Faculty

Robert Bradley Lindell, MD

Assistant Professor of Anesthesiology and Critical Care at the Hospital of the University of Pennsylvania and the Children's Hospital of Philadelphia

Department: Anesthesiology and Critical Care

Graduate Group Affiliations

Immunology

Contact information

Children’s Hospital of Philadelphia
Department of Anesthesiology and Critical Care Medicine
3401 Civic Center Boulevard
Philadelphia, PA 19104

Email:
LindellR@chop.edu

Publications

Search PubMed for articles

Education:
BA (Religion)
University of Georgia, 2007.
BS (Microbiology)
University of Georgia, 2007.
MD (Medicine)
Vanderbilt University School of Medicine, 2012.

Links
Search PubMed for articles
Laboratory website

Permanent link

> Perelman School of Medicine > Faculty > Details

Description of Clinical Expertise

As a pediatric intensivist, I provide care for critically ill children across a broad range of diagnoses. I have specific clinical expertise in managing sepsis, cytokine storm syndromes, and organ support technologies such as extracorporeal membrane oxygenation (ECMO) and therapeutic plasma exchange. I also serve as a clinical resource for evaluating patients with immune dysregulation as a member of the Dysregulated Immune Response Team.

Description of Research Expertise

I lead a translational research program focused on the immunobiology of pediatric sepsis and multi-organ dysfunction syndrome (MODS). My work integrates high-dimensional immune profiling—including proteomics, phospho-flow cytometry, and single-cell RNA sequencing—to identify immune endotypes that inform risk stratification and targeted therapies. Learn more at LindellLab.org.

Selected Publications

Ham SD, Famularo ST, Arroyo T, Fitzgerald JC, Lindell RB: Defining thrombocytopenia-associated multiple organ dysfunction in the plasma proteome. Shock Society 2025 Annual Conference on Shock June 2025.

Sheetz SA, Sayed S, Campos JS, Arroyo T, Famularo ST, Meyer NJ, Henrickson SE, Lindell RB: Dysregulated STAT3 phosphorylation and CD8+ T cell activation in hyperinflammatory pediatric sepsis. Shock Society 2025 Annual Conference on Shock June 2025.

Shraim R, Diorio C, Canna SW, Macdonald-Dunlop E, Bassiri H, Martinez Z, Mälarstig A, Abbaspour A, Teachey DT, Lindell RB, Behrens EM: A Method for Comparing Proteins Measured in Serum and Plasma by Olink® Proximity Extension Assay. Mol Cell Proteomics May 2025 Notes: In Press.

Lindell RB, Sayed S, Campos JS, Sheetz SA, Babu A, Knight MS, Mauracher AA, Hay CA, Conrey PE, Fitzgerald JC, Yehya N, Famularo ST, Arroyo T, Tustin R, Fazelinia H, Behrens EM, Teachey DT, Freeman AF, Bergerson JRE, Holland SM, Leiding JW, Weiss SL, Hall MW, Taylor D, Feng R, Wherry EJ, Meyer NJ, Henrickson SE: Aberrant STAT signaling drives T cell dysregulation in a targetable pediatric sepsis endotype. medRxiv May 2025 Notes: In Press.

Ham SD, Shraim R, Diorio C, Babu A, Behrens EM, Henrickson SE, Lindell RB: Proteomic profiling identifies shared inflammatory pathways in pediatric sepsis, MIS-C, and cytokine release syndrome. American Thoracic Society 2025 International Conference May 2025.

Ham SD, Famularo ST, Arroyo T, Fitzgerald JC, Lindell RB: Defining thrombocytopenia-associated multiple organ dysfunction in the plasma proteome. CHOP Research Institute Scientific Symposium May 2025.

Arroyo T, Kirchner V, Sheetz SA, Dickey S, Alcamo AM, Lindell RB: Computational Screening for Pediatric Sepsis using the Phoenix Sepsis Score. CHOP Research Institute Scientific Symposium May 2025.

Sheetz SA, Sayed S, Campos JS, Babu A, Arroyo T, Famularo ST, Meyer NJ, Henrickson SE, Lindell RB: Functional Deficits in STAT3 Phosphorylation and Cytokine Signaling in CD8+ T Cells from Children with Sepsis. CHOP Research Institute Scientific Symposium May 2025.

Lindell RB, Sayed S, Campos JS, Babu A, Ham SD, Sheetz SA, Famularo ST, Arroyo T, Fitzgerald JC, Yehya N, Weiss SL, Hall MW, Wherry EJ, Meyer NJ, Henrickson SE: Defining a new pediatric sepsis endotype associated with bystander T cell activation, dysregulated STAT3 signaling, and poor prognosis. American Thoracic Society 2025 International Conference May 2025.

Sheetz SA, Sayed S, Campos JS, Babu A, Arroyo T, Famularo ST, Meyer NJ, Henrickson SE, Lindell RB: Dysregulated T cell cytokine responses characterize a high-risk pediatric sepsis subphenotype. Clinical Immunology Society 2025 Annual Meeting May 2025.