Sohaib Hashmi
Visiting MD/PhD Student
University of Pennsylvania
Hometown
Karachi, Pakistan
Education
M.D., Ph.D. Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 2022
Bachelor of Science (Bioengineering) School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, 2013
Areas of Special Interest
I am interested in using cell and molecular biology tools in combination with engineering principles to create more physiologically accurate models of human disease. I have a particular interest in smooth muscle disorders of the bowel, bladder, and uterus that cause debilitating visceral myopathies. I hope to understand the mechanobiology underpinning these diseases and develop high-throughput platforms to identify new therapeutic strategies to treat these conditions. Outside of science and medicine, I enjoy cooking, hosting dinner and movie nights for my friends, and reading/watching science fiction and fantasy.
Book Chapters
Porrett PM, Hashmi SK, Shaked A. Immunosuppression: trends and tolerance? Clin Liver Dis 2014; 18:687–716.
Publications
Hashmi SK, Barka V, Yang C, Schneider S, Svitkina TM, Heuckeroth RO. Pseudo-obstruction-inducing ACTG2 R257C alters actin organization and function. JCI Insight 2020;5.: https://doi.org/10.1172/jci.insight.140604.
Hashmi SK, Ceron RH, Heuckeroth RO. Visceral Myopathy: Clinical syndromes, genetics, pathophysiology, and Fall of the Cytoskeleton. Am J Physiol Gastrointest Liver Physiol 2021. https://doi.org/10.1152/ajpgi.00066.2021.
Bromberger B, Spragan D, Hashmi S, Morrison A, Thomasson A, Nazarian S, et al. Pregnancy-Induced Sensitization Promotes Sex Disparity in Living Donor Kidney Transplantation. J Am Soc Nephrol 2017. https://doi.org/10.1681/ASN.2016101059.
Hashmi SK. Socio-economic evaluation of the parents of patients under treatment at the Oncology Unit of the National Institute of Child Health (NICH), Pak Paed J, Dec 2006; 30(4):179-83.
Hashmi FK, Hashmi SK. Attitudes of attendants and visitors at the National Institute of Child Health (NICH): Problems and solutions, Pak J Med Sci, Mar 2006; 22(1):94-6.
Hashmi SK, Baranov E, Gonzalez A, Olthoff K, Shaked A. Genomics of liver transplant injury and regeneration. Transplant Rev 2015; 29:23–32
Conference Abstracts
Hashmi SK, Barka V, Schneider S, Heuckeroth RO. Role of ACTG2 Mutations in Visceral Myopathy. Proc of 2020 AAP/ASCI/APSA Joint Meeting, Chicago, IL, April 3-5, 2020 (Meeting postponed due to Covid-19 pandemic)
Hashmi SK, Schneider S, French DL, Gadue P, Heuckeroth RO. Engineering genetic tools to study gut smooth muscle differentiation. Proc of FASEB Science Research Conference: The Smooth Muscle Conference 2019, West Palm Beach, FL, July 14-19, 2019
Hashmi SK, Schneider S, French DL, Gadue P, Heuckeroth RO. Effects of enteric neurons on smooth muscle differentiation. Proc of the 5th International Enteric Nervous System Symposium, Boston, MA, April 8-11, 2018
Khungar V, Bao-Li C, Hashmi SK, Levitsky J, Friedwald J, Emond J, Shaked A. Correlating Liver and Kidney Donor Risk Index (DRI) with gene expression in the organ biopsy prior to reperfusion, Proc of World Transplant Congress Annual Meeting 2014, July 2014
Heo SJ, Thorpe S, Driscoll T, Hashmi SK, Lee D, Mauck R. Rapid and Sustained Changes in Nuclear Architecture and Mechanics in Mesenchymal Stem Cells in Response to Dynamic Stretch, Proc of Orthopaedic Research Society (ORS) Annual Meeting 2014, March 2014
Heo SJ, Thorpe S, Driscoll T, Hashmi SK, Lee D, Mauck R. Dynamic Stretch Rapidly Alters Nuclear Structure and Increases Chromatin Condensation in Mesenchymal Stem Cells, Proc of Orthopaedic Research Society (ORS) Annual Meeting 2013, January 2013
Heo SJ, Driscoll T, Hashmi SK, Mauck R. Nuclear Remodeling During Fibrochondrogenesis Sensitizes Mesenchymal Stem Cells to Mechanical Stretch, Proc of Orthopaedic Research Society (ORS) Annual Meeting 2013, January 2013
Hashmi SK, Sullivan S, Eucker SA, Coats B, Lee J, Margulies SS. FEM-predicted Regional Tissue Strains Aligned with the White Matter Tracts Predict Axonal Injury, Proc of 30th Northeast Bioengineering Conference (NEBEC), Mar 2012.