Publications

In Situ Tumor Vaccination Using Lipid Nanoparticles to Deliver Interferon-β mRNA Cargo.
Vaccines. 2025 Feb 13;13(2); Authors: Kimura K, Aicher A, Niemeyer E, Areesawangkit P, Tilsed C, Fong KP, Papp TE, Albelda SM, Parhiz H, Predina JD

Editor's Note: Multiple Injections of Electroporated Autologous T Cells Expressing a Chimeric Antigen Receptor Mediate Regression of Human Disseminated Tumor.
Cancer research. 2024 Nov 4;84(21):3702; Authors: Zhao Y, Moon E, Carpenito C, Paulos CM, Liu X, Brennan AL, Chew A, Carroll RG, Scholler J, Levine BL, Albelda SM, June CH

Predictive Signatures for Responses to Checkpoint Blockade in Small-Cell Lung Cancer in Second-Line Therapy Do Not Predict Responses in First-Line Patients.
Cancers. 2024 Aug 8;16(16); Authors: Thompson JC, Tilsed C, Davis C, Gupta A, Melidosian B, Sun C, Kallen ME, Timmers C, Langer CJ, Albelda SM

Transcriptomic analysis-guided assessment of precision-cut tumor slices (PCTS) as an ex-vivo tool in cancer research.
Scientific reports. 2024 May 14;14(1):11006; Authors: Trivedi S, Tilsed C, Liousia M, Brody RM, Rajasekaran K, Singhal S, Albelda SM, Klampatsa A

Red blood cells function as reservoirs of tumor DNA.
American journal of physiology. Lung cellular and molecular physiology. 2024 May 1;326(5):L646-L650 Epub 2024 Mar 26; Authors: Thompson JC, Li S, Jose JS, Predina J, Gupta A, Eruslanov E, Singhal S, Albelda SM, Mangalmurti NS

Small cell, big promises: targeting small cell lung cancer with CAR T cells.
Translational lung cancer research. 2024 Apr 29;13(4):956-960 Epub 2024 Apr 24; Authors: Noguera-Ortega E, Albelda SM

Human Tumor-Associated Macrophages and Neutrophils Regulate Antitumor Antibody Efficacy through Lethal and Sublethal Trogocytosis.
Cancer research. 2024 Apr 1;84(7):1029-1047; Authors: Singhal S, Rao AS, Stadanlick J, Bruns K, Sullivan NT, Bermudez A, Honig-Frand A, Krouse R, Arambepola S, Guo E, Moon EK, Georgiou G, Valerius T, Albelda SM, Eruslanov EB

IL7 increases targeted lipid nanoparticle-mediated mRNA expression in T cells in vitro and in vivo by enhancing T cell protein translation.
Proceedings of the National Academy of Sciences of the United States of America. 2024 Mar 26;121(13):e2319856121 Epub 2024 Mar 21; Authors: Tilsed CM, Sadiq BA, Papp TE, Areesawangkit P, Kimura K, Noguera-Ortega E, Scholler J, Cerda N, Aghajanian H, Bot A, Mui B, Tam Y, Weissman D, June CH, Albelda SM, Parhiz H

Molecular Imaging in Precision-Cut Non-Small Cell Lung Cancer Slices.
The Annals of thoracic surgery. 2024 Feb;117(2):458-465 Epub 2023 Aug 10; Authors: Azari F, Kennedy GT, Chang A, Low P, Basil M, Planer J, Katzen J, Eruslanov E, Albelda S, Singhal S

CAR T cell therapy for patients with solid tumours: key lessons to learn and unlearn.
Nature reviews. Clinical oncology. 2024 Jan;21(1):47-66 Epub 2023 Oct 30; Authors: Albelda SM

A genetically encoded protein tag for control and quantitative imaging of CAR T cell therapy.
Molecular therapy : the journal of the American Society of Gene Therapy. 2023 Dec 6;31(12):3564-3578 Epub 2023 Nov 3; Authors: Lee IK, Sharma N, Noguera-Ortega E, Liousia M, Baroja ML, Etersque JM, Pham J, Sarkar S, Carreno BM, Linette GP, Puré E, Albelda SM, Sellmyer MA

Surgical Inflammation Alters Immune Response to Intraoperative Photodynamic Therapy.
Cancer research communications. 2023 Sep;3(9):1810-1822 Epub 2023 Sep 11; Authors: Davis RW 4th, Klampatsa A, Cramer GM, Kim MM, Miller JM, Yuan M, Houser C, Snyder E, Putt M, Vinogradov SA, Albelda SM, Cengel KA, Busch TM

Desmoplastic stroma restricts T cell extravasation and mediates immune exclusion and immunosuppression in solid tumors.
Nature communications. 2023 Aug 22;14(1):5110; Authors: Xiao Z, Todd L, Huang L, Noguera-Ortega E, Lu Z, Huang L, Kopp M, Li Y, Pattada N, Zhong W, Guo W, Scholler J, Liousia M, Assenmacher CA, June CH, Albelda SM, Puré E

Desmoplastic stroma restricts T cell extravasation and mediates immune exclusion and immunosuppression in solid tumors.
bioRxiv : the preprint server for biology. 2023 Aug 7; Authors: Xiao Z, Todd L, Huang L, Noguera-Ortega E, Lu Z, Huang L, Kopp M, Li Y, Pattada N, Zhong W, Guo W, Scholler J, Liousia M, Assenmacher CA, June CH, Albelda SM, Puré E

Two cases of severe pulmonary toxicity from highly active mesothelin-directed CAR T cells.
Molecular therapy : the journal of the American Society of Gene Therapy. 2023 Aug 2;31(8):2309-2325 Epub 2023 Jun 12; Authors: Haas AR, Golden RJ, Litzky LA, Engels B, Zhao L, Xu F, Taraszka JA, Ramones M, Granda B, Chang WJ, Jadlowsky J, Shea KM, Runkle A, Chew A, Dowd E, Gonzalez V, Chen F, Liu X, Fang C, Jiang S, Davis MM, Sheppard NC, Zhao Y, Fraietta JA, Lacey SF, Plesa G, Melenhorst JJ, Mansfield K, Brogdon JL, Young RM, Albelda SM, June CH, Tanyi JL

Tissue-resident memory CAR T cells with stem-like characteristics display enhanced efficacy against solid and liquid tumors.
Cell reports. Medicine. 2023 Jun 20;4(6):101053 Epub 2023 May 23; Authors: Jung IY, Noguera-Ortega E, Bartoszek R, Collins SM, Williams E, Davis M, Jadlowsky JK, Plesa G, Siegel DL, Chew A, Levine BL, Berger SL, Moon EK, Albelda SM, Fraietta JA

