The Kazanietz Laboratory
Department of Pharmacology and Institute for Translational Medicine and Therapeutics (ITMAT)

Kazanietz Lab > Bibliography

Bibliography (PUBMED)

2006

  1. Siliceo, M., Garcia-Bernal, D., Carrasco, S., Diaz-Flores, E., Moreno, M.C., Teixido, J., Kazanietz, M.G., and Merida, I. β2-chimaerin provides a diacylglycerol-dependent mechanism for regulation of CXCL12-induced adhesion and chemotaxis of T cells. J. Cell Sci. 119: 141-152 (2006).
  2. Yang, C., Liu, Y., Lemmon, M.A., and Kazanietz, M.G. Essential role for Rac and EGFR as mediators of heregulin β1 mitogenic signaling in breast cancer cells. A mechanism that involves epidermal growth factor receptor and is independent of ErbB4. Mol. Cell. Biol. 26: 831-842 (2006).
  3. Maeda, M., Kato, S., Fukushima, S., Kaneyuki, U., Fujii, T., Kazanietz, M.G., Oshima, K., and Shigemori, M. Regulation of vascular smooth muscle proliferation and migration by β2-chimaerin , a non-protein kinase C phorbol ester receptor. Int. J. Mol. Med. 17: 559-566 (2006).
  4. Coluccio Leskow, F., Holloway, B.A., Wang, H., Mullins, M., Kazanietz, M.G. The zebrafish homologue of mammalian chimaerin Rac-GAPs is implicated in epiboly progression during development. Proc. Natl. Acad. Sci. USA 103: 5373-5378 (2006).
  5. Wang, H., Yang, C., Coluccio Leskow, F., Sun, J., Canagarajah, B., Hurley, J.H., and Kazanietz, M.G. Phospholipase Cγ/diacylglycerol-dependent activation of β2-chimaerin restricts EGF-induced Rac signaling. EMBO J. 25: 2062-2074 (2006).
  6. Colon-Gonzalez, F., and Kazanietz, M.G. C1 domain exposed: from diacylglycerol binding to protein-protein interactions. Biochem. Biophys. Acta 1761:827-837 (2006) (Special issue on "Lipid Binding Domains").

2005

  1. Urtreger, A.J., Grossoni, V.C., Falbo, K.B., Kazanietz, M.G., and Bal de Kier Joffe, E.D. Atypical protein kinase C-ς modulates clonogenicity, motility and secretion of proteolytic enzymes in murine mammary cells. Mol. Carcinogenesis 42: 29-39 (2005).
  2. Yang C, Liu Y, Coluccio-Leskow F, Weaver V & Kazanietz MG: Rac-GAP-dependent inhibition of breast cancer cell proliferation by the diacylglycerol/phorbol ester receptor β2-chimaerin. J Biol Chem 280: 24363-24370, 2005.
  3. Santiago-Walker, A.E., Fikaris, A.J., Kao, G.D., Brown, E.J., Kazanietz, M.G., and Meinkoth, J.L. Protein kinase C delta stimulates apoptosis by initiating G1 phase cell cycle progression and S phase arrest. J. Biol. Chem. 280: 32107-32114 (2005).
  4. Nakagawa, M. Oliva Martinez, J.L., Kothapalli, D. Fournier, A., Assoian, R.K., and Kazanietz, M.G. Phorbol ester mediated G1 phase arrest selectively mediated by a PKCδ-dependent induction of p21cip1. J. Biol. Chem., in press (2005).
  5. Gonzalez-Guerrico, A., and Kazanietz, M.G. PKC-induced apoptosis in prostate cancer cells is mediated by an autocrine loop that activates the extrinsic apoptotic pathway. J. Biol. Chem., in press (2005).
  6. Kazanietz, M.G. Diacylglycerol signaling: targeting protein kinase C isozymes and "non'-kinase" diacylglycerol effectors. Cell. Mol. Biol. Lett. 10: 47-49 (2005).
  7. Oliva, J.L., Griner, E., and Kazanietz, M.G. PKC isozymes and diacylglycerol-regulated proteins as effectors of growth factor receptors. Growth Factors, in press (2005).
  8. Gonzalez-Guerrico, A., Meshki, J., Xiao, L., Benavides, F., Conti, C.J., and Kazanietz, M.G. Molecular mechanisms of protein kinase C-induced apoptosis in prostate cancer cells. J. Biochem. Mol. Biol. 38: 639-645 (2005).
  9. Kazanietz, M.G. Targeting protein kinase C and "non-kinase" phorbol ester receptors: emerging concepts and therapeutic implications. Biochem. Biophys. Acta 1754: 296-304 (2005) (Special issue for "Inhibitors of Protein Kinases Meeting", Warsaw, Poland).

