Faculty
Robert Bradley Lindell, MD
Assistant Professor of Anesthesiology and Critical Care at the Hospital of the University of Pennsylvania and the Children's Hospital of Philadelphia
Department: Anesthesiology and Critical Care
Graduate Group Affiliations
Contact information
Children’s Hospital of Philadelphia
Department of Anesthesiology and Critical Care Medicine
3401 Civic Center Boulevard
Philadelphia, PA 19104
Department of Anesthesiology and Critical Care Medicine
3401 Civic Center Boulevard
Philadelphia, PA 19104
Email:
LindellR@chop.edu
LindellR@chop.edu
Publications
Education:
BS (Microbiology)
University of Georgia, 2007.
AB (Religion)
University of Georgia, 2007.
MD (Medicine)
Vanderbilt University School of Medicine, 2012.
Permanent linkBS (Microbiology)
University of Georgia, 2007.
AB (Religion)
University of Georgia, 2007.
MD (Medicine)
Vanderbilt University School of Medicine, 2012.
Description of Clinical Expertise
As a pediatric intensivist, I care for critically ill children with sepsis, multiple organ dysfunction, respiratory failure, and other complex forms of critical illness. I have particular clinical expertise in pediatric sepsis, cytokine storm syndromes, critical illness in immunocompromised children, and organ support technologies such as extracorporeal membrane oxygenation (ECMO) and therapeutic plasma exchange. I also serve as a clinical resource for evaluating patients with immune dysregulation as a member of the Dysregulated Immune Response Team.Description of Research Expertise
I lead a translational research program focused on precision immunology in pediatric sepsis and multiple organ dysfunction syndrome (MODS). My work integrates plasma proteomics, high-dimensional immune phenotyping, phospho-flow cytometry, single-cell transcriptomics, and host genomics to define biologically distinct sepsis endotypes, identify treatable immune dysregulation, and develop rapid biomarker-based approaches for risk stratification and targeted immunomodulation. Learn more at LindellLab.org.Selected Publications
Hay CA, Sayed SU, Espinoza DA, Knight M, Abrams ED, Campos Duran JS, Nagy MZ, Nelson MA, Sheetz SA, Gunnala P, Gonzalez ENM, Beers J, Tewksbury C, Collins JL, Williams NN, Lindell RB, Ruffner MA, Behrens EM, Dumon KR, Parks Prout E, Henao-Mejia J, Henrickson SE: T cell dysregulation and remodeling in pediatric obesity and weight loss. bioRxiv May 2026.Chau JE, Arroyo T, Babu A, Sheetz SA, Famularo ST, Ham SD, Fitzgerald JC, Henrickson SE, Meyer NJ, Lindell RB.: Distinct proteomic signatures of hematologic and hepatic dysfunction define divergent pathobiology in pediatric MODS. Pediatric Academic Societies Annual Meeting April 2026 Notes: Oral Presentation.
Chau JE, Arroyo T, Babu A, Sheetz SA, Famularo ST, Ham SD, Fitzgerald JC, Henrickson SE, Meyer NJ, Lindell RB.: Proteomic trajectories differentiate rapid recovery and protracted organ dysfunction phenotypes in pediatric MODS. Pediatric Academic Societies Annual Meeting April 2026 Notes: Oral Presentation.
Diorio C, Myers RM, Li Y, Liu H, Belfer S, DiNofia A, Barz Leahy A, Newman H, Dolan J, Martinez Z, Elhachimi A, Lindell RB, Mullen C, Li A, Kim J, Teachey DT, Maude SL, Grupp SA, McGuire JL.: Preinfusion risk factors for the development of severe neurotoxicity following CART therapy in pediatric patients. HemaSphere 10(4): e70337, April 2026.
Ham SD, Fitzgerald JC, Lindell RB.: Pediatric Sepsis: Evolving Subphenotypes, Overlap Syndromes, and the Path to Precision Therapies. Clin Chest Med 47(1): 57-66, March 2026.
Demopoulos A, Weber MD, Liu H, Traynor D, Sayed S, Famularo ST, Arroyo T, Conlon T, Henrickson SE, Lindell RB.: Arterial Catheter-Associated Proximal Ischemic Injury in Critically Ill Children: Evidence of Endothelial Dysfunction and Immune Dysregulation. Pediatr Crit Care Med March 2026 Notes: Epub ahead of print, Mar 13, 2026.
Ham SD, Sheetz SA, Famularo ST, Arroyo T, Fitzgerald JC, Lindell RB.: Pediatric TAMOF Has a Distinct Immuno-Coagulopathic Plasma Proteomic Signature. Society of Critical Care Medicine Annual Congress March 2026 Notes: Star Research Presentation.
Campos JS, Sayed S, Dalalo MC, Mauracher AA, Knight MS, Conrey PE, Schultz AB, Hay CA, Lindell RB, Howard CA, Abrams ED, Schmitt EG, Thelin M, Bluestein S, Canna SW, Su HC, Keller MD, Delmonte OM, Forbes Satter LR, Holland SM, Bergerson JRE, Leiding JW, Romberg ND, Freeman AF, Villarino AV, Anderson MS, Cooper MA, Vogel TP, Henrickson SE.: Altered Purinergic Signaling and CD8+ T Cell Dysregulation in STAT3 GOF Syndrome. JCI Insight 2026 Notes: IN PRESS.
Lindell RB, Sayed S, Campos JS, Sheetz SA, Babu A, Knight MS, Mauracher AA, Hay CA, Conrey PE, Fitzgerald JC, Yehya N, Famularo ST, Arroyo T, Tustin R, Fazelinia H, Behrens EM, Teachey DT, Forbes Satter LR, Freeman AF, Bergerson JRE, Holland SM, Leiding JW, Weiss SL, Hall MW, Taylor DM, Feng R, Wherry EJ, Meyer NJ, Henrickson SE.: Aberrant STAT signaling and T cell dysregulation define a targetable pediatric sepsis endotype. J Clin Invest 2026 Notes: IN PRESS.
Alcamo AM, Lindell RB, Sheetz SA, Ham SD, Strayer A, Weiss SL, Nishisaki A, Pinto NP, Topjian AA, Fitzgerald JC.: New sepsis-associated morbidity and mortality in pediatric oncology patients. Front Oncol 15: 1638516, August 2025.
© The Trustees of the University of Pennsylvania | Site best viewed in a supported browser. | Site Design: PMACS Web Team.