Brett McCray

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Projects
I am interested in the role of transport machinery in the degradation of misfolded proteins and how manipulation of protein degradation pathways affects steady-state protein levels and neurotoxicity. Specifically, I am using our Drosophila model of SBMA to examine the role of microtubule-based transport in the turnover of polyglutamine-expanded androgen receptor.

Personal Background
I grew up in central Florida and did my undergraduate work at Duke University.  After a year of research at the University of Florida, I came to Penn to begin my MD/PhD training.  When I’m not pipetting or playing with flies, I enjoy playing soccer, watching Duke basketball, and being a movie, music, and book snob.

Publications

• McCray BA, Taylor JP. (2008) The role of autophagy in age-related neurodegeneration. Neurosignals 16(1), 75-84. Link

• Pandey UB, Nie Z, Batlevi Y, McCray BA, Ritson GP, Nedelsky NB, Schwartz SL, DiProspero NA, Knight MA, Schuldiner O, Padmanabhan R, Hild M, Berry DL, Garza D, Hubbert CC, Yao T-P, Baehrecke EH, Taylor JP. (2007) HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. Nature 447, 859-863. Link

Education

• Duke University, Durham, NC (B.S., 2002)

E-mail Brett