slide 1 slide 2 retroviral greats

Program

Conference Topics

  • Pathogenesis
  • Oncogenesis
  • Host Restriction Factors
  • Zoonosis and Emerging Viruses
  • Immune Responses
  • Virus - Cell Interactions
  • Retroviral Gene Therapy

Final Conference Program

Wednesday | Thursday | Friday | Saturday

Sessions take place in Mitchell Hall, College of Physicians (2nd floor), unless otherwise noted

Wednesday, October 24, 2012

5:00 - 7:00 p.m. Registration
Second Floor Foyer
6:00 - 7:00 p.m. Dinner
Ashhurst Hall
7:15 - 7:30 p.m. Opening Remarks
Mitchell Hall
7:30 - 8:15 p.m. Keynote I - Frederic Bushman, University of Pennsylvania, “Retroviral DNA Integration: Mechanism and Consequences”
8:15 - 9:30 p.m. Session I
RETROVIRAL INTEGRATION AND GENE THERAPY
Chair: John Coffin, Tufts University
8:15 – 8:40 p.m. Monica Roth, University of Medicine and Dentistry of New Jersey – RWJMS, “Targeting Delivery and Integration of MuLV Particles”
8:40 – 9:05 p.m. Stanislav Indik, University of Veterinary Medicine Vienna, “A High Titer and Integration Neutral Betaretrovirus-based Vector System for Stable Transduction of Dividing and Non-dividing Cells”
9:05 – 9:30 p.m. Lorraine Albritton, University of Tennessee Health Science Center, “In vivo Gene Delivery to the Brain Using an Entry Restricted Lentivirus Vector”

Thursday, October 25, 2012

7:30 - 8:00 a.m. Continental Breakfast
Ashhurst Hall
8:30 - 9:15 a.m. Keynote II – Beatrice Hahn, University of Pennsylvania, “SIVcpz Infection in Wild Chimpanzees: What is at Stake?”
9:15 a.m. – 12:00 p.m. Session II
ZOONOSIS, NEW VIRUSES AND ENDOGENOUS VIRUSES
Chair: Carolyn Wilson, U.S. Food and Drug Administration
9:15 – 9:40 a.m. Christine Kozak, National Institute of Allergy and Infectious Diseases, “The Avian XPR1 Gammaretrovirus Receptor is Under Positive Selection and is Disabled in Bird Species that Eat Virus-Infected Wild Mice”
9:40 – 10:05 a.m. Wenqin Xu, National Institutes of Health, “A Novel Gammaretrovirus in Koalas from U.S. Zoos”
10:05 – 10:30 a.m. Jack Lenz, Albert Einstein College of Medicine, “Evolution of HERV-K: Neanderthal and Denisovan Proviruses and Delineation of the Viral Functional Signal Peptide”
10:30 – 10:45 a.m. Coffee Break
10:45 – 11:10 a.m. Björn Nexo, Aarhus University, “Association of Human Endogenous Retroviruses with Multiple Sclerosis”
11:10 – 11:35 a.m. Beatriz Pogo, Mt. Sinai School of Medicine, “Detection of HMTV env Sequences in Hormonally Dependent Tissues”
11:35 a.m. – 12:00 p.m. Andrew Mason, University of Alberta, “Site Specific Integration of a Human Betaretrovirus Resembling Mouse Mammary Tumor Virus in the Human Genome”
12:00 – 1:30 p.m. Lunch Break
1:30 - 5:05 p.m. Session III
ONCOGENESIS AND PATHOGENESIS
Chair: Sandra Ruscetti, National Institutes of Health
1:30 – 1:55 p.m. Kathryn Jones, Frederick National Laboratory for Cancer Research, “Generation of Infectious, Emv-2-derived Retroviruses and Development of Lymphomas in MyD88 Deficient Mice”
1:55 – 2:20 p.m. James Neil, University of Glasglow, “Genetic Bottlenecks to Lymphoma Establishment and Metastasis Revealed by Insertional Mutagenesis and Next Generation Sequencing”
2:20 – 2:45 p.m. Karen Beemon, Johns Hopkins University, “Induction of B-cell Lymphomas by Avian Leukosis Virus”
2:45 – 3:10 p.m. Patrick Green, The Ohio State University, “The Role of Human T Cell Leukemia Virus Antisense Genes in Pathobiology”
3:10 – 3:25 p.m. Coffee Break
3:25 – 3:50 p.m. Yoko Aida, RIKEN, “Identification of BLV Tax Function Associated with Host Cell Transcription, Signaling, Stress Response and Immune Response Pathway by Microarray”
3:50 – 4:15 p.m. Hung Fan, University of California – Irvine, “The Role of ZFP111 in Transformation by Jaagsiekte Sheep Retrovirus”
4:15 – 4:40 p.m. David Griffiths, Moredun Research Institute, “Early Events in the Pathogenesis of Retrovirus-induced Lung Cancer”
4:40 – 5:05 p.m. Sandra Quackenbush, Colorado State University, “WDSV Retroviral Cyclin Enhances Cyclin-dependent Kinase 8 Function”
5:05 – 6:00 p.m. Break
6:00 – 7:00 p.m. Dinner
Ashhurst Hall
7:30 – 9:30 p.m. POSTER SESSION
Wine & Lite Bites
Thomson Hall – 1st Floor

