Research Description
Our goal is to understand how cells segregate their chromosomes during cell division, a fundamental property of all living organisms. Errors in chromosome segregation constitute a serious threat to human health by generating abnormal genetic makeup, a hallmark feature of cancer cells. Our focus is on the remarkable ability of chromosomal structures called kinetochores to harness force from spindle microtubules and move while coupled to dynamic microtubule ends. Using single molecule and laser trapping techniques, we reconstruct in vitro interactions between microtubules and purified kinetochore proteins, determining their ability to serve as mobile and force-bearing links. With computational models, we work to rationalize physiological kinetochore behaviors based on the quantitative properties of these individual parts. With these multidisciplinary approaches, we aim to create a comprehensive understanding of mechanisms that ensure high fidelity of chromosome segregation in normal cells and to seek new strategies to prevent pathological chromosomal instability.
Diversity & Inclusion Initiatives
- We strive to create a culture based on continuous learning, diversity, and inclusion. We embrace multiculturalism and foster equality in both the workplace and society at large. For us, diversity and inclusion are fundamental in the creation of an inspirational workplace and being different yet complementary is how we drive our research forward.