2004

  1. Frey, M.R., Clark, J.A., Bateman, N.W., Kazanietz, M.G., Black, A.R., and Black, J.D. Cell cycle- and protein kinase C-specific effects of resiniferatoxin and resiniferonol 9,13,14-orthophenyl acetate in intestinal epithelial cells. Biochem. Pharmacol. 67:1873-1886 (2004).
  2. Canagarajah B, Ho JYS, Coluccio-Leskow F, Mischak H, Saidi L, Kazanietz MG & Hurley JH: Structural mechanism for lipid activation of the Rac-specific GAP, β2-chimaerin. Cell 119: 407-418, 2004.
  3. Gavrielides, M.V., Frijhoff, A.F., Conti, C.J., and Kazanietz, M.G. Protein kinase C and prostate carcinogenesis: targeting the cell cycle and apoptosis mechanisms. Current Drug Targets 5: 431-443 (2004).

2003

  1. Li, Y., Gonzalez, M., Meinkoth, J., Field, J., Kazanietz, M.G., and Tennekoon, G. Lysophosphatidic acid promotes survival and differentiation of rat Schwann cells. J. Biol. Chem. 278: 9585-9591.[ html ] [ pdf ]
  2. Kazanietz, M.G. Pharmacological Probes for Protein Kinase C: An introduction. In "Methods in Molecular Biology: Protein Kinase C Protocols", Humana Press, Edited by: Alexandra C. Newton. Vol. 233, pp. 389-395 (2003).
  3. Kazanietz, M.G. and Patricia S. Lorenzo. Pharmacological Probes for Protein Kinase C: Phorbol esters as tools to study PKC function. In "Methods in Molecular Biology: Protein Kinase C Protocols", Humana Press, Edited by: Alexandra C. Newton. Vol. 233, pp. 423-439 (2003).
  4. Lorenzano Menna, P., Skilton, G., Coluccio Leskow, F., Alonso, D.F., Gomez, D.E., and Kazanietz, M.G. Inhibition of aggressiveness of metastatic mouse mammary carcinoma cells by the beta2-chimaerin GAP domain. Cancer Res. 63: 2284-2291(2003) [ html ] [ pdf ]