Monitoring Therapeutic Response to Anti-FAP CAR T Cells Using [18F]AlF-FAPI-74.
Clinical cancer research : an official journal of the American Association for Cancer Research. 2022 Dec 15;28(24):5330-5342; Authors: Lee IK, Noguera-Ortega E, Xiao Z, Todd L, Scholler J, Song D, Liousia M, Lohith K, Xu K, Edwards KJ, Farwell MD, June CH, Albelda SM, Puré E, Sellmyer MA

Synthetic Secoisolariciresinol Diglucoside (LGM2605) Prevents Asbestos-Induced Inflammation and Genotoxic Cell Damage in Human Mesothelial Cells.
International journal of molecular sciences. 2022 Sep 3;23(17); Authors: Pietrofesa RA, Chatterjee S, Kadariya Y, Testa JR, Albelda SM, Christofidou-Solomidou M

Na(+)/H(+)-exchanger 1 enhances antitumor activity of engineered NK-92 natural killer cells.
Cancer research communications. 2022 Aug;2(8):842-856 Epub 2022 Aug 22; Authors: Gong YY, Shao H, Li Y, Brafford P, Stine ZE, Sun J, Felsher DW, Orange JS, Albelda SM, Dang CV

CAR T cells produced in vivo to treat cardiac injury.
Science (New York, N.Y.). 2022 Jan 7;375(6576):91-96 Epub 2022 Jan 6; Authors: Rurik JG, Tombácz I, Yadegari A, Méndez Fernández PO, Shewale SV, Li L, Kimura T, Soliman OY, Papp TE, Tam YK, Mui BL, Albelda SM, Puré E, June CH, Aghajanian H, Weissman D, Parhiz H, Epstein JA

An NK-like CAR T cell transition in CAR T cell dysfunction.
Cell. 2021 Dec 9;184(25):6081-6100.e26 Epub 2021 Dec 2; Authors: Good CR, Aznar MA, Kuramitsu S, Samareh P, Agarwal S, Donahue G, Ishiyama K, Wellhausen N, Rennels AK, Ma Y, Tian L, Guedan S, Alexander KA, Zhang Z, Rommel PC, Singh N, Glastad KM, Richardson MW, Watanabe K, Tanyi JL, O'Hara MH, Ruella M, Lacey SF, Moon EK, Schuster SJ, Albelda SM, Lanier LL, Young RM, Berger SL, June CH

A human CD137×PD-L1 bispecific antibody promotes anti-tumor immunity via context-dependent T cell costimulation and checkpoint blockade.
Nature communications. 2021 Jul 21;12(1):4445; Authors: Geuijen C, Tacken P, Wang LC, Klooster R, van Loo PF, Zhou J, Mondal A, Liu YB, Kramer A, Condamine T, Volgina A, Hendriks LJA, van der Maaden H, Rovers E, Engels S, Fransen F, den Blanken-Smit R, Zondag-van der Zande V, Basmeleh A, Bartelink W, Kulkarni A, Marissen W, Huang CY, Hall L, Harvey S, Kim S, Martinez M, O'Brien S, Moon E, Albelda S, Kanellopoulou C, Stewart S, Nastri H, Bakker ABH, Scherle P, Logtenberg T, Hollis G, de Kruif J, Huber R, Mayes PA, Throsby M

Mesothelin-targeted CAR-T cell therapy for solid tumors.
Expert opinion on biological therapy. 2021 Apr;21(4):473-486 Epub 2020 Nov 12; Authors: Klampatsa A, Dimou V, Albelda SM

Serum soluble mesothelin-related protein (SMRP) and fibulin-3 levels correlate with baseline malignant pleural mesothelioma (MPM) tumor volumes but are not useful as biomarkers of response in an immunotherapy trial.
Lung cancer (Amsterdam, Netherlands). 2021 Apr;154:5-12 Epub 2021 Jan 14; Authors: Katz SI, Roshkovan L, Berger I, Friedberg JS, Alley EW, Simone CB 2nd, Haas AR, Cengel KA, Sterman DH, Albelda SM

Neoadjuvant Gene-Mediated Cytotoxic Immunotherapy for Non-Small-Cell Lung Cancer: Safety and Immunologic Activity.
Molecular therapy : the journal of the American Society of Gene Therapy. 2021 Feb 3;29(2):658-670 Epub 2020 Nov 5; Authors: Predina JD, Haas AR, Martinez M, O'Brien S, Moon EK, Woodruff P, Stadanlick J, Corbett C, Frenzel-Sulyok L, Bryski MG, Eruslanov E, Deshpande C, Langer C, Aguilar LK, Guzik BW, Manzanera AG, Aguilar-Cordova E, Singhal S, Albelda SM

Gene signature of antigen processing and presentation machinery predicts response to checkpoint blockade in non-small cell lung cancer (NSCLC) and melanoma.
Journal for immunotherapy of cancer. 2020 Oct;8(2); Authors: Thompson JC, Davis C, Deshpande C, Hwang WT, Jeffries S, Huang A, Mitchell TC, Langer CJ, Albelda SM

Ligand-Induced Degradation of a CAR Permits Reversible Remote Control of CAR T Cell Activity In Vitro and In Vivo.
Molecular therapy : the journal of the American Society of Gene Therapy. 2020 Aug 5;28(8):1932 Epub 2020 Jul 21; Authors: Richman SA, Wang LC, Moon EK, Khire UR, Albelda SM, Milone MC

Analysis and Augmentation of the Immunologic Bystander Effects of CAR T Cell Therapy in a Syngeneic Mouse Cancer Model.
Molecular therapy oncolytics. 2020 Sep 25;18:360-371 Epub 2020 Jul 15; Authors: Klampatsa A, Leibowitz MS, Sun J, Liousia M, Arguiri E, Albelda SM

Ligand-Induced Degradation of a CAR Permits Reversible Remote Control of CAR T Cell Activity In Vitro and In Vivo.
Molecular therapy : the journal of the American Society of Gene Therapy. 2020 Jul 8;28(7):1600-1613 Epub 2020 Jun 11; Authors: Richman SA, Wang LC, Moon EK, Khire UR, Albelda SM, Milone MC

4-1BB costimulation promotes CAR T cell survival through noncanonical NF-κB signaling.
Science signaling. 2020 Mar 31;13(625); Authors: Philipson BI, O'Connor RS, May MJ, June CH, Albelda SM, Milone MC

Gene signatures of tumor inflammation and epithelial-to-mesenchymal transition (EMT) predict responses to immune checkpoint blockade in lung cancer with high accuracy.
Lung cancer (Amsterdam, Netherlands). 2020 Jan;139:1-8 Epub 2019 Oct 18; Authors: Thompson JC, Hwang WT, Davis C, Deshpande C, Jeffries S, Rajpurohit Y, Krishna V, Smirnov D, Verona R, Lorenzi MV, Langer CJ, Albelda SM

