Suppression during Immunotherapy.