Kathryn M. Ferguson, Ph.D.

Assistant Professor
Department of Physiology

Other School of Medicine Affiliations

Biochemistry & Molecular Biophysics Graduate Group


B.A. University of Oxford, 1987
M.Phil. Yale University, 1992
Ph.D. Yale University, 1996

Professional Affiliations

American Society for Cell Biology
American Physiological Society
American Society for Biochemistry and Molecular Biology
American Society for the Advancement of Science


Burroughs Wellcome Fund Career Award in Biomedical Sciences, 2001
Howard Temin Award from National Cancer Institute, 2001
Damon Runyon Scholar, 2006

Representative Publications

Li S, Schmitz KR, Jeffrey PD, Wiltzius JJ, Kussie P, Ferguson KM. Structural basis for inhibition of the epidermal growth factor receptor by cetuximab, Cancer Cell 7:301-311, 2005.

Dawson JP, Berger MB, Lin CC, Schlessinger J, Lemmon MA, Ferguson KM. Epidermal growth factor receptor dimerization and activation require ligand-induced conformational changes in the dimer interface, Mol Cell Biol 25:7734-7742, 2005.

Bouyain S, Longo PA, Li S, Ferguson KM, Leahy DJ. The extracellular region of ErbB4 adopts a tethered conformation in the absence of ligand, Proc. Natl. Acad. Sci. (USA) 102:15024-15029, 2005.

Ferguson KM, Berger MB, Mendrola JM, Cho HS, Leahy DJ, Lemmon MA. EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization., Molecular Cell 11:507-517, 2003.

Burgess AW, Cho HS, Eigenbrot C, Ferguson KM, Garrett TP, Leahy DJ, Lemmon MA, Sliwkowski MX, Ward CW, Yokoyama S. An Open-and-Shut Case? Recent Insights into the Activation of EGF/ErbB Receptors, Molecular Cell 12:541-552, 2003.

( PubMed Summary)