Faculty

Daniel W. Kulp, PhD

Wistar Institute Assistant Professor of Microbiology

Department: Microbiology

Graduate Group Affiliations

Contact information

3601 Spruce St
Philadelphia, PA 19104

Office: 215-898-6587

Education:
B.A. (Computer Science, Molecular Biology, and Biochemistry)
Rutgers, The State University of New Jersey, 2004.
Ph.D. (Biochemistry and Molecular Biophysics)
The University of Pennsylvania, 2009.

Permanent link

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Selected Publications

Havenar-Daughton C, Sarker A, Kulp DW, Toy L, Hu X, Deresa I, Kalyunzhniy O, Kaushik K, Upadhyay AA, Menis S, Landais E, Cao L, Diedrich JK, Kumar S, Schiffner T, Reiss SM, Seumois G, Yates JR, Paulson JC, Bosinger SE, Wilson IA, Schief WR, Crotty S: The human naive B cell repertoire contains distinct sublcasses for a germline-targeting HIV-1 vaccine immunogen. Sci. Transl. Med. 10(448), July 2018.

Abbott RK, Lee JH, Menis S, Skog P, Rossi M, Ota T, Kulp DW, Bhullar D, Kalyuzhniy O, Havenar-Daughton C, Schief WR, Nemazee D, Crotty S: Precursor Frequency and Affinity Determine b Cell Competitive Fitness in Germinal Centers, Tested with Germline-Targeting HIV Vaccine Immunogens. Immunity 48(1): 133-146, January 2018.

Tokatlian T, Kulp DW, Mutafayan A, Jones C, Menis S, Georgeson TE, Kubitz M, Zhang M, Melo M, Silva M, Yun DS, Schief WR, Nemazee D, Crotty S: Enhancing Humoral Responses Against HIV Envelope Trimers via Nanoparticle Delivery with Stabilized Synthetic Liposomes. Scientific Reports 2018 Notes: In Press

Kulp W, Steichen JM, Pauthner M, Hu X, Schiffner T, Ligouri A, Cottrell CA, Havenar-Daughton C, Ozorowski G, Georgeson E, Kalyuzhniy O, Willis JR, Kubitz M, Adachi Y, Reiss SM, Shin M, de Val N, Ward AB, Crotty S, Burton DR, Schief WR: Structure-base design of native-like HIV-1 envelope trimers to silence non-neutralizing epitopes an eliminate CD4 binding. Nat. Commun. 8(1): 1655, Nov 2017.

Pauthner M, Havenar-Daughton C, Sok D, Nkolola JP, Bastidas R, Boopathy AV, Carnathan DG, Chandrashekar A, Cirelli KM, Cottrell CA, Eroshkin AM, Guenaga J, Kaushik K, Kulp DW, Liu J, McCoy LE, Oom AL, Ozorowski Ga, Post KW, Sharma SK, Steichen JM, de Taeye SW, Tokatlian T, Torrents de la Peña A, Butera ST, LaBranche CC, Montefiori DC, Silvestri G, Wilson IA, Irvine DJ, Sanders RW, Schief WR, Ward AB, Wyatt RT, Barouch DH, Crotty S, Burton DR: Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelop Trimer Immunization Using Optimized Approaches. Immunity 46(6): 1073-1088, June 2017.

Cao L, Diedrich JK, Kulp DW, Pauthner M, He L, Park SKR, Sok D, Su CY, Delahunty CM, Menis S, Andrabi R, Guenaga J, Georgeson E, Kubitz M, Adachi Y, Burton DR, Schief WR, Yates JR, Paulson JC: Global site-specific N-glycosylation analysis of HIV envelope glycoprotein. Nat. Commun. 8: 14954, March 2017.

Crooks ET, Osawa K, Tong T, Grimley SL, Dai YD, Whalen RG, Kulp DW, Menis S, Schief WR, Binley JM: Effects of partially dismantling the CD4 binding site glycan fence of HIV-1 Envelope glycoprotein trimers on neutralizing antibody induction. Virology 505: 193-209, 05 2017.

Steichen JM, Kulp DW, Tokatlian T, Escolano A, Dosenovic P, Stanfield RL, McCoy LE, Ozorowski G, Hu X, Kalyuzhniy O, Briney B, Schiffner T, Garces F, Freund NT, Gitlin AD, Menis S, Georgeson E, Kubitz M, Adachi Y, Jones M, Mutafyan AA, Yun DS, Mayer CT, Ward AB, Burton DR, Wilson IA, Irvine DJ, Nussenzweig MC, Schief WR: HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies. Immunity 45(3): 483-496, Sept 2016.

Sok D, Briney B, Jardine JG, Kulp DW, Menis S, Pauthner M, Wood A, Lee EC, Le KM, Jones M, Ramos A, Kalyuzhniy O, Adachi Y, Kubitz M, MacPherson S, Bradley A, Friedrich GA, Schief WR, Burton DR: Priming HIV-1 broadly neutralizing antibody precursors in human Ig loci transgenic mice. Science 353(6307): 1557-1560, Sep 2016.

Briney B, Sok D, Jardine JG, Kulp DW, Skog P, Menis S, Jacak R, Kalyuzhniy O, de Val N, Sesterhenn F, Le KM, Ramos A, Jones M, Saye-Francisco KL, Blane TR, Spencer S, Georgeson E, Hu X, Ozorowski G, Adachi Y, Kubitz M, Sarkar A, Wilson IA, Ward AB, Nemazee D, Burton DR, Schief WR: Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing Antibodies. Cell 166(6): 1459-1470.e11, Sep 2016.