Foteini Mourkioti

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Assistant Professor of Orthopaedic Surgery
Co-Director, Penn Institute of Regenerative Medicine, Musculoskeletal Regeneration Program
Department: Orthopaedic Surgery

Contact information
McKay Orthopaedic Research Laboratory
377A Stemmler Hall
3450 Hamilton Walk
Philadelphia, PA 19104-6081
Office: 215-898-8214
Fax: 215-573-2133
Lab: 215-573-3645
Graduate Group Affiliations
Education:
BA (Biology)
University of Patras, Faculty of Biology, Greece, 1998.
PhD (Genetics and Developmental Biology)
Max-Planck Institute for Biophysical Chemistry, Department Molecular Developmental Biology, Goettingen, Germany, 2002.
Post-Graduate Training
Muscle Biology, Mouse Genetics and Heart Failure, European Molecular Biology Laboratory (EMBL), Mouse Biology Unit, Italy, 2003-2008.
Stem Cell Biology, Stanford University School of Medicine, Baxter Laboratory for Stem Cell Biology, Clinical Sciences Research Center, 2009-2009.
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Description of Research Expertise

Keywords: muscle stem cells, stem cell activation, muscle disorders, mechanobiology, aging, telomeres, NF-kB signaling, muscle regeneration, stem cell regulation, muscular dystrophy, cardiomyopathy, mitochondria, oxidative stress, M2 macrophages, muscle atrophy, muscle wasting.

Selected Publications

Alexandra Stanley, Elisia Tichy, Jacob Kocan , Douglas W. Roberts, Eileen M. Shore and Foteini Mourkioti: Dynamics of skeletal muscle-resident stem cells during myogenesis in fibrodysplasia ossificans progressiva NPJ Regenerative Medicine-Nature November 2021 Notes: Paper accepted for publication (November 2021).

Nuoying Ma, Delia Chen, Paola Kuri, Edward Blake Hernandez, Jacob Kocan, Hamd Mahmood, Elisia D. Tichy, Panteleimon Rompolas and Foteini Mourkioti: Piezo1 regulates the regenerative capacity of skeletal muscles via orchestration of stem cell morphological states. In Revision November 2021.

Tichy ED, Ma N., Sidibe D., Loro E., Kocan J., Chen DZ., Khurana TS., Hasty P., Mourkioti F.: Persistent NF-κB activation in muscle stem cells induces proliferation-independent telomere shortening Cell Reports. Cell Press, 35(6), May 2021.

Lutian Yao, Elisia D. Tichy, Leilei Zhong, Sarthak Mohanty, Luqiang Wang, Emily Ai, Shuying Yang, Foteini Mourkioti1*, Ling Qin *: Gli1 defines a subset of fibroadipogenic progenitors that promote skeletal muscle regeneration with less fat accumulation. Journal of Bone and Mineral Research 36(6): 1159-1173, February 2021.

Suradip Das,, Kevin D. Browne, Franco A. Laimo, Joseph C. Maggiore, Melanie C. Hilman, Halimulati Kaisaier, Carlos A. Aguilar, Zarina S. Ali, Foteini Mourkioti, D. Kacy Cullen: Pre-Innervated Tissue Engineeried Muscle Promotes a Pro-Regenerative Microenvironment Following Volumetric Muscle Loss. Communications Biology-Nature 3(1), June 25 2020 Notes: doi: 10.1038/s42003-020-1056-4.

Sangkyun Cho, Manasvita Vashisth, Amal Abbas, Stephanie Majkut1,, Kenneth Vogel, Yuntao Xia, Irena Ivanovska, Jerome Irianto, Manorama Tewari, Elisia Tichy, Foteini Mourkioti, Hsin-Yao Tang, Roger A. Greenberg, Benjamin Prosser, and Dennis E. Discher : Mechanosensing by the lamina protects against nuclear rupture, DNA damage, and cell cycle arrest Developmental Cell 49(6): 920-935, May 2019.

Alexandra Stanley, Su-jin Heo, Robert L. Mauck, Foteini Mourkioti and Eileen M. Shore: Elevated BMP and mechanical signaling through YAP1/RhoA poises FOP mesenchymal progenitors for osteogenesis. Journal of Bone and Mineral Research 34(10): 1894-1909, May 2019.

Haupt J., Stanley A., McLeod, CM., Cosgrove BD., Culbert, AL., Wang L., Mourkioti F., Mauck RL., Shore EM.: ACVR1R206H FOP mutation alters mechanosensing and tissue stiffness during heterotopic ossification. Molecular Biology of the Cell 30(1): 17-29, January 2019.

Elisia D Tichy, David K. Sidibe, Christopher D. Greer, Nicholas M. Oyster, Panteleimon Rompolas, Nadia A. Rosenthal, Helen M. Blau and Foteini Mourkioti: A robust Pax7EGFP mouse that enables the visualization of dynamic behaviors in muscle stem cells. Skeletal Muscle 8, September 2018 Notes: doi: 10.1186/s13395-018-0169-7.

Ho PP, Lahey LJ, Mourkioti F, Kraft PE, Filareto A, Brandt M, Magnusson KEG, Finn EE, Chamberlain JS, Robinson WH, Blau HM, Steinman L.: Engineered DNA plasmid reduces immunity to dystrophin while improving muscle force in a model of gene therapy of Duchenne dystrophy. Proc Natl Acad Sci U S A. 115(39): E9182-E9191, September 2018.

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Last updated: 11/29/2021
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