Tumor Antigen Heterogeneity: The "Elephant in the Room" of Adoptive T-cell Therapy for Solid Tumors.
Cancer immunology research. 2020 Jan;8(1):2; Authors: Albelda SM

Current Advances in CAR T Cell Therapy for Malignant Mesothelioma.
Journal of cellular immunology. 2020;2(4):192-200; Authors: Klampatsa A, Albelda SM

Neutrophil content predicts lymphocyte depletion and anti-PD1 treatment failure in NSCLC.
JCI insight. 2019 Dec 19;4(24); Authors: Kargl J, Zhu X, Zhang H, Yang GHY, Friesen TJ, Shipley M, Maeda DY, Zebala JA, McKay-Fleisch J, Meredith G, Mashadi-Hossein A, Baik C, Pierce RH, Redman MW, Thompson JC, Albelda SM, Bolouri H, Houghton AM

Author Correction: Targeting cardiac fibrosis with engineered T cells.
Nature. 2019 Dec;576(7785):E2; Authors: Aghajanian H, Kimura T, Rurik JG, Hancock AS, Leibowitz MS, Li L, Scholler J, Monslow J, Lo A, Han W, Wang T, Bedi K, Morley MP, Saldana RAL, Bolar NA, McDaid K, Assenmacher CA, Smith CL, Wirth D, June CH, Margulies KB, Jain R, Puré E, Albelda SM, Epstein JA

Phase I Study of Lentiviral-Transduced Chimeric Antigen Receptor-Modified T Cells Recognizing Mesothelin in Advanced Solid Cancers.
Molecular therapy : the journal of the American Society of Gene Therapy. 2019 Nov 6;27(11):1919-1929 Epub 2019 Jul 30; Authors: Haas AR, Tanyi JL, O'Hara MH, Gladney WL, Lacey SF, Torigian DA, Soulen MC, Tian L, McGarvey M, Nelson AM, Farabaugh CS, Moon E, Levine BL, Melenhorst JJ, Plesa G, June CH, Albelda SM, Beatty GL

Targeting cardiac fibrosis with engineered T cells.
Nature. 2019 Sep;573(7774):430-433 Epub 2019 Sep 11; Authors: Aghajanian H, Kimura T, Rurik JG, Hancock AS, Leibowitz MS, Li L, Scholler J, Monslow J, Lo A, Han W, Wang T, Bedi K, Morley MP, Linares Saldana RA, Bolar NA, McDaid K, Assenmacher CA, Smith CL, Wirth D, June CH, Margulies KB, Jain R, Puré E, Albelda SM, Epstein JA

Loss of cells expressing fibroblast activation protein has variable effects in models of TGF-β and chronic bleomycin-induced fibrosis.
American journal of physiology. Lung cellular and molecular physiology. 2019 Aug 1;317(2):L271-L282 Epub 2019 Jun 12; Authors: Kimura T, Monslow J, Klampatsa A, Leibowitz M, Sun J, Liousia M, Woodruff P, Moon E, Todd L, Puré E, Albelda SM

Synthetic secoisolariciresinol diglucoside (LGM2605) inhibits Libby amphibole fiber-induced acute inflammation in mice.
Toxicology and applied pharmacology. 2019 Jul 15;375:81-93 Epub 2019 Apr 23; Authors: Christofidou-Solomidou M, Pietrofesa RA, Park K, Albelda SM, Serve KM, Keil DE, Pfau JC

Phenotypic and functional analysis of malignant mesothelioma tumor-infiltrating lymphocytes.
Oncoimmunology. 2019;8(9):e1638211 Epub 2019 Jul 13; Authors: Klampatsa A, O'Brien SM, Thompson JC, Rao AS, Stadanlick JE, Martinez MC, Liousia M, Cantu E, Cengel K, Moon EK, Singhal S, Eruslanov EB, Albelda SM

Function of Human Tumor-Infiltrating Lymphocytes in Early-Stage Non-Small Cell Lung Cancer.
Cancer immunology research. 2019 Jun;7(6):896-909 Epub 2019 May 3; Authors: O'Brien SM, Klampatsa A, Thompson JC, Martinez MC, Hwang WT, Rao AS, Standalick JE, Kim S, Cantu E, Litzky LA, Singhal S, Eruslanov EB, Moon EK, Albelda SM

Human tumor-associated monocytes/macrophages and their regulation of T cell responses in early-stage lung cancer.
Science translational medicine. 2019 Feb 13;11(479); Authors: Singhal S, Stadanlick J, Annunziata MJ, Rao AS, Bhojnagarwala PS, O'Brien S, Moon EK, Cantu E, Danet-Desnoyers G, Ra HJ, Litzky L, Akimova T, Beier UH, Hancock WW, Albelda SM, Eruslanov EB

Luminol Chemiluminescence Reports Photodynamic Therapy-Generated Neutrophil Activity In Vivo and Serves as a Biomarker of Therapeutic Efficacy.
Photochemistry and photobiology. 2019 Jan;95(1):430-438 Epub 2018 Nov 26; Authors: Davis RW 4th, Snyder E, Miller J, Carter S, Houser C, Klampatsa A, Albelda SM, Cengel KA, Busch TM

Molecular Characterization of Malignant Mesothelioma: Time for New Targets?
Cancer discovery. 2018 Dec;8(12):1508-1510; Authors: Aggarwal C, Albelda SM

A preclinical model to investigate the role of surgically-induced inflammation in tumor responses to intraoperative photodynamic therapy.
Lasers in surgery and medicine. 2018 Jul;50(5):440-450 Epub 2018 May 25; Authors: Davis RW 4th, Papasavvas E, Klampatsa A, Putt M, Montaner LJ, Culligan MJ, McNulty S, Friedberg JS, Simone CB 2nd, Singhal S, Albelda SM, Cengel KA, Busch TM

Epigenomic-Guided Mass Cytometry Profiling Reveals Disease-Specific Features of Exhausted CD8 T Cells.
Immunity. 2018 May 15;48(5):1029-1045.e5; Authors: Bengsch B, Ohtani T, Khan O, Setty M, Manne S, O'Brien S, Gherardini PF, Herati RS, Huang AC, Chang KM, Newell EW, Bovenschen N, Pe'er D, Albelda SM, Wherry EJ

Phase I Study of Intrapleural Gene-Mediated Cytotoxic Immunotherapy in Patients with Malignant Pleural Effusion.
Molecular therapy : the journal of the American Society of Gene Therapy. 2018 May 2;26(5):1198-1205 Epub 2018 Feb 21; Authors: Aggarwal C, Haas AR, Metzger S, Aguilar LK, Aguilar-Cordova E, Manzanera AG, Gómez-Hernández G, Katz SI, Alley EW, Evans TL, Bauml JM, Cohen RB, Langer CJ, Albelda SM, Sterman DH