2002

  1. Garcia-Bermejo, M.L., Coluccio Leskow, F., Fujii, T., Wang, Q., Blumberg, P.M., Ohba, M., Kuroki, T., Han, K-C., Lee, J., Marquez, V.E., and Kazanietz, M.G. DAG-lactones, a new class of PKC agonists, induce apoptosis in LNCaP prostate cancer cells by selective activation of PKCalpha. J. Biol. Chem. 277: 645-655 (2002).[ html ] [ pdf ]
  2. Wang, H., and Kazanietz, M.G. Chimaerins, novel "non-PKC" phorbol ester receptors, associate with Tmp21-I (p23). Evidence for a novel anchoring mechanism involving the chimaerin C1 domain. J. Biol. Chem. 277: 4541-4550 (2002).[ html ] [ pdf ]
  3. Roaten, J.B., Kazanietz, M.G., Caloca, M.J., Bertics, P.J., Lothstein, L., Parril, A., Israel, M., and Sweatman, T. Interaction of the novel anthracycline antitumor N-benzyladriamycin-14-valerate with the C1-regulatory domain of protein kinase C: structural requirements, isoform specificity, and correlation with drug cytotoxicity. Molec. Cancer Ther. 1: 483-492 (2002).[ abstract ]
  4. Kazanietz, M.G. Novel "non-kinase" phorbol ester receptors: the C1 domain connection. Mol. Pharmacol. 61: 759-767 (2002).[ html ] [ pdf ]
  5. Yu, D., Kazanietz, M.G., Harvey, R.G., and Penning, T.M. Polycyclic aromatic hydrocarbon o-quinones inhibit the activity of the catatytic fragment of protein kinase C. Biochemistry 41: 11888-11894 (2002).[ html ] [ pdf ]
  6. Gonzalez, M.I., Kazanietz, M.G., and Robinson, M.B. Different members of the PKC family modulate EAAC1-mediated uptake by changes in cell surface expression or transport activity. Mol. Pharmacol. 62: 901-910 (2002).[ html ] [ pdf ]
  7. Abrams, C., and Kazanietz, M.G. Platelet signaling: Protein kinase C. In "Platelets in thrombotic and non-thrombotic disorders: pathophysiology, pharmacology and therapeutics". Editors: P. Gresele, C.P. Page, V. Fuster, and J. Vermylen (2002).

2001

  1. Caloca, M.J., Wang, H.B., Delemos, A., Wang, S., and Kazanietz, M.G. Phorbol esters and related analogs regulate the subcellular localization of beta2-chimaerin, a "non-PKC" phorbol ester receptor. J. Biol. Chem. 276: 18303-18312 (2001).[ html ] [ pdf ]
  2. Roaten, J.B., Kazanietz, M.G., Sweatman, T.G., Lothstein, L., Israel, M., and Parrill, A.L. Molecular models of N-benzyladriamycin-14-valerate (AD 198) in complex with the phorbol ester-binding C1beta domain of protein kinase C-delta. J. Med. Chem. 44, 1028-1034 (2001).[ html ][ pdf ]
  3. Kazanietz, M.G., Caloca, M.J., Aizman, O., and Nowicki, S. Isoform-specific phosphorylation of renal Na+/K+-ATPase by PKC. Arch. Biochem. Biophys. 388: 74-80 (2001).[ html ] [ pdf ]
  4. Qiao, L., Zhao, L-Y., Rong, S-B., Wu, X-W., Wang, S., Fujii, T., Kazanietz, M.G., Rauser, L., Savage, J., Roth, B.L., Flippen-Anderson, J., and Kozikowski, A.P. Rational design, synthesis, and biological evaluation of rigid pyrrolidone analogs as potential inhibitors of prostate cancer cell growth. Bioorg. Med. Chem. Lett. 11: 955-959 (2001).[ abstract ]
  5. Barry, O.P., Mullans, B., Sheehan, D., Kazanietz, M.G., Shanahan, F., Collins, J.K., and O'Sullivan G.C. Constitutive ERK1/2 activation in esophagogastric rib bone marrow micrometastatic cells is MEK-independent. J. Biol. Chem. 276: 15537-15546 (2001).[ html ] [ pdf ]
  6. Barry, O.P., and Kazanietz, M.G. Protein kinase C isozymes, novel phorbol ester receptors and cancer chemotherapy. In "Current Pharmaceutical Design-Anti-Cancer Agents", Bentham Science Publishers, Editor: Alan Kozikowski, 7: 1725-1744 (2001).[ abstract ]
  7. Sanz-Navares, E., Fernandez, N., Kazanietz, M.G., and Rotenberg, S.A. Atypical protein kinase C-zeta suppresses migration of mouse melanoma cells. Cell Growth Differ. 12: 517-524 (2001).[ html ][ pdf ]
  8. Qi, H.W., Juo, P., Masuda-Robens, J., Caloca, M.J., Zhou, H., Stone, N., Kazanietz, M.G. and Chou, M.M. Caspase-mediated cleavage of the TIAM1 guanine nucleotide exchange factor during apoptosis. Cell Growth Differ. 12: 603-611 (2001).[ html ] [ pdf ]
  9. Eroles, P., Wang, H., Coluccio-Leskow, F., Fernandez, N., Tanaka, Y., Gavrielides, M.V., Fujii, T., and Kazanietz, M.G. Protein kinase C and phorbol ester receptors in prostate carcinogenesis. In "Recent Research Developments in Endocrinology" 2: 237-250 (2001).

