Faculty

Michael Silverman, MD, PhD

Assistant Professor of Pediatrics (Infectious Diseases)

Department: Pediatrics

Graduate Group Affiliations

Contact information

Children's Hospital of Philadelphia
Division of Infectious Diseases
3615 Civic Center Blvd
Philadelphia, PA 19104

Email:
silvermam1@email.chop.edu

Education:
BS (Biology)
Cornell University, 1998.
MD, PhD (Medicine and Immunology)
University of Pennsylvania School of Medicine, 2007.

Permanent link

> Perelman School of Medicine > Faculty > Details

Description of Clinical Expertise

Immunocompromised patients

Description of Research Expertise

Microbiome, Immunology, HLA, MHC, antibiotics, intestinal immune system, autoimmune (type I) diabetes, IgA deficiency, Early life immune system development

Selected Publications

Natalie A Trigg, Simon K Zhou, Jordan C Harris, Madeline N Lamonica, Molly A Nelson, Michael A Silverman, Taku Kambayashi, Colin C Conine: A lack of commensal microbiota influences the male reproductive tract intergenerationally in mice. Reproduction 169(4): e240204, March 2025.

Jean-Bernard Lubin, Paul J. Planet, Michael A. Silverman: Microbial succession at weaning is guided by microbial metabolism of host glycans. bioRxiv Page: doi: 10.1101/2025.02.20.639370, February 2025.

Siqi Linsey Zhang, Carolyn M McGann, Tereza Duranova, Jonathan Strysko, Andrew P Steenhoff, Alemayehu Gezmu, Britt Nakstad, Tonya Arscott-Mills, One Bayani, Banno Moorad, Nametso Tlhako, Melissa Richard-Greenblatt, Paul J Planet, Susan E Coffin, Michael A Silverman: Maternal and neonatal IgG against Klebsiella pneumoniae are associated with lower risk of neonatal sepsis: a case-control study of hospitalized neonates in Botswana. PLOS Global Public Health 4(12): e0003350, December 2024.

Liat Shenhav, Kelsey Fehr, Myrtha E. Reyna, Charisse Petersen, Darlene L. Y. Dai, Ruixue Dai, Vanessa Breton, Laura Rossi, Marek Smieja, Elinor Simons, Michael A. Silverman, Maayan Levy, Lars Bode, Catherine J. Field, Jean S Marshall, Theo J. Moraes, Piush J. Mandhane, Stuart E. Turvey, Padmaja Subbarao, Michael G. Surette, Meghan B. Azad: Microbial colonization programs are structured by breastfeeding and guide healthy respiratory development. Cell 187(19): 5431-5452, September 2024.

Jean-Bernard Lubin , Michael A Silverman, Paul J Planet: Comparison of gnotobiotic communities reveals milk-adapted metabolic functions and unexpected amino acid metabolism by the pre-weaning microbiome. Gut Microbes 16(1): 2387875, August 2024.

Siqi Linsey Zhang, Carolyn M McGann, Tereza Duranova, Jonathan Strysko, Andrew P Steenhoff, Alemayehu Gezmu, Britt Nakstad, Tonya Arscott-Mills, One Bayani, Banno Moorad, Nametso Tlhako, Melissa Richard-Greenblatt, Paul J Planet, Susan E Coffin, Michael A Silverman: Maternal and neonatal IgG against Klebsiella pneumoniae are associated with broad protection from neonatal sepsis: a case-control study of hospitalized neonates in Botswana. medRxiv Page: doi: 10.1101/2024.05.28.24308042, May 2024.

Jamal Green, John Deschaine, Jean-Bernard Lubin, Julia Flores, Sarah Maddux, Tereza Duranova, Logan Grimes, Paul J. Planet, Laurence C. Eisenlohr, Michael A. Silverman.: Early-life exposures to specific commensal microbes prevent type 1 diabetes. bioRxiv Page: doi.org/10.1101/2024.02.15.580579. February 2024.

Julia N. Flores, Jean-Bernard Lubin, Michael A. Silverman: The case for microbial intervention at weaning. Gut Microbes 16(1): 2414798, January 2024.

Conrey PE, Denu L, O'Boyle KC, Rozich I, Green J, Maslanka J, Lubin JB, Duranova T,Haltzman BL, Gianchett L, Oldridge DA, De Luna N, Vella LA, Allman D, Spergel J, Tanes C, Bittinger K, Henrickson SE, Silverman MA: IgA deficiency destabilizes homeostasis toward intestinal microbes and increases systemic immune dysregulation. Science Immunology 8(83): eade2335, May 2023.

Jean-Bernard Lubin, Jamal Green, Sarah Maddux, Lidiya Denu, Tereza Duranova, Matthew Lanza, Meghan Wynosky-Dolfi, Julia N Flores, Logan P Grimes, Igor E. Brodsky, Paul J. Planet, Michael A. Silverman: Arresting microbiome development limits immune system maturation and resistance to infection. Cell Host and Microbe 31(4): 554-570, April 2023.