Jonni S. Moore, Ph.D.

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Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations

Contact information
211 and 297 John Morgan Building
3620 Hamilton Walk
Philadelphia, PA 19104
Office: (215) 898-6853
Fax: (215) 898-4227
B.A. (Biology)
University of Virginia, Charlottesville, 1972.
Ph.D. (Microbiology)
Thomas Jefferson University, Philadelphia, 1984.
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Description of Research Expertise

Research Summary

Research in our laboratory centers on technology development with a focus on complex technologies, in particular cytomics. We pioneered new technology in flow cytometry liquid biopsies including the detection of extracellular vesicles as a rich source of prognostic and diagnostic information and developing this technology for diagnostics/prognostics in cardiovascular disease, traumatic brian injury and relapsing breast cancer. Most recently she has focused on the development of high dimensional deep phenotyping approaches for the identification of biomarkers of cancer responses using advance cytomic technology.
Current collaborators:
Lewis Chodosh, MD, PhD, Cancer Biology
Erica Carpenter, MBA, PhD, Department of Medicine
John Wherry, Parker Institute for Cancer Immunotherapy
Mona Kumar, MD, Neurology

Selected Publications

PadrĂ³n LJ, Maurer DM, O'Hara MH, O'Reilly EM, Wolff RA, Wainberg ZA, Ko AH, Fisher G, Rahma O, Lyman JP, Cabanski CR, Yu JX, Pfeiffer SM, Spasic M, Xu J, Gherardini PF, Karakunnel J, Mick R, Alanio C, Byrne KT, Hollmann TJ, Moore JS, Jones DD, Tognetti M, Chen RO, Yang X, Salvador L, Wherry EJ, Dugan U, O'Donnell-Tormey J, Butterfield LH, Hubbard-Lucey VM, Ibrahim R, Fairchild J, Bucktrout S, LaVallee TM, Vonderheide RH. : Sotigalimab and/or nivolumab with chemotherapy in first-line metastatic pancreatic cancer: clinical and immunologic analyses from the randomized phase 2 PRINCE trial Nat.Med. Nature Publishing Group, June 2022 Notes: doi: 10.1038/s41591-022-01829-9 Epub ahead of print.

Habertheuer, Andreas; Ram, Chirag; Schmierer, Maggie; Chatterjee, Shampa; Hu, Robert; Freas, Andrew; Zielinski, Patrick; Rogers, Wade; Silvestro, Eva M; McGrane, Michael; Moore, Jonni S; Korutla, Laxminarayana; Siddiqui, Sarmad; Xin, Yi; Rizi, Rahim; Qin Tao, Jian; Kreisel, Daniel; Naji, Ali; Ochiya, Takahiro; Vallabhajosyula, Prashanth: Circulating Donor Lung-specific Exosome Profiles Enable Noninvasive Monitoring of Acute Rejection in a Rodent Orthotopic Lung Transplantation Model. Transplantation 106 (4): 754-766, 2022.

Moore, J: Howard M. Shapiro: Remembering Cytometry's Muse. Cytometry Part A 99(12): 1169, December 2021 Notes: doi: 10.1002/cyto.a.24515.

Morchauser, A, Yang, Z, Murphy, W, Tian, S, Issadore, D, Moore, J. : Implementation of a single cell double-emulsion droplet assay in a shared resource laboratory. CytoVirtual Interactive 2021 June 2021 Notes: Presented as a video poster at virtual conference.

Jones,D, Schretzenmair, RD, Jakobowski, J, Brake-Silla, N, Peterson, T, Steichen, A, Wu, A, Balderas, R, Moore, J. : Development of a 35-color high parameter immune monitoring panel using a novel spectral cytometer. CytoVirtual Interactive 2021 June 2021 Notes: Video poster at virtual conferences.

Ionita, M, Rogers, W, Schretzenmair, R, Jones, D, Greenplate, A, Moore, J, Wang, L-S.: HitMapper: High throughput mapper for relational analysis of cell states. CytoVirtual Interactive 2021 June 2021 Notes: Presented as a video poster at virtual conference.

Fu W, Ho PC, Liu CL, Tzeng KT, Nayeem N, Moore JS, Wang LS, Chou SY: Reconcile the debate over protective effects of BCG vaccine against COVID-19. Sci Rep 11(1), April 2021 Notes: doi: 10.1038/s41598-021-87731-9.

Ionita M, Jones D, Moore J, Schretenmair R, Wang L-S, Rogers W.: Tailor: Targeting heavy tails in flow cytometry data with fast mixture modeling. Cytometry A 99(2): 133-144, February 2021 Notes: doi: 10.1002/cyto.a.24307.

Rogers W, Ionita M, Moore J: PanoplyCF: A New R Package for Manifold Learning Clustering via Binning. CYTO Virtual 2020 https://learning.isac-net.org/cytovirtual2020 August 2020 Notes: Abstract accepted for poster presentation at CYTO Virtual 2020.

Chislock E, Woodfield G, Graves J, Pan T-C, Pant D, Chen Y, Shih N, Bayne L, Blanchard T, Smith M, Murphy W, Morchauser A, DeMuth W, Pletcher C, Moore J, Yu L, Bornheimer S, , Feldman M, Nayak A, DeMichele A, Chodosh L.: Development of a Flow Cytometry-Based Assay for Clinical Detection and Molecular Characterization of Breast Cancer Disseminated Tumor Cells in Bone Marrow. CYTO Virtual 2020 https://learning.isac-net.org/cytovirtual2020 August 2020 Notes: Abstract selected for oral presentation (by Elisabeth Chislock) at CYTO Virtual 2020.

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Last updated: 06/17/2022
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