NIH R21-NS082953 (PI: Felix W. Wehrli, Ph.D.)
Feasibility of Direct Quantitative Magnetic Resonance Imaging of Myelin
To develop and evaluate 3D zero-echo-time (ZTE) quantitative MRI acquisition and analysis methods involving tissue water suppression and compressed sensing reconstruction, with subsequent translation to a 3T clinical imager toward a long term goal of translation to the clinic as an alternative and possibly superior technique for regional myelin quantification in patients with myelin abnormalities and for providing means to evaluate treatment effectiveness.
NIH R01-AG038693 (PI: Felix W. Wehrli, Ph.D.)
MRI-Based Assessment of Structural and Mechanical Implications of Osteoporosis
To address the hypothesis that bone mechanical competence can be predicted on the basis of high-resolution MRI in human cadaver specimens comparing mechanical test results with computational biomechanics and apply the methodology to postmenopausal women at risk of fracture by comparing the structural and mechanical parameters with vertebral deformity status.
NIH R21-HD069390 (PI: Felix W. Wehrli, Ph.D.)
MRI-based Method for Quantifying CMRO2 in Humans
To further develop and implement a new method for quantifying CMRO2, based on an integrated measurement of arterio-venous oxygen difference via MRI susceptometry and simultaneous quantification of total cerebral blood flow via ungated phase contrast MRI.
NIH R01-HL109545 (PI: Felix W. Wehrli, Ph.D.)
MRI Assessment of Vascular Reactivity
To develop and translate to the clinic novel imaging methodology that enable diagnosis of the earliest stages of disease thereby allowing for lifestyle changes and early intervention in subjects at risk.
NIH R01-AR055647 (PI: Felix W. Wehrli, Ph.D.)
Osteoporosis Treatment Response Assessed by Micromechanical Modeling of MRI Data.
To evaluate changes in bone mechanical competence in early postmenopausal women undergoing mechanical stimulation via image-based computational biomechanics.
NIH R01-HL122754 (PI: Felix W. Wehrli, Ph.D.)
Neurometabolic Assessment of Obstructive Sleep Apnea by MRI
To test the hypothesis that patients with obstructive sleep apnea have abnormal neurometabolism and impaired neurovascular reactivity and that treatment with continuous positive airway pressure partially reverses these conditions.
Institute of Translational Medicine and Therapeutics (PI: Felix W. Wehrli, Ph.D., Richard Schwab, M.D.)
Implications of Obstructive Sleep Apnea on Neurovascular Reactivity Assessed by Time-Resolved MRI Oximetry
To apply a recently developed method in the PI’s laboratory for measuring the cerebral metabolic rate of oxygen consumption (CMRO2) in patients with obstructive sleep apnea.
NIH R03-AR064577 (PI: Chamith Rajapakse, Ph.D.)
Role of Local Strain in Osteogenic Response to Vibration Therapy in Humans
To design a non-invasive high-resolution imaging-based method suitable for analyzing strains at bone’s micro-structural level in humans and application of this technique to determine the role of micro-structural strain distribution in the anabolic response to daily LMMS (low magnitude mechanical stimulation) treatment in patients with renal disease
NIH K25-HL111422 (PI: Michael Langham, Ph.D.)
Surrogate Measures of Endothelial Dysfunction with Integrated MRI
To further develop and evaluate a noninvasive MRI procedure as part of a single one-hour examination to detect early signs of cardiovascular diseases.