Program

Conference Topics

• Pathogenesis
• Oncogenesis
• Host Restriction Factors
• Zoonosis and Emerging Viruses
• Immune Responses
• Virus - Cell Interactions
• Retroviral Gene Therapy

Final Conference Program

Wednesday | Thursday | Friday | Saturday

Sessions take place in Mitchell Hall, College of Physicians (2nd floor), unless otherwise noted

Wednesday, October 24, 2012

5:00 - 7:00 p.m.	Registration Second Floor Foyer
6:00 - 7:00 p.m.	Dinner Ashhurst Hall
7:15 - 7:30 p.m.	Opening Remarks Mitchell Hall
7:30 - 8:15 p.m.	Keynote I - Frederic Bushman, University of Pennsylvania, “Retroviral DNA Integration: Mechanism and Consequences”
8:15 - 9:30 p.m.	Session I
RETROVIRAL INTEGRATION AND GENE THERAPY
Chair:	John Coffin, Tufts University
8:15 – 8:40 p.m.	Monica Roth, University of Medicine and Dentistry of New Jersey – RWJMS, “Targeting Delivery and Integration of MuLV Particles”
8:40 – 9:05 p.m.	Stanislav Indik, University of Veterinary Medicine Vienna, “A High Titer and Integration Neutral Betaretrovirus-based Vector System for Stable Transduction of Dividing and Non-dividing Cells”
9:05 – 9:30 p.m.	Lorraine Albritton, University of Tennessee Health Science Center, “In vivo Gene Delivery to the Brain Using an Entry Restricted Lentivirus Vector”

Thursday, October 25, 2012

7:30 - 8:00 a.m.	Continental Breakfast Ashhurst Hall
8:30 - 9:15 a.m.	Keynote II – Beatrice Hahn, University of Pennsylvania, “SIVcpz Infection in Wild Chimpanzees: What is at Stake?”
9:15 a.m. – 12:00 p.m.	Session II
ZOONOSIS, NEW VIRUSES AND ENDOGENOUS VIRUSES
Chair:	Carolyn Wilson, U.S. Food and Drug Administration
9:15 – 9:40 a.m.	Christine Kozak, National Institute of Allergy and Infectious Diseases, “The Avian XPR1 Gammaretrovirus Receptor is Under Positive Selection and is Disabled in Bird Species that Eat Virus-Infected Wild Mice”
9:40 – 10:05 a.m.	Wenqin Xu, National Institutes of Health, “A Novel Gammaretrovirus in Koalas from U.S. Zoos”
10:05 – 10:30 a.m.	Jack Lenz, Albert Einstein College of Medicine, “Evolution of HERV-K: Neanderthal and Denisovan Proviruses and Delineation of the Viral Functional Signal Peptide”
10:30 – 10:45 a.m.	Coffee Break
10:45 – 11:10 a.m.	Björn Nexo, Aarhus University, “Association of Human Endogenous Retroviruses with Multiple Sclerosis”
11:10 – 11:35 a.m.	Beatriz Pogo, Mt. Sinai School of Medicine, “Detection of HMTV env Sequences in Hormonally Dependent Tissues”
11:35 a.m. – 12:00 p.m.	Andrew Mason, University of Alberta, “Site Specific Integration of a Human Betaretrovirus Resembling Mouse Mammary Tumor Virus in the Human Genome”
12:00 – 1:30 p.m.	Lunch Break
1:30 - 5:05 p.m.	Session III
ONCOGENESIS AND PATHOGENESIS
Chair:	Sandra Ruscetti, National Institutes of Health
1:30 – 1:55 p.m.	Kathryn Jones, Frederick National Laboratory for Cancer Research, “Generation of Infectious, Emv-2-derived Retroviruses and Development of Lymphomas in MyD88 Deficient Mice”
1:55 – 2:20 p.m.	James Neil, University of Glasglow, “Genetic Bottlenecks to Lymphoma Establishment and Metastasis Revealed by Insertional Mutagenesis and Next Generation Sequencing”
2:20 – 2:45 p.m.	Karen Beemon, Johns Hopkins University, “Induction of B-cell Lymphomas by Avian Leukosis Virus”
2:45 – 3:10 p.m.	Patrick Green, The Ohio State University, “The Role of Human T Cell Leukemia Virus Antisense Genes in Pathobiology”
3:10 – 3:25 p.m.	Coffee Break
3:25 – 3:50 p.m.	Yoko Aida, RIKEN, “Identification of BLV Tax Function Associated with Host Cell Transcription, Signaling, Stress Response and Immune Response Pathway by Microarray”
3:50 – 4:15 p.m.	Hung Fan, University of California – Irvine, “The Role of ZFP111 in Transformation by Jaagsiekte Sheep Retrovirus”
4:15 – 4:40 p.m.	David Griffiths, Moredun Research Institute, “Early Events in the Pathogenesis of Retrovirus-induced Lung Cancer”
4:40 – 5:05 p.m.	Sandra Quackenbush, Colorado State University, “WDSV Retroviral Cyclin Enhances Cyclin-dependent Kinase 8 Function”
5:05 – 6:00 p.m.	Break
6:00 – 7:00 p.m.	Dinner Ashhurst Hall
7:30 – 9:30 p.m.	POSTER SESSION Wine & Lite Bites Thomson Hall – 1st Floor