Synthetic Lignan Secoisolariciresinol Diglucoside (LGM2605) Reduces Asbestos-Induced Cytotoxicity in an Nrf2-Dependent and -Independent Manner.
Antioxidants (Basel, Switzerland). 2018 Mar 2;7(3); Authors: Pietrofesa RA, Chatterjee S, Park K, Arguiri E, Albelda SM, Christofidou-Solomidou M

Novel therapies for malignant pleural mesothelioma.
The Lancet. Oncology. 2018 Mar;19(3):e161-e172; Authors: Scherpereel A, Wallyn F, Albelda SM, Munck C

Human neutrophils can mimic myeloid-derived suppressor cells (PMN-MDSC) and suppress microbead or lectin-induced T cell proliferation through artefactual mechanisms.
Scientific reports. 2018 Feb 16;8(1):3135; Authors: Negorev D, Beier UH, Zhang T, Quatromoni JG, Bhojnagarwala P, Albelda SM, Singhal S, Eruslanov E, Lohoff FW, Levine MH, Diamond JM, Christie JD, Hancock WW, Akimova T

Intra-tumoral delivery of CXCL11 via a vaccinia virus, but not by modified T cells, enhances the efficacy of adoptive T cell therapy and vaccines.
Oncoimmunology. 2018;7(3):e1395997 Epub 2018 Jan 9; Authors: Moon EK, Wang LS, Bekdache K, Lynn RC, Lo A, Thorne SH, Albelda SM

Circulating tumor cells as a predictive biomarker in patients with small cell lung cancer undergoing chemotherapy.
Lung cancer (Amsterdam, Netherlands). 2017 Oct;112:118-125 Epub 2017 Aug 12; Authors: Aggarwal C, Wang X, Ranganathan A, Torigian D, Troxel A, Evans T, Cohen RB, Vaidya B, Rao C, Connelly M, Vachani A, Langer C, Albelda S

Chimeric Antigen Receptor (CAR) T Cell Therapy for Malignant Pleural Mesothelioma (MPM).
Cancers. 2017 Sep 1;9(9); Authors: Klampatsa A, Haas AR, Moon EK, Albelda SM

Human lung tumor FOXP3+ Tregs upregulate four "Treg-locking" transcription factors.
JCI insight. 2017 Aug 17;2(16); Authors: Akimova T, Zhang T, Negorev D, Singhal S, Stadanlick J, Rao A, Annunziata M, Levine MH, Beier UH, Diamond JM, Christie JD, Albelda SM, Eruslanov EB, Hancock WW

The Era of Checkpoint Blockade in Lung Cancer: Taking the Brakes Off the Immune System.
Annals of the American Thoracic Society. 2017 Aug;14(8):1248-1260; Authors: Moon EK, Langer CJ, Albelda SM

Early detection of pemetrexed-induced inhibition of thymidylate synthase in non-small cell lung cancer with FLT-PET imaging.
Oncotarget. 2017 Apr 11;8(15):24213-24223; Authors: Chen X, Yang Y, Berger I, Khalid U, Patel A, Cai J, Farwell MD, Langer C, Aggarwal C, Albelda SM, Katz SI

Mouse versus Human Neutrophils in Cancer: A Major Knowledge Gap.
Trends in cancer. 2017 Feb;3(2):149-160 Epub 2017 Jan 19; Authors: Eruslanov EB, Singhal S, Albelda SM

CAR T Cell Therapy for Solid Tumors.
Annual review of medicine. 2017 Jan 14;68:139-152 Epub 2016 Nov 17; Authors: Newick K, O'Brien S, Moon E, Albelda SM

The Synthetic Lignan Secoisolariciresinol Diglucoside Prevents Asbestos-Induced NLRP3 Inflammasome Activation in Murine Macrophages.
Oxidative medicine and cellular longevity. 2017;2017:7395238 Epub 2017 Sep 13; Authors: Pietrofesa RA, Woodruff P, Hwang WT, Patel P, Chatterjee S, Albelda SM, Christofidou-Solomidou M

Ubiquitin-specific Protease-7 Inhibition Impairs Tip60-dependent Foxp3+ T-regulatory Cell Function and Promotes Antitumor Immunity.
EBioMedicine. 2016 Nov;13:99-112 Epub 2016 Oct 15; Authors: Wang L, Kumar S, Dahiya S, Wang F, Wu J, Newick K, Han R, Samanta A, Beier UH, Akimova T, Bhatti TR, Nicholson B, Kodrasov MP, Agarwal S, Sterner DE, Gu W, Weinstock J, Butt TR, Albelda SM, Hancock WW

Diacylglycerol Kinases (DGKs): Novel Targets for Improving T Cell Activity in Cancer.
Frontiers in cell and developmental biology. 2016;4:108 Epub 2016 Oct 17; Authors: Riese MJ, Moon EK, Johnson BD, Albelda SM

Tumor-associated neutrophils display a distinct N1 profile following TGFβ modulation: A transcriptomics analysis of pro- vs. antitumor TANs.
Oncoimmunology. 2016;5(11):e1232221 Epub 2016 Sep 13; Authors: Shaul ME, Levy L, Sun J, Mishalian I, Singhal S, Kapoor V, Horng W, Fridlender G, Albelda SM, Fridlender ZG

Pilot and Feasibility Trial Evaluating Immuno-Gene Therapy of Malignant Mesothelioma Using Intrapleural Delivery of Adenovirus-IFNα Combined with Chemotherapy.
Clinical cancer research : an official journal of the American Association for Cancer Research. 2016 Aug 1;22(15):3791-800 Epub 2016 Mar 11; Authors: Sterman DH, Alley E, Stevenson JP, Friedberg J, Metzger S, Recio A, Moon EK, Haas AR, Vachani A, Katz SI, Sun J, Heitjan DF, Hwang WT, Litzky L, Yearley JH, Tan KS, Papasavvas E, Kennedy P, Montaner LJ, Cengel KA, Simone CB 2nd, Culligan M, Langer CJ, Albelda SM

Lectin-type oxidized LDL receptor-1 distinguishes population of human polymorphonuclear myeloid-derived suppressor cells in cancer patients.
Science immunology. 2016 Aug;1(2) Epub 2016 Aug 5; Authors: Condamine T, Dominguez GA, Youn JI, Kossenkov AV, Mony S, Alicea-Torres K, Tcyganov E, Hashimoto A, Nefedova Y, Lin C, Partlova S, Garfall A, Vogl DT, Xu X, Knight SC, Malietzis G, Lee GH, Eruslanov E, Albelda SM, Wang X, Mehta JL, Bewtra M, Rustgi A, Hockstein N, Witt R, Masters G, Nam B, Smirnov D, Sepulveda MA, Gabrilovich DI

