Perelman School of Medicine at the University of Pennsylvania
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The Department of Radiation Oncology is in the new Perelman Center. Occupying approximately 80,000 square feet on the Concourse Level, the new treatment facilities includes the most advanced proton and conventional radiation treatment modalities available as well as public spaces designed for the highest levels of patient comfort.


Koch Lab

Cameron J. Koch , Ph.D.
Professor
Cameron J. Koch
Radiation Oncology, University of Pennsylvania,
185 John Morgan Bldg.,
3620 Hamilton Walk,
Philadelphia, PA 19104-6702
Phone: 215-898-0073
Fax: 215-898-0090
KOCHC@MAIL.MED.UPENN.EDU
 
Lab Members:
 
W. Tim Jenkins, M.S.
Position in Lab: Laboratory Manager
Education: Rutgers University, B.A.
University of Texas, M.S.
Email: wtj@mail.med.upenn.edu
 

Areas of Interest and Expertise

Measurement of radioresistant hypoxic tumor cells in vivo using:
  • immunohistochemistry and/or flow cytometry
  • non-invasive imaging
  • Quantification of tissue pO2
  • Control and measurement of oxygen concentration and thiols
  • Quantitative Fluorescence Microscopy
  • Oxidative damage (primarily sulfydryl to disulfide) of DNA repair systems
  • Effects of oxygen and oxygen radicals in biological or biochemical systems
  • Development of fluorine-based PET imaging methods
  • Automated chemical synthesis
  • Mechanisms of action of radiation sensitizing and radiation protecting agents (survival or DNA damage)
  • Models for competitive reactions of radiation modifying agents
  • Metabolism of thiols and nitroheterocyclics (including cytotoxicity)
  • Measurement of intracellular drug concentrations


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