Guo-li Ming, M.D., Ph.D.

faculty photo
Perelman Professor of Neuroscience
Department: Neuroscience
Graduate Group Affiliations

Contact information
Perelman School of Medicine
Department of Neuroscience
415 Curie Blvd
Clinical Research Building room 111A
Philadelphia, PA 19104
Office: 2157466686
M.D. (Medicine (OBGYN))
Tongji Medical University, P. R. China, 1994.
Ph.D. (Biology)
University of California at San Diego, California, 2002.
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Description of Research Expertise

Neurobiology of mental disorders
Neural development
human induced pluripotent stem cells
cell signalling
cell and molecular biology

Research in Dr. Guo-li Ming's laboratory centers on understanding molecular mechanisms underlying neurodevelopment and how its dysregulation may contribute to developmental neurological disorders. The lab uses a combination of experimental approaches that include molecular biology, biochemistry, mouse genetics, imaging, electrophysiology, electron microscopy, optogenetic manipulations, next generation sequencing, and behavioral tests to study neural development. We have been using two complementary model systems, the genetically modified mouse system and patient-derived induced pluripotent stem cell (iPSC) model systems. We are interested in addressing a broad range of topics, from neuronal migration, axon and dendritic development, synapse formation, circuitry integration to plasticity of developing neurons, and functional regeneration of mature neurons.

Selected Publications

Zhou Y, Su Y, Li S, Kennedy BC, Zhang DY, Bond AM, Sun Y, Jacob F, Lu L, Hu P, Viaene AN, Helbig I, Kessler SK, Lucas T, Salinas RD, Gu X, Chen HI, Wu H, Kleinman JE, Hyde TM, Nauen DW, Weinberger DR, Ming GL, Song H.: Molecular landscapes of human hippocampal immature neurons across lifespan. Nature 2022.

Huang WK, Wong SZH, Pather SR, Nguyen PTT, Zhang F, Zhang DY, Zhang Z, Lu L, Fang W, Chen L, Fernandes A, Su Y, Song H, Ming GL.: Generation of hypothalamic arcuate organoids from human induced pluripotent stem cells. Cell Stem Cell 28: 1657-1670, Sep 2021.

Kim NS, Wen Z, Liu J, Zhou Y, Guo Z, Xu C, Lin YT, Yoon KJ, Park J, Cho M, Kim M, Wang X, Yu H, Sakamuru S, Christian KM, Hsu KS, Xia M, Li W, Ross CA, Margolis RL, Lu XY, Song H, Ming GL.: Pharmacological rescue in patient iPSC and mouse models with a rare DISC1 mutation. Nat Commun 12: 1398, Mar 2021.

Jacob F, Pather SR, Huang WK, Zhang F, Wong SZH, Zhou H, Cubitt B, Fan W, Chen CZ, Xu M, Pradhan M, Zhang DY, Zheng W, Bang AG, Song H, Carlos de la Torre J, Ming GL.: Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism Predominates in Choroid Plexus Epithelium. Cell Stem Cell 27: 937-950, Dec 2020.

Qian X, Su Y, Adam CD, Deutschmann AU, Pather SR, Goldberg EM, Su K, Li S, Lu L, Jacob F, Nguyen PTT, Huh S, Hoke A, Swinford-Jackson SE, Wen Z, Gu X, Pierce RC, Wu H, Briand LA, Chen HI, Wolf JA, Song H, Ming GL.: Sliced Human Cortical Organoids for Modeling Distinct Cortical Layer Formation. Cell Stem Cell 26: 766-781, May 2020.

Jacob F, Salinas RD, Zhang DY, Nguyen PTT, Schnoll JG, Wong SZH, Thokala R, Sheikh S, Saxena D, Prokop S, Liu DA, Qian X, Petrov D, Lucas T, Chen HI, Dorsey JF, Christian KM, Binder ZA, Nasrallah M, Brem S, O'Rourke DM, Ming GL, Song H.: A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intra-tumoral Heterogeneity. Cell 180: 188-204, Jan 2020.

Oh Yohan, Zhang Feiran, Wang Yaqing, Lee Emily M, Choi In Young, Lim Hotae, Mirakhori Fahimeh, Li Ronghua, Huang Luoxiu, Xu Tianlei, Wu Hao, Li Cui, Qin Cheng-Feng, Wen Zhexing, Wu Qing-Feng, Tang Hengli, Xu Zhiheng, Jin Peng, Song Hongjun, Ming Guo-Li, Lee Gabsang: Zika virus directly infects peripheral neurons and induces cell death. Nature neuroscience Jul 2017.

Kang Eunchai, Jiang Danye, Ryu Yun Kyoung, Lim Sanghee, Kwak Minhye, Gray Christy D, Xu Michael, Choi Jun H, Junn Sue, Kim Jieun, Xu Jing, Schaefer Michele, Johns Roger A, Song Hongjun, Ming Guo-Li, Mintz C David: Early postnatal exposure to isoflurane causes cognitive deficits and disrupts development of newborn hippocampal neurons via activation of the mTOR pathway. PLoS biology 15(7): e2001246, Jul 2017.

Ming Guo-Li, Song Hongjun, Tang Hengli: Racing to Uncover the Link between Zika Virus and Microcephaly. Cell stem cell 20(6): 749-753, Jun 2017.

Wen Zhexing, Song Hongjun, Ming Guo-Li: How does Zika virus cause microcephaly? Genes & development 31(9): 849-861, May 2017.

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Last updated: 08/29/2023
The Trustees of the University of Pennsylvania