Friday, October 26, 2012

7:30 – 8:30 a.m. Continental Breakfast
Ashhurst Hall
8:30 – 9:15 a.m. Keynote III – Stephen Goff, Columbia University, “Old and New Players in the Silencing of Retroviral DNAs in Embryonic Stem Cells: TRIM28 and Zfp809, but now also YY1 and EBP1”
9:15am – 12:55pm Session IV
EARLY EVENTS AND RESTRICTION FACTORS
Chair: Anna Skalka, Fox Chase Cancer Center
9:15 – 9:40 a.m. Marc Sitbon, Institut de Génétique Moléculaire de Montpellier, “XPR1, the Receptor for Xenotropic and Polytropic MLV is the First Described Inorganic Phosphate Exporter of Vertebrates”
9:40 – 10:05 a.m. Jonathan Stoye, MRC-National Institute for Medical Research, “Restriction Factor Recognition of Retroviral Capsid”
10:05 – 10:30 a.m. Jaya Sastri, Loyola University Chicago, “An alpha-helix in the Linker2 Region of TRIM5 Governs Assembly and Retroviral Restriction”
10:30 – 10:55 a.m. Jim Riley, University of Pennsylvania, “Human TRIM5alpha Fails to Restrict HIV-1 due to Lack of Stability and Inability to Accumulate in Cytoplasmic Bodies”
10:55 – 11:15 a.m. Coffee Break
11:15 – 11:40 a.m. Valgerdur Andresdottir, University of Iceland, “The Maedi-Visna Virus Vif Protein Has More Than One Function”
11:40 a.m. – 12:05 p.m. Susan Ross, University of Pennsylvania, “MLV glyco-Gag Enhances Viral Core Stability and Blocks Access of APOBEC3 and other Cytosolic Sensors to the Reverse Transcription Complex”
12:05 – 12:30 p.m. Vineet KewalRamani, National Cancer Institute, “CPSF6 and TNPO3 Interactions Regulate HIV-1 Infection”
12:30 – 12:55 p.m. Mamuka Kvaratskhelia, The Ohio State University, “Structural Basis for High Affinity Binding of LEDGF PWWP to Mononucleosomes”
1:00 – 2:00 p.m. Lunch Break
2:00 – 5:30 p.m. Afternoon Break/Barnes Foundation Tour
  Dinner on your own

Saturday, October 27, 2012

8:00 – 9:00 a.m. Continental Breakfast
Ashhurst Hall
9:00 – 11:45 a.m. Session V
IMMUNE RESPONSES
Chair: Paula Pitha-Rowe, Johns Hopkins University
9:00 – 9:25 a.m. Tatyana Golovkina, The University of Chicago, “The Role of Commensal Bacteria in Retroviral Infections”
9:25 – 9:50 a.m. Edward Browne, Massachusetts Institute of Technology, “TLR7 Regulates Innate and Adaptive Immunity to Retroviral Infection”
9:50 – 10:15 a.m. Masaaki Miyazawa, Kinki University School of Medicine, “Rapid Production of Virus-neutralizing IgM antibodies and Protection against Lethal Retroviral Infection in Mice Deficient of Activation-induced Cytidine Deaminase (AID)”
10:15 – 10:30 a.m. Coffee Break
10:30 – 10:55 a.m. Arifa Khan, U.S. Food and Drug Administration, “Influence of Naturally-occurring Simian Foamy Viruses on SIV Infection and Disease Progression in the Rhesus Macaque Model”
10:55 – 11:20 a.m. William Green, Geisel School of Medicine at Dartmouth, “Myeloid-Drived Suppressor Cells in Murine Retrovirus-induced AIDS: inhibition of the T-cell and B-celll responsiveness that defines the immunodeficiency”
11:20 – 11:45 a.m. Susan Carpenter, Iowa State University, “Strategies of Lentivirus Persistence: Immune Evasion vs. Viral Fitness”
11:45 a.m. – 1:30p.m. Lunch Break
1:30 – 4:15 p.m. Session VI
ASSEMBLY AND ACCESSORY PROTEINS
Chair: Alan Rein, National Institutes of Health
1:30 – 1:55 p.m. Jaisri Lingappa, University of Washington, “The HIV-1 Gag Major Homology Region Binds to ABCE1, a Highly Conserved Cellular Factor that Facilitates Capsid Assembly”
1:55 – 2:20 p.m. Leslie Parent, Penn State College of Medicine, “Evidence for a Novel Paradigm of Retroviral RNA Packaging”
2:20 – 2:45 p.m. Andrew Dayton, CBER/Food and Drug Administration, “Two Discrete Constitutive Transport Elements in Xenotropic Murine Leukemia Virus-related Virus mRNA”
2:45 – 3:00 p.m. Coffee Break
3:00 – 3:25 p.m. David Brighty, University of Dundee, “Multiple Blocks to HIV-1 Rev Activity in Murine Cells”
3:25 – 3:50 p.m. Jaquelin Dudley, The University of Texas at Austin, “MMTV REM is a Bi-Functional Precursor Protein”
3:50 – 4:15 p.m. Jacob Hochman, Hebrew University of Jerusalem, “MMTV-p14, a Signal Peptide with Tumor Modulating Characteristics”
4:15 – 4:20 p.m. Closing Remarks
6:00 – 10:00 p.m. Closing Banquet – Pennsylvania Academy of Fine Arts

Sunday, October 28, 2012

Hotel Check-Out