Faculty

32 1a 2a

61 16

Shaon Sengupta, MBBS, MPH, FAAP

Assistant Professor of Pediatrics (Neonatology & Newborn Services)

7 61

Department: Pediatrics

4 1 23

1f Graduate Group Affiliations 8

46 Contact information
51

Children's Hospital of Philadelphia
20 Abramson Research Center
17 3615 Curie Blvd
15 Office: 1102C
2c Lab 1103
Philadelphia, PA 19104

2e Office: 267-426-6628
32 Fax: 215-590-4267
24

4 3 3 3 2 4 b 1f

13 Education:
21 a MBBS c
5f All India Institute of Medical Sciences, India (Medicine and Surgery) , 2006.
21 9 MPH c
66 Johns Hopkins Bloomberg School of Public Health (Epidemiology and Statistics), 2008.
c

3 27

Links
5c Twitter website
c

5 3 3 92 Permanent link
2 29

d1 SOM Home » BGS Home » NGG Home » Faculty a

1e 1d

Description of Research Expertise

78 Circadian biology, Lung inflammation, Neonatal lung injury, Influenza, Lung regeneration, Lung organoids
e 29

Selected Publications

130 Forrest KM, Towers ME, Paul O, Cho H, Padmini MV, Naik A, Lim HK, Issah Y, Tang SY, Deshmukh HS, Abt MC, Hudock KM, Eisenlohr LC, Grant GR, Brooks TG, Sengupta S.: Role of IL-10 signaling in the circadian control of host response to influenza infection. 2 37 Mucosal Immunol. 20, Nov 2025.

143 Paul O, Brooks TG, Assi L, Shetty A, Towers M, Forrest KM, Cameron A, Sehgal A, Grant GR, Sengupta S.: Effect of external cues on clock-driven protection from Influenza A infection. JCI Page: In press, Nov 2025 Notes: doi: 10.1101/2025.03.03.641279.

155 Sengupta S*, Lee Y, Tao JQ, Akolia I, Louneva N, Forrest K, Paul O, Brooks TG, Grant GR, Sehgal A, Chatterjee S*: Circadian Control of Pulmonary Endothelial Signaling occurs via NADPH oxidase 2-NLRP3 pathway. J Biol Rhythms 40(6): doi: 10.1177, September 2025 Notes: epub ahead of print 2f *- co-corresponding author.

16f Stevens J, Culberson E, Kinder J, Ramiriqui A, Gray J, Bonfield M, Shao TY, Al Gharaibeh F, Peterson L, Steinmeyer S, Eshleman EM, Negi S, Zacharias W, Pryhuber G, Paul O, Sengupta S, Alenghat T, Way SS, Deshmukh H.: Microbiota-derived inosine programs protective CD8+ T cell responses against influenza in newborns. 3e Cell 188(16): 4239-4256, August 2025.

fb Sengupta S, Smith DF, Koritala BSC: Circadian Rhythms, Immune Regulation, and the Risk for Sepsis: Circadian Rhythms and Neonatal Care. Clin Perinatol 52(1): 185-197, March 2025.

124 Brooks TG, Lahens NF, Mrčela A, Yang J, Purohit S, Naik A, Ricciotti E, Sengupta S, Choi PS, Grant GR: Sources of non-uniform coverage in short-read RNA-Seq data. bioRxiv Feb 2025 Notes: doi: 10.1101/2025.01.30.634337.

129 Musa AO, Faber SR, Forrest K, Smith KP, Sengupta S, López CB: Identification of distinct genotypes in circulating RSV A strains based on variants in the virus replication-associated genes. J Virol 98(8): e0099024, Aug 2024.

15f Thomas Brooks , Nicholas Lahens , Antonijo Mrčela , Dimitra Sarantopoulou , Soumyashant Nayak , Amruta Naik , Shaon Sengupta , Peter Choi, G.R. Grant: BEERS2: RNA-Seq simulation through high fidelity in silico modeling. bioRxiv April 2024 Notes: doi: 10.1101/2023.04.21.537847.

17d Naik A, Forrest K, Paul O, Issah Y, Valekunja UK, Tang SY, Reddy AB, Hennessy E, Brooks TS, Chaudhry F, Babu A, Morley M, Zepp JA, Grant GR, FitzGerald GA, Sehgal A, Worthen GS, Frank DB, Morrisey EE, Sengupta S.: Circadian regulation of lung repair and regeneration. JCI Insight 8(16): e164720, August 2023.

141 Cox SL, O’Siorain JR, He Y, Lordan R, Naik A, Tang SY, Sengupta S, FitzGerald GA, Carroll RG, Curtis AM: Circadian disruption in lung fibroblasts enhances NF-κB activity to exacerbate neutrophil recruitment. FASEB J 37(2): e22753, February 2023.

2c

7 1d

2c back to top
26 Last updated: 11/25/2025
34 The Trustees of the University of Pennsylvania c

1 49 2 2 1a 32 34