Penn IMIG

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Welcome to Penn IMIG

Recent advances in microscopy have made it possible to examine the spatiotemporal regulation of protein movements within cells and cell movements within tissues. Recognizing that many recent cutting edge advances in cancer immunology derive from the application of these new tools, investigators from across the Penn campus have banded together to form the Penn Immunology Microscopy Interest Group (Penn IMIG). Group members meet regularly to discuss research, exchange ideas and reagents, and help one another address common problems. In addition to promoting collaborative science among member labs, Penn IMIG aims to advance the use of microscopy techniques across the Penn community to study problems relevant to cancer biology and immunology.

Our interests are diverse and include:

  • the role of molecular chaperones during B cell differentiation and growth factor production
  • the function of biological membranes as they relate to immune cell signaling and intracellular membrane sorting
  • the mechanisms by which regulated actin dynamics promote the function of T cells and antigen presenting cells
  • the control and function of calcium (Ca2+) responses in lymphocytes
  • immune responses to parasitic infections like T. gondii
  • the role of T lymphocytes in combating infection and destroying cancerous tissue
  • the effect of cytoskeletal events on Natural Killer (NK) cell function and regulation
  • asymmetric cell division as a way for mobile, non-polarized cells to generate cell fate diversity among their progeny
University of Penn
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University of Penn - Vet
University of Penn - Vet