Faculty

Kyong-Mi Chang, MD

faculty photo
Professor of Medicine
Department: Medicine
Graduate Group Affiliations

Contact information
Corporal Michael J. Crescenz VA Medical Center
Medical Research Building A424
3900 Woodland Avenue
Philadelphia, PA 19104
Office: (215) 823-5893
Lab: (215) 823-5800 ext 6730
Education:
A.B. (Chemistry, Mathematics, and Fine Arts)
Bryn Mawr College, 1983.
M.D.
The Medical College of Pennsylvania, 1987.
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Description of Research Expertise

Dr. Chang's research expertise is in immune mechanisms of viral persistence and disease pathogenesis with a focus on human hepatitis C and B viruses, +/- HIV confection. As the Co-PI of a VA-funded genetic study of cardiometabolic diseases using the VA's Million Veterans Program (MVP), Dr. Chang is also conducting population-based genomic analyses of cardiometabolic disorders including NAFLD and liver disease progression to cirrhosis and HCC. Finally, Dr. Chang participates in VA-funded clinical and translational research involving patients with COVID-19.

Description of Clinical Expertise

Dr. Chang's clinical area of expertise is in the evaluation, treatment and study of patients with acute and chronic viral hepatitis B and C, with and without HIV coinfection. She established and directed the active GI/Liver clinic at the Philadelphia VA Medical Center in 1999-2012. She continues to supervise GI fellows and rotating students/residents in the GI/Liver clinic to date.

Description of Other Expertise

Dr. Chang is the Associate Chief of Research (ACOS/R&D) and Associate Dean for Research at the Philadelphia Corporal Michael J Crescenz VA Medical Center (CMCVAMC), which is academically affiliated with the University of Pennsylvania. As such, Dr. Chang has the administrative oversight in developing VA-based and/or VA-funded research (e.g. via VA Career Development Award, VA Merit Review, Cooperative Studies Program and MVP research). She is also committed to mentoring VA-based researchers both locally and nationally.

Selected Publications

Clarke SL, Huang RDL, Hilliard AT, Tcheandjieu C, Lynch J, Damrauer SM, Chang KM, Tsao PS, Assimes TL: Race and Ethnicity Stratification for Polygenic Risk Score Analyses May Mask Disparities in Hispanics. Circulation Jul (ePub) 2022.

Shah S, Halvorson A, McBay B, Dorn C, Wilson O, Tuteja S, Chang KM, Cho K, Hauger R, Suzuki A, Hunt C, Siew E, Matheny M, Hung A, Greevy R, Roumie C: Proton-pump inhibitor use is not associated with severe COVID-19-related outcomes: a propensity score-weighted analysis of a national veteran cohort. Gut 71(7), Jul (ePub 2021 Oct 18) 2022.

Feld JJ, King WC, Ghany MG, Chang KM, Terrault N, Perrillo RP, Khalili M, Hinerman AS, Janssen H, Lok AS: Characteristics of older patients with immunotolerant chronic hepatitis B virus infection. Clin Gastroenterol Hepatol July (Pub ahead of print) 2022.

Vujkovic M, Ramdas S, Lorenz KM, Guo X, Darlay R, Cordell HJ, He J, Gindin Y, Chung C, Myers RP, Schneider CV, Park J, Lee KM, Serper M, Carr RM, Kaplan DE, Haas ME, MacLean MT, Witschey WR, Zhu X, Tcheandjieu C, Kember RL, Kranzler HR, Verma A, Giri A, Klarin DM, Sun YV, Huang J, Huffman JE, Townsend Creasy K, Hand NJ, Liu CT, Long MT, Yao J, Budoff M, Tan J, Li X, Lin HJ, Chen YI, Taylor KD, Chang RK, Krauss RM, Vilarinho S, Brancale J, Nielsen JB, Locke AE, Jones MB, Verweij N, Baras A, Reddy KR, Neuschwander-Tetri BA, Schwimmer JB, Sanyal AJ, Chalasani N, Ryan KA, Mitchell BD, Gill D, Wells AD, Manduchi E, Saiman Y, Mahmud N, Miller DR, Reaven PD, Phillips LS, Muralidhar S, DuVall SL, Lee JS, Assimes TL, Pyarajan S, Cho K, Edwards TL, Damrauer SM, Wilson PW, Gaziano JM, O'Donnell CJ, Khera AV, Grant SFA, Brown CD, Tsao PS, Saleheen D, Lotta LA, Bastarache L, Anstee QM, Daly AK, Meigs JB, Rotter JI, Lynch JA, Rader DJ, Voight BF, Chang KM.: A multi-ancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease, with histological and radiological validation. Nature Genetics 54, June 2022.

