Research Description

Our goal is to understand how cells segregate their chromosomes during cell division, a fundamental property of all living organisms. Errors in chromosome segregation constitute a serious threat to human health by generating abnormal genetic makeup, a hallmark feature of cancer cells. Our focus is on the remarkable ability of chromosomal structures called kinetochores to harness force from spindle microtubules and move while coupled to dynamic microtubule ends.  Using single molecule and laser trapping techniques, we reconstruct in vitro interactions between microtubules and purified kinetochore proteins, determining their ability to serve as mobile and force-bearing links.  With computational models, we work to rationalize physiological kinetochore behaviors based on the quantitative properties of these individual parts. With these multidisciplinary approaches, we aim to create a comprehensive understanding of mechanisms that ensure high fidelity of chromosome segregation in normal cells and to seek new strategies to prevent pathological chromosomal instability.

Commitment to Discovery and Integrity

• Our laboratory seeks to advance scientific knowledge by exploring the fundamental principles of nature and uncovering insights to drive medical innovation. We uphold the highest standards of integrity, ensuring that our work is guided by evidence, rigorous inquiry, and a commitment to truth. We foster a culture of continuous learning, collaboration, and intellectual curiosity, embracing diversity, inclusion, and multiculturalism as essential to innovation. Through these values, we strive to expand the boundaries of knowledge and create meaningful benefits for society.