The Kazanietz Laboratory
Department of Pharmacology and Institute for Translational Medicine and Therapeutics (ITMAT)

Kazanietz Lab > Bibliography

Bibliography (PUBMED)


  1. Siliceo, M., Garcia-Bernal, D., Carrasco, S., Diaz-Flores, E., Moreno, M.C., Teixido, J., Kazanietz, M.G., and Merida, I. β2-chimaerin provides a diacylglycerol-dependent mechanism for regulation of CXCL12-induced adhesion and chemotaxis of T cells. J. Cell Sci. 119: 141-152 (2006).
  2. Yang, C., Liu, Y., Lemmon, M.A., and Kazanietz, M.G. Essential role for Rac and EGFR as mediators of heregulin β1 mitogenic signaling in breast cancer cells. A mechanism that involves epidermal growth factor receptor and is independent of ErbB4. Mol. Cell. Biol. 26: 831-842 (2006).
  3. Maeda, M., Kato, S., Fukushima, S., Kaneyuki, U., Fujii, T., Kazanietz, M.G., Oshima, K., and Shigemori, M. Regulation of vascular smooth muscle proliferation and migration by β2-chimaerin , a non-protein kinase C phorbol ester receptor. Int. J. Mol. Med. 17: 559-566 (2006).
  4. Coluccio Leskow, F., Holloway, B.A., Wang, H., Mullins, M., Kazanietz, M.G. The zebrafish homologue of mammalian chimaerin Rac-GAPs is implicated in epiboly progression during development. Proc. Natl. Acad. Sci. USA 103: 5373-5378 (2006).
  5. Wang, H., Yang, C., Coluccio Leskow, F., Sun, J., Canagarajah, B., Hurley, J.H., and Kazanietz, M.G. Phospholipase Cγ/diacylglycerol-dependent activation of β2-chimaerin restricts EGF-induced Rac signaling. EMBO J. 25: 2062-2074 (2006).
  6. Colon-Gonzalez, F., and Kazanietz, M.G. C1 domain exposed: from diacylglycerol binding to protein-protein interactions. Biochem. Biophys. Acta 1761:827-837 (2006) (Special issue on "Lipid Binding Domains").


  1. Urtreger, A.J., Grossoni, V.C., Falbo, K.B., Kazanietz, M.G., and Bal de Kier Joffe, E.D. Atypical protein kinase C-ς modulates clonogenicity, motility and secretion of proteolytic enzymes in murine mammary cells. Mol. Carcinogenesis 42: 29-39 (2005).
  2. Yang C, Liu Y, Coluccio-Leskow F, Weaver V & Kazanietz MG: Rac-GAP-dependent inhibition of breast cancer cell proliferation by the diacylglycerol/phorbol ester receptor β2-chimaerin. J Biol Chem 280: 24363-24370, 2005.
  3. Santiago-Walker, A.E., Fikaris, A.J., Kao, G.D., Brown, E.J., Kazanietz, M.G., and Meinkoth, J.L. Protein kinase C delta stimulates apoptosis by initiating G1 phase cell cycle progression and S phase arrest. J. Biol. Chem. 280: 32107-32114 (2005).
  4. Nakagawa, M. Oliva Martinez, J.L., Kothapalli, D. Fournier, A., Assoian, R.K., and Kazanietz, M.G. Phorbol ester mediated G1 phase arrest selectively mediated by a PKCδ-dependent induction of p21cip1. J. Biol. Chem., in press (2005).
  5. Gonzalez-Guerrico, A., and Kazanietz, M.G. PKC-induced apoptosis in prostate cancer cells is mediated by an autocrine loop that activates the extrinsic apoptotic pathway. J. Biol. Chem., in press (2005).
  6. Kazanietz, M.G. Diacylglycerol signaling: targeting protein kinase C isozymes and "non'-kinase" diacylglycerol effectors. Cell. Mol. Biol. Lett. 10: 47-49 (2005).
  7. Oliva, J.L., Griner, E., and Kazanietz, M.G. PKC isozymes and diacylglycerol-regulated proteins as effectors of growth factor receptors. Growth Factors, in press (2005).
  8. Gonzalez-Guerrico, A., Meshki, J., Xiao, L., Benavides, F., Conti, C.J., and Kazanietz, M.G. Molecular mechanisms of protein kinase C-induced apoptosis in prostate cancer cells. J. Biochem. Mol. Biol. 38: 639-645 (2005).
  9. Kazanietz, M.G. Targeting protein kinase C and "non-kinase" phorbol ester receptors: emerging concepts and therapeutic implications. Biochem. Biophys. Acta 1754: 296-304 (2005) (Special issue for "Inhibitors of Protein Kinases Meeting", Warsaw, Poland).


