Welcome to the Penn Pancreatic Cancer Research Center!
The Penn Pancreatic Cancer Research Center (PCRC) is committed to delivering high-quality care for patients with pancreatic cancer. We take a multidisciplinary approach — integrating Medical Oncology, Surgery, Gastroenterology, Radiation Oncology, and Pathology — to deliver comprehensive and personalized options to our patients.
The American Cancer Society has reported that last year pancreatic cancer became the third leading cause of cancer death in the U.S., surpassing breast cancer (see Cancer Statistics). One encouraging piece of this report is that the five-year relative survival rate for pancreatic cancer has moved to 8 percent (from 5 percent several years ago). At the Penn Pancreatic Cancer Research Center (PCRC), we understand the urgent need to develop better treatments and cures for patients.
Our fantastic PCRC Nurse Navigator, Trish Gambino, was featured in an article from Let's Win! Pancreatic Cancer.Research Advances
Shown below are four journal covers created by our researchers featuring recent work.
The laboratories of Erica Carpenter and David Issadore have been developing new ways of extracting molecular information about pancreatic tumors from the blood:
- Ko J, Bhagwat N, Black T, Yee SS, Na YJ, Fisher SA, Kim J, Carpenter EL, Stanger BZ, Issadore D. miRNA profiling of magnetic nanopore-isolated extracellular vesicles for the diagnosis of pancreatic cancer. Cancer Res. 2018 Jul 1;78(13):3688-3697.
- Bhagwat N, Dulmage K, Pletcher CH Jr., Wang L, DeMuth W, Sen M, Balli D, Yee SS, Sa S, Tong F, Yu L, Moore JS, Stanger BZ, Dixon EP, Carpenter EL. An integrated flow cytometry-based platform for isolation and molecular characterization of circulating tumor single cells and clusters. Sci Rep. 2018 Mar; 8(1):5035.
Work from the laboratories of Anil Rustgi and Ben Stanger shows how tumor plasticity (the ability of tumor cells to adopt new features) influences metastasis in pancreatic cancer:
- Reichert M, Bakir B, Moreira L, Pitarresi JR, Feldmann K, Simon L, Suzuki K, Maddipati R, Rhim AD, Schlitter AM, Kriegsmann M, Weichert W, Wirth M, Schuck K, Schneider G, Saur D, Reynolds AB, Klein-Szanto AJ, Pehlivanoglu B, Memis B, Adsay NV, Rustgi AK. Regulation of Epithelial Plasticity Determines Metastatic Organotropism in Pancreatic Cancer. Dev Cell 2018 Jun 18;45(6):696-711.
- Aiello NM, Maddipati R, Norgard RJ, Balli D, Li J, Yuan S, Yamazoe T, Black T, Sahmoud A, Furth EE, Bar-Sagi D, Stanger BZ. EMT Subtype Influences Epithelial Plasticity and Mode of Cell Migration. Dev Cell 2018 Jun 18;45(6):681-695.
- (Highlighted in Developmental Cell): Lo HC, Zhang XH. EMT in Metastasis: Finding the Right Balance. Dev Cell 2018 Jun 18;45(6):663-665.
Work from the laboratories of Robert Vonderheide and Ben Stanger probes the molecular wiring of tumors that renders them sensitive or resistant to immune therapies (Penn Press Release):
- Li J, Byrne KT, Yan F, Yamazoe T, Chen Z, Baslan T, Richman LP, Lin JH, Sun YH, Rech AJ, Balli D, Hay CA, Sela Y, Merrell AJ, Liudahl SM, Gordon N, Norgard RJ, Yuan S, Yu S, Chao T, Ye S, Eisinger-Mathason TSK, Faryabi RB, Tobias JW, Lowe SW, Coussens LM, Wherry EJ, Vonderheide RH, Stanger BZ. Tumor Cell-Intrinsic Factors Underlie Heterogeneity of Immune Cell Infiltration and Response to Immunotherapy. Immunity 2018 Jul 17;49(1):178-193.
For more of our published research, see the Publications page: https://www.med.upenn.edu/pcrc/publications.html.
Information for clinical trials
We believe in the power of clinical trials in caring for patients and conquering this disease.
For more information, click here.
PCRC Purplestride Team, under the leadership of Team Captain Trish Gambino, RN, exceeded its fundraising goal. With… https://t.co/HQRAXKjRq6
Penn PCRC 10 months, 1 week ago
PCRC Clinical Researcher Kim Reiss Binder's pancreatic cancer clinical trial (UPCC 05217) was featured in Forbes: https://t.co/k69P6IYIXN
Penn PCRC 1 year ago
We need your help! Ride with us, donate, or volunteer for the Breakthrough Bike Challenge on Saturday, September 17: https://t.co/NbkeYGnVcf
Penn PCRC 1 year ago
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