Faculty

Jorge Ivan Alvarez, PhD

faculty photo
Assistant Professor of Pathobiology
Department: Pathobiology
Graduate Group Affiliations

Contact information
380 South University Avenue
H412
Philadelphia, PA 19104
Education:
BSc (Microbiology)
Universidad de los Andes, 1997.
PhD (Microbiology and Immunology)
UTHSCSA, 2007.
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Description of Research Expertise

The Alvarez lab aims to define how CNS-intrinsic signals modulate immune cell function within different neurovascular niches. Upon infection or injury, the concerted actions of both systems create a balance between immune attack and tissue repair to promote healing. Nonetheless, during disease these protective mechanisms can be inadequate or aberrant, leading to persistent inflammation and long-term sequelae. As the first line of defense against chemicals and blood-borne molecules, the CNS barriers shield the delicate CNS microenvironment from the constant fluctuations of the periphery. They are composed of the blood-brain barrier (BBB) and the blood-meningeal barrier (BMB). However, their roles during neuroinflammation remain poorly characterized. Thus, my research program has been built to identify the mechanisms regulating the immune and neurovascular interactions initiating at the level of the CNS barriers and progressing to the perivascular space into the brain parenchyma. Currently, we use a combination of ex-vivo, in vitro, in vivo, and post-mortem approaches to determine the neurovascular mechanisms supporting the pathogenesis of neuroinflammatory diseases like multiple sclerosis (MS) and neuropsychiatric disorders.


Selected Publications

Crockett, A. M., Kebir, H., Anderson, S. A., Jyonouchi, S., Romberg, N., Alvarez, J. I.: 22q11.2 Deletion-Associated Blood-Brain Barrier Permeability Potentiates Systemic Capillary Leak Syndrome Neurologic Features. 44(4): 87, 2024.

Crockett, A. M., Kebir, H., Benallegue, N., Adelman, P., Gur, R. E., Sullivan, K., Anderson, S. A., Alvarez, J. I.: Immune status of the murine 22q11.2 deletion syndrome model. 53(1): e2249840, 2023.

Linnerbauer, M., Beyer, T., Nirschl, L., Farrenkopf, D., Lößlein, L., Vandrey, O., Peter, A., Tsaktanis, T., Kebir, H., Laplaud, D., Oellinger, R., Engleitner, T., Alvarez, J. I., Rad, R., Korn, T., Hemmer, B., Quintana, F. J., Rothhammer, V.: PD-L1 positive astrocytes attenuate inflammatory functions of PD-1 positive microglia in models of autoimmune neuroinflammation. 14(1): 5555, 2023.

Li, C., Niu, C., Bi, H., Zhao, J., Ivan Alvarez, J., Yuan, F., Gai, X., Wei, L., Du, Y., Qiao, Y., Kebir, H., Xiao, Y., Yang, H.: Tibetan mineral-herbal medicine Zuotai alleviates the depressive-like behaviors in chronic restraint-stressed mice while regulating stress hormone, inflammation and monoamine. 14: 1098378, 2023.

Benallegue, N., Kebir, H., Alvarez, J. I.: Neuroinflammation: Extinguishing a blaze of T cells. 311(1): 151-176, 2022.

Koronyo-Hamaoui, M., Gaire, B. P., Frautschy, S. A., Alvarez, J. I.: Editorial: Role of Inflammation in Neurodegenerative Diseases. 13: 958487, 2022.

Fournier, A. P., Zandee, S., Charabati, M., Peelen, E., Tastet, O., Alvarez, J. I., Kebir, H., Bourbonnière, L., Larouche, S., Lahav, B., Klement, W., Tea, F., Bouthillier, A., Moumdjian, R., Cayrol, R., Duquette, P., Girard, M., Larochelle, C., Arbour, N., Prat, A.: CLMP Promotes Leukocyte Migration Across Brain Barriers in Multiple Sclerosis. 9(6), 2022.

Benallegue, N., Kebir, H., Kapoor, R., Crockett, A., Li, C., Cheslow, L., Abdel-Hakeem, M. S., Gesualdi, J., Miller, M. C., Wherry, E. J., Church, M. E., Blanco, M. A., Alvarez, J. I.: The hedgehog pathway suppresses neuropathogenesis in CD4 T cell-driven inflammation. 144(6): 1670-1683, 2021.

Crockett, A. M., Ryan, S. K., Vásquez, A. H., Canning, C., Kanyuch, N., Kebir, H., Ceja, G., Gesualdi, J., Zackai, E., McDonald-McGinn, D., Viaene, A., Kapoor, R., Benallegue, N., Gur, R., Anderson, S. A., Alvarez, J. I.: Disruption of the blood-brain barrier in 22q11.2 deletion syndrome. 144(5): 1351-1360, 2021.

Church, M. E., Ceja, G., McGeehan, M., Miller, M. C., Farias, P., Sánchez, M. D., Swain, G. P., Assenmacher, C. A., Stopa, E. G., Vite, C. H., Bar-Or, A., Alvarez, J. I.: Meningeal B Cell Clusters Correlate with Submeningeal Pathology in a Natural Model of Multiple Sclerosis. 207(1): 44-54, 2021.

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Last updated: 07/01/2024
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