Meredith Jackrel is a Research Associate in the lab. She received her Ph.D. in Chemistry from Yale University in 2010 and graduated from the College of New Jersey with a BS in Chemistry in 2004. In 2011, Meredith won an American Heart Association Post-Doctoral Fellowship! In 2014, Meredith was selected as a finalist for the Regeneron Prize for Creative Innovation in a Postdoctoral Fellow and also won a Target ALS Springboard Fellowship.
Jackrel, M.E.^, and J. Shorter^. (2017). Protein-remodeling factors as potential therapeutics for neurodegenerative disease. Front. Neurosci. In press. (^Co-corresponding author).
Yasuda, K., S.F. Clatterbuck-Soper, M.E. Jackrel, J. Shorter, and S. Mili. (2017). Cytoplasmic FUS inclusions disrupt Kinesin-1 leading to loss of detyrosinated microtubules and RNA mislocalization. J. Cell Biol. In press.
Yokom, A.L., S.N. Gates, M.E. Jackrel, K.L. Mack, M. Su, J. Shorter, and D.R. Southworth. (2016). Spiral architecture of the Hsp104 disaggregase reveals the basis for polypeptide translocation. Nat. Struct. Mol. Biol. 23(9):830-7. pdf file link
Torrente, M.P., E. Chuang, M.M. Noll, M.E. Jackrel, M.S. Go, and J. Shorter. (2016). Mechanistic insights into Hsp104 potentiation. J. Biol. Chem. 291(10):5101-5115. pdf file link
Jackrel, M.E., K. Yee, A. Tariq, A.I. Chen, and J. Shorter. (2015). Disparate mutations confer therapeutic gain of Hsp104 function. ACS Chem. Biol. 10(12):2672-9. pdf file link
Jackrel, M.E., and J. Shorter. (2015). Engineering enhanced protein disaggregases for neurodegenerative disease. Prion 9(2):90-109. pdf file link
Sweeny, E.A., M.E. Jackrel, M.S. Go, M.A. Sochor, B.M. Razzo, M.E. DeSantis, K. Gupta, and J. Shorter. (2015). The Hsp104 N-terminal domain enables disaggregase plasticity and potentiation. Mol. Cell. 57(5):836-849. pdf file link
Jackrel, M.E., A. Tariq, K. Yee, R. Weitzman, and J. Shorter. (2014). Isolating potentiated Hsp104 variants using yeast proteinopathy models. J. Vis. Exp. 93:e52089 doi:10.3791/52089. pdf file link
Jackrel, M.E., and J. Shorter. (2014). Potentiated Hsp104 variants suppress toxicity of diverse neurodegenerative disease-linked proteins. Dis. Model Mech. 7(10):1175-1184. pdf file link
Jackrel, M.E., and J. Shorter. (2014). Reversing deleterious protein aggregation with re-engineered protein disaggregases. Cell Cycle. 13(9):1379-1383. pdf file link
Jackrel, M.E., M.E. DeSantis, B.A. Martinez, L.M. Castellano, R.M. Stewart, K.A. Caldwell, G.A. Caldwell, and J. Shorter. (2014). Potentiated Hsp104 variants antagonize diverse proteotoxic misfolding events. Cell. 156:170–182. pdf file link
DeSantis, M.E., E.H. Leung, E.A. Sweeny, M.E. Jackrel, M. Cushman-Nick, A. Neuhaus-Follini, S. Vashist, M.A. Sochor, M.N. Knight, and J. Shorter. (2012). Operational Plasticity Enables Hsp104 to Disaggregate Diverse Amyloid and Non-Amyloid Clients. Cell. 151:778-793. pdf file link
Jackrel, M.E. and J. Shorter. (2011). Shock and awe: unleashing the heat shock response to treat Huntington disease. J. Clin. Invest. 121(8): 2972-2975. pdf file link
Jackrel, M.E., A.L. Cortajarena, T.Y. Liu and L.Regan. (2010). Screening libraries to identify proteins with desired binding activities using a split-GFP reassembly assay. ACS Chem Biol. 5 (6): 553–562. pdf file link
Jackrel, M.E., R. Valverde and L. Regan. (2009) Redesign of a protein - peptide interaction: characterization and applications. Protein Science. 18(4): 762-74. pdf file link
Champion, E.A., B.H. Lane, M.E. Jackrel, L.Regan and S.J. Baserga. (2008). A direct interaction between the Utp6 half-a-tetratricopeptide repeat domain and a specific peptide in Utp21 is essential for efficient pre-rRNA processing. Mol Cell Biol. 28(21): 6547-56. pdf file link