October 19, 2017

Paul Tichenell, Ph.D.

Insulin Signaling Molecule in Liver Controls Levels of Triglyceride in Blood

A new animal study shows how insulin controls the movement and storage of fat molecules in the liver and how a breakdown in this system could lead to non-alcoholic fatty liver disease and changes in circulating lipid levels associated with cardiovascular disease. Researchers from the Perelman School of Medicine at the University of Pennsylvania published their findings in the Journal of Clinical Investigation (JCI).

“The production of triglyceride in the liver and its secretion into blood are closely linked to nutrient availability and insulin levels,” said senior author Paul Titchenell, PhD, an assistant professor of Physiology and a member of the Institute for Diabetes, Obesity, and Metabolism. “After a meal, insulin tells the liver to package and secrete excess nutrients into triglyceride-rich lipid particles into the blood for use by the rest of the body.”

Penn Medicine Press Release

September 18, 2017

Michael Rickels, MD, MS

Minidose Glucagon for Exercise-Induced Hypoglycemia in T1D

Results of a recent Penn study led by Michael Rickels, M.D., M.S. was presented at the European Association for the study of Diabetes (EASD) 2017 Annual Meeting in Lisbon, Portugal. Dr. Rickels presentation of this study was covered by Medscape's editorial staff.

Read more: Medscape article

September 14, 2017

Dr. Agarwal and Senator Booker

Dr. Agarwal Advocates for diabetes care in Washington, D.C.

Shivani Agarwal, M.D., M.P.H. pictured with Senator Cory Booker went before congress to advocate for diabetes care.

July 13, 2017

Shivani Agawal, MD, MPH

Health Issues Millennials (and Their Parents) Need to Stop Ignoring

Shivani Agarwal, MD, MPH, an assistant professor of Medicine in Endocrinology, Diabetes, and Metabolism, is quoted in a Reader’s Digest story discussing some of the health issues millennials should pay more attention to in order to lead long, healthy lives.

Read More Reader’s Digest Article

June 14, 2017

Molecular Pilot Light Prepares Body’s Heating System For the Cold

Penn Animal Study Discovers New Molecular Player in Burning Sugar and Fat to Boost Metabolism

Mitchell Lazar, MD, PhDThis week in Nature, a team from the Perelman School of Medicine at the University of Pennsylvania detail a molecule that acts as a molecular pilot light required to turn on the brown fat furnace.

Brown fat burns sugar and fat to produce radiant heat in the body. Researchers have turned their attention to these cells because some of the sugar and fat they burn is stored in the body and might otherwise lead to increases in white fat, the form that increases in obesity.

“To harness the fat-burning potential of brown fat we must better understand how the body burns fuel to stay warm and how this relates to the storage of excess fuel as white fat in obesity,” said senior author Mitchell Lazar, MD, PhD, director of the Institute for Diabetes, Obesity, and Metabolism (IDOM) and the Willard and Rhoda Ware Professor in Diabetes and Metabolic Diseases

Read More - Penn Press Release

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