NIH R21-NS082953 (PI: Felix W. Wehrli, Ph.D.)
Feasibility of Direct Quantitative Magnetic Resonance Imaging of Myelin
To develop and evaluate 3D zero-echo-time (ZTE) quantitative MRI acquisition and analysis methods involving tissue water suppression and compressed sensing reconstruction, with subsequent translation to a 3T clinical imager toward a long term goal of translation to the clinic as an alternative and possibly superior technique for regional myelin quantification in patients with myelin abnormalities and for providing means to evaluate treatment effectiveness.
NIH R01-AG038693 (PI: Felix W. Wehrli, Ph.D.)
MRI-Based Assessment of Structural and Mechanical Implications of Osteoporosis
To address the hypothesis that bone mechanical competence can be predicted on the basis of high-resolution MRI in human cadaver specimens comparing mechanical test results with computational biomechanics and apply the methodology to postmenopausal women at risk of fracture by comparing the structural and mechanical parameters with vertebral deformity status.
NIH R21-HD069390 (PI: Felix W. Wehrli, Ph.D.)
MRI-based Method for Quantifying CMRO2 in Humans
To further develop and implement a new method for quantifying CMRO2, based on an integrated measurement of arterio-venous oxygen difference via MRI susceptometry and simultaneous quantification of total cerebral blood flow via ungated phase contrast MRI.
NIH R01-HL109545 (PI: Felix W. Wehrli, Ph.D.)
MRI Assessment of Vascular Reactivity
To develop and translate to the clinic novel imaging methodology that enable diagnosis of the earliest stages of disease thereby allowing for lifestyle changes and early intervention in subjects at risk.
NIH R01-AR055647 (PI: Felix W. Wehrli, Ph.D.)
Osteoporosis Treatment Response Assessed by Micromechanical Modeling of MRI Data.
To evaluate changes in bone mechanical competence in early postmenopausal women undergoing mechanical stimulation via image-based computational biomechanics.
W81XWH-10-1-0714 (PI: David Hackney, M.D., Felix W. Wehrli, Ph.D., Alan Tessler, M.D.)
Magnetic Resonance Characterization of Axonal Response to Spinal Cord Injury
To use high-resolution q-space MR, ultrashort TE (UTE) MR, and inhomogeneous magnetization transfer (IMTR) imaging to determine the nature and extent of axonal damage after cord injury.
NIH R01-AR058004 (PI: X. Edward Guo, Ph.D., Elizabeth Shane, Ph.D., Felix W. Wehrli, Ph.D.)
Clinical Bone Mechanics Using HR-pQCT and μMRI
To examine the accuracy and reproducibility of multi-modality image-based finite-element modeling for assessment of bone mechanical competence.
NIH R01-HL075649 (PI: Emile Mohler, M.D., Thomas Floyd, M.D.)
The Microcirculation in Claudication and Exercise Rehabilitation
To understand the pathophysiology of PAD progression and symptom origin to provide a basis for new noninvasive methods of evaluation and novel therapeutic strategies.
NIH R01-AR050068 (PI: Felix W. Wehrli, Ph.D.)
Bone Water and Mineralization Measured by Nuclear Magnetic Resonance
To provide a noninvasive method for probing the intrinsic properties of bone in lab animals and ultimately in humans.
NIH R01-DK075648 (PI: Mary Leonard, M.D.)
Changes in Skeletal Microarchitecture Following Renal Transplantation
To examine trabecular bone volume and micro-architecture using MRI.
NIH T32-EB000814 (PI: Felix W. Wehrli, Ph.D.)
To train two predoctoral and two postdoctoral basic science trainees in quantitative MRI methodology for a period of two years.
Institute of Translational Medicine and Therapeutics (PI: Felix W. Wehrli, Ph.D., Richard Schwab, M.D.)
Implications of Obstructive Sleep Apnea on Neurovascular Reactivity Assessed by Time-Resolved MRI Oximetry
To apply a recently developed method in the PI’s laboratory for measuring the cerebral metabolic rate of oxygen consumption (CMRO2) in patients with obstructive sleep apnea.
Commonwealth of PA (PI: Anna Childress, Ph.D.)
CURE Addiction Center of Excellence: Brain Mechanisms of Relapse and Recovery
To use functional magnetic resonance imaging (fMRI) and specific probes of reward and inhibition as biomarkers to predict drug use during and after treatment in patients addicted to cocaine, marijuana and prescription opioids.
NIH R21-AR061751 (PI: Dawn Elliott, Ph.D.)
Noninvasive Measurement of Intervertebral Disc Mechanics with MR Elastography
To apply Magnetic Resonance Elastography to measure elastic properties of the disc from intact disc segments and to correlate those properties with degeneration.
NIH R01-AR050052 (PI: Dawn Elliott, Ph.D.)
Disc Mechanics and Altered Loading in Degeneration
To quantify internal AF stress and strain and the effect of degenerative state (reduced NP pressure, AF tears), hydration, and dynamic loading on internal disc mechanics using an integrated experimental and modeling approach.
NIH K25-AR060283 (PI: Chamith Rajapakse, Ph.D.)
Computational Biomechanics for Prediction of Osteoporotic Vertebral Fracture Risk
To develop a multiple regression model composed of mechanical and morphological parameters derived at extremities using finite-element and morphological analysis for the purpose of vertebral fracture prediction.
NIH R03-AR064577 (PI: Chamith Rajapakse, Ph.D.)
Role of Local Strain in Osteogenic Response to Vibration Therapy in Humans
To design a non-invasive high-resolution imaging-based method suitable for analyzing strains at bone’s micro-structural level in humans and application of this technique to determine the role of micro-structural strain distribution in the anabolic response to daily LMMS (low magnitude mechanical stimulation) treatment in patients with renal disease
NIH K25-HL111422 (PI: Michael Langham, Ph.D.)
Surrogate Measures of Endothelial Dysfunction with Integrated MRI
To further develop and evaluate a noninvasive MRI procedure as part of a single one-hour examination to detect early signs of cardiovascular diseases.
NIH F31-AG042289 (PI: Alan Seifert)
An MRI-Based Method for Measuring Bone Mineral and Matrix Densities in Humans
To adapt MRI-based methods for bone matrix and mineral density measurements, proven on animal specimens in specialized hardware, into a single quantitative examination that can be performed on humans in order to distinguish between osteoporosis and disorders of impaired mineralization using clinical MRI equipment and without the risks associated with ionizing radiation.
American Heart Association (PI: Erin Englund)
Functional Evaluation of the Peripheral Vasculature Using MRI
To further develop the method Perfusion And T2*/Oximetry (PATO) by systematically assessing each portion of the sequence in phantom and in vivo studies and to investigate the method’s ability to detect disease presence and severity, to correlate PATO data to other physiologic data, and to determine the ability of PATO to discern a treatment effect.