Microcirculation in Shock
Principal Investigator: John C. Greenwood, MD, MSTR
Email: john.greenwood@pennmedicine.upenn.edu
John Greenwood is an Assistant Professor in the Departments Emergency Medicine & Anesthesiology and Critical Care at the University of Pennsylvania. He studied Medicine at Jefferson Medical College and completed residency in Emergency Medicine at the University of Maryland where he also served as Chief Resident and Faculty Development fellow during that time. John then stayed at the University of Maryland to complete his fellowship in Critical Care Medicine, with additional training in ECMO support.
His research interests are focused on circulatory shock, resuscitation, tissue perfusion, and microcirculatory function, with a goal to improve therapeutic interventions and patient outcomes from acute critical illnesses.
John Greenwood's Recent Publications
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Anaerobic Lactate Production Is Associated With Decreased Microcirculatory Blood Flow and Decreased Mitochondrial Respiration Following Cardiovascular Surgery With Cardiopulmonary Bypass.
Critical care medicine. 2024 Apr 5; Authors: Greenwood JC, Talebi FM, Jang DH, Spelde AE, Gordon EK, Horak J, Acker MA, Kilbaugh TJ, Shofer FS, Augoustides JGT, Brenner JS, Muzykantov VR, Bakker J, Abella BS -
Investigation of Cerebral Mitochondrial Injury in a Porcine Survivor Model of Carbon Monoxide Poisoning.
Journal of medical toxicology : official journal of the American College of Medical Toxicology. 2024 Jan;20(1):39-48 Epub 2023 Oct 17; Authors: Mavroudis CD, Lewis A, Greenwood JC, Kelly M, Ko TS, Forti RM, Shin SS, Shofer FS, Ehinger JK, Baker WB, Kilbaugh TJ, Jang DH -
Low postoperative perfused vessel density is associated with increased soluble endothelial cell adhesion molecules during circulatory shock after cardiac surgery.
Microvascular research. 2023 Nov;150:104595 Epub 2023 Aug 22; Authors: Greenwood JC, Talebi FM, Jang DH, Spelde AE, Gordon EK, Horak J, Acker MA, Kilbaugh TJ, Shofer FS, Augoustides JGT, Bakker J, Brenner JS, Muzykantov VR, Abella BS -
Cell-Free DNA as a Biomarker in a Rodent Model of Chlorpyrifos Poisoning Causing Mitochondrial Dysfunction.
Journal of medical toxicology : official journal of the American College of Medical Toxicology. 2023 Oct;19(4):352-361 Epub 2023 Jul 31; Authors: Kao SH, Shofer FS, Greenwood JC, Alomaja O, Ranganathan A, Piel S, Mesaros C, Shin SS, Ehinger JK, Kilbaugh TJ, Jang DH -
Alteration in Cerebral Metabolism in a Rodent Model of Acute Sub-lethal Cyanide Poisoning.
Journal of medical toxicology : official journal of the American College of Medical Toxicology. 2023 Apr;19(2):196-204 Epub 2023 Feb 9; Authors: Alomaja O, Shofer FS, Greenwood JC, Piel S, Clayman C, Mesaros C, Kao SH, Shin SS, Ehinger JK, Kilbaugh TJ, Jang DH -
Results of a Pilot Study for a Pharmacy Discharge Review in Neurosurgical Patients: A Quality-Safety Initiative.
Cureus. 2023 Mar;15(3):e36067 Epub 2023 Mar 13; Authors: Greenwood JC, Gutierrez K, McDermott M -
Differences and Disparities in Ageism Affecting Older US Adults: A Review.
Current epidemiology reports. 2023 Mar;10(1):17-32 Epub 2022 Dec 29; Authors: Allen JO, Elias LK, Greenwood JC -
Correction to: Preliminary Research: Application of Non-Invasive Measure of Cytochrome c Oxidase Redox States and Mitochondrial Function in a Porcine Model of Carbon Monoxide Poisoning.
Journal of medical toxicology : official journal of the American College of Medical Toxicology. 2023 Jan;19(1):53; Authors: Lewis A, Forti RM, Alomaja O, Mesaros C, Piel S, Greenwood JC, Talebi FM, Mavroudis CD, Kelly M, Kao SH, Shofer FS, Ehinger JK, Kilbaugh TJ, Baker WB, Jang DH -
Topical nitroglycerin to detect reversible microcirculatory dysfunction in patients with circulatory shock after cardiovascular surgery: an observational study.
Scientific reports. 2022 Sep 10;12(1):15257; Authors: Greenwood JC, Talebi FM, Jang DH, Spelde AE, Tonna JE, Gutsche JT, Horak J, Acker MA, Kilbaugh TJ, Shofer FS, Augoustides JGT, Bakker J, Brenner JS, Muzykantov VR, Abella BS -
Protocol for the MicroRESUS study: The impact of circulatory shock and resuscitation on microcirculatory function and mitochondrial respiration after cardiovascular surgery.
PloS one. 2022;17(8):e0273349 Epub 2022 Aug 26; Authors: Greenwood JC, Talebi FM, Jang DH, Spelde AE, Kilbaugh TJ, Shofer FS, Acker MA, Augoustides JGT, Bakker J, Meyer NJ, Brenner JS, Muzykantov VR, Abella BS