Lin Guo is a Research Associate in the lab. She received her bachelor’s degree in Chemistry from Peking University in 2005 and her Ph.D. in Chemistry in 2011 from The University of Pennsylvania where she developed spectroscopic methods to study protein folding and peptide-membrane interaction. In 2014, Lin won a post-doctoral fellowship from the Ellison Medical Foundation and American Federation for Aging Research. In 2016. Lin won an Alzheimer's Association Research Fellowship.


L. Guo and J. Shorter. Biology and pathobiology of TDP-43 and emergent therapeutic strategies. Cold Spring Harb Perspect Med. 2016, doi: 10.1101/cshperspect.a024554. pdf file link

L. Guo and J. Shorter. It's raining liquids: RNA tunes viscoelasticity and dynamics of membraneless organelles. Mol. Cell. 2015, 60, 189-192. pdf file link

L. Guo and F. Gai. Simple Method to Enhance the Photostability of the Fluorescence Reporter R6G for Prolonged Single-Molecule Studies. J. Phys. Chem. A. 2013, 117, 6164-6170. pdf link

D. Chow, L. Guo, F. Gai, and M. Goulian. Fluorescence correlation spectroscopy measurements of the membrane protein TetA in Escherichia coli suggest rapid diffusion at short length scales. PLoS ONE. 2012, 7(10):e48600. pdf link

Y-H. Wang, A. Collins, L. Guo, K. B. Smith-Dupont, F. Gai, T. Svitkina and P. A. Janmey. Divalent cation-induced cluster formation by polyphosphoinositides in model membranes. J. Am. Chem. Soc. 2012, 134, 3387-3395. pdf link

L. Guo, K. B. Smith-Dupont and F. Gai. Diffusion as a probe of peptide-induced membrane domain formation. Biochemistry. 2011, 50, 2291-2297. pdf link

J. M. G. Rogers*, A. Polishchuk*, L. Guo*, J. Wang, W. F. DeGrado and F. Gai. Photoinduced electron transfer and fluorophore motion as a probe of the conformational dynamics of membrane proteins: application to the influenza A M2 proton channel. Langmuir. 2011, 27, 3815-3821. (*Equal Contribution). pdf link

L. Guo and F. Gai. Heterogeneous diffusion of a membrane-bound pHLIP peptide. Biophys. J. 2010, 98, 2914-2922. pdf link

K. B. Smith-Dupont*, L. Guo* and F. Gai. Diffusion as a probe of the heterogeneity of antimicrobial peptide-membrane interactions. Biochemistry. 2010, 49, 4672-4678. (*Equal Contribution). pdf link

L. Guo, J. H. Park, T. Lee, P. Chowdhury, M. Lim and F. Gai. Probing the role of hydration in the unfolding transitions of carbonmonoxy myoglobin and apomyoglobin. J. Phys. Chem. B. 2009, 113, 6158-6163. pdf link

S. Mukherjee, M. Waegele, P. Chowdhury, L. Guo and F. Gai. Effect of macromolecular crowding on the folding kinetics of protein secondary structures. J. Mol. Biol. 2009, 393, 227-236. pdf link

L. Guo, P. Chowdhury, J. M. Glasscock and F. Gai. Denaturant induced expansion and compaction of a multi-domain protein: IgG. J. Mol. Biol. 2008, 384, 1029-1036. pdf link

S. Yang, H. Wang, L. Guo, Y. Liu and A. Cao. Interaction of fullerenol with lysozyme investigated by experimental and computational approaches. Nanotechnology. 2008, 19, 395101-395107. pdf link

L. Guo, P. Chowdhury, J. Y. Fang and F. Gai. Heterogeneous and anomalous diffusion inside lipid tubules.  J. Phys. Chem. B. 2007, 111, 14244-14249. pdf link








Department of Biochemistry & Biophysics
University of Pennsylvania