Origin and Role of a Subset of Tumor-Associated Neutrophils with Antigen-Presenting Cell Features in Early-Stage Human Lung Cancer.
Cancer cell. 2016 Jul 11;30(1):120-135 Epub 2016 Jun 30; Authors: Singhal S, Bhojnagarwala PS, O'Brien S, Moon EK, Garfall AL, Rao AS, Quatromoni JG, Stephen TL, Litzky L, Deshpande C, Feldman MD, Hancock WW, Conejo-Garcia JR, Albelda SM, Eruslanov EB

Augmentation of CAR T-cell Trafficking and Antitumor Efficacy by Blocking Protein Kinase A Localization.
Cancer immunology research. 2016 Jun;4(6):541-51 Epub 2016 Apr 4; Authors: Newick K, O'Brien S, Sun J, Kapoor V, Maceyko S, Lo A, Puré E, Moon E, Albelda SM

Chimeric antigen receptor T-cell therapy for solid tumors.
Molecular therapy oncolytics. 2016;3:16006 Epub 2016 Apr 13; Authors: Newick K, Moon E, Albelda SM

Asbestos Induces Oxidative Stress and Activation of Nrf2 Signaling in Murine Macrophages: Chemopreventive Role of the Synthetic Lignan Secoisolariciresinol Diglucoside (LGM2605).
International journal of molecular sciences. 2016 Mar 1;17(3):322; Authors: Pietrofesa RA, Velalopoulou A, Albelda SM, Christofidou-Solomidou M

Flaxseed lignans enriched in secoisolariciresinol diglucoside prevent acute asbestos-induced peritoneal inflammation in mice.
Carcinogenesis. 2016 Feb;37(2):177-87 Epub 2015 Dec 17; Authors: Pietrofesa RA, Velalopoulou A, Arguiri E, Menges CW, Testa JR, Hwang WT, Albelda SM, Christofidou-Solomidou M

Blockade of Programmed Death 1 Augments the Ability of Human T Cells Engineered to Target NY-ESO-1 to Control Tumor Growth after Adoptive Transfer.
Clinical cancer research : an official journal of the American Association for Cancer Research. 2016 Jan 15;22(2):436-47 Epub 2015 Aug 31; Authors: Moon EK, Ranganathan R, Eruslanov E, Kim S, Newick K, O'Brien S, Lo A, Liu X, Zhao Y, Albelda SM

Valproic acid improves second-line regimen of small cell lung carcinoma in preclinical models.
ERJ open research. 2015 Oct;1(2) Epub 2015 Oct 19; Authors: Hubaux R, Vandermeers F, Cosse JP, Crisanti C, Kapoor V, Albelda SM, Mascaux C, Delvenne P, Hubert P, Willems L

The Optical Biopsy: A Novel Technique for Rapid Intraoperative Diagnosis of Primary Pulmonary Adenocarcinomas.
Annals of surgery. 2015 Oct;262(4):602-9; Authors: Kennedy GT, Okusanya OT, Keating JJ, Heitjan DF, Deshpande C, Litzky LA, Albelda SM, Drebin JA, Nie S, Low PS, Singhal S

CD11b+Ly6G+ cells inhibit tumor growth by suppressing IL-17 production at early stages of tumorigenesis.
Oncoimmunology. 2016;5(1):e1061175 Epub 2015 Jul 28; Authors: Liu Y, O'Leary CE, Wang LS, Bhatti TR, Dai N, Kapoor V, Liu P, Mei J, Guo L, Oliver PM, Albelda SM, Worthen GS

Tumor-Promoting Desmoplasia Is Disrupted by Depleting FAP-Expressing Stromal Cells.
Cancer research. 2015 Jul 15;75(14):2800-2810 Epub 2015 May 15; Authors: Lo A, Wang LS, Scholler J, Monslow J, Avery D, Newick K, O'Brien S, Evans RA, Bajor DJ, Clendenin C, Durham AC, Buza EL, Vonderheide RH, June CH, Albelda SM, Puré E

Generation of Potent T-cell Immunotherapy for Cancer Using DAP12-Based, Multichain, Chimeric Immunoreceptors.
Cancer immunology research. 2015 Jul;3(7):815-26 Epub 2015 May 4; Authors: Wang E, Wang LC, Tsai CY, Bhoj V, Gershenson Z, Moon E, Newick K, Sun J, Lo A, Baradet T, Feldman MD, Barrett D, Puré E, Albelda S, Milone MC

Surgical cytoreduction restores the antitumor efficacy of a Listeria monocytogenes vaccine in malignant pleural mesothelioma.
Immunology letters. 2015 Jul;166(1):28-35 Epub 2015 May 18; Authors: Kennedy GT, Judy BF, Bhojnagarwala P, Moon EK, Fridlender ZG, Albelda SM, Singhal S

Promoting metastasis: neutrophils and T cells join forces.
Cell research. 2015 Jul;25(7):765-6 Epub 2015 May 26; Authors: Fridlender ZG, Albelda SM, Granot Z

An optimized disaggregation method for human lung tumors that preserves the phenotype and function of the immune cells.
Journal of leukocyte biology. 2015 Jan;97(1):201-9 Epub 2014 Oct 30; Authors: Quatromoni JG, Singhal S, Bhojnagarwala P, Hancock WW, Albelda SM, Eruslanov E

Bioanalytical techniques for detecting biomarkers of response to human asbestos exposure.
Bioanalysis. 2015;7(9):1157-73; Authors: Mesaros C, Worth AJ, Snyder NW, Christofidou-Solomidou M, Vachani A, Albelda SM, Blair IA

Tumor-associated neutrophils stimulate T cell responses in early-stage human lung cancer.
The Journal of clinical investigation. 2014 Dec;124(12):5466-80 Epub 2014 Nov 10; Authors: Eruslanov EB, Bhojnagarwala PS, Quatromoni JG, Stephen TL, Ranganathan A, Deshpande C, Akimova T, Vachani A, Litzky L, Hancock WW, Conejo-Garcia JR, Feldman M, Albelda SM, Singhal S

Intraoperative near-infrared imaging can identify pulmonary nodules.
The Annals of thoracic surgery. 2014 Oct;98(4):1223-30 Epub 2014 Aug 5; Authors: Okusanya OT, Holt D, Heitjan D, Deshpande C, Venegas O, Jiang J, Judy R, DeJesus E, Madajewski B, Oh K, Wang M, Albelda SM, Nie S, Singhal S

