Faculty

Robert Lyle Bowman, Ph.D.

Assistant Professor of Cancer Biology

Department: Cancer Biology

Graduate Group Affiliations

Contact information

421 Curie Blvd
Philadelphia, PA 19104

Email:
robert.bowman@pennmedicine.upenn.edu

Education:
BA (Molecular Cellular Biology Honors)
Vanderbilt University, 2010.
PhD (Cancer Biology (Mentor: Johanna Joyce))
Gerstner Sloan Kettering Graduate Program, 2016.

Permanent link

> Perelman School of Medicine > Faculty > Details

Selected Publications

Dunbar A, Kim D, Lu M, Farina M, Bowman RL, Yang JL, Park YC, Karzai A, Xiao W, Zaroogian Z, O'Connor K, Mowla S, Gobbo F, Verachi P, Martelli F, Sarli G, Xia L, Elmansy N, Kleppe M, Chen Z, Xiao Y, McGovern EM, Snyder J, Krishnan A, Hill CE, Cordner KB, Zouak A, Salama ME, Yohai J, Tucker E, Chen JJ, Zhou J, McConnell TS, Migliaccio AR, Koche RP, Rampal RK, Fan R, Levine RL, Hoffman R: CXCL8/CXCR2 signaling mediates bone marrow fibrosis and represents a therapeutic target in myelofibrosis. Blood 2023 Notes: Epub ahead of print.

Stahl M, Derkach A, Farnoud N, Bewersdorf JP, Robinson T, Famulare C, Cho C, Devlin S, Menghrajani K, Patel MA, Cai SF, Miles LA, Bowman RL, Geyer MB, Dunbar A, Epstein-Peterson ZD, McGovern E, Schulman J, Glass JL, Taylor J, Viny AD, Stein EM, Getta B, Arcila ME, Gao Q, Barker J, Shaffer BC, Papadopoulos EB, Gyurkocza B, Perales MA, Abdel-Wahab O, Levine RL, Giralt SA, Zhang Y, Xiao W, Pai N, Papaemmanuil E, Tallman MS, Roshal M, Goldberg AD: Molecular predictors of immunophenotypic measurable residual disease clearance in acute myeloid leukemia. American Journal of Hematology 98(1): 79-89, 2023 Notes: DOI: 10.1002/ajh.26757.

Schwede R, Jahn K, Miles LA, Bowman RL, Kuipers J, Robinson TM, Ediriwickrema A, Gentles AJ, Levine R, Beerenwinkel N, Takahashi K, Majeti R: Characterizing the order of mutation acquisition in acute myeloid leukemia using large-scale single-cell sequencing Proceedings of the AACR Special Conference: Acute Myeloid Leukemia and Myelodysplastic Syndrome 2023.

Xu JJ, Alija B, Braunstein S, Pantazi J, Sudunagunta VS, Bowman RL, Viny AD: Cohesin Dependency in Npm1c/+ and Flt3-ITD Mutant Hematopoietic Stem and Progenitor Cells. Blood 140 2022.

Andrew Dunbar, Robert L Bowman, Young Park, Franco Izzo, Robert M Myers, Abdul Karzai, Won Jun Kim, Inés Fernández Maestre, Michael R Waarts, Abbas Nazir, Wenbin Xiao, Max Brodsky, Mirko Farina, Louise Cai, Sheng F Cai, Benjamin Wang, Wenbin An, Julie Yang, Shoron Mowla, Shira E Eisman, Tanmay Mishra, Remie Houston, Emily Guzzardi, Anthony R Martinez Benitez, Aaron D Viny, Richard Koche, Dan A Landau, Ross L Levine: Jak2V617F Reversible Activation Shows an Essential Requirement for Jak2V617F in Myeloproliferative Neoplasms (MPNs). Blood 140 2022.

Robinson T, Bowman RL, Persaud S, Liu Y, Gao Q, Zhang JP, Sun X, Sciambi A, Llanso A, Famulare X: Single cell genotypic and phenotypic analysis of measurable residual disease in acute myeloid leukemia. Blood 140 2022.

Bowman RL, Hennessey RC, Weiss TJ, Tallman DA, Crawford ER, Murphy BM, Webb A, Zhang S, La Perle KM, Burd CJ, Levine RL, Shain AH, Burd CE.: UVB mutagenesis differs in Nras- and Braf-mutant mouse models of melanoma. Life Science Alliance 4(9), 2021 Notes: DOI: 10.26508/lsa.202101135.

Xiao W, Chan A, Waarts MR, Mishra T, Liu Y, Cai SF, Yao J, Gao Q, Bowman RL, Koche RP, Csete IS, DelGaudio NL, Derkach A, Baik J, Yanis S, Famulare CA, Patel M, Arcila ME, Stahl M, Rampal RK, Tallman MS, Zhang Y, Dogan A, Goldberg AD, Roshal M, Levine RL.: Plasmacytoid dendritic cell expansion defines a distinct subset of RUNX1-mutated acute myeloid leukemia Blood Page: 1377-1391, 2021.

Klemm F, Möckl A, Salamero-Boix A, Alekseeva T, Schäffer A, Schulz M, Niesel K, Maas RR, Groth M, Elie BT, Bowman RL, Hegi ME, Daniel RT, Zeiner PS, Zinke J, Harter PN, Plate KH, Joyce JA, Sevenich L.: Compensatory CSF2-driven macrophage activation promotes adaptive resistance to CSF1R inhibition in breast-to-brain metastasis. Nature Cancer 2(10), 2021 Notes: DOI: 10.1038/s43018-021-00254-0.

Maas RR, Soukup K, Klemm F, Kornete M, Bowman RL, Bedel R, Marie DN, Álvarez-Prado ÁF, Labes D, Wilson A, Brouland JP, Daniel RT, Hegi ME, Joyce JA.: An integrated pipeline for comprehensive analysis of immune cells in human brain tumor clinical samples. Nature Protocols 16(10): 4692-4721, 2021 Notes: DOI: 10.1038/s41596-021-00594-2.