Faculty

David A. Hill, MD, PhD, FAAP, FACAAI, FAAAAI

Assistant Professor of Pediatrics

Department: Pediatrics

Graduate Group Affiliations

Contact information

Children's Hospital of Philadelphia
Division of Allergy and Immunology
Department of Pediatrics
Abramson Pediatric Research Center, Room 1208B
3615 Civic Center Blvd.
Philadelphia, PA 19104

Office: 215-590-2549
Fax: 267-426-0363
Lab: 267-426-7777

Publications

Search PubMed for articles

Education:
BS (Biological Sciences, with honors)
Carnegie Mellon University, Elizabeth Jones Lab, 2005.
PhD (Cell and Molecular Biology)
University of Pennsylvania Perelman School of Medicine, David Artis Lab, 2011.
MD (Medicine)
University of Pennsylvania Perelman School of Medicine, 2013.

Links
Search PubMed for articles
Clinical Profile
Lab Website
Research Profile

Permanent link

> Perelman School of Medicine > Faculty > Details

Description of Clinical Expertise

Food allergy, eosinophilic esophagitis, obesity-associated asthma.

Description of Research Expertise

The Hill Lab seeks to understand the causes of allergy and obesity, as well as the immunometabolic overlap between these two highly prevalent conditions. We use the unique approach of letting clinical data guide our mechanistic studies of the innate and adaptive arms of the immune system in transgenic and gene-targeted mice and patient samples. Our goal is to translate our discoveries into the development of novel preventative, diagnostic, and therapeutic approaches for human disease.

Selected Publications

Chini J, McCright S, Hill DA: Hepatic CD9 regulates adipose tissue inflammation and function during obesity. AAP/ASCI/APSA Joint Meeting, Chicago, IL. Apr 2023 Notes: Poster presentation.

Xiao Y, Batmanov K, Hu W, Zhu K, Tom AY, Guan D, Jiang C, Cheng L, McCright SJ, Yang EC, Lanza MR, Liu Y, Hill DA, Lazar MA: Hepatocytes demarcated by EphB2 contribute to the progression of nonalcoholic steatohepatitis. Science Translational Medicine 15(682), Feb 2023.

Gabryszewski SJ, Dudley J, Shu D, Faerber JA, Grundmeier RW, Fiks AG, Spergel JM, Hill DA: Features of pediatric eosinophilic esophagitis in a multi-state electronic health record-based cohort. American Academy of Allergy, Asthma & Immunology Annual Meeting, San Antonio, TX; The Journal of Allergy and Clinical Immunology Feb 2023.

Paneru BD, Chini J, Miller J, Joannas LD, Henao-Mejia J, Tichenell PM, Merrick DM, Lim HW, Lazar M, Hill DA: Macrophage-derived miR-6236 potentiates adipocyte insulin signaling to prevent hyperglycemia during obesity. Midwinter Conference of Immunologists, Asilomar, CA. Jan 2023 Notes: Poster presentation.

Gabryszewski SJ, Dudley JW, Shu D, Faerber JA, Grundmeier RW, Fiks AG, Hill DA: Patterns in the development of pediatric allergy. Pediatrics Pending, 2023.

Capucilli P, Hill DA: Effects of oral immunotherapy on immune tolerance. Annals of Allergy, Asthma & Immunology 129(6): 659-660, Dec 2022.

Vakili S, Paneru B, Guerrier CM, Miller J, Baumrin E, Forrestel A, Lynn K, Frank I, Lo Re V, Collman RG, Hill DA (corresponding): Altered adipose tissue macrophage populations in people with HIV on integrase inhibitor-containing ART. AIDS 36(11): 1493-1500, Sep 2022.

Sterling JK, Baumann B, Foshe S, Voigt A, Guttha S, Alnemri A, McCright SJ, Li M, Zauhar RJ, Montezuma SR, Kapphahn RJ, Chavali VRM, Hill DA, Ferrington DA, Stambolian D, Mullins RF, Merrick D, and Dunaief JL: Inflammatory adipose activates a nutritional immunity pathway leading to retinal dysfunction. Cell Reports 39(11): 110942, Jun 2022.

Spergel BS, Ruffner MA, Godwin B, Liacouras CA, Cianferoni A, Gober L, Hill DA, Brown-Whitehorn TA, Chaiboonma K, Aceves SA, Muir AM, Spergel JM: Improvement in Eosinophilic Esophagitis when using Dupilumab for other Indications or Compassionate Use. Annals of Allergy, Asthma & Immunology 128(5): 589-593, May 2022.

Hill DA: The importance of using core outcome measures during therapeutic studies of eosinophilic esophagitis. The Journal of Allergy and Clinical Immunology 149(2): 541-542, Feb 2022.