Neutrophils recruit regulatory T-cells into tumors via secretion of CCL17--a new mechanism of impaired antitumor immunity.
International journal of cancer. 2014 Sep 1;135(5):1178-86 Epub 2014 Feb 27; Authors: Mishalian I, Bayuh R, Eruslanov E, Michaeli J, Levy L, Zolotarov L, Singhal S, Albelda SM, Granot Z, Fridlender ZG

Multifactorial T-cell hypofunction that is reversible can limit the efficacy of chimeric antigen receptor-transduced human T cells in solid tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research. 2014 Aug 15;20(16):4262-73 Epub 2014 Jun 11; Authors: Moon EK, Wang LC, Dolfi DV, Wilson CB, Ranganathan R, Sun J, Kapoor V, Scholler J, Puré E, Milone MC, June CH, Riley JL, Wherry EJ, Albelda SM

Intraoperative near-infrared imaging can distinguish cancer from normal tissue but not inflammation.
PloS one. 2014;9(7):e103342 Epub 2014 Jul 29; Authors: Holt D, Okusanya O, Judy R, Venegas O, Jiang J, DeJesus E, Eruslanov E, Quatromoni J, Bhojnagarwala P, Deshpande C, Albelda S, Nie S, Singhal S

Mesothelin-specific chimeric antigen receptor mRNA-engineered T cells induce anti-tumor activity in solid malignancies.
Cancer immunology research. 2014 Feb;2(2):112-20; Authors: Beatty GL, Haas AR, Maus MV, Torigian DA, Soulen MC, Plesa G, Chew A, Zhao Y, Levine BL, Albelda SM, Kalos M, June CH

Targeting fibroblast activation protein in tumor stroma with chimeric antigen receptor T cells can inhibit tumor growth and augment host immunity without severe toxicity.
Cancer immunology research. 2014 Feb;2(2):154-66 Epub 2013 Nov 12; Authors: Wang LC, Lo A, Scholler J, Sun J, Majumdar RS, Kapoor V, Antzis M, Cotner CE, Johnson LA, Durham AC, Solomides CC, June CH, Puré E, Albelda SM

Giving oncolytic vaccinia virus more BiTE.
Molecular therapy : the journal of the American Society of Gene Therapy. 2014 Jan;22(1):6-8; Authors: Albelda SM, Thorne SH

Use of circulating tumor cell technology (CELLSEARCH) for the diagnosis of malignant pleural effusions.
Annals of the American Thoracic Society. 2013 Dec;10(6):582-9; Authors: Schwed Lustgarten DE, Thompson J, Yu G, Vachani A, Vaidya B, Rao C, Connelly M, Udine M, Tan KS, Heitjan DF, Albelda S

Modifying tumor-associated macrophages: An important adjunct to immunotherapy.
Oncoimmunology. 2013 Dec 1;2(12):e26620 Epub 2013 Oct 21; Authors: Fridlender ZG, Albelda SM

Overcoming intrinsic inhibitory pathways to augment the antineoplastic activity of adoptively transferred T cells: Re-tuning your CAR before hitting a rocky road.
Oncoimmunology. 2013 Nov 1;2(11):e26492 Epub 2013 Oct 10; Authors: Wang LC, Riese MJ, Moon EK, Albelda SM

Thrombospondin-1 mediates oncogenic Ras-induced senescence in premalignant lung tumors.
The Journal of clinical investigation. 2013 Oct;123(10):4375-89 Epub 2013 Sep 9; Authors: Baek KH, Bhang D, Zaslavsky A, Wang LC, Vachani A, Kim CF, Albelda SM, Evan GI, Ryeom S

Inhibition of p300 impairs Foxp3⁺ T regulatory cell function and promotes antitumor immunity.
Nature medicine. 2013 Sep;19(9):1173-7 Epub 2013 Aug 18; Authors: Liu Y, Wang L, Predina J, Han R, Beier UH, Wang LC, Kapoor V, Bhatti TR, Akimova T, Singhal S, Brindle PK, Cole PA, Albelda SM, Hancock WW

Immunological effects of the TGFβ-blocking antibody GC1008 in malignant pleural mesothelioma patients.
Oncoimmunology. 2013 Aug 1;2(8):e26218 Epub 2013 Aug 27; Authors: Stevenson JP, Kindler HL, Papasavvas E, Sun J, Jacobs-Small M, Hull J, Schwed D, Ranganathan A, Newick K, Heitjan DF, Langer CJ, McPherson JM, Montaner LJ, Albelda SM

The timing of TGF-β inhibition affects the generation of antigen-specific CD8+ T cells.
BMC immunology. 2013 Jul 17;14:30; Authors: Quatromoni JG, Suzuki E, Okusanya O, Judy BF, Bhojnagarwala P, Venegas O, Eruslanov E, Predina JD, Albelda SM, Singhal S

T cells expressing chimeric antigen receptors can cause anaphylaxis in humans.
Cancer immunology research. 2013 Jul;1(1):26-31 Epub 2013 Apr 7; Authors: Maus MV, Haas AR, Beatty GL, Albelda SM, Levine BL, Liu X, Zhao Y, Kalos M, June CH

Enhanced effector responses in activated CD8+ T cells deficient in diacylglycerol kinases.
Cancer research. 2013 Jun 15;73(12):3566-77 Epub 2013 Apr 10; Authors: Riese MJ, Wang LC, Moon EK, Joshi RP, Ranganathan A, June CH, Koretzky GA, Albelda SM

Thymidylate synthase and folyl-polyglutamate synthase are not clinically useful markers of response to pemetrexed in patients with malignant pleural mesothelioma.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2013 Apr;8(4):469-77; Authors: Lustgarten DE, Deshpande C, Aggarwal C, Wang LC, Saloura V, Vachani A, Wang LP, Litzky L, Feldman M, Creaney J, Nowak AK, Langer C, Inghilleri S, Stella G, Albelda SM

The receptor for advanced glycation end products mediates lung endothelial activation by RBCs.
American journal of physiology. Lung cellular and molecular physiology. 2013 Feb 15;304(4):L250-63 Epub 2012 Dec 28; Authors: Mangalmurti NS, Friedman JL, Wang LC, Stolz D, Muthukumaran G, Siegel DL, Schmidt AM, Lee JS, Albelda SM

Changes in the local tumor microenvironment in recurrent cancers may explain the failure of vaccines after surgery.
Proceedings of the National Academy of Sciences of the United States of America. 2013 Jan 29;110(5):E415-24 Epub 2012 Dec 27; Authors: Predina J, Eruslanov E, Judy B, Kapoor V, Cheng G, Wang LC, Sun J, Moon EK, Fridlender ZG, Albelda S, Singhal S

Prevention of alveolar destruction and airspace enlargement in a mouse model of pulmonary lymphangioleiomyomatosis (LAM).
Science translational medicine. 2012 Oct 3;4(154):154ra134; Authors: Goncharova EA, Goncharov DA, Fehrenbach M, Khavin I, Ducka B, Hino O, Colby TV, Merrilees MJ, Haczku A, Albelda SM, Krymskaya VP