Friday, October 26, 2012

7:30 – 8:30 a.m.	Continental Breakfast Ashhurst Hall
8:30 – 9:15 a.m.	Keynote III – Stephen Goff, Columbia University, “Old and New Players in the Silencing of Retroviral DNAs in Embryonic Stem Cells: TRIM28 and Zfp809, but now also YY1 and EBP1”
9:15am – 12:55pm	Session IV
EARLY EVENTS AND RESTRICTION FACTORS
Chair:	Anna Skalka, Fox Chase Cancer Center
9:15 – 9:40 a.m.	Marc Sitbon, Institut de Génétique Moléculaire de Montpellier, “XPR1, the Receptor for Xenotropic and Polytropic MLV is the First Described Inorganic Phosphate Exporter of Vertebrates”
9:40 – 10:05 a.m.	Jonathan Stoye, MRC-National Institute for Medical Research, “Restriction Factor Recognition of Retroviral Capsid”
10:05 – 10:30 a.m.	Jaya Sastri, Loyola University Chicago, “An alpha-helix in the Linker2 Region of TRIM5 Governs Assembly and Retroviral Restriction”
10:30 – 10:55 a.m.	Jim Riley, University of Pennsylvania, “Human TRIM5alpha Fails to Restrict HIV-1 due to Lack of Stability and Inability to Accumulate in Cytoplasmic Bodies”
10:55 – 11:15 a.m.	Coffee Break
11:15 – 11:40 a.m.	Valgerdur Andresdottir, University of Iceland, “The Maedi-Visna Virus Vif Protein Has More Than One Function”
11:40 a.m. – 12:05 p.m.	Susan Ross, University of Pennsylvania, “MLV glyco-Gag Enhances Viral Core Stability and Blocks Access of APOBEC3 and other Cytosolic Sensors to the Reverse Transcription Complex”
12:05 – 12:30 p.m.	Vineet KewalRamani, National Cancer Institute, “CPSF6 and TNPO3 Interactions Regulate HIV-1 Infection”
12:30 – 12:55 p.m.	Mamuka Kvaratskhelia, The Ohio State University, “Structural Basis for High Affinity Binding of LEDGF PWWP to Mononucleosomes”
1:00 – 2:00 p.m.	Lunch Break
2:00 – 5:30 p.m.	Afternoon Break/Barnes Foundation Tour
	Dinner on your own

Saturday, October 27, 2012

8:00 – 9:00 a.m.	Continental Breakfast Ashhurst Hall
9:00 – 11:45 a.m.	Session V
IMMUNE RESPONSES
Chair:	Paula Pitha-Rowe, Johns Hopkins University
9:00 – 9:25 a.m.	Tatyana Golovkina, The University of Chicago, “The Role of Commensal Bacteria in Retroviral Infections”
9:25 – 9:50 a.m.	Edward Browne, Massachusetts Institute of Technology, “TLR7 Regulates Innate and Adaptive Immunity to Retroviral Infection”
9:50 – 10:15 a.m.	Masaaki Miyazawa, Kinki University School of Medicine, “Rapid Production of Virus-neutralizing IgM antibodies and Protection against Lethal Retroviral Infection in Mice Deficient of Activation-induced Cytidine Deaminase (AID)”
10:15 – 10:30 a.m.	Coffee Break
10:30 – 10:55 a.m.	Arifa Khan, U.S. Food and Drug Administration, “Influence of Naturally-occurring Simian Foamy Viruses on SIV Infection and Disease Progression in the Rhesus Macaque Model”
10:55 – 11:20 a.m.	William Green, Geisel School of Medicine at Dartmouth, “Myeloid-Drived Suppressor Cells in Murine Retrovirus-induced AIDS: inhibition of the T-cell and B-celll responsiveness that defines the immunodeficiency”
11:20 – 11:45 a.m.	Susan Carpenter, Iowa State University, “Strategies of Lentivirus Persistence: Immune Evasion vs. Viral Fitness”
11:45 a.m. – 1:30p.m.	Lunch Break
1:30 – 4:15 p.m.	Session VI
ASSEMBLY AND ACCESSORY PROTEINS
Chair:	Alan Rein, National Institutes of Health
1:30 – 1:55 p.m.	Jaisri Lingappa, University of Washington, “The HIV-1 Gag Major Homology Region Binds to ABCE1, a Highly Conserved Cellular Factor that Facilitates Capsid Assembly”
1:55 – 2:20 p.m.	Leslie Parent, Penn State College of Medicine, “Evidence for a Novel Paradigm of Retroviral RNA Packaging”
2:20 – 2:45 p.m.	Andrew Dayton, CBER/Food and Drug Administration, “Two Discrete Constitutive Transport Elements in Xenotropic Murine Leukemia Virus-related Virus mRNA”
2:45 – 3:00 p.m.	Coffee Break
3:00 – 3:25 p.m.	David Brighty, University of Dundee, “Multiple Blocks to HIV-1 Rev Activity in Murine Cells”
3:25 – 3:50 p.m.	Jaquelin Dudley, The University of Texas at Austin, “MMTV REM is a Bi-Functional Precursor Protein”
3:50 – 4:15 p.m.	Jacob Hochman, Hebrew University of Jerusalem, “MMTV-p14, a Signal Peptide with Tumor Modulating Characteristics”
4:15 – 4:20 p.m.	Closing Remarks
6:00 – 10:00 p.m.	Closing Banquet – Pennsylvania Academy of Fine Arts

Sunday, October 28, 2012

Hotel Check-Out