  1. Frey, M.R., Clark, J.A., Bateman, N.W., Kazanietz, M.G., Black, A.R., and Black, J.D. Cell cycle- and protein kinase C-specific effects of resiniferatoxin and resiniferonol 9,13,14-orthophenyl acetate in intestinal epithelial cells. Biochem. Pharmacol. 67:1873-1886 (2004).
  2. Canagarajah B, Ho JYS, Coluccio-Leskow F, Mischak H, Saidi L, Kazanietz MG & Hurley JH: Structural mechanism for lipid activation of the Rac-specific GAP, β2-chimaerin. Cell 119: 407-418, 2004.
  3. Gavrielides, M.V., Frijhoff, A.F., Conti, C.J., and Kazanietz, M.G. Protein kinase C and prostate carcinogenesis: targeting the cell cycle and apoptosis mechanisms. Current Drug Targets 5: 431-443 (2004).


  1. Li, Y., Gonzalez, M., Meinkoth, J., Field, J., Kazanietz, M.G., and Tennekoon, G. Lysophosphatidic acid promotes survival and differentiation of rat Schwann cells. J. Biol. Chem. 278: 9585-9591.[ html ] [ pdf ]
  2. Kazanietz, M.G. Pharmacological Probes for Protein Kinase C: An introduction. In "Methods in Molecular Biology: Protein Kinase C Protocols", Humana Press, Edited by: Alexandra C. Newton. Vol. 233, pp. 389-395 (2003).
  3. Kazanietz, M.G. and Patricia S. Lorenzo. Pharmacological Probes for Protein Kinase C: Phorbol esters as tools to study PKC function. In "Methods in Molecular Biology: Protein Kinase C Protocols", Humana Press, Edited by: Alexandra C. Newton. Vol. 233, pp. 423-439 (2003).
  4. Lorenzano Menna, P., Skilton, G., Coluccio Leskow, F., Alonso, D.F., Gomez, D.E., and Kazanietz, M.G. Inhibition of aggressiveness of metastatic mouse mammary carcinoma cells by the beta2-chimaerin GAP domain. Cancer Res. 63: 2284-2291(2003) [ html ] [ pdf ]