Lower serum endocan levels are associated with the development of acute lung injury after major trauma.
Journal of critical care. 2012 Oct;27(5):522.e11-7 Epub 2011 Sep 29; Authors: Mikkelsen ME, Shah CV, Scherpereel A, Lanken PN, Lassalle P, Bellamy SL, Localio AR, Albelda SM, Meyer NJ, Christie JD

Cytoreduction surgery reduces systemic myeloid suppressor cell populations and restores intratumoral immunotherapy effectiveness.
Journal of hematology & oncology. 2012 Jun 28;5:34; Authors: Predina JD, Kapoor V, Judy BF, Cheng G, Fridlender ZG, Albelda SM, Singhal S

Mesothelin, a novel immunotherapy target for triple negative breast cancer.
Breast cancer research and treatment. 2012 Jun;133(2):799-804 Epub 2012 Mar 15; Authors: Tchou J, Wang LC, Selven B, Zhang H, Conejo-Garcia J, Borghaei H, Kalos M, Vondeheide RH, Albelda SM, June CH, Zhang PJ

Tumor-associated neutrophils: friend or foe?
Carcinogenesis. 2012 May;33(5):949-55 Epub 2012 Mar 16; Authors: Fridlender ZG, Albelda SM

Treating tumors with a vaccinia virus expressing IFNβ illustrates the complex relationships between oncolytic ability and immunogenicity.
Molecular therapy : the journal of the American Society of Gene Therapy. 2012 Apr;20(4):736-48 Epub 2011 Oct 18; Authors: Wang LC, Lynn RC, Cheng G, Alexander E, Kapoor V, Moon EK, Sun J, Fridlender ZG, Isaacs SN, Thorne SH, Albelda SM

Vascular endothelial-targeted therapy combined with cytotoxic chemotherapy induces inflammatory intratumoral infiltrates and inhibits tumor relapses after surgery.
Neoplasia (New York, N.Y.). 2012 Apr;14(4):352-9; Authors: Judy BF, Aliperti LA, Predina JD, Levine D, Kapoor V, Thorpe PE, Albelda SM, Singhal S

Transcriptomic analysis comparing tumor-associated neutrophils with granulocytic myeloid-derived suppressor cells and normal neutrophils.
PloS one. 2012;7(2):e31524 Epub 2012 Feb 14; Authors: Fridlender ZG, Sun J, Mishalian I, Singhal S, Cheng G, Kapoor V, Horng W, Fridlender G, Bayuh R, Worthen GS, Albelda SM

Peripheral immune cell gene expression predicts survival of patients with non-small cell lung cancer.
PloS one. 2012;7(3):e34392 Epub 2012 Mar 29; Authors: Kossenkov AV, Dawany N, Evans TL, Kucharczuk JC, Albelda SM, Showe LC, Showe MK, Vachani A

Urinary volatile compounds as biomarkers for lung cancer.
Bioscience, biotechnology, and biochemistry. 2012;76(4):679-84 Epub 2012 Apr 7; Authors: Hanai Y, Shimono K, Matsumura K, Vachani A, Albelda S, Yamazaki K, Beauchamp GK, Oka H

A trial of intrapleural adenoviral-mediated Interferon-α2b gene transfer for malignant pleural mesothelioma.
American journal of respiratory and critical care medicine. 2011 Dec 15;184(12):1395-9 Epub 2011 Jun 3; Authors: Sterman DH, Haas A, Moon E, Recio A, Schwed D, Vachani A, Katz SI, Gillespie CT, Cheng G, Sun J, Papasavvas E, Montaner LJ, Heitjan DF, Litzky L, Friedberg J, Culligan M, June CH, Carroll RG, Albelda SM

Gene therapy for lung neoplasms.
Clinics in chest medicine. 2011 Dec;32(4):865-85 Epub 2011 Oct 7; Authors: Vachani A, Moon E, Wakeam E, Haas AR, Sterman DH, Albelda SM

Curcumin suppresses growth of mesothelioma cells in vitro and in vivo, in part, by stimulating apoptosis.
Molecular and cellular biochemistry. 2011 Nov;357(1-2):83-94 Epub 2011 May 19; Authors: Wang Y, Rishi AK, Wu W, Polin L, Sharma S, Levi E, Albelda S, Pass HI, Wali A

Activation of mitogen-activated protein kinases by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) plays an important role in macrophage stimulation.
Biochemical pharmacology. 2011 Nov 1;82(9):1175-85 Epub 2011 Jul 26; Authors: Sun J, Wang LC, Fridlender ZG, Kapoor V, Cheng G, Ching LM, Albelda SM

Progression of human bronchioloalveolar carcinoma to invasive adenocarcinoma is modeled in a transgenic mouse model of K-ras-induced lung cancer by loss of the TGF-β type II receptor.
Cancer research. 2011 Nov 1;71(21):6665-75 Epub 2011 Sep 12; Authors: Borczuk AC, Sole M, Lu P, Chen J, Wilgus ML, Friedman RA, Albelda SM, Powell CA

Resection of non-small cell lung cancers reverses tumor-induced gene expression changes in the peripheral immune system.
Clinical cancer research : an official journal of the American Association for Cancer Research. 2011 Sep 15;17(18):5867-77 Epub 2011 Aug 1; Authors: Kossenkov AV, Vachani A, Chang C, Nichols C, Billouin S, Horng W, Rom WN, Albelda SM, Showe MK, Showe LC

Pharmacologic activation of the innate immune system to prevent respiratory viral infections.
American journal of respiratory cell and molecular biology. 2011 Sep;45(3):480-8 Epub 2010 Dec 10; Authors: Cheng G, Wang LC, Fridlender ZG, Cheng GS, Chen B, Mangalmurti NS, Saloura V, Yu Z, Kapoor V, Mozdzanowska K, Moon E, Sun J, Kreindler JL, Cohen NA, Caton AJ, Erikson J, Albelda SM

Targeted endothelial delivery of nanosized catalase immunoconjugates protects lung grafts donated after cardiac death.
Transplantation. 2011 Aug 27;92(4):380-7; Authors: Preissler G, Loehe F, Huff IV, Ebersberger U, Shuvaev VV, Bittmann I, Hermanns I, Kirkpatrick JC, Fischer K, Eichhorn ME, Winter H, Jauch KW, Albelda SM, Muzykantov VR, Wiewrodt R

Expression of a functional CCR2 receptor enhances tumor localization and tumor eradication by retargeted human T cells expressing a mesothelin-specific chimeric antibody receptor.
Clinical cancer research : an official journal of the American Association for Cancer Research. 2011 Jul 15;17(14):4719-30 Epub 2011 May 24; Authors: Moon EK, Carpenito C, Sun J, Wang LC, Kapoor V, Predina J, Powell DJ Jr, Riley JL, June CH, Albelda SM

