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David A. Hill
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Assistant Professor of Pediatrics (Allergy/Immunology)
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Department: Pediatrics
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Graduate Group Affiliations
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- Immunology 6b
- Cell and Molecular Biology e
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Contact information
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Children's Hospital of Philadelphia
2a Division of Allergy and Immunology
20 Department of Pediatrics
36 Abramson Pediatric Research Center, Room 1208B
3a 3615 Civic Center Blvd.
Philadelphia, PA 19104
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2a Division of Allergy and Immunology
20 Department of Pediatrics
36 Abramson Pediatric Research Center, Room 1208B
3a 3615 Civic Center Blvd.
Philadelphia, PA 19104
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Office: 215-590-2549
32 Fax: 215-590-6849
32 Lab: 267-426-7777
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32 Fax: 215-590-6849
32 Lab: 267-426-7777
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Publications
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Education:
21 7 BS 2d (Biological Sciences, with honors) c
48 Carnegie Mellon University, Elizabeth Jones Lab, 2005.
21 8 PhD 27 (Cell and Molecular Biology) c
57 University of Pennsylvania School of Medicine, David Artis Lab, 2011.
21 7 MD 15 (Medicine) c
46 University of Pennsylvania School of Medicine, 2013.
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Permanent link21 7 BS 2d (Biological Sciences, with honors) c
48 Carnegie Mellon University, Elizabeth Jones Lab, 2005.
21 8 PhD 27 (Cell and Molecular Biology) c
57 University of Pennsylvania School of Medicine, David Artis Lab, 2011.
21 7 MD 15 (Medicine) c
46 University of Pennsylvania School of Medicine, 2013.
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Description of Clinical Expertise
52 Food allergy, eosinophilic esophagitis, obesity-associated asthma.71
Description of Research Expertise
230 The Hill Lab investigates how diet and metabolism impact immune health and contribute to inflammatory diseases. Our research focuses on key areas such as food allergies, obesity-associated asthma, and immunometabolism. By integrating clinical epidemiology with mechanistic studies in animal models and patient samples, we aim to uncover the underlying mechanisms that drive immune responses. Our goal is to translate these findings into innovative preventative, diagnostic, and therapeutic strategies to improve human health and combat disease.e 29
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14a Dilollo J, Guerrier CM, De La Torre ISR, Martin E, Lee S, Pratt M, Vinnakota P, Faig W, Paessler ME, Spergel JM, Hill DA: Evaluation of Functional T-Cell Assays that Predict Causal Allergens in Eosinophilic Esophagitis. Diagnostics Page: In Press, Dec 2025.
f2 Hill DA: Explaining Divergent Food Allergy Phenotypes Through Failures in T and B Cell Tolerance. Journal of Allergy and Clinical Immunology 156(6): 1511-1513, Dec 2025.
10b Gabryszewski SJ, Dudley J, Faerber JA, Grundmeier RW, Fiks AG, Spergel JM, Hill DA: Guidelines for early food introduction and patterns of food allergy. Pediatrics 156(5): e2024070516, Nov 2025.
11b Clement RL , Dilollo J, Rodríguez-López EM, Guerrier CM, Hill DA: IFNγ signaling impairs regulatory B cell function resulting in worse control of esophageal food allergy. Allergy 80(10): 2824-2836, Oct 2025.
132 Pandey D, Chini J, McCright S, Hill DA: A CD9-dependent, liver-adipose tissue axis regulates inflammation and metabolic dysfunction during obesity. 2025 Joslin International Symposium. Boston, MA. Oct 2025 Notes: Poster presentation.
16d Wolfset N, Muir AB, Benitez A, Williams D, Torre IDL, Ruffner MA, Hill DA, Cazeau C, Angello JT, Radwan A, Durrani S, DeMarchi S, Spergel JM: Efficacy of dupilumab on facilitated food reintroduction in eosinophilic esophagitis. Clinical Gastroenterology and Hepatology 3(25): 745-1, Sep 2025.