  1. Garcia-Bermejo, M.L., Coluccio Leskow, F., Fujii, T., Wang, Q., Blumberg, P.M., Ohba, M., Kuroki, T., Han, K-C., Lee, J., Marquez, V.E., and Kazanietz, M.G. DAG-lactones, a new class of PKC agonists, induce apoptosis in LNCaP prostate cancer cells by selective activation of PKCalpha. J. Biol. Chem. 277: 645-655 (2002).[ html ] [ pdf ]
  2. Wang, H., and Kazanietz, M.G. Chimaerins, novel "non-PKC" phorbol ester receptors, associate with Tmp21-I (p23). Evidence for a novel anchoring mechanism involving the chimaerin C1 domain. J. Biol. Chem. 277: 4541-4550 (2002).[ html ] [ pdf ]
  3. Roaten, J.B., Kazanietz, M.G., Caloca, M.J., Bertics, P.J., Lothstein, L., Parril, A., Israel, M., and Sweatman, T. Interaction of the novel anthracycline antitumor N-benzyladriamycin-14-valerate with the C1-regulatory domain of protein kinase C: structural requirements, isoform specificity, and correlation with drug cytotoxicity. Molec. Cancer Ther. 1: 483-492 (2002).[ abstract ]
  4. Kazanietz, M.G. Novel "non-kinase" phorbol ester receptors: the C1 domain connection. Mol. Pharmacol. 61: 759-767 (2002).[ html ] [ pdf ]
  5. Yu, D., Kazanietz, M.G., Harvey, R.G., and Penning, T.M. Polycyclic aromatic hydrocarbon o-quinones inhibit the activity of the catatytic fragment of protein kinase C. Biochemistry 41: 11888-11894 (2002).[ html ] [ pdf ]
  6. Gonzalez, M.I., Kazanietz, M.G., and Robinson, M.B. Different members of the PKC family modulate EAAC1-mediated uptake by changes in cell surface expression or transport activity. Mol. Pharmacol. 62: 901-910 (2002).[ html ] [ pdf ]
  7. Abrams, C., and Kazanietz, M.G. Platelet signaling: Protein kinase C. In "Platelets in thrombotic and non-thrombotic disorders: pathophysiology, pharmacology and therapeutics". Editors: P. Gresele, C.P. Page, V. Fuster, and J. Vermylen (2002).


  1. Caloca, M.J., Wang, H.B., Delemos, A., Wang, S., and Kazanietz, M.G. Phorbol esters and related analogs regulate the subcellular localization of beta2-chimaerin, a "non-PKC" phorbol ester receptor. J. Biol. Chem. 276: 18303-18312 (2001).[ html ] [ pdf ]
  2. Roaten, J.B., Kazanietz, M.G., Sweatman, T.G., Lothstein, L., Israel, M., and Parrill, A.L. Molecular models of N-benzyladriamycin-14-valerate (AD 198) in complex with the phorbol ester-binding C1beta domain of protein kinase C-delta. J. Med. Chem. 44, 1028-1034 (2001).[ html ][ pdf ]
  3. Kazanietz, M.G., Caloca, M.J., Aizman, O., and Nowicki, S. Isoform-specific phosphorylation of renal Na+/K+-ATPase by PKC. Arch. Biochem. Biophys. 388: 74-80 (2001).[ html ] [ pdf ]
  4. Qiao, L., Zhao, L-Y., Rong, S-B., Wu, X-W., Wang, S., Fujii, T., Kazanietz, M.G., Rauser, L., Savage, J., Roth, B.L., Flippen-Anderson, J., and Kozikowski, A.P. Rational design, synthesis, and biological evaluation of rigid pyrrolidone analogs as potential inhibitors of prostate cancer cell growth. Bioorg. Med. Chem. Lett. 11: 955-959 (2001).[ abstract ]
  5. Barry, O.P., Mullans, B., Sheehan, D., Kazanietz, M.G., Shanahan, F., Collins, J.K., and O'Sullivan G.C. Constitutive ERK1/2 activation in esophagogastric rib bone marrow micrometastatic cells is MEK-independent. J. Biol. Chem. 276: 15537-15546 (2001).[ html ] [ pdf ]
  6. Barry, O.P., and Kazanietz, M.G. Protein kinase C isozymes, novel phorbol ester receptors and cancer chemotherapy. In "Current Pharmaceutical Design-Anti-Cancer Agents", Bentham Science Publishers, Editor: Alan Kozikowski, 7: 1725-1744 (2001).[ abstract ]
  7. Sanz-Navares, E., Fernandez, N., Kazanietz, M.G., and Rotenberg, S.A. Atypical protein kinase C-zeta suppresses migration of mouse melanoma cells. Cell Growth Differ. 12: 517-524 (2001).[ html ][ pdf ]
  8. Qi, H.W., Juo, P., Masuda-Robens, J., Caloca, M.J., Zhou, H., Stone, N., Kazanietz, M.G. and Chou, M.M. Caspase-mediated cleavage of the TIAM1 guanine nucleotide exchange factor during apoptosis. Cell Growth Differ. 12: 603-611 (2001).[ html ] [ pdf ]
  9. Eroles, P., Wang, H., Coluccio-Leskow, F., Fernandez, N., Tanaka, Y., Gavrielides, M.V., Fujii, T., and Kazanietz, M.G. Protein kinase C and phorbol ester receptors in prostate carcinogenesis. In "Recent Research Developments in Endocrinology" 2: 237-250 (2001).