Verma A, Huffman JE, Gao L, Minnier J, Wu WC, Cho K, Ho YL, Gorman BR, Pyarajan S, Rajeevan N, Garcon H, Joseph J, McGeary JE, Suzuki A, Reaven PD, Wan ES, Lynch JA, Petersen JM, Meigs JB, Freiberg MS, Gatsby E, Lynch KE, Zekavat SM, Natarajan P, Dalal S, Jhala DN, Arjomandi M, Bonomo RA, Thompson TK, Pathak GA, Zhou JJ, Donskey CJ, Madduri RK, Wells QS, Gelernter J, Huang RDL, Polimanti R, Chang KM, Liao KP, Tsao PS, Sun YV, Wilson PWF, O'Donnell CJ, Hung AM, Gaziano JM, Hauger RL, Iyengar SK, Luoh SW: Association of Kidney Comorbidities and Acute Kidney Failure With Unfavorable Outcomes After COVID-19 in Individuals With the Sickle Cell Trait. JAMA Intern Med Jun 2022.

Verma A, Minnier J, Wan ES, Huffman JE, Gao L, Joseph J, Ho YL, Wu WC, Cho K, Gorman BR, Rajeevan N, Pyarajan S, Garcon H, Meigs JB, Sun YV, Reaven PD, McGeary JE, Suzuki A, Gelernter J, Lynch JA, Peterson JM, Zekavat SM, Natarajan P, Dalal S, Jhala DN, Arjomandi M, Gatsby E, Lynch KE, Bonomo RA, Freiberg M, Pathak GA, Zhou JJ, Donskey CJ, Madduri RK, Wells QS, Huang RD, Polimanti R, Chang KM, Liao KP, Tsao PS, Wilson PWF, Hung A, O'Donnell CJ, Gaziano JM, Hauger RL, Iyengar SK, Luoh SW: A MUC5B Gene Polymorphism, rs35705950-T Confers Protective Effects Against COVID-19 Hospitalization but not Severe Disease or Mortality. Am J Respir Crit Care Med Jun 2022.

Tuteja S, Yu Z, Wilson O, Chen HC, Wendt F, Chung CP, Shah SC, Hunt CM, Suzuki A, Chanfreau C, Gorman BR, Joseph J, Luoh SW, Napolioni V, Robinson-Cohen C, Tao R, Zhou J, Chang KM, Hung AM: Pharmacogenetic variants and risk of remdesivir-associated liver enzyme elevations in Million Veteran Program participants hospitalized with COVID-19. Clin Translational Sci Jun 2022.

Raghavan S, Huang J, Tcheandjieu C, Huffman JE, Litkowski E, Liu C, Ho YA, Hunter-Zinck H, Zhao H, Marouli E, North KE, Lange E, Lange LA, Voight BF, Gaziano JM, Pyarajan S, Hauser ER, Tsao PS, Wilson PWF, Chang KM, Cho K, O'Donnell CJ, Sun YV, Assimes TL: A multi-population phenome-wide association study of genetically-predicted height in the Million Veteran Program. PLoS Genet Jun 2022.

Verma A, Tsao NL, Thomann LO, Ho YL, Iyengar SK, Luoh SW, Carr R, Crawford DC, Efird JT, Huffman JE, Hung A, Ivey KL, Levin MG, Lynch J, Natarajan P, Pyarajan S, Bick AG, Costa L, Genovese G, Hauger R, Madduri R, Pathak GA, Polimanti R, Voight B, Vujkovic M, Zekavat SM, Zhao H, Ritchie MD; VA Million Veteran Program COVID-19 Science Initiative, Chang KM, Cho K, Casas JP, Tsao PS, Gaziano JM, O'Donnell C, Damrauer SM, Liao KP.: A Phenome-Wide Association Study of genes associated with COVID-19 severity reveals shared genetics with complex diseases in the Million Veteran Program. PLoS Genet 18: e1010113, Apr 2022.

Hung AM, Shah SC, Bick AG, Yu Z, Chen HC, Hunt CM, Wendt F, Wilson O, Greevy RA, Chung CP, Suzuki A, Ho YL, Akwo E, Polimanti R, Zhou J, Reaven P, Tsao PS, Gaziano JM, Huffman JE, Joseph J, Luoh SW, Iyengar S, Chang KM, Casas JP, Matheny ME, O'Donnell CJ, Cho K, Tao R, Susztak K, Robinson-Cohen C, Tuteja S, Siew ED; VA Million Veteran Program COVID-19 Science Initiative.: APOL1 Risk Variants, Acute Kidney Injury, and Death in Participants With African Ancestry Hospitalized With COVID-19 From the Million Veteran Program. JAMA Intern Med 182: 386-395, Apr 2022.

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Last updated: 07/22/2022
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