Faculty

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Michael S. Haney, Ph.D.

Assistant Professor of Pathology and Laboratory Medicine

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Department: Pathology and Laboratory Medicine

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1f Graduate Group Affiliations 8

46 Contact information
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Department of Pathology and Laboratory Medicine
23 University of Pennsylvania
4b Stellar - Chance Laboratories, 6th Floor
Philadelphia, PA 19104

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13 Education:
21 9 B.A. 36 (Molecular and Cell Biology (Neurobiology)) c
3b University of California, Berkeley, 2010.
21 a Ph.D. 15 (Genetics) c
3f Stanford University School of Medicine, 2018.
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Links
4e Lab website
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5 3 3 92 Permanent link
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Description of Research Expertise

63 Research Interests: Role of microglia in neurodegenerative disease and brain aging
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70 Keywords: microglia, alzheimer's disease, neuroimmunology, neurodegeneration, aging, functional genomics
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1b5 Research Summary: The Haney lab investigates the cellular mechanisms by which microglia and peripheral immune cells damage or support neuronal function in neurodegenerative disease and aging. Approaches we use in the lab are in vivo CRISPR screens in mouse models of aging and neurodegeneration, CRISPR screens in iPSC derived microglia and neurons, transcriptomic and epigenetic measurements, and cellular/biochemical assays.
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2e Personal lab webpage: www.haneylab.org/
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Selected Publications

1e1 Haney MS, Pálovics R, Munson CN, Long C, Johansson PK, Yip O, Dong W, Rawat E, West E, Schlachetzki JCM, Tsai A, Guldner IH, Lamichhane BS, Smith A, Schaum N, Calcuttawala K, Shin A, Wang YH, Wang C, Koutsodendris N, Serrano GE, Beach TG, Reiman EM, Glass CK, Abu-Remaileh M, Enejder A, Huang Y, Wyss-Coray T: APOE4/4 is linked to damaging lipid droplets in Alzheimer's disease microglia. Nature March 2024.

3bb John V Pluvinage, Thomas Ngo, Camille Fouassier, Maura McDonagh, Brandon B Holmes, Christopher M Bartley, Sravani Kondapavulur, Charlotte Hurabielle, Aaron Bodansky, Vincent Pai, Sam Hinman, Ava Aslanpour, Bonny D Alvarenga, Kelsey C Zorn, Colin Zamecnik, Adrian McCann, Andoni I Asencor, Trung Huynh, Weston Browne, Asritha Tubati, Michael S Haney, Vanja C Douglas, Martineau Louine, Bruce AC Cree, Stephen L Hauser, William Seeley, Sergio E Baranzini, James A Wells, Serena Spudich, Shelli Farhadian, Prashanth S Ramachandran, Leslie Gillum, Chadwick M Hales, Julie Zikherman, Mark S Anderson, Jinoos Yazdany, Bryan Smith, Avindra Nath, Gina Suh, Eoin P Flanagan, Ari J Green, Ralph Green, Jeffrey M Gelfand, Joseph L DeRisi, Samuel J Pleasure, Michael R Wilson: Transcobalamin receptor antibodies in autoimmune vitamin B12 central deficiency. Science translational medicine 2024.

2df Hamilton Oh, Jarod Rutledge, Daniel Nachun, Róbert Pálovics, Olamide Abiose, Patricia Moran-Losada, Divya Channappa, Deniz Urey, Kate Kim, Yun Ju Sung, Lihua Wang, Jigyasha Timsina, Dan Western, Ellen Liu, Pat Kohlfeld, John Budde, Edward N. Wilson, Yann Guen, Michael Haney, Andrew C. Yang, Taylor M. Maurer, Sanish Sathyan, Zihuai He, Michael Greicius, Katrin I. Andreasson, Erica F. Weiss, Stephen B. Montgomery, Sofiya Milman, Nir Barzilai, Anthony Wagner, Elizabeth Mormino, Carlos Cruchaga, Benoit Lehallier, Victor W. Henderson, Frank Longo, Tony Wyss-Coray.: Organ aging signatures in the plasma proteome track health and disease. Nature December 2023.

1e6 Michael S Haney, Archana Shankar, Ian Hsu, Masashi Miyauchi, Robert Palovics, Hwei Minn Khoo, Kyomi J Igarashi, Joydeep Bhadury, Christy Munson, Paul K Mack, Tze-Kai Tan, Tony Wyss-Coray, Hiromitsu Nakauchi, Adam C Wilkinson: Large-scale in vivo CRISPR screens identify SAGA complex members as a key regulators of HSC lineage commitment and aging. BioRxiv no volume(no issue): no pages, July 2022 Notes: Preprint.

18b Iram T, Kern F, Kaur A, Myneni S, Morningstar AR, Shin H, Garcia MA, Yerra L, Palovics R, Yang AC, Hahn O, Lu N, Shuken SR, Haney MS, Lehallier B, Iyer M, Luo J, Zetterberg H, Keller A, Zuchero JB, Wyss-Coray T.: Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17. Nature 605(7910): 509-515, May 2022.

1ad Vest RT, Chou CC, Zhang H, Haney MS, Li L, Laqtom NN, Chang B, Shuken S, Nguyen A, Yerra L, Yang AC, Green C, Tanga M, Abu-Remaileh M, Bassik MC, Frydman J, Luo J, Wyss-Coray T.: Small molecule C381 targets the lysosome to reduce inflammation and ameliorate disease in models of neurodegeneration. Proc Natl Acad Sci U S A 119(11): e2121609119, March 2022.

1c2 Pálovics R, Keller A, Schaum N, Tan W, Fehlmann T, Borja M, Kern F, Bonanno L, Calcuttawala K, Webber J, McGeever A; Tabula Muris Consortium; Luo J, Pisco AO, Karkanias J, Neff NF, Darmanis S, Quake SR, Wyss-Coray T.: Molecular hallmarks of heterochronic parabiosis at single-cell resolution. Nature 603(7900): 309-314, March 2022 Notes: Member of the Tabula Muris Consortium.

1f1 Pluvinage JV, Sun J, Claes C, Flynn RA, Haney MS, Iram T, Meng X, Lindemann R, Riley NM, Danhash E, Chadarevian JP, Tapp E, Gate D, Kondapavulur S, Cobos I, Chetty S, Pașca AM, Pașca SP, Berry-Kravis E, Bertozzi CR, Blurton-Jones M, Wyss-Coray T.: The CD22-IGF2R interaction is a therapeutic target for microglial lysosome dysfunction in Niemann-Pick type C. Science Translational Medicine 13(62): eabg2919, December 2021.

bb Li Q, Haney MS.: The role of glia in protein aggregation. Neurobiology of Disease 143(No issue): 105015, Sep 2020.

212 Schaum N, Lehallier B, Hahn O, Pálovics R, Hosseinzadeh S, Lee SE, Sit R, Lee DP, Losada PM, Zardeneta ME, Fehlmann T, Webber JT, McGeever A, Calcuttawala K, Zhang H, Berdnik D, Mathur V, Tan W, Zee A, Tan M; Tabula Muris Consortium; Pisco AO, Karkanias J, Neff NF, Keller A, Darmanis S, Quake SR, Wyss-Coray T.: Ageing hallmarks exhibit organ-specific temporal signatures. Nature 583(7817): 596-602, July 2020 Notes: Member of the Tabula Muris Consortium.

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