Publications

*For a complete list please see: Full Publication List

• Rodriguez LR, Tang SY, Roque Barboza W, Murthy A, Tomer Y, Cai T-Q, Iyer S, Chavez K, Das US, Ghosh S, Cooper CH, Dimopoulos TT, Babu A, Connelly C, FitzGerald GA, Beers MF. PGF2α signaling drives fibrotic remodeling and fibroblast population dynamics in mice. JCI Insight. 2023 December 22; 8(24). PMID: 37934604. 

• Katzen, J., Rodriguez, L., Tomer, Y., Babu, A., Zhao, M., Murthy, A., Carson, P., Barrett, M., Basil, M.C., Carl, J., Leach, J.P., Morley, M., McGraw, M.D., Mulugeta, S., Pelura, T., Rosen, G., Morrisey, E.E., Beers, M.F. Disruption of proteostasis causes IRE1 mediated reprogramming of alveolar epithelial cells. Proceedings of the National Academy of Sciences Aug 20 2022; 119, e2123187119.  PMID: PMCID9618079 
• Alysandratos KD, Russo S, Petcherski A, Taddeo EP, Acin-Perez R, Villacorta-Martin C, Jean JC, Mulugeta S, Rodriguez LR, Blum BC, Hekman RM, Hix OT, Minakin K, Vedaie M, Kook S, Tilston-Lunel AM, Varelas X, Wambach JA, Cole FS, Hamvas A, Young LR, Liesa M, Emili A, Guttentag SH, Shirihai OS, Beers MF, Kotton DN.  Patient-specific iPSCs carrying an SFTPC mutation reveal the intrinsic alveolar epithelial dysfunction at the inception of interstitial lung disease. Cell Reports 2021 Aug 31; 36 (9). PMCID: PMC8432578
• Venosa A, Cowman S, Katzen J, Tomer Y, Armstrong BS, Mulugeta S, Beers MF.  Role of CCR2 ⁺ Myeloid Cells in Inflammation Responses Driven by Expression of a Surfactant Protein-C Mutant in the Alveolar Epithelium. Front Immunol. 2021 Apr 22; PMCID: PMC8101410
• Katzen J, Beers MF. Contributions of alveolar epithelial cell quality control to pulmonary fibrosis. J Clin Invest. 2020 Sep 1; 130, 5088–5099. PMCID: PMC7524463.
• Venosa A, Katzen J, Tomer Y, Kopp M, Jamil S, Russo SJ, Mulugeta S, Beers MF. Epithelial Expression of an Interstitial Lung Disease–Associated Mutation in Surfactant Protein-C Modulates Recruitment and Activation of Key Myeloid Cell Populations in Mice. J Immunol May 1, 2019, 202 (9) 2760-277. PMCID: PMC6478557
• Katzen J, Wagner BD, Venosa A, Kopp M, Tomer Y, Russo SJ, Headen AC, Basil MC, Stark JM, Mulugeta S, Deterding RR, Beers MF. An SFTPC BRICHOS mutant links epithelial ER stress and spontaneous lung fibrosis. JCI Insight. 2019 Mar 21;4(6). PMCID: PMC6483196.
• Nureki SI, Tomer Y, Venosa A, Katzen J, Russo SJ, Jamil S, Barrett M, Nguyen V, Kopp M, Mulugeta S, Beers MF. Expression of mutant Sftpc in murine alveolar epithelia drives spontaneous lung fibrosis. J Clin Invest. 2018 Aug 31;128(9):4008-4024. PMCID: PMC6118576.
• Beers MF and Moodley Y. When Is An Alveolar Type 2 Cell An Alveolar Type 2 Cell? A Conundrum for Lung Stem Cell Biology and Regenerative Medicine. American Journal Respiratory Cell Molecular Biology  57(1): 18-25 2017.
• Jacob A, Morley M, Hawkins F, McCauley KB, Jean JC, Heins H, Na CL, Weaver TE, Vedaie M, Hurley K, Hinds A, Russo SJ, Kook S, Zacharias W, Ochs M, Traber K, Quinton LJ, Crane A, Davis BR, White FV, Wambach J, Whitsett JA, Cole FS, Morrisey EE, Guttentag SH, Beers MF, Kotton DN. Differentiation of Human Pluripotent Stem Cells into Functional Lung Alveolar Epithelial Cells. Cell Stem Cell. 2017 Oct 5;21(4):472-488.e10. PMCID: PMC5755620.
• Hawkins A, Guttentag SH,  Deterding R, Funkhouser, WK,  Goralski, JL, Chatterjee S,  Mulugeta S, and Beers MF**. A non-BRICHOS SFTPC mutant (SP-CI73T) linked to interstitial lung disease promotes a late block in macroautophagy disrupting cellular proteostasis and mitophagy.  Am J Physiol: Lung Cell Mol Physiol. 308: L33-47 2015
• Mulugeta S, Nureki S-I, and Beers MF. Lost After Translation: Insights From The Surfactant System For The Role Of Epithelial Cell Quality Control In Parenchymal Lung Disease.  Am J. Physiology: Lung Cell Mol. Physiol 309: L507-25 2015 PMCID: PMC4572416
• Beers MF and Morrisey E.  The Three R’s Of Lung Health and Disease: Repair, Remodeling, and Regeneration.   J. Clin. Investigation 121(6):2065–2073 2011.  PMCID: PMC3104764
• Maguire JA, Mulugeta S, and Beers MF. Endoplasmic reticulum stress induced by Surfactant Protein C BRICHOS mutants promotes proinflammatory signaling by epithelial cells.  Am J Respir Cell Mol Biol. 2011 Mar;44(3):404-14. PMCID: PMC3095939.
• Kotorashvili A, Russo SJ, Mulugeta S, Guttentag S, and Beers MF.  Anterograde transport of surfactant protein C proprotein to distal processing compartments requires PPDY mediated association with NEDD4 ubiquitin ligases. J. Biological Chemistry 284 (24):16667–678 2009.