The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo.
Nature immunology. 2011 Jun 26;12(8):761-9; Authors: Woodfin A, Voisin MB, Beyrau M, Colom B, Caille D, Diapouli FM, Nash GB, Chavakis T, Albelda SM, Rainger GE, Meda P, Imhof BA, Nourshargh S

Gene therapy for mesothelioma.
Current treatment options in oncology. 2011 Jun;12(2):173-80; Authors: Vachani A, Moon E, Albelda SM

Novel variants in the PRDX6 Gene and the risk of Acute Lung Injury following major trauma.
BMC medical genetics. 2011 May 31;12:77; Authors: Rushefski M, Aplenc R, Meyer N, Li M, Feng R, Lanken PN, Gallop R, Bellamy S, Localio AR, Feinstein SI, Fisher AB, Albelda SM, Christie JD

ANGPT2 genetic variant is associated with trauma-associated acute lung injury and altered plasma angiopoietin-2 isoform ratio.
American journal of respiratory and critical care medicine. 2011 May 15;183(10):1344-53 Epub 2011 Jan 21; Authors: Meyer NJ, Li M, Feng R, Bradfield J, Gallop R, Bellamy S, Fuchs BD, Lanken PN, Albelda SM, Rushefski M, Aplenc R, Abramova H, Atochina-Vasserman EN, Beers MF, Calfee CS, Cohen MJ, Pittet JF, Christiani DC, O'Keefe GE, Ware LB, May AK, Wurfel MM, Hakonarson H, Christie JD

Modulation of endothelial targeting by size of antibody-antioxidant enzyme conjugates.
Journal of controlled release : official journal of the Controlled Release Society. 2011 Feb 10;149(3):236-41 Epub 2010 Oct 31; Authors: Shuvaev VV, Tliba S, Pick J, Arguiri E, Christofidou-Solomidou M, Albelda SM, Muzykantov VR

Monocyte chemoattractant protein-1 blockade inhibits lung cancer tumor growth by altering macrophage phenotype and activating CD8+ cells.
American journal of respiratory cell and molecular biology. 2011 Feb;44(2):230-7 Epub 2010 Apr 15; Authors: Fridlender ZG, Kapoor V, Buchlis G, Cheng G, Sun J, Wang LC, Singhal S, Snyder LA, Albelda SM

Vesicular stomatitis virus-induced immune suppressor cells generate antagonism between intratumoral oncolytic virus and cyclophosphamide.
Molecular therapy : the journal of the American Society of Gene Therapy. 2011 Jan;19(1):140-9 Epub 2010 Oct 26; Authors: Willmon C, Diaz RM, Wongthida P, Galivo F, Kottke T, Thompson J, Albelda S, Harrington K, Melcher A, Vile R

Multiple injections of electroporated autologous T cells expressing a chimeric antigen receptor mediate regression of human disseminated tumor.
Cancer research. 2010 Nov 15;70(22):9053-61 Epub 2010 Oct 5; Authors: Zhao Y, Moon E, Carpenito C, Paulos CM, Liu X, Brennan AL, Chew A, Carroll RG, Scholler J, Levine BL, Albelda SM, June CH

Advanced glycation end products on stored red blood cells increase endothelial reactive oxygen species generation through interaction with receptor for advanced glycation end products.
Transfusion. 2010 Nov;50(11):2353-61; Authors: Mangalmurti NS, Chatterjee S, Cheng G, Andersen E, Mohammed A, Siegel DL, Schmidt AM, Albelda SM, Lee JS

Chemotherapy delivered after viral immunogene therapy augments antitumor efficacy via multiple immune-mediated mechanisms.
Molecular therapy : the journal of the American Society of Gene Therapy. 2010 Nov;18(11):1947-59 Epub 2010 Aug 3; Authors: Fridlender ZG, Sun J, Singhal S, Kapoor V, Cheng G, Suzuki E, Albelda SM

Preclinical evidence for a beneficial impact of valproate on the response of small cell lung cancer to first-line chemotherapy.
European journal of cancer (Oxford, England : 1990). 2010 Jun;46(9):1724-34 Epub 2010 May 5; Authors: Hubaux R, Vandermeers F, Crisanti MC, Kapoor V, Burny A, Mascaux C, Albelda SM, Willems L

Activation of the nucleotide oligomerization domain signaling pathway by the non-bacterially derived xanthone drug 5'6-dimethylxanthenone-4-acetic acid (Vadimezan).
The Journal of biological chemistry. 2010 Apr 2;285(14):10553-62 Epub 2010 Jan 29; Authors: Cheng G, Sun J, Fridlender ZG, Wang LC, Ching LM, Albelda SM

A phase I trial of repeated intrapleural adenoviral-mediated interferon-beta gene transfer for mesothelioma and metastatic pleural effusions.
Molecular therapy : the journal of the American Society of Gene Therapy. 2010 Apr;18(4):852-60 Epub 2010 Jan 12; Authors: Sterman DH, Recio A, Haas AR, Vachani A, Katz SI, Gillespie CT, Cheng G, Sun J, Moon E, Pereira L, Wang X, Heitjan DF, Litzky L, June CH, Vonderheide RH, Carroll RG, Albelda SM

Gene therapy for mesothelioma and lung cancer.
American journal of respiratory cell and molecular biology. 2010 Apr;42(4):385-93 Epub 2010 Feb 16; Authors: Vachani A, Moon E, Wakeam E, Albelda SM

Urinary volatile compounds as biomarkers for lung cancer: a proof of principle study using odor signatures in mouse models of lung cancer.
PloS one. 2010 Jan 27;5(1):e8819; Authors: Matsumura K, Opiekun M, Oka H, Vachani A, Albelda SM, Yamazaki K, Beauchamp GK

Evaluation of an attenuated vesicular stomatitis virus vector expressing interferon-beta for use in malignant pleural mesothelioma: heterogeneity in interferon responsiveness defines potential efficacy.
Human gene therapy. 2010 Jan;21(1):51-64; Authors: Saloura V, Wang LC, Fridlender ZG, Sun J, Cheng G, Kapoor V, Sterman DH, Harty RN, Okumura A, Barber GN, Vile RG, Federspiel MJ, Russell SJ, Litzky L, Albelda SM

CCL2 blockade augments cancer immunotherapy.
Cancer research. 2010 Jan 1;70(1):109-18 Epub 2009 Dec 22; Authors: Fridlender ZG, Buchlis G, Kapoor V, Cheng G, Sun J, Singhal S, Crisanti MC, Wang LC, Heitjan D, Snyder LA, Albelda SM