Perelman School of Medicine at the University of Pennsylvania

Department of Neuroscience

Postdoctoral Research Position

NIH/NIDA T32 Translational Addiction Research Fellowship


The Center for the Studies of Addiction at the University of Pennsylvania Perelman School of Medicine invites applications for a Post-Doctoral Fellow with strong technical skills in neuroimaging, and a potential interest in the clinical neuroscience of addiction, for a position in our NIH/NIDA T32 Translational Addiction Research Fellowship. The selected candidate will become a member of our inter-disciplinary clinical neuroimaging laboratory with ongoing, funded projects in cocaine, nicotine and alcohol addiction. The T32 Fellowship position is funded up to three years.

Our laboratory is especially focused on understanding brain vulnerabilities that may underlie the difficult clinical problem of relapse, with the goal of improving addiction treatment. Within this general domain - we are pursuing several vulnerabilities (e.g., heightened response of motivational/reward circuit response to drug cues; poor frontal modulation of the limbic response to appetitive and aversive/stress cues; poor inhibition, impaired decision-making, etc.) using brain measures both as predictors of relapse, and as brain targets for medication discovery. Recently, we have begun to combine brain imaging and hypothesis-driven genetics with the goal of understanding the heterogeneity in relapse, and in medication response, for our clinical populations. Though our primary tool is MRI (BOLD, ASL, and structural), we also have ongoing neuroligand (SPECT) imaging. We have significant existing datasets, offering a technically-skilled post-doc a stream of immediate publication opportunities.

Our addictions research group is part of an extensive network of neuroimaging efforts across several research Centers and schools at Penn (Perelman School of Medicine, School of Arts and Sciences, Annenberg School of Communications, Wharton School of Business), and the adjacent Children's Hospital of Philadelphia. The imaging resources include multiple MR scanners, as well as capabilities for MRS, MEG, PET, and soon-to-come, concurrent MRI-PET scanning. Our custom, web-based neuroinformatics software, WISDM, enables rapid sharing and display of raw data and imaging results, facilitating collaborations within and beyond our lab.

Successful candidates will have strong communication skills and clear technical expertise, including prior experience with one or more statistical packages for neuroimaging (e.g., SPM, FSL, AFNI). Demonstrated ability to apply more advanced tools (e.g., connectivity, causal modeling, FIR, etc.), and to integrate imaging and non-imaging (behavioral measures; genetics) will be an advantage. The ability to publish research findings is important for this position. Candidates will have completed a PhD in a relevant discipline (e.g., engineering, biomedical engineering, biophysics, mathematics, neuroscience, cognitive neuroscience, psychology, etc.).

The University of Pennsylvania is an Equal Opportunity/Affirmative Action Employer. Minorities and women are strongly encouraged to apply. US Citizenship or Permanent Resident status (green card) is required. Applications will be considered until the position is filled. Please e-mail a CV, a one-page letter of your interest in, and potential fit for, the position, and the names of 3 references to the laboratory director and NIDA T32 Director, Dr. Anna Rose Childress (

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