image
image
image
PARTNERS IN RESEARCH: CNDR || IOA || UDALL || Penn ADC
image

Immunotherapy Targeting Parkinson's Disease Transmission in Animal Models

John Q. Trojanowski, MD, PhD John Q. Trojanowski, MD, PhD
Project Leader
   

Parkinson's disease studies at Penn

Project Description

The project will determine if unique synthetic a-syn PFF strains characterized by Project III differentially transmit LBD and cross-seed tau NFTs following injection into the brains of M83 mice, using methods established in our laboratory to assess behavior, neuropathology and cerebrospinal fluid (CSF) levels of a-syn and tau in these mice.

Penn Udall Center for Parkinson's Research Public Health StatementWe will also determine if enriched fractions of LBs/LNs from PD substantia nigra (SN) versus PDD/DLB cingulate cortex (CC) contain distinct a-syn strains that differentially transmit LBD and cross-seed tau NFTs following injection into the brains of M83 mice using the same methods as in Aim 1.

Finally, we will conduct proof of concept (POC) studies in M83 mice injected with pathological a-syn to determine if immunization with monoclonal antibodies (MAbs), identified by Project III to neutralize a-syn transmission, abrogates induction and spread of a-syn pathology in vivo.

Publications