2000

  1. Fujii, T., Garcia-Bermejo, M.L., Bernabo, J.L., Caamano, J., Ohba, M., Kuroki, T., Li, L., Yuspa, S.H., and Kazanietz, M.G. Involvement of PKCdelta in phorbol ester-induced apoptosis in LNCaP prostate cancer cells. Lack of proteolytic cleavage of PKCdelta. J. Biol. Chem. 275: 7574-7582 (2000).[ html ] [ pdf ]
  2. Fernandez, N., Caloca, M.J., Meinkoth, J., and Kazanietz, M.G. Atypical PKC-zeta stimulates thyrotropin-independent proliferation in rat thyroid cells. Endocrinology 141: 146-152 (2000).[ html ][ pdf ]
  3. Gala?Ln, M.A., Garcia-Bermejo, M.L., Troyano, A., Vilaboa, N.E., de Blas, E., Kazanietz, M.G., and Aller, P. Stimulation of p38 mitogen-activated protein kinase is an early regulatory event for the cadmium-induced apoptosis in human promonocytic cells. J. Biol. Chem. 275: 11418-11424 (2000).[ html ] [ pdf ]
  4. Kazanietz, M.G. Protein kinase C and novel receptors for the phorbol esters and the second messenger diacylglycerol. Medicina (B. Aires) 60: 685-688 (2000).[ abstract ]
  5. Kazanietz, M.G., Caloca, M.J., Garcia-Bermejo, M.L., Reilly, M., Eroles, P., Fujii, T., and Wang, H-B. Pharmacology of the receptors for the phorbol ester tumor promoters: multiple receptors with different biochemical properties (Review). Biochem. Pharmacol. 60: 1417-1424 (2000).[ html ] [ pdf ]
  6. Aroca, P., Santos, E., Kazanietz, M.G. Recombinant C1beta domain of PKCdelta triggers meiotic maturation upon microinjection in Xenopus laevis oocytes. FEBS Lett. 483: 27-31 (2000).[ html ][ pdf ]
  7. Kazanietz, M.G. Eyes wide shut: protein kinase C isozymes are not the only receptors for the phorbol ester tumor promoters (Review). Mol. Carcinogenesis 28: 5-11 (2000).[ pdf ]

1999

  1. Caloca, M.J., Garcia-Bermejo, M.L., Blumberg, P.M., Lewin, N.L., Kremmer, E., Mischak, H., Wang, S., Nacro, K., Bienfait, B., Marquez, V.E., Kazanietz, M.G. beta2-chimaerin is a novel target for diacylglycerol: binding properties and changes in subcellular localization mediated by ligand binding to its C1 domain. Proc. Natl. Acad. Sci. USA 96: 11854-11859 (1999).[ html ] [ pdf ]
  2. Barry, O.P., Kazanietz, M.G., Pratico, D., and FitzGerald, G.A. Transcellular signaling by bioactive lipids: activation of protein kinase C by platelet microparticle arachidonic acid. J. Biol. Chem. 274: 7545-7556 (1999).[ html ] [ pdf ]
  3. Gomez, D.E., Skilton, G., Alonso, D.F., and Kazanietz, M.G. The role of protein kinase C and novel phorbol ester receptors in tumor cell invasion and metastasis (Review). Oncology Reports 6: 1363-1370 (1999).[ abstract ]
  4. Ron, D., and Kazanietz, M.G. New insights into the regulation of protein kinase C and novel phorbol ester receptors (Review). FASEB J. 13: 1658-1676 (1999). (also, cover of the Journal).[ html ] [ pdf ]