Gullbrand Laboratory

Welcome to Gullbrand Laboratory

The Gullbrand Lab studies how aberrant structure-function relationships across the spine contribute to the initiation and progression of degenerative disc disease. Our work spans multiple length scales across model systems of disease and human tissue. We probe spinal tissues by employing a suite of biomechanical and bioimaging tools, elucidating connections between tissue structure and degeneration of intervertebral discs, vertebral bones, cartilage endplates, and facet joints. Our group also focuses on utilizing this knowledge to inform the development of tissue-engineering-based approaches for disc regeneration. Central to this work, in collaboration with Harvey Smith, MD and Robert Mauck, PhD, is the translation of a whole tissue engineered intervertebral disc replacement towards clinical application in human patients. 

The Gullbrand lab is uniquely situated in the Translational Musculoskeletal Research Center at the Philadelphia Corporal Michael J. Crescenz VA Medical Center.

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Congratulations to Dr. Sarah Gullbrand and Coauthors on European Cells and Materials Publication
April 23, 2024
Congratulations to Dr. Gullbrand and coauthors on their publication in European Cells and Materials. The study, entitled "Intervertebral Disc Degeneration Instigates Vertebral Endplate Remodeling and Facet Joint Pathology in a Large Animal Model," characterizes the degenerative changes that occur across all substructures of the spine following induction of intervertebral disc degeneration in an initially healthy spine using chondroitinase ABC.

Congratulations to Cait Barrett on winning Best Podium at Drexel's Orthopaedic Research Day
April 21, 2024
Congratulations to Caitlin Barrett on winning Best Podium at Drexel's Orthopaedic Research Day for her podium entitled "Innervation and Inflammation Correlate with Structural and Mechanical Changes in a Large Animal Model of Intervertebral Disc Degeneration"

Columbia University Invites Dr. Gullbrand to Speak
March 05, 2024
Dr. Gullbrand gave a seminar today entitled "Disc-Facet and Disc-Endplate Crosstalk During Spinal Degeneration and Repair" as part of Columbia University's Orthopaedic Surgery Seminars in Musculoskeletal Research series.

Congratulations to Emily Sharp on Receiving ORS Spine Section Poster Award
February 06, 2024
Congratulations to all members of the Gullbrand Lab on their presentations at the Orthopaedic Research Society's 2024 Conference in Long Beach, California! Notably, PhD student Emily Sharp received the ORS Spine Section Poster Award for her outstanding project "A 'Clickable' Hydrogel for Annulus Fibrosis Repair After Intervertebral Disc Herniation." Dr. Sarah Gullbrand also presented during the Spine Biomechanics and Wearables session, highlighting our work understanding how rigid plate fixation of a tissue engineered disc replacement impacts adjacent facet degeneration over short and long durations in a large animal model.

Congratulations to Dr. Victoria Muir and Coauthors on Advanced Healthcare Materials Publication
January 05, 2024
Congratulations to Dr. Victoria Muir and coauthors on their latest publication "Injectable Radiopaque Hyaluronic Acid Granular Hydrogels for Intervertebral Disc Repair" in Advanced Healthcare Materials.

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