  1. Fujii, T., Garcia-Bermejo, M.L., Bernabo, J.L., Caamano, J., Ohba, M., Kuroki, T., Li, L., Yuspa, S.H., and Kazanietz, M.G. Involvement of PKCdelta in phorbol ester-induced apoptosis in LNCaP prostate cancer cells. Lack of proteolytic cleavage of PKCdelta. J. Biol. Chem. 275: 7574-7582 (2000).[ html ] [ pdf ]
  2. Fernandez, N., Caloca, M.J., Meinkoth, J., and Kazanietz, M.G. Atypical PKC-zeta stimulates thyrotropin-independent proliferation in rat thyroid cells. Endocrinology 141: 146-152 (2000).[ html ][ pdf ]
  3. Gala?Ln, M.A., Garcia-Bermejo, M.L., Troyano, A., Vilaboa, N.E., de Blas, E., Kazanietz, M.G., and Aller, P. Stimulation of p38 mitogen-activated protein kinase is an early regulatory event for the cadmium-induced apoptosis in human promonocytic cells. J. Biol. Chem. 275: 11418-11424 (2000).[ html ] [ pdf ]
  4. Kazanietz, M.G. Protein kinase C and novel receptors for the phorbol esters and the second messenger diacylglycerol. Medicina (B. Aires) 60: 685-688 (2000).[ abstract ]
  5. Kazanietz, M.G., Caloca, M.J., Garcia-Bermejo, M.L., Reilly, M., Eroles, P., Fujii, T., and Wang, H-B. Pharmacology of the receptors for the phorbol ester tumor promoters: multiple receptors with different biochemical properties (Review). Biochem. Pharmacol. 60: 1417-1424 (2000).[ html ] [ pdf ]
  6. Aroca, P., Santos, E., Kazanietz, M.G. Recombinant C1beta domain of PKCdelta triggers meiotic maturation upon microinjection in Xenopus laevis oocytes. FEBS Lett. 483: 27-31 (2000).[ html ][ pdf ]
  7. Kazanietz, M.G. Eyes wide shut: protein kinase C isozymes are not the only receptors for the phorbol ester tumor promoters (Review). Mol. Carcinogenesis 28: 5-11 (2000).[ pdf ]


  1. Caloca, M.J., Garcia-Bermejo, M.L., Blumberg, P.M., Lewin, N.L., Kremmer, E., Mischak, H., Wang, S., Nacro, K., Bienfait, B., Marquez, V.E., Kazanietz, M.G. beta2-chimaerin is a novel target for diacylglycerol: binding properties and changes in subcellular localization mediated by ligand binding to its C1 domain. Proc. Natl. Acad. Sci. USA 96: 11854-11859 (1999).[ html ] [ pdf ]
  2. Barry, O.P., Kazanietz, M.G., Pratico, D., and FitzGerald, G.A. Transcellular signaling by bioactive lipids: activation of protein kinase C by platelet microparticle arachidonic acid. J. Biol. Chem. 274: 7545-7556 (1999).[ html ] [ pdf ]
  3. Gomez, D.E., Skilton, G., Alonso, D.F., and Kazanietz, M.G. The role of protein kinase C and novel phorbol ester receptors in tumor cell invasion and metastasis (Review). Oncology Reports 6: 1363-1370 (1999).[ abstract ]
  4. Ron, D., and Kazanietz, M.G. New insights into the regulation of protein kinase C and novel phorbol ester receptors (Review). FASEB J. 13: 1658-1676 (1999). (also, cover of the Journal).[ html ] [ pdf ]