Executive Difficulty in Parkinson's Disease with Dementia
Project Description |
2010 Progess Report |  |
Advances in Past Year |
Publications | |
 Murray Grossman, MD, EdDProject Leader |
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Project Description
Executive resources like planning and organization are crucial for day-to-day conversation. Without these resources, communicative efficacy is lost. There are major consequences to these difficulties, and activities of daily living suffer immensely.
In our project, we will be examining the organization of discourse. There are large-scale speech samples. We will also be examining the comprehension of organizational components of scripts, that is, story-like stimuli. In addition to studies of difficulties in patients, we will be 
assessing the neural basis for these difficulties by correlating their speech and comprehension impairments with structural MRI studies of the brain. Finally, we will be using fMRI (functional magnetic resonance imaging) to assess the neural basis for these organizational components of speech and comprehension inhealthy young adults.
Significant Scientific Advances in the Past Year
The results from the past year emphasize the specific cognitive and language deficits of patients with DLB/PDD, illustrate differences in the quality of the cognitive impairment in DLB compared to PDD, and provide important information concerning the role of executive disorders in language and communication.
Publications
- Peelle, J. E., Troiani, V., Grossman, M.: Interaction between process and content in semantic memory: An fMRI study of noun feature knowledge. Neuropsychologia 47:995-1003, 2009. PMC2675540
- Peelle, J.E., Troiani, V., Gee, J., Moore, P., McMillan, C., Vesely, L., Grossman, M.: Sentence comprehension and voxel-based morphometry in progressive nonfluent aphasia, semantic dementia, and nonaphasic frontotemporal dementia. Journal of Neurolinguistics 21:418-432, 2008. PMC2598754
- Ash, S., Moore, P., Vesely, L., Gunawardena, D., McMillan, C., Anderson, C., Avants, B., Grossman, M.: Non-fluent speech in frontotemporal lobar degeneration. Journal of Neurolinguistics 22:370-383, 2009. PMC20074786
- Listerud, J., Anderson, C., Moore, P., Libon, D.J., Grossman, M.: Neuropsychological patterns in MRI-defined subgroups of patients with degenerative dementia. Journal of the International Neuropsychological Society 15:459-470, 2009.
- Das, S.R., Avants, B.B., Grossman, M., Gee, J.C.: Registration-based cortical thickness measurement. NeuroImage 45:867-879, 2009. PMC19150502
- Whitney, C., Weis, S., Krings, T., Huber, W., Grossman, M., Kircher, T.: Task-dependent modulations of prefrontal and hippocampal activity during intrinsic word production. Journal of Cognitive Neuroscience 21:697-712, 2009.
- Grossman, M.: Primary progressive aphasia: Clinical-pathological correlations. Nature Reviews Neurology 6;88-97, 2010. PMC20139998
- Avants, B., Cook, P.A., Ungar, L., Gee, J.C., Grossman, M.: Dementia induces correlated reductions in white matter integrity and cortical thickness: A multivariate neuroimaging study with sparse canonical correlation analysis. NeuroImage 50;1004-1016, 2010. PMC20083207
- Yu, C.-E., Bird, T.D., Bekris, L.M., Leverenz, J.B., Steinbart, E., Galloway, N.M., Feldman, H., Woltjer, R., Miller, C.A., Wood, E.M.,, Grossman, M., McCluskey L., Clark C.M., Neumann, M., Danek, A., Galasko, D.R., Arnold, S.E., Chen-Plotkin, A., Karydas, A., Miller, B.L., Trojanowski, J.Q., Lee, V.M.-Y., Schellenberg, G.D., Van Deerlin, V.M. The spectrum of mutations in progranulin: A collaborative study screening 545 cases of neurodegeneration. Arch. Neurol., 67:161-170, 2010. PMC20142524
- Ash S, Moore P, Antani S, McCawley G, Work M, Grossman M. Trying to tell a tale: Discourse impairments in progressive aphasia and frontotemporal dementia. Neurol, 66:1405-1413, 2006.
- Cosentino S, Chute D, Libon D, Moore P, Grossman M. How does the brain represent scripts?: A study of executive processes and semantic knowledge in dementia. Neuropsychol, 20:307-318, 2006.
- Novais-Santos S, Gee J, Shah MS, Troiani V, Work M, Grossman M. Resolving sentence ambiguity with planning and working memory resources: Evidence from fMRI. NeuroImage 37:361-378, 2007.