Ekaterina L. Grishchuk, Ph.D.

faculty photo
Associate Professor of Physiology
Department: Physiology

Contact information
Physiology Department
Perelman School of Medicine
University of Pennsylvania
415 Curie Blvd.
675A Clinical Research Building
Philadelphia, PA 19104
Office: (215) 746-8178
Fax: (215) 573-2273
Lab: (215) 746-8177
M.S. (Physics, specialization in Biophysics)
Moscow State University, Russia, 1990.
Ph.D. (Molecular, Cellular and Developmental Biology)
University of Colorado, Boulder, USA, 1997.
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Description of Research Expertise

Mechanisms that drive and control chromosome motions in mitosis

Selected Publications

Zaytsev Anatoly V, Dario Segura-Peña, Maxim Godzi, Abram Calderon, Edward R. Ballister, Rumen Stamatov, Alyssa M. Mayo, Laura Peterson, Ben E. Black, Fazly I. Ataullakhanov, Michael A. Lampson, Ekaterina L. Grishchuk : Bistability of a coupled Aurora B kinase-phosphatase system in cell division. eLife Jan 2016.

Zaytsev Anatoly V, Mick Jeanne E, Maslennikov Evgeny, Nikashin Boris, DeLuca Jennifer G, Grishchuk Ekaterina L: Multisite phosphorylation of the NDC80 complex gradually tunes its microtubule-binding affinity. Molecular Biology of the Cell 26(10): 1829-44, May 2015.

Barisic Marin, Sousa Ricardo S, Tripathy Suvranta K, Magiera Maria M, Zaytsev Anatoly V, Pereira Ana L, Janke Carsten, Grishchuk* Ekaterina L, Maiato* Helder: Microtubule detyrosination guides chromosomes during mitosis. Science 348(6236): 799-803, May 2015.

Zakharov Pavel, Gudimchuk Nikita, Voevodin Vladimir, Tikhonravov Alexander, Ataullakhanov Fazoil I, Grishchuk Ekaterina L : Molecular and mechanical causes of microtubule catastrophe and aging Biophysical Journal 109: 2574-91, Dec 2015.

Zaytsev Anatoly V, Sundin Lynsie, DeLuca Keith F, Grishchuk* Ekaterina L, DeLuca* Jennifer R: Accurate phosphoregulation of kinetochore-microtubule affinity requires unconstrained molecular interactions. Journal of Cell Biology 206(1): 45-59, Jun 2014.

Gudimchuk Nikita, Vitre Benjamin, Kim Yumi, Kiyatkin Anatoly, Cleveland Don W, Ataullakhanov Fazly I, Grishchuk Ekaterina L : Kinetochore kinesin CENP-E is a processive bi-directional tracker of dynamic microtubule tips Nature Cell Biology 15(9): 1079-88, Sep 2013.

Volkov Vladimir A, Zaytsev Anatoly V, Gudimchuk Nikita, Grissom Paula M, Gintsburg Anatoly L, Ataullakhanov Fazly I, McIntosh J Richard, Grishchuk Ekaterina L: Long tethers provide high-force coupling of the Dam1 ring to shortening microtubules. Proceedings of the National Academy of Sciences of the United States of America 110(19): 7708-13, May 2013.

McIntosh J Richard, Grishchuk Ekaterina L, Morphew Mary K, Efremov Artem K, Zhudenkov Kirill, Volkov Vladimir A, Cheeseman Iain M, Desai Arshad, Mastronarde David N, Ataullakhanov Fazly I: Fibrils connect microtubule tips with kinetochores: a mechanism to couple tubulin dynamics to chromosome motion. Cell 135(2): 322-33, Oct 2008.

Grishchuk Ekaterina L, Efremov Artem K, Volkov Vladimir A, Spiridonov Ilia S, Gudimchuk Nikita, Westermann Stefan, Drubin David, Barnes Georjana, McIntosh J Richard, Ataullakhanov Fazly I: The Dam1 ring binds microtubules strongly enough to be a processive as well as energy-efficient coupler for chromosome motion. Proceedings of the National Academy of Sciences of the United States of America 105(40): 15423-8, Oct 2008.

Grishchuk Ekaterina L, Molodtsov Maxim I, Ataullakhanov Fazly I, McIntosh J Richard: Force production by disassembling microtubules. Nature 438(7066): 384-8, Nov 2005.

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Last updated: 04/15/2021
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