Meredith Jackrel is a post-doctoral researcher. She received her Ph.D. in Chemistry from Yale University in 2010 and graduated from the College of New Jersey with a BS in Chemistry in 2004. In 2011, Meredith won an American Heart Association Post-Doctoral Fellowship!


Jackrel, M.E., and J. Shorter. (2014). Reversing deleterious protein aggregation with re-engineered protein disaggregases. Cell Cycle. http://dx.doi.org/10.4161/cc.28709 pdf file link

Jackrel, M.E., M.E. DeSantis, B.A. Martinez, L.M. Castellano, R.M. Stewart, K.A. Caldwell, G.A. Caldwell, and J. Shorter. (2014). Potentiated Hsp104 variants antagonize diverse proteotoxic misfolding events. Cell. 156:170–182. pdf file link

DeSantis, M.E., E.H. Leung, E.A. Sweeny, M.E. Jackrel, M. Cushman-Nick, A. Neuhaus-Follini, S. Vashist, M.A. Sochor, M.N. Knight, and J. Shorter. (2012). Operational Plasticity Enables Hsp104 to Disaggregate Diverse Amyloid and Non-Amyloid Clients. Cell. 151:778-793. pdf file link

Jackrel, M.E. and J. Shorter. (2011). Shock and awe: unleashing the heat shock response to treat Huntington disease. J. Clin. Invest. 121(8): 2972-2975. pdf file link

Jackrel, M.E., A.L. Cortajarena, T.Y. Liu and L.Regan. (2010). Screening libraries to identify proteins with desired binding activities using a split-GFP reassembly assay. ACS Chem Biol. 5 (6): 553–562. pdf file link

Jackrel, M.E., R. Valverde and L. Regan. (2009) Redesign of a protein - peptide interaction: characterization and applications. Protein Science. 18(4): 762-74. pdf file link

Champion, E.A., B.H. Lane, M.E. Jackrel, L.Regan and S.J. Baserga. (2008). A direct interaction between the Utp6 half-a-tetratricopeptide repeat domain and a specific peptide in Utp21 is essential for efficient pre-rRNA processing. Mol Cell Biol. 28(21): 6547-56. pdf file link



Department of Biochemistry & Biophysics
University of Pennsylvania