Faculty

David A. Hill, MD, PhD, FAAP, FACAAI, FAAAAI

Assistant Professor of Pediatrics (Allergy/Immunology)

Department: Pediatrics

Graduate Group Affiliations

Contact information

Children's Hospital of Philadelphia
Division of Allergy and Immunology
Department of Pediatrics
Abramson Pediatric Research Center, Room 1208B
3615 Civic Center Blvd.
Philadelphia, PA 19104

Office: 215-590-2549
Fax: 215-590-6849
Lab: 267-426-7777

Publications

Search PubMed for articles

Education:
BS (Biological Sciences, with honors)
Carnegie Mellon University, Elizabeth Jones Lab, 2005.
PhD (Cell and Molecular Biology)
University of Pennsylvania School of Medicine, David Artis Lab, 2011.
MD (Medicine)
University of Pennsylvania School of Medicine, 2013.

Links
Search PubMed for articles
Research Profile
Lab Website
Clinical Profile

Permanent link

> Perelman School of Medicine > Faculty > Details

Description of Clinical Expertise

Food allergy, eosinophilic esophagitis, obesity-associated asthma.

Description of Research Expertise

The Hill Lab investigates how diet and metabolism impact immune health and contribute to inflammatory diseases. Our research focuses on key areas such as food allergies, obesity-associated asthma, and immunometabolism. By integrating clinical epidemiology with mechanistic studies in animal models and patient samples, we aim to uncover the underlying mechanisms that drive immune responses. Our goal is to translate these findings into innovative preventative, diagnostic, and therapeutic strategies to improve human health and combat disease.

Selected Publications

Clement RL , Dilollo J, Rodríguez-López EM, Guerrier CM, Hill DA: IFNγ signaling impairs regulatory B cell function resulting in worse control of esophageal food allergy. Allergy May 2025.

Dilollo J, Hu A, Qu H, Canziani KE, Clement RL, McCright SJ, Shreffler WG, Hakonarson H, Spergel JM, Cerosaletti K, Hill DA: A molecular basis for milk allergen immune recognition in eosinophilic esophagitis. Journal of Allergy and Clinical Immunology 155(4): 1396-1399, April 2025.

Harding L, McCright S, Hill DA: Dietary stearate alters lung myeloid cell metabolism and causes inflammasome-dependent IL-1β cytokine production. American Academy of Allergy, Asthma & Immunology Annual Meeting Annual Meeting Discovery Session. San Deigo, CA. Feb 2025.

Clement R, Hill DA: IFNү promotes Treg-derived TGFβ production which exacerbates eosinophilic esophagitis. American Academy of Allergy, Asthma & Immunology Annual Meeting Annual Meeting Discovery Session. San Deigo, CA. Feb 2025.

Dilollo J, Hu A, Qu H, Canziani KE, Clement RL, McCright SJ, Shreffler WG, Hakonarson H, Spergel JM, Cerosaletti K, Hill DA: Characterization of a circulating milk-specific TCR clonotype in a child with EoE milk allergy. American Academy of Allergy, Asthma & Immunology Annual Meeting Annual Meeting. San Deigo, CA; The Journal of Allergy and Clinical Immunology 155(2): AB33, Feb 2025 Notes: Poster presentation.

Wolfset N, Muir AB, Benitez A, Williams D, Torre IDL, Ruffner MA, Hill DA, Cazeau C, Angello JT, Radwan A, Durrani S, DeMarchi S, Spergel JM: Efficacy of dupilumab on facilitated food reintroduction in eosinophilic esophagitis. Clinical Gastroenterology and Hepatology Accepted 2025.

Gabryszewski SJ, Dudley J, Faerber JA, Grundmeier RW, Fiks AG, Spergel JM, Hill DA: Guidelines for early food introduction and patterns of food allergy. Pediatrics Accepted 2025.

McCright SJ, Harding O, ChiniJ, DeMarco N, Hung LY, Pastore C, Lu W, Rabinowitz J, Henao-Mejia J, Herbert DR, Young LR, Hill DA: Dietary long chain fatty acids shape innate immune cell tone and modulate inflammatory responses in the lung. Science Translational Medicine Accepted 2025.

Dilollo J, Hu A, Qu H, Canziani KE, Clement RL, McCright SJ, Shreffler WG, Hakonarson H, Spergel JM, Cerosaletti K, Hill DA: Companion to: A molecular basis for milk allergen immune recognition in eosinophilic esophagitis. bioRxiv Nov 2024. Notes: This is a supplement to Dilollo et al, JACI 2025 that contains non-redundant data that supports the conclusions of the parent manuscript.

Betancourt A, Harding O, Hill DA: Effects of Dietary Saturated Fatty Acid on Macrophage Metabolism. Annual Biomedical Research Conference for Minoritized Scientists (ABRCMS). Pittsburgh, PA. Nov 2024.