The Kazanietz Laboratory
Department of Pharmacology and Institute for Translational Medicine and Therapeutics (ITMAT)

Kazanietz Lab > Research Projects > Regulation

Regulation of PKC Activity by Carcinogens

Polycyclic Aromatic Hydrocarbons (PAHs) are ubiquitous environmental pollutants and may be the causative agents in human lung cancer. They are procarcinogens and require metabolic activation to exert their deleterious effects. PAHs require metabolic activation to exert their carcinogenic effects. Aldo-keto reductases (AKRs) oxidize PAH trans-dihydrodiol proximate carcinogens to their corresponding reactive and redox-active o-quinones. PAH o-quinones inhibit PKC isozymes, and therefore they can have epigenetic effects that can influence tumor promotion.

  1. Effect of PAH o-quinones on PKC activity.

Representative papers (PubMed)

  1. Yu, D., Kazanietz, M.G., Harvey, R.G., and Penning, T.M. Polycyclic aromatic hydrocarbon o-quinones inhibit the activity of the catatytic fragment of protein kinase C. Biochemistry 41: 11888-11894 (2002). [ html ] [ pdf ]