173 McCright SJ, Harding O, ChiniJ, DeMarco N, Hung LY, Pastore C, Lu W, Rabinowitz J, Henao-Mejia J, Herbert DR, Young LR, Hill DA: Dietary long chain fatty acids shape innate immune cell tone and modulate inflammatory responses in the lung. Science Translational Medicine 17(813): eadp5653, Aug 2025.
161 Dilollo J, Hu A, Qu H, Canziani KE, Clement RL, McCright SJ, Shreffler WG, Hakonarson H, Spergel JM, Cerosaletti K, Hill DA: A molecular basis for milk allergen immune recognition in eosinophilic esophagitis. Journal of Allergy and Clinical Immunology 155(4): 1396-1399, Apr 2025.
172 Harding L, McCright S, Hill DA: Dietary stearate alters lung myeloid cell metabolism and causes inflammasome-dependent IL-1β cytokine production. American Academy of Allergy, Asthma & Immunology Annual Meeting Annual Meeting Discovery Session. San Diego, CA. Feb 2025 Notes: Poster presentation.
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Selected Publications
19a Rodríguez-López E, Clement RL, Lal M, Zhou Y, Carro SD, Assenmacher CA, Gautam R, Beers J, Muir AB, Spergel JM, Ruffner MA, Eisenlohr LC, Hill DA: Esophageal epithelial cell-intrinsic MHCII regulates food antigen-dependent eosinophilic esophagitis in an IFNγ-dependent manner. Clinical & Experimental Allergy Page: In press, Dec 2025.14a Dilollo J, Guerrier CM, De La Torre ISR, Martin E, Lee S, Pratt M, Vinnakota P, Faig W, Paessler ME, Spergel JM, Hill DA: Evaluation of Functional T-Cell Assays that Predict Causal Allergens in Eosinophilic Esophagitis. Diagnostics Page: In Press, Dec 2025.
f2 Hill DA: Explaining Divergent Food Allergy Phenotypes Through Failures in T and B Cell Tolerance. Journal of Allergy and Clinical Immunology 156(6): 1511-1513, Dec 2025.
10b Gabryszewski SJ, Dudley J, Faerber JA, Grundmeier RW, Fiks AG, Spergel JM, Hill DA: Guidelines for early food introduction and patterns of food allergy. Pediatrics 156(5): e2024070516, Nov 2025.
11b Clement RL , Dilollo J, Rodríguez-López EM, Guerrier CM, Hill DA: IFNγ signaling impairs regulatory B cell function resulting in worse control of esophageal food allergy. Allergy 80(10): 2824-2836, Oct 2025.
132 Pandey D, Chini J, McCright S, Hill DA: A CD9-dependent, liver-adipose tissue axis regulates inflammation and metabolic dysfunction during obesity. 2025 Joslin International Symposium. Boston, MA. Oct 2025 Notes: Poster presentation.
16d Wolfset N, Muir AB, Benitez A, Williams D, Torre IDL, Ruffner MA, Hill DA, Cazeau C, Angello JT, Radwan A, Durrani S, DeMarchi S, Spergel JM: Efficacy of dupilumab on facilitated food reintroduction in eosinophilic esophagitis. Clinical Gastroenterology and Hepatology 3(25): 745-1, Sep 2025.
173 McCright SJ, Harding O, ChiniJ, DeMarco N, Hung LY, Pastore C, Lu W, Rabinowitz J, Henao-Mejia J, Herbert DR, Young LR, Hill DA: Dietary long chain fatty acids shape innate immune cell tone and modulate inflammatory responses in the lung. Science Translational Medicine 17(813): eadp5653, Aug 2025.
161 Dilollo J, Hu A, Qu H, Canziani KE, Clement RL, McCright SJ, Shreffler WG, Hakonarson H, Spergel JM, Cerosaletti K, Hill DA: A molecular basis for milk allergen immune recognition in eosinophilic esophagitis. Journal of Allergy and Clinical Immunology 155(4): 1396-1399, Apr 2025.
172 Harding L, McCright S, Hill DA: Dietary stearate alters lung myeloid cell metabolism and causes inflammasome-dependent IL-1β cytokine production. American Academy of Allergy, Asthma & Immunology Annual Meeting Annual Meeting Discovery Session. San Diego, CA. Feb 2025 Notes: Poster presentation.
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