Postdoctoral Positions - Currently Closed
Postdoctoral positions are available in the research group of Professor Josh Wand in the Department of Biochemistry & Biophysics and the Johnson Research Foundation of the Perelman School of Medicine at the University of Pennsylvania. Located in Philadelphia, the University of Pennsylvania is a cosmopolitan center of advanced research across the spectrum of the life and physical sciences.
Areas of current interest in the Wand laboratory are:
- creative uses of high pressure NMR to explore protein structural cooperativity
- NMR spectroscopy of encapsulated proteins dissolved in low viscosity fluids to examine protein hydration and hydration dependent dynamics
- uses of reverse micelle encapsulation in structural biology especially membrane-anchored proteins
- development and use of advanced NMR relaxation methods to illuminate the character of protein motion and to provide a dynamic proxy for conformational entropy in a variety of functional contexts such as ligand binding, catalysis and evolution
- development of NMR data collection strategies and associated software particularly in the realm of sparse sampling
- validation of molecular dynamics simulations
- studies of membrane proteins in nanodisc model membranes with an emphasis on dynamics
- applications of confined space in fragment-based drug discovery
Extensive NMR instrumentation is available.
See wandlab.org for additional information. Candidates should hold the Ph.D. degree or equivalent and have extensive experience in protein biophysics and/or NMR spectroscopy. Applicants should forward a c.v. and have two letters of reference sent directly to Professor Wand.